ATE143375T1 - Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode - Google Patents

Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode

Info

Publication number
ATE143375T1
ATE143375T1 AT91901286T AT91901286T ATE143375T1 AT E143375 T1 ATE143375 T1 AT E143375T1 AT 91901286 T AT91901286 T AT 91901286T AT 91901286 T AT91901286 T AT 91901286T AT E143375 T1 ATE143375 T1 AT E143375T1
Authority
AT
Austria
Prior art keywords
thyrotropine
receptor
thryrotropine
tshr
tsh
Prior art date
Application number
AT91901286T
Other languages
English (en)
Inventor
Marc Parmentier
Frederic Libert
Jacques Dumont
Gilbert Vassart
Original Assignee
Brahms Diagnostica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brahms Diagnostica Gmbh filed Critical Brahms Diagnostica Gmbh
Application granted granted Critical
Publication of ATE143375T1 publication Critical patent/ATE143375T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/854—Glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT91901286T 1989-12-14 1990-12-12 Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode ATE143375T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89403493A EP0433509B1 (de) 1989-12-14 1989-12-14 Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide

Publications (1)

Publication Number Publication Date
ATE143375T1 true ATE143375T1 (de) 1996-10-15

Family

ID=8203015

Family Applications (2)

Application Number Title Priority Date Filing Date
AT89403493T ATE145240T1 (de) 1989-12-14 1989-12-14 Polypeptide mit thyrotropinrezeptor-aktivität, kodierende nukleinsäuresequenzen für solche rezeptoren und verwendung dieser polypeptide
AT91901286T ATE143375T1 (de) 1989-12-14 1990-12-12 Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT89403493T ATE145240T1 (de) 1989-12-14 1989-12-14 Polypeptide mit thyrotropinrezeptor-aktivität, kodierende nukleinsäuresequenzen für solche rezeptoren und verwendung dieser polypeptide

Country Status (10)

Country Link
US (1) US6228597B1 (de)
EP (2) EP0433509B1 (de)
JP (1) JP3090682B2 (de)
AT (2) ATE145240T1 (de)
AU (1) AU641209B2 (de)
CA (1) CA2046917C (de)
DE (2) DE68927461T2 (de)
DK (1) DK0458940T3 (de)
ES (2) ES2092998T3 (de)
WO (1) WO1991009121A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
DE69033990T2 (de) * 1989-05-05 2003-02-13 Genentech, Inc. Glykoprotein-Hormonrezeptor-Moleküle
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体
EP0482598A3 (en) * 1990-10-24 1993-05-19 Ishihara Sangyo Kaisha, Ltd. Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism
EP0719858A3 (de) * 1994-12-27 1997-12-29 Tosoh Corporation Myeloma Zell-Linie die den rekombinanten menschlichen Rezeptor für das thyroid-stimulierenden Hormon exprimiert
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE19801154A1 (de) * 1998-01-14 1999-07-15 Brahms Diagnostica Gmbh Verfahren zur Herstellung von gereinigten und gegebenenfalls markierten TSH-Rezeptor-Präparaten, neue radioiodierte TSH-Rezeptor-Präparate, und die Verwendung derartiger Präparate in Diagnostik und Therapie
DE19907094C1 (de) 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
WO2001027634A2 (de) * 1999-10-12 2001-04-19 Ulrich Loos Verfahren zur bestimmung von autoantikörpern gegen den tsh-rezeptor
WO2002034042A2 (en) * 2000-10-26 2002-05-02 Deltagen, Inc. Knockout mice thyroid stimulating hormone receptor (tsh-r) gene
GB2376016A (en) * 2001-05-30 2002-12-04 Nadir R Farid Thyrotropin receptor (TSHR) domain cleavage catalysed by the metalloprotease ADAM 10
ES2736165T3 (es) * 2001-08-23 2019-12-26 Rsr Ltd Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas
JP4744147B2 (ja) 2002-11-26 2011-08-10 ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー アフィニティー精製抗体を用いた甲状腺刺激ホルモン受容体自己抗体の同定
KR101468830B1 (ko) 2005-06-24 2014-12-03 바이엘 크롭사이언스 엔.브이. 식물 세포벽의 반응성을 변경하는 방법
US8097699B2 (en) 2006-08-30 2012-01-17 Rsr Limited Crystal structure of thyroid stimulating hormone receptor
US8350012B2 (en) * 2007-01-25 2013-01-08 Cedars-Sinai Medical Center Inverse agonist monoclonal antibody that suppresses thyrotropin receptor constitutive activity
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
US20240426837A1 (en) * 2021-09-22 2024-12-26 Xiamen Innobiomax Biotechnology Co., Ltd. Recombinant thyroid-stimulating hormone receptor protein, preparation method and application thereof
WO2026028159A1 (en) 2024-07-31 2026-02-05 Biohaven Therapeutics Ltd. Bifunctional degraders for the treatment of graves' disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4448764A (en) * 1982-07-06 1984-05-15 Pierce Chemical Company Direct-acting iodinating reagent
DE3609271A1 (de) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper
US5144007A (en) * 1988-11-03 1992-09-01 La Jolla Cancer Research Foundation Thyroid hormone receptor
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体

Also Published As

Publication number Publication date
JP3090682B2 (ja) 2000-09-25
EP0433509A2 (de) 1991-06-26
CA2046917A1 (en) 1991-06-15
AU7038691A (en) 1991-07-18
EP0433509A3 (en) 1991-07-24
ES2092998T3 (es) 1996-12-16
WO1991009121A2 (en) 1991-06-27
DE68927461D1 (de) 1996-12-19
DE69028695T2 (de) 1997-02-20
JPH04506752A (ja) 1992-11-26
CA2046917C (en) 2003-07-01
DK0458940T3 (da) 1996-11-11
WO1991009121A3 (en) 1991-09-19
EP0458940A1 (de) 1991-12-04
ATE145240T1 (de) 1996-11-15
US6228597B1 (en) 2001-05-08
DE69028695D1 (de) 1996-10-31
DE68927461T2 (de) 1997-03-20
AU641209B2 (en) 1993-09-16
EP0458940B1 (de) 1996-09-25
EP0433509B1 (de) 1996-11-13
ES2091317T3 (es) 1996-11-01

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Legal Events

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EELA Cancelled due to lapse of time