ATE145140T1 - Kokain-rezeptor bindungsliganden - Google Patents

Kokain-rezeptor bindungsliganden

Info

Publication number
ATE145140T1
ATE145140T1 AT91916141T AT91916141T ATE145140T1 AT E145140 T1 ATE145140 T1 AT E145140T1 AT 91916141 T AT91916141 T AT 91916141T AT 91916141 T AT91916141 T AT 91916141T AT E145140 T1 ATE145140 T1 AT E145140T1
Authority
AT
Austria
Prior art keywords
pct
receptor binding
binding ligands
beta
sec
Prior art date
Application number
AT91916141T
Other languages
English (en)
Inventor
Michael J Kuhar
Frank Ivy Carroll
John W Boja
Anita H Lewin
Philip Abraham
Original Assignee
Res Triangle Inst
Nat Inst Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst, Nat Inst Health filed Critical Res Triangle Inst
Application granted granted Critical
Publication of ATE145140T1 publication Critical patent/ATE145140T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT91916141T 1990-08-09 1991-08-09 Kokain-rezeptor bindungsliganden ATE145140T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/564,755 US5128118A (en) 1990-08-09 1990-08-09 Cocaine receptor binding ligands

Publications (1)

Publication Number Publication Date
ATE145140T1 true ATE145140T1 (de) 1996-11-15

Family

ID=24255753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91916141T ATE145140T1 (de) 1990-08-09 1991-08-09 Kokain-rezeptor bindungsliganden

Country Status (11)

Country Link
US (2) US5128118A (de)
EP (1) EP0542903B1 (de)
JP (1) JP3350049B2 (de)
AT (1) ATE145140T1 (de)
AU (1) AU650059B2 (de)
CA (1) CA2089070C (de)
DE (1) DE69123151T2 (de)
DK (1) DK0542903T3 (de)
ES (1) ES2099167T3 (de)
GR (1) GR3022529T3 (de)
WO (1) WO1992002260A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706880B2 (en) 1990-08-09 2004-03-16 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US6531483B1 (en) 1990-08-09 2003-03-11 Research Triangle Institute Cocaine receptor binding ligands
US6329520B1 (en) 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5380848A (en) * 1990-08-09 1995-01-10 Research Triangle Institute Cocaine receptor binding ligands
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US7011813B2 (en) * 1990-08-09 2006-03-14 Research Triangle Institute Cocaine receptor binding ligands
US5935953A (en) * 1990-08-09 1999-08-10 Research Triangle Institute Methods for controlling invertebrate pests using cocaine receptor binding ligands
US7189737B2 (en) * 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US6123917A (en) * 1990-08-09 2000-09-26 Research Triangle Institute Method for making cocaine receptor binding ligands and intermediates therefor
DE69233536D1 (de) * 1991-11-15 2005-08-25 Res Triangle Inst Res Triangle Kokainrezeptor bindende Liganden
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5760055A (en) * 1992-03-13 1998-06-02 Wake Forest University Biologically active tropane derivatives
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
AU5088993A (en) * 1992-08-24 1994-03-15 President And Fellows Of Harvard College Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
AU701227B2 (en) * 1993-09-10 1999-01-21 Cytomed, Inc Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
US5565185A (en) * 1994-07-20 1996-10-15 Merck Frosst Canada, Inc. Process for the preparation of radiolabeled meta-halobenzylguanidine
US5763490A (en) * 1994-09-20 1998-06-09 University Of South Carolina Treating prostate cancer with tartrate ions
ES2385202T3 (es) * 1995-06-06 2012-07-19 Ge Healthcare Limited Sondas neurológicas yodadas para el mapeo de sitios de recaptación de monoamina
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
BR9707636A (pt) * 1996-02-22 1999-07-27 Neurosearch As Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivo
US6447747B1 (en) 1996-10-29 2002-09-10 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
WO1998048824A1 (en) * 1997-05-01 1998-11-05 Emory University Bioactive peptides derived from cocaine and amphetamine regulated transcript protein
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
JP2002501921A (ja) * 1998-01-28 2002-01-22 ニューロサーチ、アクティーゼルスカブ 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
EP1212103B1 (de) 1999-04-26 2004-11-03 Emory University 4-fluoroalkyl-3-halophenyl nortropane
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
US6479509B1 (en) 2000-05-22 2002-11-12 Research Triangle Institute Method of promoting smoking cessation
US6538010B1 (en) 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
DE20120708U1 (de) 2001-10-09 2002-08-01 Blundell, Paul, Sommerville, Mass. Tropan-Analoga zur Inhibierung des Monoamin-Transports
US7381733B2 (en) * 2001-11-30 2008-06-03 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
WO2003093412A2 (en) * 2002-04-30 2003-11-13 Emory University Tumor imaging compounds
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
JP2009505947A (ja) * 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
AU2006262425C1 (en) * 2005-06-23 2012-06-21 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
EP2539706B1 (de) 2010-02-24 2015-03-04 Research Triangle Institute Arylpiperazin-opioid-rezeptor-antagonisten
WO2018168643A1 (ja) * 2017-03-17 2018-09-20 日本メジフィジックス株式会社 イオフルパンの製造方法
KR20200142039A (ko) * 2018-04-10 2020-12-21 스카이호크 테라퓨틱스, 인코포레이티드 암 치료용 화합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4041040A (en) * 1976-09-22 1977-08-09 Hoffmann-La Roche Inc. Ecgonine derivative
US4179567A (en) * 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
US4366154A (en) * 1981-11-09 1982-12-28 Sandoz, Inc. Tropyl derivatives
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5288872A (en) * 1992-03-13 1994-02-22 Wake Forest University Compounds for treatment of neurodegenerative diseases

Also Published As

Publication number Publication date
CA2089070A1 (en) 1992-02-10
DK0542903T3 (da) 1997-04-21
JP3350049B2 (ja) 2002-11-25
EP0542903A4 (en) 1993-08-04
US5413779A (en) 1995-05-09
EP0542903A1 (de) 1993-05-26
AU650059B2 (en) 1994-06-09
DE69123151T2 (de) 1997-03-13
EP0542903B1 (de) 1996-11-13
JPH06503556A (ja) 1994-04-21
GR3022529T3 (en) 1997-05-31
CA2089070C (en) 2003-07-29
DE69123151D1 (de) 1996-12-19
ES2099167T3 (es) 1997-05-16
US5128118A (en) 1992-07-07
WO1992002260A1 (en) 1992-02-20
AU8519591A (en) 1992-03-02

Similar Documents

Publication Publication Date Title
DE69123151D1 (de) Kokain-rezeptor bindungsliganden
ATE347892T1 (de) Verwendung von nmda-antagonisten zur behandlung von schmerzen
AU675804B2 (en) Novel fibronectin receptors
CA2103887A1 (en) Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
HUT74246A (en) Anti-gp39 antibodies and uses therefor
ITTO910545A1 (it) Tubazione integrata per carburante
EP0873361A4 (de) Kernrezeptor-Liganden und Liganden bindenden Domänen
DE69127487D1 (de) Verfahren zum Nachweis der Alzheimer-Krankheit
EP0141079A3 (en) Monoclonal antibodies specific for membrane-associated antigens
CA2057010A1 (en) Anti-idiotypic antibody which induces an immune response against a glycosphingolipid and use thereof
FI906230A0 (fi) Konsol till hinderridningsstolpe.
AU2626488A (en) 5-ht3 receptor antagonists for treatment of cough and bronchoconstriction
TW272197B (de)
NO20002149L (no) FremgangsmÕte for Õ redusere avhengighet hos pattedyr
CA2172819A1 (en) Use of Anti-Idiotypic Antibodies to Prevent Hyperacute Rejection of Xenografts
ITMI911998A1 (it) Dispositivo abradente agglomerato particolarmente per burattatura e simili nonche&#39; procedimento realizzativo.
EP0697894A4 (de) Dopamin d-3 und serotonin (5-ht 1a) rezeptor-liganden und bildgebunde mittel
EP0670494A3 (de) Immunotest für Anti-Treponema-Pallidum Antikörper.
FI915380A7 (fi) Kaksitahtimoottoriin tarkoitettu polttoainekoostumus
ATE106886T1 (de) Azabicycloamide und -ester als 5-ht3-receptor- antagonisten.
IT1211367B (it) Gruppo di braccio tergitore per autoveicoli e simili
ATE156711T1 (de) Nicht-zellzahlverringernde cd4-spezifische monoklonale antikörper zur behandlung von insulinabhängigem diabetes mellitus (iddm)
IT1158020B (it) Metodologia per la preparazione dell&#39;antigene toxotossina adsorbito su emazie di montone
SE8503198L (sv) Hjelpanordning for underlettande av spofiske
FI943029A0 (fi) Menetelmä kolinergisina aineina käyttökelpoisten atsabisyklo- ja atsasyklo-oksiimien ja -amiinien valmistamiseksi

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time