ATE143730T1 - Lipidmembranen fur biosensoranwendungen - Google Patents

Lipidmembranen fur biosensoranwendungen

Info

Publication number
ATE143730T1
ATE143730T1 AT93911493T AT93911493T ATE143730T1 AT E143730 T1 ATE143730 T1 AT E143730T1 AT 93911493 T AT93911493 T AT 93911493T AT 93911493 T AT93911493 T AT 93911493T AT E143730 T1 ATE143730 T1 AT E143730T1
Authority
AT
Austria
Prior art keywords
layer
thiolipid
pct
phospholipid
gold
Prior art date
Application number
AT93911493T
Other languages
English (en)
Inventor
Holger Lang
Bernd Koenig
Horst Vogel
Original Assignee
Ecole Polytech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytech filed Critical Ecole Polytech
Application granted granted Critical
Publication of ATE143730T1 publication Critical patent/ATE143730T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
AT93911493T 1992-04-22 1993-04-21 Lipidmembranen fur biosensoranwendungen ATE143730T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92303592 1992-04-22

Publications (1)

Publication Number Publication Date
ATE143730T1 true ATE143730T1 (de) 1996-10-15

Family

ID=8211339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93911493T ATE143730T1 (de) 1992-04-22 1993-04-21 Lipidmembranen fur biosensoranwendungen

Country Status (6)

Country Link
US (1) US5756355A (de)
EP (1) EP0637384B1 (de)
JP (1) JPH07508342A (de)
AT (1) ATE143730T1 (de)
DE (1) DE69305160T2 (de)
WO (1) WO1993021528A1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010055581A1 (en) 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
SE9403245D0 (sv) * 1994-09-26 1994-09-26 Pharmacia Biosensor Ab Improvements relating to bilayer lipid membranes
AUPM950094A0 (en) * 1994-11-16 1994-12-08 Australian Membrane And Biotechnology Research Institute Detection device and method
DE4444893A1 (de) * 1994-12-16 1996-06-20 Merck Patent Gmbh Peptide und synthetische Zellmembranen
WO1996038726A1 (en) * 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
AUPN366995A0 (en) * 1995-06-20 1995-07-13 Australian Membrane And Biotechnology Research Institute Self-assembly of bilayer membrane sensors
AU692107B2 (en) * 1995-06-20 1998-05-28 Ambri Limited Detection of small analytes
AUPN366895A0 (en) * 1995-06-20 1995-07-13 Australian Membrane And Biotechnology Research Institute Detection of small analytes
US5879878A (en) * 1995-06-20 1999-03-09 Australian Membrane And Biotechnology Research Institute Method of producing a first layer electrode membrane for a biosensor
EP0842418A4 (de) * 1995-08-01 2004-08-18 Ambri Ltd Sensor mit verbundmembran
DE19607279A1 (de) 1996-02-27 1997-08-28 Bayer Ag Durch Festkörper unterstützte Membran-Biosensoren
US6107080A (en) * 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
DE19622628A1 (de) * 1996-06-05 1997-12-11 Boehringer Mannheim Gmbh Stabilisierung von Metallkonjugaten
SE9602545L (sv) 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
DE69735601T2 (de) * 1996-11-29 2007-10-18 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer-membranen und ihre anwendungsverfahren
US6699719B2 (en) * 1996-11-29 2004-03-02 Proteomic Systems, Inc. Biosensor arrays and methods
US6503452B1 (en) 1996-11-29 2003-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biosensor arrays and methods
US7169272B2 (en) * 1997-04-30 2007-01-30 Board Of Trustees Of The University Of Arkansas Microfabricated recessed disk microelectrodes: characterization in static and convective solutions
AUPO717197A0 (en) * 1997-06-04 1997-07-03 Australian Membrane And Biotechnology Research Institute Improved biosensor
GB9712386D0 (en) 1997-06-14 1997-08-13 Univ Coventry Biosensor
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
US7229841B2 (en) 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
ATE393912T1 (de) 1998-02-04 2008-05-15 Invitrogen Corp Microarrays und ihre verwendungen
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
WO1999067640A1 (en) * 1998-06-22 1999-12-29 The Regents Of The University Of California Triggered optical biosensor
JP3297861B2 (ja) * 1998-06-29 2002-07-02 日本航空電子工業株式会社 めっき材
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6500571B2 (en) 1998-08-19 2002-12-31 Powerzyme, Inc. Enzymatic fuel cell
CN1075442C (zh) * 1998-08-28 2001-11-28 清华大学 聚苯乙烯作为基底的生物敏感膜及其制备方法
AU2898500A (en) 1999-03-02 2000-09-21 Helix Biopharma Corporation Biosensor device and method
US6977155B2 (en) * 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
US7678539B2 (en) 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
US7138238B2 (en) 2001-02-06 2006-11-21 Auburn University Ligand sensor devices and uses thereof
AU2002243129B2 (en) * 2001-03-14 2007-07-19 Ge Healthcare Bio-Sciences Ab Method of preparing supported lipid film membranes and use thereof
SE0100875D0 (sv) * 2001-03-14 2001-03-14 Biacore Ab Method of preparing supported lipid film membranes and use thereof
DE10112505C1 (de) * 2001-03-15 2003-01-30 Iongate Biosciences Gmbh Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung
US20030113606A1 (en) * 2001-04-13 2003-06-19 Rosalyn Ritts Biocompatible membranes of block copolymers and fuel cells produced therewith
US20030049511A1 (en) * 2001-04-13 2003-03-13 Rosalyn Ritts Stabilized biocompatible membranes of block copolymers and fuel cells produced therewith
US20030129469A1 (en) * 2001-04-13 2003-07-10 Sun Hoi-Cheong Steve Fuel cell with fuel concentrate metering
US20030031911A1 (en) * 2001-04-13 2003-02-13 Rosalyn Ritts Biocompatible membranes and fuel cells produced therewith
WO2003016040A1 (en) * 2001-04-16 2003-02-27 The Regents Of The University Of California Membrane mimetic architectures on nanoporous materials
FR2828491B1 (fr) * 2001-08-07 2003-10-10 Warner Lambert Co Nouvelle membrane supportee, preparation et utilisations
AU2002324944A1 (en) * 2001-09-07 2003-03-24 The Arizona Board Of Regents On Behalf Of The University Of Arizona Distinguishing agonists, antagonists, and inverse agonists using pwr
DE10222588B4 (de) * 2002-05-22 2008-09-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Biomimetische Systeme aus Lipidmembranen gebunden an ein Substrat
DE10224567B4 (de) * 2002-06-03 2014-10-23 Boehringer Ingelheim Vetmedica Gmbh Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Anordnung
EP1369692A3 (de) * 2002-06-04 2003-12-17 Interuniversitaire Microelectronica Centrum vzw ( IMEC) Sensoroberfläche
US7547381B2 (en) * 2003-09-26 2009-06-16 Agency For Science, Technology And Research And National University Of Singapore Sensor array integrated electrochemical chip, method of forming same, and electrode coating
JP2008504216A (ja) 2003-12-02 2008-02-14 サイトイミューン サイエンシズ インコーポレイテッド モノクローナル抗体の生成のための方法および組成物
US20060094053A1 (en) * 2004-11-04 2006-05-04 Dimitrios Stamou Self-assembled arrays of lipid-bilayer vesicles
WO2007061981A2 (en) * 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
CN101495656B (zh) * 2006-06-07 2017-02-08 纽约哥伦比亚大学理事会 采用带修饰的核苷酸通过纳米通道进行dna序列测定
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009062151A1 (en) 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
JP5105535B2 (ja) * 2008-03-25 2012-12-26 国立大学法人東京工業大学 匂いセンサ用感応膜および匂いセンサ素子
JP5539962B2 (ja) 2008-04-25 2014-07-02 ノースウェスタン、ユニバーシティ コレステロールを隔離するのに適したナノ構造体
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
EP2525780B1 (de) 2010-01-19 2022-09-07 Northwestern University Synthetische nanostrukturen mit nukleinsäuren und/oder anderen einheiten
US8324914B2 (en) * 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US9605307B2 (en) * 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US20120052188A1 (en) * 2010-02-08 2012-03-01 Genia Technologies, Inc. Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
CN103282518B (zh) 2010-12-17 2016-11-16 纽约哥伦比亚大学理事会 使用经修饰的核苷酸和纳米孔检测的dna边合成边测序
US9121059B2 (en) 2010-12-22 2015-09-01 Genia Technologies, Inc. Nanopore-based single molecule characterization
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
US9850534B2 (en) 2012-02-16 2017-12-26 Genia Technologies, Inc. Methods for creating bilayers for use with nanopore sensors
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
WO2013154999A2 (en) 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Method of preparation of nanopore and uses thereof
JP2015525077A (ja) 2012-06-15 2015-09-03 ジェニア・テクノロジーズ・インコーポレイテッド チップの構成および高精度な核酸配列決定
ES2779699T3 (es) 2012-06-20 2020-08-18 Univ Columbia Secuenciación de ácidos nucleicos mediante detección en nanoporos de moléculas de etiqueta
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US10732183B2 (en) 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
CA2919268C (en) 2013-07-25 2023-09-05 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
EP3060918B1 (de) 2013-10-23 2019-09-18 Genia Technologies, Inc. Schnelle molekulare erfassung mit nanoporen
US9567630B2 (en) 2013-10-23 2017-02-14 Genia Technologies, Inc. Methods for forming lipid bilayers on biochips
US10240195B2 (en) 2014-03-24 2019-03-26 The Trustees Of Columbia University In The City Of New York Chemical methods for producing tagged nucleotides
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
BR112017007012A2 (pt) 2014-10-06 2018-03-06 Exicure Inc compostos anti-tnf
WO2016081911A2 (en) 2014-11-21 2016-05-26 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
JP6400483B2 (ja) * 2015-01-06 2018-10-03 国立大学法人神戸大学 ナノギャップ構造型基板
US10078092B2 (en) 2015-03-18 2018-09-18 Northwestern University Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules
CA3023451A1 (en) 2016-05-06 2017-11-09 Exicure, Inc. Liposomal spherical nucleic acid (sna) constructs presenting antisense oligonucleotides (aso) for specific knockdown of interleukin 17 receptor mrna
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018132685A1 (en) * 2017-01-12 2018-07-19 Nanotech Biomachines, Inc. Quantitative measurement of membrane protein function on a biosensor
WO2018201090A1 (en) 2017-04-28 2018-11-01 Exicure, Inc. Synthesis of spherical nucleic acids using lipophilic moieties
CN111100789B (zh) * 2018-12-24 2023-08-11 天津大学 一种基于特超声声孔效应的磷脂膜开孔系统及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
JP2682859B2 (ja) * 1987-07-27 1997-11-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション レセプター膜
DE68926118T2 (de) * 1988-08-18 1996-08-22 Australian Membrane And Biotechnology Research Institute Ltd. Commonwealth Scientific And Industrial Research Organization, North Ryde, Neusuedwales Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren
IL93020A (en) * 1990-01-09 1995-06-29 Yeda Res & Dev Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules
DE69232641T2 (de) * 1991-03-27 2003-02-20 Ambri Ltd., Chatswood Ionisches reservoir an der oberfläche einer elektrode

Also Published As

Publication number Publication date
DE69305160D1 (de) 1996-11-07
EP0637384A1 (de) 1995-02-08
EP0637384B1 (de) 1996-10-02
JPH07508342A (ja) 1995-09-14
WO1993021528A1 (en) 1993-10-28
US5756355A (en) 1998-05-26
DE69305160T2 (de) 1997-04-30

Similar Documents

Publication Publication Date Title
DE69305160D1 (de) Lipidmembranen fur biosensoranwendungen
JP3213341B2 (ja) バイオセンサー
US7510882B2 (en) Method and biosensor for analysis
CA2251674C (en) Biosensor device and method
US6300141B1 (en) Card-based biosensor device
Taylor et al. An acetylcholine receptor-based biosensor for the detection of cholinergic agents
MXPA94006538A (en) Immunoassayo de complementacion enzimaticaelectroquim
DK0820593T3 (da) Måleindretning
Sant et al. Development of a creatinine-sensitive sensor for medical analysis
Yang et al. Biosensors and their Applications
EP2154522A3 (de) Biosensor
US20060076249A1 (en) Measuring device and measuring method for detecting analytes
Dzantiev et al. Determination of the herbicide chlorsulfuron by amperometric sensor based on separation-free bienzyme immunoassay
US5955379A (en) Biosensor device and method
US20090311670A1 (en) Apparatus and method for measuring concentration of molecules through a barrier
Ameur et al. Impedimetric measurements on polarized functionalized platinum electrodes: application to direct immunosensing
Turner Immunosensors: The next generation
BR9712504A (pt) Ensaio para a detecção de anticorpos contra p53
KR890013480A (ko) 아날라이트 물질의 측정방법 및 장치
Saito et al. ISFET glucose sensor for undiluted serum sample measurement
Satake et al. Interfacial pH Behavior at a Cell/Gate Insulator Nanogap Induced by Allergic Responses
GB2218808A (en) Detecting device
AU2001287451A1 (en) Biosensor assay device and method
JPH03505920A (ja) 検出方法
RU96110599A (ru) Способ диагностики лепры

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee