NO923453L - Preparater omfattende et tramadolmateriale og en av kodein, oksykodon eller hydrokodon, samt deres anvendelse - Google Patents

Preparater omfattende et tramadolmateriale og en av kodein, oksykodon eller hydrokodon, samt deres anvendelse

Info

Publication number: NO923453L
Authority: NO; Norway
Prior art keywords: compositions; hydrocodone; oxycodone; tramadol material; code
Prior art date: 1991-09-06

Application number

NO92923453A

Other languages

English (en)

Other versions

NO300197B1 (no

NO923453D0 (no

Inventor

Robert B Raffa

Jeffrey L Vaught

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-06

Filing date

1992-09-04

Publication date

1993-03-08

1992-09-04 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1992-09-04 Publication of NO923453D0 publication Critical patent/NO923453D0/no

1993-03-08 Publication of NO923453L publication Critical patent/NO923453L/no

1997-04-28 Publication of NO300197B1 publication Critical patent/NO300197B1/no

Links

OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 5
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title abstract 3
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 title abstract 3
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title abstract 3
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title abstract 3
229960000240 hydrocodone Drugs 0.000 title abstract 3
239000000463 material Substances 0.000 title abstract 3
229960002085 oxycodone Drugs 0.000 title abstract 3
229960004380 tramadol Drugs 0.000 title abstract 3
TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title abstract 3
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 6
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 4
229960004126 codeine Drugs 0.000 abstract 2
206010010774 Constipation Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
206010038678 Respiratory depression Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229940127240 opiate Drugs 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1
230000000294 tussive effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Dental Preparations (AREA)
Fats And Perfumes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO923453A 1991-09-06 1992-09-04 Preparater omfattende tramadol og et opioid NO300197B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75592391A	1991-09-06	1991-09-06

Publications (3)

Publication Number	Publication Date
NO923453D0 NO923453D0 (no)	1992-09-04
NO923453L true NO923453L (no)	1993-03-08
NO300197B1 NO300197B1 (no)	1997-04-28

Family

ID=25041253

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO923453A NO300197B1 (no)	1991-09-06	1992-09-04	Preparater omfattende tramadol og et opioid

Country Status (22)

Country	Link
US (1)	US5468744A (no)
EP (1)	EP0534628B1 (no)
JP (1)	JP3244540B2 (no)
KR (1)	KR100236666B1 (no)
CN (1)	CN1051705C (no)
AT (1)	ATE145330T1 (no)
AU (1)	AU657351B2 (no)
CA (1)	CA2077637C (no)
DE (1)	DE69215316T2 (no)
DK (1)	DK0534628T3 (no)
ES (1)	ES2096726T3 (no)
GR (1)	GR3022515T3 (no)
HU (1)	HU217584B (no)
IL (1)	IL103070A (no)
MX (1)	MX9205106A (no)
MY (1)	MY110317A (no)
NO (1)	NO300197B1 (no)
NZ (1)	NZ244250A (no)
PH (1)	PH31112A (no)
TW (1)	TW271394B (no)
ZA (1)	ZA926732B (no)
ZW (1)	ZW14392A1 (no)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122004000032I2 (de)	1991-09-06	2006-02-09	Mcneilab Inc	Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung
US5958459A (en) *	1991-12-24	1999-09-28	Purdue Pharma L.P.	Opioid formulations having extended controlled released
US5968551A (en)	1991-12-24	1999-10-19	Purdue Pharma L.P.	Orally administrable opioid formulations having extended duration of effect
US5478577A (en) *	1993-11-23	1995-12-26	Euroceltique, S.A.	Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
NZ260408A (en) *	1993-05-10	1996-05-28	Euro Celtique Sa	Controlled release preparation comprising tramadol
IL110014A (en)	1993-07-01	1999-11-30	Euro Celtique Sa	Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en)	1993-07-01	2010-06-22	Purdue Pharma Lp	Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) *	1993-07-27	1999-03-09	Euro-Celtique S.A.	Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
KR100354702B1 (ko)	1993-11-23	2002-12-28	유로-셀티크 소시에떼 아노뉨	약학조성물의제조방법및서방형조성물
US5891471A (en)	1993-11-23	1999-04-06	Euro-Celtique, S.A.	Pharmaceutical multiparticulates
US5843480A (en)	1994-03-14	1998-12-01	Euro-Celtique, S.A.	Controlled release diamorphine formulation
GB9422154D0 (en)	1994-11-03	1994-12-21	Euro Celtique Sa	Pharmaceutical compositions and method of producing the same
US5965161A (en)	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
US6017963A (en) *	1995-11-14	2000-01-25	Euro-Celtique, S.A.	Formulation for intranasal administration
GB9523566D0 (en) *	1995-11-17	1996-01-17	Euro Celtique Sa	Pharmaceutical formulation
DE19601744C2 (de) *	1996-01-19	1998-04-16	Gruenenthal Gmbh	Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19641576C1 (de) *	1996-10-09	1998-05-07	Gruenenthal Gmbh	Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten
DE19712398A1 (de) *	1997-03-25	1998-10-01	Gruenenthal Gmbh	Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
DE69809055T2 (de)	1997-07-15	2003-06-05	Russinsky Ltd., Cork	Verfahren zur herstellung von reinem cis-tramadol
US6156342A (en) *	1998-05-26	2000-12-05	Andex Pharmaceuticals, Inc.	Controlled release oral dosage form
US6608073B1 (en)	1998-10-14	2003-08-19	New Millennium Pharmaceutical Research, Inc.	Intranasal codeine for the rapid suppression of cough and rapid relief of pain
US6806294B2 (en)	1998-10-15	2004-10-19	Euro-Celtique S.A.	Opioid analgesic
DE19918325A1 (de)	1999-04-22	2000-10-26	Euro Celtique Sa	Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
US20030118641A1 (en) *	2000-07-27	2003-06-26	Roxane Laboratories, Inc.	Abuse-resistant sustained-release opioid formulation
EP1210118B1 (en)	1999-08-20	2004-12-08	Ortho-McNeil Pharmaceutical, Inc.	Composition comprising a tramadol material and an anticonvulsant drug
DE19940740A1 (de) *	1999-08-31	2001-03-01	Gruenenthal Gmbh	Pharmazeutische Salze
PE20010623A1 (es)	1999-10-05	2001-07-07	Gruenenthal Chemie	Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
EP2295043A1 (en)	1999-10-29	2011-03-16	Euro-Celtique S.A.	Controlled release hydrocodone formulations
US6297286B1 (en) *	1999-11-09	2001-10-02	Darwin Discovery, Ltd.	Therapeutic use and formulation
AU2002227383B2 (en)	2000-10-30	2004-07-08	Euro-Celtique S.A.	Controlled release hydrocodone formulations
EP1354868A4 (en) *	2000-12-29	2004-09-29	Otkrytoe Aktsionernoe Obchestv	TERTIARY AMINE WITH PERFLUORED RING AS A BASE FOR GAS-TRANSPORTING EMULSIONS AND DEVICE FOR THEIR PRODUCTION
NZ528935A (en)	2001-03-16	2004-10-29	Dmi Biosciences Inc	Method of delaying ejaculation
RU2196765C2 (ru) *	2001-04-09	2003-01-20	Федеральное государственное унитарное предприятие Новокузнецкий научно-исследовательский химико-фармацевтический институт	Способ выделения и очистки (rr,ss)-2-[(диметиламино)метил]-1-(3-метоксифенил)циклогексанола (трамадола) гидрохлорида
US20110104214A1 (en)	2004-04-15	2011-05-05	Purdue Pharma L.P.	Once-a-day oxycodone formulations
UA81224C2 (uk)	2001-05-02	2007-12-25	Euro Celtic S A	Дозована форма оксикодону та її застосування
AU2002364517A1 (en)	2001-11-30	2003-06-17	Sepracor Inc.	Tramadol analogs and uses thereof
EP1364649A1 (en) *	2002-05-23	2003-11-26	Cilag AG	Adduct of topiramate and tramadol hydrochioride and uses thereof
US20040058946A1 (en) *	2002-07-05	2004-03-25	Buchwald Stephen L.	Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
JP2006514986A (ja) *	2002-12-13	2006-05-18	シラグ・アクチエンゲゼルシヤフト	トラマドールおよびトピラメートを含んでなる制御放出調製物
AU2007225022A1 (en) *	2006-03-15	2007-09-20	Biotech Pharmaceuticals Pty Ltd	Non-codeine opioid analgesic process and formulations
MX2010005680A (es) *	2007-11-23	2010-12-21	Protect Pharmaceutical Corp	Composiciones de tapentadol.
US20090264454A1 (en) *	2008-04-16	2009-10-22	Nickell Robert P	Combined hydrocodone and analgesic formulation and method
US20100003322A1 (en) *	2008-07-03	2010-01-07	Lai Felix S	Enteric coated hydrophobic matrix formulation
US20100190752A1 (en)	2008-09-05	2010-07-29	Gruenenthal Gmbh	Pharmaceutical Combination
US10702485B2 (en)	2011-07-09	2020-07-07	Syntrix Biosystems Inc.	Compositions and methods for overcoming resistance to tramadol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652589A (en) *	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
WO1993002707A1 (de) *	1991-08-06	1993-02-18	Byk Gulden Lomberg Chemische Fabrik Gmbh	Neue antidiarrhoica
AU2062892A (en) *	1991-08-16	1993-02-18	Mcneil-Ppc, Inc.	Potentiation of antitussive effect of dextromethorphan

1992
- 1992-09-04 DE DE69215316T patent/DE69215316T2/de not_active Expired - Lifetime
- 1992-09-04 AT AT92308076T patent/ATE145330T1/de active
- 1992-09-04 MX MX9205106A patent/MX9205106A/es unknown
- 1992-09-04 ZA ZA926732A patent/ZA926732B/xx unknown
- 1992-09-04 MY MYPI92001591A patent/MY110317A/en unknown
- 1992-09-04 AU AU22185/92A patent/AU657351B2/en not_active Expired
- 1992-09-04 DK DK92308076.6T patent/DK0534628T3/da active
- 1992-09-04 ES ES92308076T patent/ES2096726T3/es not_active Expired - Lifetime
- 1992-09-04 PH PH44893A patent/PH31112A/en unknown
- 1992-09-04 NO NO923453A patent/NO300197B1/no not_active IP Right Cessation
- 1992-09-04 EP EP92308076A patent/EP0534628B1/en not_active Expired - Lifetime
- 1992-09-04 HU HU9202845A patent/HU217584B/hu unknown
- 1992-09-04 CA CA002077637A patent/CA2077637C/en not_active Expired - Lifetime
- 1992-09-04 ZW ZW14392A patent/ZW14392A1/xx unknown
- 1992-09-05 KR KR1019920016227A patent/KR100236666B1/ko not_active Expired - Lifetime
- 1992-09-05 CN CN92111382A patent/CN1051705C/zh not_active Expired - Lifetime
- 1992-09-06 IL IL10307092A patent/IL103070A/en not_active IP Right Cessation
- 1992-09-07 NZ NZ244250A patent/NZ244250A/en not_active IP Right Cessation
- 1992-09-07 JP JP26269392A patent/JP3244540B2/ja not_active Expired - Lifetime
- 1992-11-10 TW TW081108967A patent/TW271394B/zh not_active IP Right Cessation
1994
- 1994-06-30 US US08/268,382 patent/US5468744A/en not_active Expired - Lifetime
1997
- 1997-02-12 GR GR960403334T patent/GR3022515T3/el unknown

Also Published As

Publication number	Publication date
CN1071835A (zh)	1993-05-12
EP0534628A1 (en)	1993-03-31
NZ244250A (en)	1994-01-26
JPH06107540A (ja)	1994-04-19
CA2077637C (en)	2007-01-09
MY110317A (en)	1998-04-30
NO300197B1 (no)	1997-04-28
ES2096726T3 (es)	1997-03-16
DE69215316T2 (de)	1997-03-20
US5468744A (en)	1995-11-21
PH31112A (en)	1998-02-23
EP0534628B1 (en)	1996-11-20
TW271394B (no)	1996-03-01
IL103070A (en)	1996-10-16
KR100236666B1 (ko)	2000-03-02
HUT63556A (en)	1993-09-28
ATE145330T1 (de)	1996-12-15
CN1051705C (zh)	2000-04-26
GR3022515T3 (en)	1997-05-31
MX9205106A (es)	1993-05-01
KR930005617A (ko)	1993-04-20
AU657351B2 (en)	1995-03-09
IL103070A0 (en)	1993-02-21
HU9202845D0 (en)	1992-11-30
DE69215316D1 (de)	1997-01-02
ZA926732B (en)	1994-03-04
DK0534628T3 (da)	1996-12-09
CA2077637A1 (en)	1993-03-07
AU2218592A (en)	1993-03-11
NO923453D0 (no)	1992-09-04
JP3244540B2 (ja)	2002-01-07
HU217584B (hu)	2000-02-28
ZW14392A1 (en)	1994-05-11

Legal Events

Date	Code	Title	Description
2012-09-10	MK1K	Patent expired

Publication	Publication Date	Title
DK0534628T3 (da)	1996-12-09	Præparater indeholdende et tramadolmateriale og enhver blandt kodein, oxykodon eller hydrokodon, samt anvendelse deraf
DK0566709T5 (da)	2009-05-18	Præparat indeholdende et tramadolmateriale og acetaminophen og anvendelse deraf
ZA928372B (en)	1994-04-29	Composition comprising a tramadol material and a nonsteroidal anti-inflammatory drug
DK0532348T3 (da)	1996-02-05	Tramadol-N-oxidmateriale, enantiomerer og præparater deraf og deres anvendelse
EP1992641A3 (en)	2009-07-29	GLP-1 analogues
MY114755A (en)	2003-01-31	Composition comprising a tramadol material and acetaminophen and its use.
FI955423L (fi)	1995-11-10	Elektroninen "Chiplock"-lukko
IE871053L (en)	1987-12-13	Resist compositions