ATE345135T1 - Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen - Google Patents

Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen

Info

Publication number
ATE345135T1
ATE345135T1 AT02803752T AT02803752T ATE345135T1 AT E345135 T1 ATE345135 T1 AT E345135T1 AT 02803752 T AT02803752 T AT 02803752T AT 02803752 T AT02803752 T AT 02803752T AT E345135 T1 ATE345135 T1 AT E345135T1
Authority
AT
Austria
Prior art keywords
treatment
dopamine
rupup
ischemic diseases
tropane derivatives
Prior art date
Application number
AT02803752T
Other languages
English (en)
Inventor
Jorgen Scheel-Krueger
Lars Christian B Ronn
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE345135T1 publication Critical patent/ATE345135T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT02803752T 2001-11-30 2002-11-28 Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen ATE345135T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200101781 2001-11-30

Publications (1)

Publication Number Publication Date
ATE345135T1 true ATE345135T1 (de) 2006-12-15

Family

ID=8160868

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02803752T ATE345135T1 (de) 2001-11-30 2002-11-28 Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen

Country Status (7)

Country Link
US (1) US7381733B2 (de)
EP (1) EP1453511B1 (de)
JP (1) JP2005511639A (de)
AT (1) ATE345135T1 (de)
AU (1) AU2002365288A1 (de)
DE (1) DE60216142T2 (de)
WO (1) WO2003045388A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1483237A4 (de) * 2002-03-28 2006-07-05 Harvard College Tropanverbindungen
JP2006517567A (ja) 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
AR045141A1 (es) 2003-07-31 2005-10-19 Neurosearch As Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas.
BRPI0416691A (pt) * 2003-11-18 2007-01-30 Boehringer Ingelheim Int forma de preparação farmacêutica sólida
DE102004004965B4 (de) * 2004-01-31 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates
US20080200498A1 (en) * 2005-07-12 2008-08-21 Angelo Ceci Pharmaceutical Composition For The Treatment Of Disorders Of Sexual Desire
GB0703998D0 (en) * 2007-03-01 2007-04-11 Glaxo Group Ltd Novel salt
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179567A (en) * 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
AU672052B2 (en) 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
DK154192D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Heterocycliske forbindelser
AU671163B2 (en) 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672644B2 (en) 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
CN1043763C (zh) 1994-04-19 1999-06-23 纽罗研究公司 莨菪烷衍生物及其制备方法和应用
RU2139857C1 (ru) 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
TR199800780T2 (xx) 1995-11-02 1998-07-21 Neurosearch A/S Kayna�m�� tropan t�revleri, haz�rlan��lar� ve kullan�mlar�.
ZA971525B (en) * 1996-02-22 1997-10-21 Neurosearch As Tropane derivatives, their preparation and use.
WO2001028550A1 (en) 1999-10-15 2001-04-26 Mayo Foundation For Medical Education And Research Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia
JP2004520396A (ja) 2001-02-15 2004-07-08 ニューロサーチ、アクティーゼルスカブ 過剰な又は不十分な細胞死によって特徴づけられる疾患の治療

Also Published As

Publication number Publication date
US20050020621A1 (en) 2005-01-27
AU2002365288A1 (en) 2003-06-10
JP2005511639A (ja) 2005-04-28
EP1453511B1 (de) 2006-11-15
US7381733B2 (en) 2008-06-03
DE60216142D1 (de) 2006-12-28
WO2003045388A1 (en) 2003-06-05
DE60216142T2 (de) 2007-09-06
EP1453511A1 (de) 2004-09-08

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