ATE144713T1 - Antikörper gegen menschlichen interleukin-6- rezeptor - Google Patents

Antikörper gegen menschlichen interleukin-6- rezeptor

Info

Publication number
ATE144713T1
ATE144713T1 AT90307879T AT90307879T ATE144713T1 AT E144713 T1 ATE144713 T1 AT E144713T1 AT 90307879 T AT90307879 T AT 90307879T AT 90307879 T AT90307879 T AT 90307879T AT E144713 T1 ATE144713 T1 AT E144713T1
Authority
AT
Austria
Prior art keywords
antibodies
receptor
human interleukin
competitive
monoclonal antibody
Prior art date
Application number
AT90307879T
Other languages
English (en)
Inventor
Tadamitsu Kishimoto
Original Assignee
Tadamitsu Kishimoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tadamitsu Kishimoto filed Critical Tadamitsu Kishimoto
Application granted granted Critical
Publication of ATE144713T1 publication Critical patent/ATE144713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT90307879T 1989-07-20 1990-07-19 Antikörper gegen menschlichen interleukin-6- rezeptor ATE144713T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18601689 1989-07-20

Publications (1)

Publication Number Publication Date
ATE144713T1 true ATE144713T1 (de) 1996-11-15

Family

ID=16180912

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90307879T ATE144713T1 (de) 1989-07-20 1990-07-19 Antikörper gegen menschlichen interleukin-6- rezeptor

Country Status (10)

Country Link
EP (1) EP0409607B1 (de)
JP (1) JP2998976B2 (de)
KR (1) KR100214759B1 (de)
AT (1) ATE144713T1 (de)
CA (1) CA2021594C (de)
DE (2) DE69029015T2 (de)
ES (1) ES2093017T3 (de)
HK (1) HK49497A (de)
NL (1) NL300387I1 (de)
SG (1) SG42954A1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05236966A (ja) * 1991-04-25 1993-09-17 Chugai Pharmaceut Co Ltd ヒトインターロイキン−６レセプターに対するマウスモノクローナル抗体の可変領域をコードするｄｎａ
EP0628639B1 (de) 1991-04-25 1999-06-23 Chugai Seiyaku Kabushiki Kaisha Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor
FR2694767B1 (fr) * 1992-08-13 1994-10-21 Innotherapie Lab Sa Anticorps monoclonaux anti-IL6R, et leurs applications.
AU7967294A (en) * 1993-10-06 1995-05-01 Board Of Regents, The University Of Texas System A monoclonal anti-human il-6 receptor antibody
US8017121B2 (en) 1994-06-30 2011-09-13 Chugai Seiyaku Kabushika Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
US5763211A (en) * 1994-09-14 1998-06-09 Progenitor, Inc. Isolated nucleic acid encoding Hu-B1.219, a novel human hematopoietin
US6355237B1 (en) 1994-09-14 2002-03-12 Progenitor, Inc. Methods for using the obese gene and its gene product to stimulate hematopoietic development
US6451523B1 (en) 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US5643748A (en) 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
US5912123A (en) * 1994-09-14 1999-06-15 Progenitor, Inc. Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology
US5856098A (en) * 1994-09-14 1999-01-05 Progenitor, Inc. Detection of a leptin receptor variant
PT783893E (pt) * 1994-10-07 2012-05-24 Chugai Pharmaceutical Co Ltd Inibição do crescimento anormal das células sinoviais usando antagonistas de il-6 como componente ativo
CN1306963C (zh) * 1994-10-21 2007-03-28 岸本忠三 用于治疗il－6产生所致疾病的药物组合物
JP3458512B2 (ja) 1995-02-23 2003-10-20 東ソー株式会社 骨密度の変動推定方法又は骨そしょう症の診断方法及びこれに用いる試薬キット
AU1833197A (en) * 1996-01-18 1997-08-11 Progenitor, Inc. Detection of a leptin receptor variant and methods for regulating obesity
DK0923941T3 (da) 1996-06-27 2006-09-18 Chugai Pharmaceutical Co Ltd Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
US8632778B2 (en) 2000-08-11 2014-01-21 Chugai Seiyaku Kabushiki Kaisha Stabilized anti-interleukin-6 antibody-containing preparations
DE60133029T2 (de) 2000-10-25 2009-03-12 Chugai Seiyaku K.K. Mittel zur prävention oder behandlung von psoriasis mit einem il-6-antagonist als wirkstoff
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
KR101193708B1 (ko) * 2003-10-17 2012-10-22 추가이 세이야쿠 가부시키가이샤 중피종 치료제
AR058135A1 (es) 2005-10-21 2008-01-23 Chugai Pharmaceutical Co Ltd Agentes para el tratamiento de cardiopatias
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
TW200803894A (en) 2005-11-25 2008-01-16 Univ Keio Prostate cancer therapeutic agents
CA2637917C (en) 2006-01-27 2015-11-24 Keio University Therapeutic agents for diseases involving choroidal neovascularization
EP2025346B1 (de) 2006-04-07 2016-08-10 Osaka University Mittel zur förderung der muskelregeneration
US8080248B2 (en) 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
ES2398076T3 (es) * 2006-06-02 2013-03-13 Regeneron Pharmaceuticals, Inc. Anticuerpos de alta afinidad contra el receptor de IL-6 humano
CN101528778A (zh) * 2006-08-18 2009-09-09 埃博灵克斯股份有限公司 用于治疗与il-6-介导的信号传导相关的疾病和病症的针对il-6r的氨基酸序列以及包括其的多肽
EP2057191A1 (de) 2006-08-18 2009-05-13 Ablynx N.V. Gegen il-6r gerichtete aminosäuresequenzen und polypeptide, die diese enthalten, zur behandlung von mit der durch il-6 vermittelten signalübertragung assoziierten krankheiten und erkrankungen
WO2008071685A1 (en) * 2006-12-13 2008-06-19 Ablynx N.V. Polypeptides specific for complexes involved in receptor-mediated signaling, such as the il-6/il-6 receptor complex
EP2174667B1 (de) 2007-07-26 2017-01-04 Osaka University Mittel zur behandlung von augenentzündungen mit interleukin-6-rezeptorhemmer als wirkstoff
CA2701155C (en) 2007-10-02 2016-11-22 Chugai Seiyaku Kabushiki Kaisha Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient
WO2009140348A2 (en) 2008-05-13 2009-11-19 Novimmune Sa Anti-il-6/il-6r antibodies and methods of use thereof
TWI528973B (zh) 2008-06-05 2016-04-11 Chugai Pharmaceutical Co Ltd Nerve infiltration inhibitor
WO2010115995A2 (en) 2009-04-10 2010-10-14 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
NZ595461A (en) 2009-04-10 2013-01-25 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
AU2010278067B2 (en) 2009-07-31 2016-10-27 Shin Maeda Cancer metastasis inhibitor
WO2011051231A1 (en) 2009-10-26 2011-05-05 F. Hoffmann-La Roche Ag Method for the production of a glycosylated immunoglobulin
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
JP6051049B2 (ja) 2010-05-28 2016-12-21 中外製薬株式会社 抗腫瘍ｔ細胞応答増強剤
US10138302B2 (en) 2011-09-23 2018-11-27 Ablynx N.V. Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
EP3009518B1 (de) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Verfahren zur vorhersage einer posttherapeutischen prognose von patienten mit schubförmig remittierender multipler sklerose (rrms) und verfahren zur bestimmung der anwendbarkeit der neuartigen therapie
CN105378480B (zh) 2013-07-04 2018-06-12 豪夫迈·罗氏有限公司 检测血清样品中抗药物抗体的干扰抑制性免疫测定
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
CA2963712A1 (en) 2014-10-21 2016-04-28 Ablynx Nv Treatment of il-6r related diseases
EP3620531A4 (de) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry Verfahren zur vorhersage und beurteilung der therapeutischen wirkung bei erkrankungen im zusammenhang mit il-6 und neutrophilen
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
BR112021014377A2 (pt) 2019-01-31 2021-12-28 Regeneron Pharma Composições e métodos para o tratamento de artrite idiopática juvenil
AU2020261431A1 (en) 2019-04-24 2021-12-09 Regeneron Pharmaceuticals, Inc. Methods of diagnosis and treatment of rheumatoid arthritis
EP3980459A1 (de) 2019-06-04 2022-04-13 Sanofi Biotechnology Zusammensetzungen und verfahren zur schmerzbehandlung bei patienten mit rheumatoider arthritis
KR20230123497A (ko) 2020-12-18 2023-08-23 아블린쓰 엔.브이. IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드
WO2025198912A1 (en) 2024-03-21 2025-09-25 Hoffmann-La Roche Inc. Methods of treating myasthenia gravis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2598666B2 (ja) * 1987-10-19 1997-04-09 忠三 岸本 抗ヒトｂｃｄｆモノクローナル抗体
US5171840A (en) * 1988-01-22 1992-12-15 Tadamitsu Kishimoto Receptor protein for human B cell stimulatory factor-2

Also Published As

Publication number Publication date
EP0409607A2 (de) 1991-01-23
EP0409607B1 (de) 1996-10-30
ES2093017T3 (es) 1996-12-16
EP0409607A3 (en) 1991-06-12
JPH03139293A (ja) 1991-06-13
KR100214759B1 (ko) 1999-08-02
HK49497A (en) 1997-04-25
DE122009000023I1 (de) 2009-08-06
DE69029015T2 (de) 1998-01-22
DE122009000023I2 (de) 2010-12-16
NL300387I1 (nl) 2009-07-01
CA2021594A1 (en) 1991-01-21
CA2021594C (en) 2002-01-08
SG42954A1 (en) 1997-10-17
JP2998976B2 (ja) 2000-01-17
DE69029015D1 (de) 1996-12-05

Similar Documents

Publication Publication Date Title
ATE144713T1 (de) Antikörper gegen menschlichen interleukin-6- rezeptor
DK666389A (da) Monoklonalt antistof
FI913891A7 (fi) Uusi monoklonaalinen vasta-aine uutta antigeenia vastaan, joka liittyy ihmisen kasvaimiin
KR900702007A (ko) T세포 항원 수용체의 지어부위와 반응하는 단클론항체
NO980030L (no) Monoklonale antistoffer som binder CD40-L
FI925631L (fi) Monoklonala antikroppar
FI954347L (fi) Monoklonaaliset vasta-ainekoostumukset ja monoklonaalisia vasta-aineita tuottavat hybridomat
DE69319662D1 (de) Monoklonale Antikörper gegen GP130-Protein
DE3854502D1 (de) Gegen hiv-antigene spezifischer monoklonaler antikörper.
NO177311C (no) Anti-fucosylceramid monoklonalt antistoff
DE3850993D1 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
DE3780256D1 (de) Anti-pci-monoklonaler antikoerper.
DK717888A (da) Monoklonale antistoffer
NO890116L (no) Monoklonale antistoffer.
DK474189A (da) Monoklonalt antistof
DE69021921D1 (de) Monoklonale Antikörper gegen den C-Terminus von ANP.
EP0229107A4 (de) Menschliche monoklonale antikörper gegen pseudomonas-aeruginosa-exotoxin.
DK134487D0 (da) Monoklonalt antistof med affinitet for humant interleukin-2
FI915333A7 (fi) T-lymfotrooppisten retrovirusten monoklonaalisia vasta-aineita
DE69023717D1 (de) Monoklonaler Antikörper.
DK413389A (da) Monoklonale antistoffer
DE69020315D1 (de) Monoklonaler antikörper gegen c-reaktives protein.
DE68916088D1 (de) Anti-CPBII-monoklonaler Antikörper.
DK220688D0 (da) Monoklonalt antistof
DE69026453D1 (de) Antirhodopsiner monoklonaler Antikörper and seine Verwendung