ATE145330T1 - Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung - Google Patents

Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung

Info

Publication number
ATE145330T1
ATE145330T1 AT92308076T AT92308076T ATE145330T1 AT E145330 T1 ATE145330 T1 AT E145330T1 AT 92308076 T AT92308076 T AT 92308076T AT 92308076 T AT92308076 T AT 92308076T AT E145330 T1 ATE145330 T1 AT E145330T1
Authority
AT
Austria
Prior art keywords
compositions
codeine
oxycode
hydrocode
compositions containing
Prior art date
Application number
AT92308076T
Other languages
English (en)
Inventor
Robert B Raffa
Jeffrey L Vaught
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Application granted granted Critical
Publication of ATE145330T1 publication Critical patent/ATE145330T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Dental Preparations (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT92308076T 1991-09-06 1992-09-04 Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung ATE145330T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75592391A 1991-09-06 1991-09-06

Publications (1)

Publication Number Publication Date
ATE145330T1 true ATE145330T1 (de) 1996-12-15

Family

ID=25041253

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92308076T ATE145330T1 (de) 1991-09-06 1992-09-04 Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung

Country Status (22)

Country Link
US (1) US5468744A (de)
EP (1) EP0534628B1 (de)
JP (1) JP3244540B2 (de)
KR (1) KR100236666B1 (de)
CN (1) CN1051705C (de)
AT (1) ATE145330T1 (de)
AU (1) AU657351B2 (de)
CA (1) CA2077637C (de)
DE (1) DE69215316T2 (de)
DK (1) DK0534628T3 (de)
ES (1) ES2096726T3 (de)
GR (1) GR3022515T3 (de)
HU (1) HU217584B (de)
IL (1) IL103070A (de)
MX (1) MX9205106A (de)
MY (1) MY110317A (de)
NO (1) NO300197B1 (de)
NZ (1) NZ244250A (de)
PH (1) PH31112A (de)
TW (1) TW271394B (de)
ZA (1) ZA926732B (de)
ZW (1) ZW14392A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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DE122004000032I2 (de) 1991-09-06 2006-02-09 Mcneilab Inc Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
NZ260408A (en) * 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
KR100354702B1 (ko) 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
GB9523566D0 (en) * 1995-11-17 1996-01-17 Euro Celtique Sa Pharmaceutical formulation
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19641576C1 (de) * 1996-10-09 1998-05-07 Gruenenthal Gmbh Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
DE69809055T2 (de) 1997-07-15 2003-06-05 Russinsky Ltd., Cork Verfahren zur herstellung von reinem cis-tramadol
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
US6608073B1 (en) 1998-10-14 2003-08-19 New Millennium Pharmaceutical Research, Inc. Intranasal codeine for the rapid suppression of cough and rapid relief of pain
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
US20030118641A1 (en) * 2000-07-27 2003-06-26 Roxane Laboratories, Inc. Abuse-resistant sustained-release opioid formulation
EP1210118B1 (de) 1999-08-20 2004-12-08 Ortho-McNeil Pharmaceutical, Inc. Zusammensetzung enthaltend ein tramadol und ein antikonvulsives arzneimittel
DE19940740A1 (de) * 1999-08-31 2001-03-01 Gruenenthal Gmbh Pharmazeutische Salze
PE20010623A1 (es) 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
EP2295043A1 (de) 1999-10-29 2011-03-16 Euro-Celtique S.A. Hydrocodon-Formulierungen mit gesteuerter Freisetzung
US6297286B1 (en) * 1999-11-09 2001-10-02 Darwin Discovery, Ltd. Therapeutic use and formulation
AU2002227383B2 (en) 2000-10-30 2004-07-08 Euro-Celtique S.A. Controlled release hydrocodone formulations
EP1354868A4 (de) * 2000-12-29 2004-09-29 Otkrytoe Aktsionernoe Obchestv Tertiäre amine mit perfluoriertem ring als basis für gastransportierende emulsionen und vorrichtung zu deren herstellung
NZ528935A (en) 2001-03-16 2004-10-29 Dmi Biosciences Inc Method of delaying ejaculation
RU2196765C2 (ru) * 2001-04-09 2003-01-20 Федеральное государственное унитарное предприятие Новокузнецкий научно-исследовательский химико-фармацевтический институт Способ выделения и очистки (rr,ss)-2-[(диметиламино)метил]-1-(3-метоксифенил)циклогексанола (трамадола) гидрохлорида
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
UA81224C2 (uk) 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
EP1364649A1 (de) * 2002-05-23 2003-11-26 Cilag AG Topirimat-Tramadol Addukt und seine Verwendung
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
JP2006514986A (ja) * 2002-12-13 2006-05-18 シラグ・アクチエンゲゼルシヤフト トラマドールおよびトピラメートを含んでなる制御放出調製物
AU2007225022A1 (en) * 2006-03-15 2007-09-20 Biotech Pharmaceuticals Pty Ltd Non-codeine opioid analgesic process and formulations
MX2010005680A (es) * 2007-11-23 2010-12-21 Protect Pharmaceutical Corp Composiciones de tapentadol.
US20090264454A1 (en) * 2008-04-16 2009-10-22 Nickell Robert P Combined hydrocodone and analgesic formulation and method
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
WO1993002707A1 (de) * 1991-08-06 1993-02-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue antidiarrhoica
AU2062892A (en) * 1991-08-16 1993-02-18 Mcneil-Ppc, Inc. Potentiation of antitussive effect of dextromethorphan

Also Published As

Publication number Publication date
CN1071835A (zh) 1993-05-12
EP0534628A1 (de) 1993-03-31
NZ244250A (en) 1994-01-26
JPH06107540A (ja) 1994-04-19
CA2077637C (en) 2007-01-09
MY110317A (en) 1998-04-30
NO300197B1 (no) 1997-04-28
ES2096726T3 (es) 1997-03-16
DE69215316T2 (de) 1997-03-20
US5468744A (en) 1995-11-21
PH31112A (en) 1998-02-23
EP0534628B1 (de) 1996-11-20
TW271394B (de) 1996-03-01
IL103070A (en) 1996-10-16
KR100236666B1 (ko) 2000-03-02
HUT63556A (en) 1993-09-28
CN1051705C (zh) 2000-04-26
GR3022515T3 (en) 1997-05-31
MX9205106A (es) 1993-05-01
KR930005617A (ko) 1993-04-20
AU657351B2 (en) 1995-03-09
IL103070A0 (en) 1993-02-21
HU9202845D0 (en) 1992-11-30
DE69215316D1 (de) 1997-01-02
ZA926732B (en) 1994-03-04
DK0534628T3 (da) 1996-12-09
CA2077637A1 (en) 1993-03-07
AU2218592A (en) 1993-03-11
NO923453D0 (no) 1992-09-04
JP3244540B2 (ja) 2002-01-07
HU217584B (hu) 2000-02-28
ZW14392A1 (en) 1994-05-11
NO923453L (no) 1993-03-08

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UEP Publication of translation of european patent specification