ATE145241T1 - Polypeptid, das zur interaktion mit thrombin fähig ist - Google Patents

Polypeptid, das zur interaktion mit thrombin fähig ist

Info

Publication number
ATE145241T1
ATE145241T1 AT91202009T AT91202009T ATE145241T1 AT E145241 T1 ATE145241 T1 AT E145241T1 AT 91202009 T AT91202009 T AT 91202009T AT 91202009 T AT91202009 T AT 91202009T AT E145241 T1 ATE145241 T1 AT E145241T1
Authority
AT
Austria
Prior art keywords
thrombin
gla
amino acid
polypeptide
glu
Prior art date
Application number
AT91202009T
Other languages
English (en)
Inventor
Michitaka Zushi
Komakazu Gomi
Shuji Yamamoto
Koji Suzuki
Akio Matsuda
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Application granted granted Critical
Publication of ATE145241T1 publication Critical patent/ATE145241T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT91202009T 1990-08-03 1991-08-05 Polypeptid, das zur interaktion mit thrombin fähig ist ATE145241T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20497890 1990-08-03

Publications (1)

Publication Number Publication Date
ATE145241T1 true ATE145241T1 (de) 1996-11-15

Family

ID=16499445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91202009T ATE145241T1 (de) 1990-08-03 1991-08-05 Polypeptid, das zur interaktion mit thrombin fähig ist

Country Status (9)

Country Link
US (1) US5574007A (de)
EP (1) EP0474273B1 (de)
KR (1) KR930008093B1 (de)
AT (1) ATE145241T1 (de)
AU (1) AU632958B2 (de)
CA (1) CA2048425C (de)
DE (1) DE69123106T2 (de)
ES (1) ES2093674T3 (de)
HK (1) HK1000968A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
US6949357B2 (en) * 1997-06-05 2005-09-27 Abbott Laboratories Reagents and methods useful for detecting diseases of the urinary tract
WO2003033515A1 (en) * 2001-10-15 2003-04-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
WO2003061687A1 (fr) * 2002-01-18 2003-07-31 Asahi Kasei Pharma Corporation Preparation a concentration elevee de thrombomoduline soluble
US6706068B2 (en) 2002-04-23 2004-03-16 Bret A. Ferree Artificial disc replacements with natural kinematics
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
HK1080372A1 (zh) * 2002-05-01 2006-04-28 Schering Aktiengesellschaft 作为抗凝剂的新型组织因子目标抗体
WO2008044631A1 (en) * 2006-10-06 2008-04-17 Asahi Kasei Pharma Corporation Therapeutic and/or ameliorating agent for disseminated intravascular coagulation
ES2496596T3 (es) 2007-03-23 2014-09-19 Asahi Kasei Pharma Corporation Método para producir trombomodulina soluble de gran pureza
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
NZ602852A (en) 2010-04-30 2014-03-28 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
DK2781221T3 (da) 2011-11-15 2020-06-02 Asahi Kasei Pharma Corp Medicin til behandling og/eller forbedring af sepsis
WO2020084853A1 (ja) 2018-10-22 2020-04-30 旭化成ファーマ株式会社 凝固異常を伴う敗血症の治療及び／又は改善のための医薬
CN112608965B (zh) * 2021-01-15 2022-08-05 华东理工大学 利用深海链霉菌生产怡莱霉素e的培养基及其制备方法
CN113429459B (zh) * 2021-06-16 2022-07-26 昆明医科大学第一附属医院 一种抗血小板多肽及其药物组合物与其应用
WO2023172783A2 (en) * 2022-01-07 2023-09-14 The Government Of The United States, As Represented By The Secretary Of The Army Hemostatic composition containing recombinant human clotting factors, and method of producing
CN120365400B (zh) * 2025-06-26 2025-10-31 山东大学 一种东亚钳蝎来源多肽及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005053A1 (fr) * 1987-01-08 1988-07-14 Asahi Kasei Kogyo Kabushiki Kaisha Peptide servant a accelerer l'activation de la proteine c avec de la thrombine
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
CA2042399A1 (en) * 1989-09-25 1991-03-26 Shuji Yamamoto Isolated physiologically active human thrombomodulin polypeptide

Also Published As

Publication number Publication date
KR930008093B1 (ko) 1993-08-25
ES2093674T3 (es) 1997-01-01
EP0474273A3 (en) 1992-04-08
KR920004419A (ko) 1992-03-27
CA2048425C (en) 1998-04-21
US5574007A (en) 1996-11-12
EP0474273A2 (de) 1992-03-11
AU632958B2 (en) 1993-01-14
HK1000968A1 (en) 1998-05-15
DE69123106T2 (de) 1997-04-10
DE69123106D1 (de) 1996-12-19
EP0474273B1 (de) 1996-11-13
CA2048425A1 (en) 1992-02-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee