ATE144420T1 - Verwendung von riluzol zur behandlung von parkinson und den parkinson-syndromen - Google Patents

Verwendung von riluzol zur behandlung von parkinson und den parkinson-syndromen

Info

Publication number: ATE144420T1
Authority: AT; Austria
Prior art keywords: parkinson; pct; riluzole; syndromes; treat
Prior art date: 1993-01-07

Application number

AT94903935T

Other languages

English (en)

Inventor

Alain Boireau

Adam Doble

Pierre Dubedat

Erik Louvel

Mireille Meunier

Jean-Marie Miquet

Jean-Marie Stutzmann

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-07

Filing date

1994-01-03

Publication date

1996-11-15

1994-01-03 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE144420T1 publication Critical patent/ATE144420T1/de

Links

FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 title abstract 2
229960004181 riluzole Drugs 0.000 title abstract 2
208000011580 syndromic disease Diseases 0.000 title 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000027089 Parkinsonian disease Diseases 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT94903935T 1993-01-07 1994-01-03 Verwendung von riluzol zur behandlung von parkinson und den parkinson-syndromen ATE144420T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9300074A FR2700117B1 (fr)	1993-01-07	1993-01-07	Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.

Publications (1)

Publication Number	Publication Date
ATE144420T1 true ATE144420T1 (de)	1996-11-15

Family

ID=9442862

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94903935T ATE144420T1 (de)	1993-01-07	1994-01-03	Verwendung von riluzol zur behandlung von parkinson und den parkinson-syndromen
AT94903936T ATE141792T1 (de)	1993-01-07	1994-01-03	Verwendung von carbamazepine und oxcarbazepine zur behandlung von parkinson und den parkinson- syndromen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT94903936T ATE141792T1 (de)	1993-01-07	1994-01-03	Verwendung von carbamazepine und oxcarbazepine zur behandlung von parkinson und den parkinson- syndromen

Country Status (23)

Country	Link
US (2)	US5674885A (de)
EP (2)	EP0678026B1 (de)
JP (2)	JP3120153B2 (de)
KR (2)	KR100298807B1 (de)
AT (2)	ATE144420T1 (de)
AU (3)	AU677279B2 (de)
CA (2)	CA2153341A1 (de)
CZ (2)	CZ284363B6 (de)
DE (2)	DE69400799T2 (de)
DK (2)	DK0678026T3 (de)
ES (2)	ES2091689T3 (de)
FR (1)	FR2700117B1 (de)
GR (2)	GR3020975T3 (de)
HU (2)	HU217136B (de)
IL (3)	IL108286A0 (de)
MX (2)	MX9307885A (de)
NO (2)	NO307495B1 (de)
PL (2)	PL309594A1 (de)
RU (1)	RU2221563C2 (de)
SK (2)	SK279758B6 (de)
UA (1)	UA29464C2 (de)
WO (3)	WO1994015607A1 (de)
ZA (3)	ZA9428B (de)

Families Citing this family (34)

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US6119094A (en) *	1996-02-29	2000-09-12	Electronic Data Systems Corporation	Automated system for identifying alternate low-cost travel arrangements
EP1043996A2 (de) *	1998-01-09	2000-10-18	Mor-Research Applications Ltd.	Behandlung von dyskinesien
US6417210B1 (en) *	1998-01-09	2002-07-09	Mor-Research Applications Ltd.	Treatment of dyskinesias and Parkinson's disease with riluzole and levodopa
FR2774592B1 (fr) *	1998-02-06	2000-03-17	Rhone Poulenc Rorer Sa	Application du 2-amino-6-trifluoromethoxybenzothiazole pour la prevention ou le traitement des dysfonctionnements du cervelet
FR2777781B1 (fr) *	1998-04-24	2004-04-09	Rhone Poulenc Rorer Sa	Associations riluzole et l-dopa pour le traitement de la maladie de parkinson
FR2787028B1 (fr)	1998-12-15	2002-10-18	Aventis Pharma Sa	Utilisation du riluzole dans le traitement des traumatismes acoustiques
US6506378B1 (en)	1998-12-16	2003-01-14	Arch Development Corporation	Vesicular monoamine transporter gene therapy in Parkinson's disease
FR2801793B1 (fr) *	1999-12-01	2003-07-04	Aventis Pharma Sa	Association d'une ergoline et de riluzole et son utilisation comme medicament
ES2211373T1 (es) *	2001-02-12	2004-07-16	Teva Pharmaceutical Industries Ltd.	Nuevas formas cristalinas de oxcarbazepina y procedimientos para su preparacion.
US20050070524A1 (en) *	2003-06-06	2005-03-31	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders
WO2005037276A1 (en) *	2003-10-09	2005-04-28	Aventis Pharma S.A.	Use of riluzole for the treatment of essential tremor
CA2471666C (en) *	2004-06-18	2009-10-13	Apotex Pharmachem Inc.	An improved process for the preparation of oxcarbazepine and related intermediates
EP1924326B1 (de)	2005-08-25	2016-10-12	Steven Michael Weiss	Reduzierung von myokard-schaden und inzidenz von arrhythmien durch verlust, verringerung oder unterbrechung des koronaren blutflusses
US20070248684A1 (en) *	2006-01-31	2007-10-25	Sigal Blau	Pharmaceutical formulations of oxcarbazepine and methods for its preparation
US20070178164A1 (en) *	2006-01-31	2007-08-02	Sigal Blau	Pharmaceutical formulations of oxcarbazepine and methods for its preparation
GB0603008D0 (en) *	2006-02-14	2006-03-29	Portela & Ca Sa	Method
ES2396051T3 (es) *	2006-04-26	2013-02-18	Supernus Pharmaceuticals, Inc.	Preparaciones de liberación controlada de oxcarbazepina que tienen perfil de liberación sigmoidal
CA2699411A1 (en) *	2007-09-14	2009-03-19	Scil Technology Gmbh	Neuroendocrine factors for treatment of degenerative diseases
MX353752B (es)	2009-01-20	2018-01-26	Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct	Los ácidos sórbico y benzoico y sus derivados aumentan la actividad de un neurofármaco.
WO2011017319A1 (en)	2009-08-03	2011-02-10	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Methods of treating disorders associated with protein polymerization
US8809617B2 (en) *	2009-11-05	2014-08-19	The University of Pittsburgh—Of the Commonwealth System of Higher Education	Automated high-content live animal drug screening using C. elegans
US9072772B2 (en)	2009-11-05	2015-07-07	University of Pittsburgh—of the Commonwealth System of Higher Education	Methods of treating disorders associated with protein aggregation
US9463186B2 (en)	2013-04-15	2016-10-11	Northwestern University	Treatment for dopaminergic disorders
CA3027300C (en)	2016-06-13	2023-08-08	Syneurx International (Taiwan) Corp.	Co-crystals of lithium benzoate and uses thereof
WO2017215593A1 (en)	2016-06-13	2017-12-21	Syneurx International (Taiwan) Corp.	Co-crystals of sodium benzoate and uses thereof
US11369579B2 (en)	2016-10-24	2022-06-28	Syneurx International (Taiwan) Corp.	Polymorphic forms of sodium benzoate and uses thereof
US10336679B2 (en)	2016-10-24	2019-07-02	Syneurx International (Taiwan) Corp.	Polymorphic forms of sodium benzoate and uses thereof
EP3638283B1 (de) *	2017-06-14	2024-07-17	Lario Therapeutics Ltd.	Antagonisten von calciumkanälen vom typ cav2.3 r zur behandlung von neurodegenerativen erkrankungen
US10322114B2 (en)	2017-07-31	2019-06-18	Above And Beyond Nb, Llc	Formulation of a riluzole solution with beta-cyclodextrins
US10098861B1 (en)	2017-10-24	2018-10-16	Syneurx International (Taiwan) Corp.	Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof
EP4031135A4 (de)	2019-09-20	2023-10-18	Icahn School of Medicine at Mount Sinai	Formulierungen mit kontrollierter freisetzung von riluzol und deren verwendungen
CN114948868B (zh) *	2021-04-16	2023-04-14	上海奥科达医药科技股份有限公司	一种拉莫三嗪水合物的晶体形式、其制备方法及包含其的组合物
EP4780448A1 (de) *	2023-09-18	2026-07-29	Aribio Co., Ltd.	Lamotrigin- und rivastigmin-kombinationen zur behandlung neurodegenerativer erkrankungen
US12605388B2 (en)	2024-09-25	2026-04-21	Azurity Pharmaceuticals Ireland Limited	Lamotrigine salts, co-crystals, and compositions

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Publication number	Priority date	Publication date	Assignee	Title
US2948718A (en) *		1960-08-09		New n-heterocyclic compounds
CH500196A (de) *	1969-03-10	1970-12-15	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Azepinderivaten
FR2492258A1 (fr) *	1980-10-17	1982-04-23	Pharmindustrie	Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4431641A (en) *	1980-10-17	1984-02-14	Ciba-Geigy Corporation	Pharmaceutical compositions having antiepileptic and antineuralgic action
GB8613183D0 (en) *	1986-05-30	1986-07-02	Wellcome Found	Triazine salt
FR2619713B1 (fr) *	1987-08-25	1990-08-31	Rhone Poulenc Sante	Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement des troubles du sommeil et de la depression
DE4118740A1 (de) *	1991-06-05	1992-12-10	Schering Ag	Neue kombinationspraeparate zur behandlung des morbus parkinson
FR2699077B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.

1993
- 1993-01-07 FR FR9300074A patent/FR2700117B1/fr not_active Expired - Lifetime
- 1993-12-13 MX MX9307885A patent/MX9307885A/es not_active IP Right Cessation
1994
- 1994-01-03 SK SK867-95A patent/SK279758B6/sk not_active IP Right Cessation
- 1994-01-03 AU AU58189/94A patent/AU677279B2/en not_active Ceased
- 1994-01-03 ES ES94903936T patent/ES2091689T3/es not_active Expired - Lifetime
- 1994-01-03 DK DK94903936.6T patent/DK0678026T3/da active
- 1994-01-03 AU AU58190/94A patent/AU5819094A/en not_active Abandoned
- 1994-01-03 DE DE69400799T patent/DE69400799T2/de not_active Expired - Lifetime
- 1994-01-03 JP JP06515742A patent/JP3120153B2/ja not_active Expired - Fee Related
- 1994-01-03 RU RU2000127693/15A patent/RU2221563C2/ru active
- 1994-01-03 CA CA002153341A patent/CA2153341A1/fr not_active Abandoned
- 1994-01-03 KR KR1019950702793A patent/KR100298807B1/ko not_active Expired - Lifetime
- 1994-01-03 PL PL94309594A patent/PL309594A1/xx unknown
- 1994-01-03 EP EP94903936A patent/EP0678026B1/de not_active Expired - Lifetime
- 1994-01-03 AU AU58188/94A patent/AU684059B2/en not_active Expired
- 1994-01-03 DE DE69400435T patent/DE69400435T2/de not_active Expired - Fee Related
- 1994-01-03 JP JP6515743A patent/JPH08505379A/ja active Pending
- 1994-01-03 EP EP94903935A patent/EP0678023B1/de not_active Expired - Lifetime
- 1994-01-03 HU HU9502063A patent/HU217136B/hu unknown
- 1994-01-03 UA UA95073383A patent/UA29464C2/uk unknown
- 1994-01-03 PL PL94309596A patent/PL309596A1/xx unknown
- 1994-01-03 ES ES94903935T patent/ES2092890T3/es not_active Expired - Lifetime
- 1994-01-03 WO PCT/FR1994/000005 patent/WO1994015607A1/fr not_active Ceased
- 1994-01-03 AT AT94903935T patent/ATE144420T1/de active
- 1994-01-03 HU HU9502065A patent/HUT72074A/hu unknown
- 1994-01-03 CA CA002153340A patent/CA2153340C/fr not_active Expired - Lifetime
- 1994-01-03 US US08/446,734 patent/US5674885A/en not_active Expired - Lifetime
- 1994-01-03 CZ CZ951765A patent/CZ284363B6/cs unknown
- 1994-01-03 WO PCT/FR1994/000004 patent/WO1994015610A1/fr not_active Ceased
- 1994-01-03 WO PCT/FR1994/000003 patent/WO1994015601A1/fr not_active Ceased
- 1994-01-03 US US08/446,735 patent/US5658900A/en not_active Expired - Fee Related
- 1994-01-03 DK DK94903935.8T patent/DK0678023T3/da active
- 1994-01-03 SK SK866-95A patent/SK279645B6/sk unknown
- 1994-01-03 CZ CZ951764A patent/CZ284928B6/cs not_active IP Right Cessation
- 1994-01-03 AT AT94903936T patent/ATE141792T1/de not_active IP Right Cessation
- 1994-01-04 ZA ZA9428A patent/ZA9428B/xx unknown
- 1994-01-04 ZA ZA9426A patent/ZA9426B/xx unknown
- 1994-01-04 ZA ZA9432A patent/ZA9432B/xx unknown
- 1994-01-05 MX MX9400287A patent/MX9400287A/es unknown
- 1994-01-06 IL IL10828694A patent/IL108286A0/xx unknown
- 1994-01-06 IL IL10828494A patent/IL108284A/en not_active IP Right Cessation
- 1994-01-06 IL IL10828594A patent/IL108285A0/xx unknown
1995
- 1995-06-12 NO NO952309A patent/NO307495B1/no not_active IP Right Cessation
- 1995-06-12 NO NO952310A patent/NO952310D0/no unknown
- 1995-07-06 KR KR1019950702794A patent/KR960700059A/ko not_active Withdrawn
1996
- 1996-09-11 GR GR960400811T patent/GR3020975T3/el unknown
- 1996-10-24 GR GR960401906T patent/GR3021438T3/el unknown

Also Published As

Publication number	Publication date
CA2153340C (fr)	2002-12-17
JP3120153B2 (ja)	2000-12-25
CZ176495A3 (en)	1995-12-13
US5658900A (en)	1997-08-19
DK0678026T3 (da)	1996-09-16
SK279645B6 (sk)	1999-01-11
GR3021438T3 (en)	1997-01-31
CA2153341A1 (fr)	1994-07-21
IL108284A (en)	1999-03-12
KR960700059A (ko)	1996-01-19
CA2153340A1 (fr)	1994-07-21
ZA9426B (en)	1994-08-11
JPH08505379A (ja)	1996-06-11
NO952309L (no)	1995-06-12
ZA9432B (en)	1994-08-11
CZ284928B6 (cs)	1999-04-14
HUT72328A (en)	1996-04-29
NO952309D0 (no)	1995-06-12
WO1994015610A1 (fr)	1994-07-21
AU5818994A (en)	1994-08-15
RU2221563C2 (ru)	2004-01-20
EP0678026A1 (de)	1995-10-25
DE69400435D1 (de)	1996-10-02
WO1994015607A1 (fr)	1994-07-21
IL108286A0 (en)	1994-04-12
SK86795A3 (en)	1995-11-08
EP0678023B1 (de)	1996-10-23
EP0678026B1 (de)	1996-08-28
DK0678023T3 (da)	1996-11-25
AU5818894A (en)	1994-08-15
ATE141792T1 (de)	1996-09-15
DE69400799T2 (de)	1997-03-13
JPH08505378A (ja)	1996-06-11
PL309596A1 (en)	1995-10-30
MX9400287A (es)	1994-07-29
CZ176595A3 (en)	1995-12-13
HU217136B (hu)	1999-11-29
MX9307885A (es)	1994-07-29
NO952310L (no)	1995-06-12
FR2700117B1 (fr)	1995-02-03
AU677279B2 (en)	1997-04-17
ZA9428B (en)	1994-08-11
PL309594A1 (en)	1995-10-30
SK86695A3 (en)	1996-05-08
ES2091689T3 (es)	1996-11-01
CZ284363B6 (cs)	1998-11-11
FR2700117A1 (fr)	1994-07-08
NO952310D0 (no)	1995-06-12
KR960700054A (ko)	1996-01-19
SK279758B6 (sk)	1999-03-12
IL108285A0 (en)	1994-04-12
EP0678023A1 (de)	1995-10-25
HU9502065D0 (en)	1995-09-28
GR3020975T3 (en)	1996-12-31
ES2092890T3 (es)	1996-12-01
WO1994015601A1 (fr)	1994-07-21
US5674885A (en)	1997-10-07
HUT72074A (en)	1996-03-28
DE69400435T2 (de)	1997-03-06
DE69400799D1 (de)	1996-11-28
HU9502063D0 (en)	1995-09-28
NO307495B1 (no)	2000-04-17
KR100298807B1 (ko)	2001-11-22
IL108284A0 (en)	1994-04-12
UA29464C2 (uk)	2000-11-15
AU5819094A (en)	1994-08-15
AU684059B2 (en)	1997-12-04

Legal Events

Date	Code	Title	Description
1997-05-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69400799D1 (de)	1996-11-28	Verwendung von riluzol zur behandlung von parkinson und den parkinson-syndromen
DE69317578D1 (de)	1998-04-23	Verwendung von riluzole zur behandlung von traumatischen neurologischen-schädigungen
DE69507029D1 (de)	1999-02-11	Pharmazeutische zusammensetzungen enthaltend einen opiat antagonist und calcium salze, ihre verwendung zur behandlung von endorphin-vermittelten krankheiten
ATE200672T1 (de)	2001-05-15	Alkoxyalkylcarbamate von imidazo(1,2-a)pyridinen
ATE201598T1 (de)	2001-06-15	Verwendung von moxonidin zur behandlung neuropathischer schmerzen
ATE143947T1 (de)	1996-10-15	N-acylpyrrolidine und arzneimittel zur behandlung oder prophylaxe von mit ckk und gastrin in zusammenhang stehenden krankheiten
ATE331523T1 (de)	2006-07-15	Statin-therapie zur verbesserung der aufrechterhaltung der kognitiven funktion
DE69421705D1 (de)	1999-12-23	Verwendung von Efaroxan und dessen Derivaten zur Herstellung eines Arzneimittels zur Behandlung neurogenerativer Erkrankungen
ATE203671T1 (de)	2001-08-15	Imidazolochinoxalinone zur behandlung zentralnervöser erkrankungen
ZA9427B (en)	1994-08-11	Use of riluzole for promoting restoration following radiation