ATE144513T1 - Pyrrolopyrimidinderivate, ihre herstellung und verwendung - Google Patents

Pyrrolopyrimidinderivate, ihre herstellung und verwendung

Info

Publication number
ATE144513T1
ATE144513T1 AT89302851T AT89302851T ATE144513T1 AT E144513 T1 ATE144513 T1 AT E144513T1 AT 89302851 T AT89302851 T AT 89302851T AT 89302851 T AT89302851 T AT 89302851T AT E144513 T1 ATE144513 T1 AT E144513T1
Authority
AT
Austria
Prior art keywords
group
coor
pyrrolopyrimide
derivatives
preparation
Prior art date
Application number
AT89302851T
Other languages
English (en)
Inventor
Hiroshi Akimoto
Takenori Hitaka
Tetsuo Miwa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26412276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE144513(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE144513T1 publication Critical patent/ATE144513T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT89302851T 1988-03-24 1989-03-22 Pyrrolopyrimidinderivate, ihre herstellung und verwendung ATE144513T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7114988 1988-03-24
JP24537988 1988-09-29

Publications (1)

Publication Number Publication Date
ATE144513T1 true ATE144513T1 (de) 1996-11-15

Family

ID=26412276

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89302851T ATE144513T1 (de) 1988-03-24 1989-03-22 Pyrrolopyrimidinderivate, ihre herstellung und verwendung

Country Status (12)

Country Link
US (4) US4997838A (de)
EP (1) EP0334636B1 (de)
KR (1) KR960015967B1 (de)
CN (1) CN1029970C (de)
AT (1) ATE144513T1 (de)
CA (1) CA1340794C (de)
DE (1) DE68927354T2 (de)
DK (1) DK173980B1 (de)
ES (1) ES2092994T3 (de)
GR (1) GR3021733T3 (de)
HU (3) HU908458D0 (de)
NO (1) NO169490C (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK0460116T3 (da) * 1989-02-27 1998-03-30 Biocryst Pharm Inc 9-substitueret-8-usubstitueret-9-deazaguaniner
JP3015957B2 (ja) * 1989-05-29 2000-03-06 武田薬品工業株式会社 ピロロ［２，３―ｄ］ピリミジン誘導体およびその製造法
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2031769A1 (en) * 1989-12-08 1991-06-09 Hiroshi Akimoto Pyrrolopyrimidine derivatives, their production and use
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
EP0492316A1 (de) * 1990-12-14 1992-07-01 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Derivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
DE69216509T2 (de) * 1991-08-12 1997-05-28 Takeda Chemical Industries Ltd Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
ATE173251T1 (de) * 1991-08-21 1998-11-15 Eisai Co Ltd Kondensierte pyrimidinderivate als antitumorverbindungen
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
US5235053A (en) 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US5278307A (en) * 1992-09-25 1994-01-11 Eli Lilly And Company Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates
CZ283281B6 (cs) * 1992-09-25 1998-02-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
EP0831829B1 (de) * 1995-06-07 2003-08-20 Pfizer Inc. Heterocyclische kondensierte pyrimidin-derivate
AU1794697A (en) * 1996-03-06 1997-09-22 Novartis Ag 7-alkyl-pyrrolo{2,3-d}pyrimidines
CA2263907A1 (en) * 1996-08-30 1998-03-05 Christopher Leighon Jordan Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
CN1246295C (zh) * 1997-09-26 2006-03-22 伊莱利利公司 用于制造抗叶酸剂的方法和中间体
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6066732A (en) * 1998-08-21 2000-05-23 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
MXPA01012206A (es) * 1999-05-24 2002-06-21 Sankyo Co Composiciones farmaceuticas que contienen anticuerpo anti-fas.
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6229413B1 (en) 1999-10-19 2001-05-08 General Electric Company Support of stationary conductors for a circuit breaker
EA006227B1 (ru) 1999-12-10 2005-10-27 Пфайзер Продактс Инк. СОЕДИНЕНИЯ ПИРРОЛО[2,3-d]ПИРИМИДИНА
DE60100750T2 (de) * 2000-02-25 2004-07-29 Eli Lilly And Co., Indianapolis NEUE KRISTALLINE FORM VON N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]-PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMINSÄURE UND VERFAHREN FÜR IHRE HERSTELLUNG
US6380829B1 (en) 2000-11-21 2002-04-30 General Electric Company Motor operator interlock and method for circuit breakers
US6902811B2 (en) * 2001-06-28 2005-06-07 Toray Industries, Inc. Epoxy resin composition excellent in weather resistance and fiber-reinforced composite materials
AU2003276591A1 (en) 2002-11-26 2004-06-18 Pfizer Products Inc. Method of treatment of transplant rejection
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
BRPI0806632A2 (pt) * 2007-01-19 2011-09-06 Chelsea Therapeutics Inc composto, composição farmacêutica, método para o tratamento de uma condição selecionada a partir do grupo constituìdo de proliferação celular anormal, inflamação, asma e artrite
MX2009010568A (es) * 2007-04-03 2009-10-22 Reddys Lab Ltd Dr Formas solidas de pemetrexed.
US20090253720A1 (en) * 2008-04-07 2009-10-08 Chelsea Therapeutics, Inc. Antifolate compositions
HRP20140395T1 (hr) 2008-08-20 2014-06-06 Zoetis Llc SPOJEVI PIROLO[2,3-d]PIRIMIDINA
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
WO2011005832A1 (en) * 2009-07-08 2011-01-13 Chelsea Therapeutics, Inc. Stable crystalline polymorphs of the dipotassium salt of (s) -2- {4- [2- (2, 4-diamin0-quinaz0lin-6-yl) -ethyl] -benzoylamino} -4-methylenξ-penta nedioic acid
US8530653B2 (en) * 2009-11-06 2013-09-10 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
US20110237609A1 (en) * 2010-03-29 2011-09-29 Chelsea Therapeutics, Inc. Antifolate compositions
EP2595628A1 (de) 2010-07-19 2013-05-29 Bayer HealthCare LLC Wirkstoffkombinationen mit fluorsubstituiertem omega-carboxyaryl-diphenylharnstoff zur behandlung und prävention von erkrankungen und zuständen
WO2012017443A1 (en) 2010-08-02 2012-02-09 Neon Laboratories Ltd. Process for preparation of highly pure dialkyl pemetrexed
WO2012056285A1 (en) 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
WO2012078708A1 (en) 2010-12-07 2012-06-14 Chelsea Therapeutics, Inc. Combination comprising methotrexate and an antifolate compound
US9051322B2 (en) * 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法
EP3675864A4 (de) * 2017-08-31 2022-02-16 Duquesne University of The Holy Spirit Erste vertreter von shmt2- und mthfd2-inhibitoren als antitumormittel
NL2022471B1 (en) 2019-01-29 2020-08-18 Vationpharma B V Solid state forms of oclacitinib

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater

Also Published As

Publication number Publication date
US5539113A (en) 1996-07-23
HUT51624A (en) 1990-05-28
DE68927354T2 (de) 1997-03-20
NO169490B (no) 1992-03-23
CN1029970C (zh) 1995-10-11
DE68927354D1 (de) 1996-11-28
HU215928B (hu) 1999-03-29
HUT55396A (en) 1991-05-28
KR960015967B1 (ko) 1996-11-25
EP0334636B1 (de) 1996-10-23
DK173980B1 (da) 2002-03-25
CN1037513A (zh) 1989-11-29
NO891206D0 (no) 1989-03-20
KR890014543A (ko) 1989-10-24
US4997838A (en) 1991-03-05
DK143789A (da) 1989-09-25
CA1340794C (en) 1999-10-19
NO169490C (no) 1992-07-01
ES2092994T3 (es) 1996-12-16
HU203105B (en) 1991-05-28
NO891206L (no) 1989-09-25
HU908458D0 (en) 1991-07-29
GR3021733T3 (en) 1997-02-28
US5106974A (en) 1992-04-21
EP0334636A3 (de) 1991-05-02
EP0334636A2 (de) 1989-09-27
US5296600A (en) 1994-03-22
DK143789D0 (da) 1989-03-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time