ATE144774T1 - Verfahren zur herstellung von pyrrolo (2,3- d)pyrimidinen - Google Patents

Verfahren zur herstellung von pyrrolo (2,3- d)pyrimidinen

Info

Publication number: ATE144774T1
Authority: AT; Austria
Prior art keywords: ethyl; pyrimidines; diaminopyrrolo; pyrimidin; benzoate
Prior art date: 1991-12-04

Application number

AT92120057T

Other languages

English (en)

Inventor

Edward C Taylor

Hemantkumar H Patel

Original Assignee

Univ Princeton

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-04

Filing date

1992-11-25

Publication date

1996-11-15

1992-11-25 Application filed by Univ Princeton filed Critical Univ Princeton

1996-11-15 Application granted granted Critical

1996-11-15 Publication of ATE144774T1 publication Critical patent/ATE144774T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title 1
-1 5-Substituted pyrrolo[2,3-d]pyrimidines Chemical class 0.000 abstract 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
GRXFIDLCISVXKU-UHFFFAOYSA-N ethyl 4-[2-(2,4-diamino-7h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1CCC1=CN=C2C1=C(N)N=C(N)N2 GRXFIDLCISVXKU-UHFFFAOYSA-N 0.000 abstract 1
OMXHAYIEAUQTAV-UHFFFAOYSA-N ethyl 4-[2-(5-amino-4-cyanofuran-3-yl)ethyl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1CCC1=COC(N)=C1C#N OMXHAYIEAUQTAV-UHFFFAOYSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229960002989 glutamic acid Drugs 0.000 abstract 1
239000012038 nucleophile Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)

AT92120057T 1991-12-04 1992-11-25 Verfahren zur herstellung von pyrrolo (2,3- d)pyrimidinen ATE144774T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/802,192 US5254687A (en)	1991-12-04	1991-12-04	Process for the preparation of pyrrolo[2,3-d]pyrimidines

Publications (1)

Publication Number	Publication Date
ATE144774T1 true ATE144774T1 (de)	1996-11-15

Family

ID=25183085

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92120057T ATE144774T1 (de)	1991-12-04	1992-11-25	Verfahren zur herstellung von pyrrolo (2,3- d)pyrimidinen

Country Status (9)

Country	Link
US (1)	US5254687A (de)
EP (1)	EP0549886B1 (de)
JP (1)	JPH05247045A (de)
AT (1)	ATE144774T1 (de)
CA (1)	CA2084490C (de)
DE (1)	DE69214925T2 (de)
DK (1)	DK0549886T3 (de)
ES (1)	ES2093756T3 (de)
GR (1)	GR3021938T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992017478A1 (en) *	1991-04-08	1992-10-15	Duquesne University Of The Holy Ghost	5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5958930A (en) *	1991-04-08	1999-09-28	Duquesne University Of The Holy Ghost	Pyrrolo pyrimidine and furo pyrimidine derivatives
US5877178A (en) *	1991-04-08	1999-03-02	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US5508281A (en) *	1991-04-08	1996-04-16	Duquesne University Of The Holy Ghost	Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods of using these derivatives
US5939420A (en) *	1991-04-08	1999-08-17	Duquesne University Of The Holy Ghost	Pyrrolo 2,3d!derivatives
US5502187A (en) *	1992-04-03	1996-03-26	The Upjohn Company	Pharmaceutically active bicyclic-heterocyclic amines
US6962920B2 (en) *	1992-09-23	2005-11-08	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US5834469A (en) *	1994-06-09	1998-11-10	Smithkline Beecham Corporation	Endothelin receptor antagonists
US6537999B2 (en)	1996-06-06	2003-03-25	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US7863444B2 (en)	1997-03-19	2011-01-04	Abbott Laboratories	4-aminopyrrolopyrimidines as kinase inhibitors
US6066732A (en) *	1998-08-21	2000-05-23	The Trustees Of Princeton University	Process for the preparation of pyrrolo[2,3-d]pyrimidines
US6713474B2 (en)	1998-09-18	2004-03-30	Abbott Gmbh & Co. Kg	Pyrrolopyrimidines as therapeutic agents
JP2003509428A (ja)	1999-09-17	2003-03-11	アボツト・ゲー・エム・ベー・ハー・ウント・コンパニー・カーゲー	治療薬としてのピラゾロピリミジン
US7071199B1 (en)	1999-09-17	2006-07-04	Abbott Gmbh & Cco. Kg	Kinase inhibitors as therapeutic agents
CN100379729C (zh) *	2006-04-06	2008-04-09	海南天源康泽医药科技有限公司	硝基化合物及其在培美曲塞制备中的应用
CN101417998B (zh)	2007-10-24	2012-10-24	重庆医药工业研究院有限责任公司	一种培美曲塞盐的纯化方法
CN102372719B (zh) *	2010-08-26	2013-10-30	齐鲁制药有限公司	培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
WO2014145576A2 (en)	2013-03-15	2014-09-18	Northwestern University	Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer
NZ630292A (en)	2013-11-25	2015-02-27	Shilpa Medicare Ltd	Process for crystalline pemetrexed dipotassium salt

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1935009C3 (de) *	1969-07-10	1973-10-31	Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen	Verfahren zur Herstellung von Furanen
US4199584A (en) *	1977-05-27	1980-04-22	Imperial Chemical Industries Limited	Pesticidal active furo[2,3-d] pyrimidine derivatives, compositions containing the same and use thereof
US4439225A (en) *	1982-06-14	1984-03-27	Shell Oil Company	Herbicidal cyano-tetrahydrofuranylmethyl ether and cyano-tetrahydropyranylmethyl ether derivatives
US5047519A (en)	1986-07-02	1991-09-10	E. I. Du Pont De Nemours And Company	Alkynylamino-nucleotides
US4895946A (en)	1987-10-26	1990-01-23	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
NO169490C (no)	1988-03-24	1992-07-01	Takeda Chemical Industries Ltd	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
IL96531A (en)	1989-12-11	1995-08-31	Univ Princeton	History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)

1991
- 1991-12-04 US US07/802,192 patent/US5254687A/en not_active Expired - Fee Related
1992
- 1992-11-25 EP EP92120057A patent/EP0549886B1/de not_active Expired - Lifetime
- 1992-11-25 AT AT92120057T patent/ATE144774T1/de active
- 1992-11-25 ES ES92120057T patent/ES2093756T3/es not_active Expired - Lifetime
- 1992-11-25 DK DK92120057.2T patent/DK0549886T3/da active
- 1992-11-25 DE DE69214925T patent/DE69214925T2/de not_active Expired - Fee Related
- 1992-12-02 JP JP4323303A patent/JPH05247045A/ja active Pending
- 1992-12-03 CA CA002084490A patent/CA2084490C/en not_active Expired - Fee Related
1996
- 1996-12-06 GR GR960403355T patent/GR3021938T3/el unknown

Also Published As

Publication number	Publication date
CA2084490C (en)	1998-08-25
ES2093756T3 (es)	1997-01-01
EP0549886A1 (de)	1993-07-07
JPH05247045A (ja)	1993-09-24
CA2084490A1 (en)	1993-06-05
EP0549886B1 (de)	1996-10-30
DK0549886T3 (da)	1996-11-25
DE69214925T2 (de)	1997-03-06
US5254687A (en)	1993-10-19
DE69214925D1 (de)	1996-12-05
GR3021938T3 (en)	1997-03-31

Publication	Publication Date	Title
ATE144774T1 (de)	1996-11-15	Verfahren zur herstellung von pyrrolo (2,3- d)pyrimidinen
FI935672A0 (fi)	1993-12-16	Substituerade pyrazoler
DE59309902D1 (de)	2000-01-20	Azachinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
PL293316A1 (en)	1993-08-23	Method of obtaining quinozolinone derivatives
DE69837346D1 (de)	2007-04-26	Anilidderivate, deren herstellung und verwendung
ATE308526T1 (de)	2005-11-15	Verfahren zu herstellung von 4,6- dichloropyrimidine
DE59209965D1 (de)	2002-10-17	Chinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
DE59510726D1 (de)	2003-07-24	Verfahren zur Herstellung von 2,5-Diamino-4,6-dichlorpyrimidin
ATE19776T1 (de)	1986-05-15	Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0882721A4 (de)	1999-12-22	4-substituierte 2,7-dideoxy-7-fluoro-2,3-didehydro-sialsäuren
DE59309756D1 (de)	1999-10-07	4-Iminochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung
FI903624A0 (fi)	1990-07-18	Analogiamenetelmä terapeuttisesti käyttökelpoisten N,N'-bis(alkoksi- ja hydroksialkyyli)pyridiini-2,4-dikarboksyylihappodiamidien valmistamiseksi
DK0640608T3 (da)	2002-03-18	Mellemprodukter til syntese af cephalosporiner
NO180779C (no)	1997-06-18	Pyridinderivater, fremgangsmåte for deres fremstilling, anvendelse derav, sett omfattende slike, og utgangsforbindelse for fremgangsmåten
DE59309077D1 (de)	1998-11-26	Verfahren zur Herstellung von 2-Halogen-4,6-dialkoxypyrimidinen
DE59307402D1 (de)	1997-10-30	Lösliche Salze von 4-Amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5 -carbonsäure- N-methyl-N-(3-trifluormethyl-phenyl)- amid, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und Ausgangsprodukte
EP0251079A3 (en)	1989-10-25	3-substituted 1-(2-halogenoalkoxy-benzensulfonyl)-3-heteroaryl(thio)urea
DE68914392D1 (de)	1994-05-11	Verwendung von oxydierten Polyamiden, speziell NN'-Bis-(3-propionaldehyd)-1-4-diaminobutan als Immunsuppressiva.
AU629324B2 (en)	1992-10-01	Benzimidazoles