ATE142640T1 - Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten - Google Patents

Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten

Info

Publication number: ATE142640T1
Authority: AT; Austria
Prior art keywords: derivatives; triterpender; receptor antagonists; containing same; endothelin receptor
Prior art date: 1993-06-11

Application number

AT94304165T

Other languages

English (en)

Inventor

Toshiro Konoike

Yoshitaka Araki

Tetsuyoshi Hayashi

Kensuke Sakurai

Takehiko Tozyo

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1994-06-09

Publication date

1996-09-15

1994-06-09 Application filed by Shionogi & Co filed Critical Shionogi & Co

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE142640T1 publication Critical patent/ATE142640T1/de

Links

229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
239000002308 endothelin receptor antagonist Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004185 ester group Chemical group 0.000 abstract 2
230000002503 metabolic effect Effects 0.000 abstract 2
102000002045 Endothelin Human genes 0.000 abstract 1
108050009340 Endothelin Proteins 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
150000003648 triterpenes Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94304165T 1993-06-11 1994-06-09 Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten ATE142640T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP14041693		1993-06-11

Publications (1)

Publication Number	Publication Date
ATE142640T1 true ATE142640T1 (de)	1996-09-15

Family

ID=15268217

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT95112524T ATE165811T1 (de)	1993-06-11	1994-06-09	Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n
AT94304165T ATE142640T1 (de)	1993-06-11	1994-06-09	Triterpenderivate und diese enthaltende endothelinrezeptor antagonisten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT95112524T ATE165811T1 (de)	1993-06-11	1994-06-09	Zwischenprodukte für die herstellung von endothelinrezeptor-antagonist-triterpen-derivat n

Country Status (11)

Country	Link
US (2)	US5463107A (de)
EP (2)	EP0628569B1 (de)
JP (1)	JP2724114B2 (de)
KR (1)	KR100201015B1 (de)
CN (2)	CN1041938C (de)
AT (2)	ATE165811T1 (de)
DE (2)	DE69400506T2 (de)
DK (1)	DK0628569T3 (de)
ES (2)	ES2116663T3 (de)
GR (1)	GR3021952T3 (de)
TW (1)	TW272974B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2116663T3 (es)	1993-06-11	1998-07-16	Shionogi & Co	Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.
TR199701497T1 (xx) *	1995-06-02	1998-06-22	Shionogi & Co., Ltd.	Beyin �demini �nleyen terkip.
WO1997027314A1 (fr) *	1996-01-23	1997-07-31	Shionogi & Co., Ltd.	Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse
JP2007217438A (ja) *	2001-07-17	2007-08-30	Shionogi & Co Ltd	注射用医薬製剤
TWI232102B (en)	2001-07-17	2005-05-11	Shionogi & Co	A pharmaceutical formulation for injection
CA2480096A1 (en) *	2002-03-22	2003-10-02	Shionogi & Co., Ltd.	Process for producing triterpene derivatives
US20070009444A1 (en) *	2003-06-04	2007-01-11	Hiroshi Yamaguchi	Method for preparing powder exhibiting low susceptibility to electrification
TWI335335B (en) *	2004-03-24	2011-01-01	Shionogi & Co	A novel crystal of a triterpene derivative
EP1757573A4 (de)	2004-05-14	2008-05-07	Shionogi & Co	Oxidationsreaktion von alkohol mit wasserstoffperoxid und wolframkatalysator
WO2006077801A1 (ja) *	2005-01-18	2006-07-27	Shionogi & Co., Ltd.	ミリセロン誘導体の製造方法
KR20080077381A (ko) *	2005-12-21	2008-08-22	시오노기세이야쿠가부시키가이샤	허혈성 뇌졸중 치료제 또는 치료 방법
US7795306B2 (en) *	2006-03-03	2010-09-14	Inderjit Kumar Dev	Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB
US20070207989A1 (en) *	2006-03-03	2007-09-06	Savipu Pharmaceuticals	Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US7323476B2 (en) *	2006-03-03	2008-01-29	Savipu Pharmaceuticals	Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070243273A1 (en) *	2006-04-12	2007-10-18	Savipu Pharmaceuticals	Reduction of the Deleterious Effects of Tobacco Smoking
US20080017207A1 (en) *	2006-07-18	2008-01-24	Savipu Pharmaceuticals	Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) *	2007-02-05	2008-08-07	Savipu Pharmaceuticals	Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) *	2007-07-17	2009-01-22	Inderjit Kumar Dev	Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0526642T3 (da) *	1991-01-29	1998-10-19	Shionogi & Co	Triterpenderivat
ES2116663T3 (es)	1993-06-11	1998-07-16	Shionogi & Co	Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.

1994
- 1994-06-09 ES ES95112524T patent/ES2116663T3/es not_active Expired - Lifetime
- 1994-06-09 DK DK94304165.7T patent/DK0628569T3/da active
- 1994-06-09 JP JP6127420A patent/JP2724114B2/ja not_active Expired - Fee Related
- 1994-06-09 ES ES94304165T patent/ES2094622T3/es not_active Expired - Lifetime
- 1994-06-09 EP EP94304165A patent/EP0628569B1/de not_active Expired - Lifetime
- 1994-06-09 DE DE69400506T patent/DE69400506T2/de not_active Expired - Lifetime
- 1994-06-09 AT AT95112524T patent/ATE165811T1/de not_active IP Right Cessation
- 1994-06-09 EP EP95112524A patent/EP0682009B1/de not_active Expired - Lifetime
- 1994-06-09 TW TW083105247A patent/TW272974B/zh not_active IP Right Cessation
- 1994-06-09 AT AT94304165T patent/ATE142640T1/de not_active IP Right Cessation
- 1994-06-09 DE DE69410081T patent/DE69410081T2/de not_active Expired - Lifetime
- 1994-06-10 US US08/258,392 patent/US5463107A/en not_active Expired - Lifetime
- 1994-06-10 CN CN94102805A patent/CN1041938C/zh not_active Expired - Fee Related
- 1994-06-10 KR KR1019940013068A patent/KR100201015B1/ko not_active Expired - Fee Related
1995
- 1995-07-26 US US08/507,211 patent/US5587505A/en not_active Expired - Lifetime
1996
- 1996-12-10 GR GR960403369T patent/GR3021952T3/el unknown
1998
- 1998-05-20 CN CN98109227A patent/CN1070183C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5463107A (en)	1995-10-31
EP0682009A2 (de)	1995-11-15
US5587505A (en)	1996-12-24
ES2116663T3 (es)	1998-07-16
TW272974B (de)	1996-03-21
DE69400506T2 (de)	1997-02-13
EP0682009B1 (de)	1998-05-06
CN1070183C (zh)	2001-08-29
DE69410081T2 (de)	1998-10-08
ATE165811T1 (de)	1998-05-15
CN1041938C (zh)	1999-02-03
GR3021952T3 (en)	1997-03-31
CN1215725A (zh)	1999-05-05
EP0628569A1 (de)	1994-12-14
KR950000663A (ko)	1995-01-03
JP2724114B2 (ja)	1998-03-09
ES2094622T3 (es)	1997-01-16
EP0682009A3 (de)	1997-02-05
JPH0753484A (ja)	1995-02-28
EP0628569B1 (de)	1996-09-11
DE69410081D1 (de)	1998-06-10
KR100201015B1 (ko)	1999-06-15
DK0628569T3 (da)	1996-09-30
DE69400506D1 (de)	1996-10-17
CN1106368A (zh)	1995-08-09

Legal Events

Date	Code	Title	Description
1997-04-15	UEP	Publication of translation of european patent specification
2012-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69400506D1 (de)	1996-10-17	Triterpenderivate und diese enthaltende Endothelinrezeptor Antagonisten
ES2086270T5 (es)	2001-02-01	Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos.
MX9102407A (es)	1994-05-31	4 arilpiperazinas y 4-arilpiperidinas novedosas.
SE9604786D0 (sv)	1996-12-20	New compounds
DK1920764T3 (da)	2012-07-02	Fluprostenolisopropylester til anvendelse i behandling af glaukom og okulær hypertension
ATE164588T1 (de)	1998-04-15	Triterpenderivat
DE69713582D1 (de)	2002-08-01	Zimtsäurederivate und deren verwendung als integrin-antagonisten
EP0896533A4 (de)	1999-04-28	Pentafluorobenzensulfonamiden und analoge
ES2172580T3 (es)	2002-10-01	1,3-oxatiolanos sustituidos con propiedades antiviricas.
PE13391A1 (es)	1991-04-17	Procedimiento de preparacion de derivados de piperazina
ES2087038A1 (es)	1996-07-01	Nuevas piperidinas con actividad antagonista del paf.
ES2106531T3 (es)	1997-11-01	Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
BR8902929A (pt)	1990-03-20	Artigo vendavel
DK0573218T3 (da)	2001-06-18	4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse
ATE161531T1 (de)	1998-01-15	Acridine-1,8-dionderivate als therapeutisches mittel
NO915021L (no)	1991-12-19	Nye metylenbisfosfonsyrederivater
IL90559A0 (en)	1990-01-18	Analgetic derivatives of phenothiazine
FI923662A0 (fi)	1992-08-14	Terapeutiska medel.
ATE110569T1 (de)	1994-09-15	Pharmazeutische zusammensetzung zur verbesserung von dysuria.
IL101506A0 (en)	1992-12-30	Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
NZ216125A (en)	1988-10-28	Isoxazoles and pharmaceutical compositions
EP0802179A4 (de)	2000-04-05	Derivate substituierter amidinonaphthylester
DE59504374D1 (de)	1999-01-14	Verwendung von Deoxyspergualin zur Herstellung eines Arzneimittels zur Behandlung von entzündlich-hyperreaktiven Erkrankungen
IE781545L (en)	1979-02-01	Benzimidazole-2-derivatives.
ATE92461T1 (de)	1993-08-15	Gegen die zerebrale insuffizienz wirksame verbindungen.