ATE145333T1 - Hirudin enthaltende orale arzneimittel - Google Patents

Hirudin enthaltende orale arzneimittel

Info

Publication number: ATE145333T1
Authority: AT; Austria
Prior art keywords: drugs containing; oral drugs; containing hirudin; hirudin; oral
Prior art date: 1990-07-23

Application number

AT91111733T

Other languages

English (en)

Inventor

Riccardo Niada

Adriano Butti

Original Assignee

Iketon Farmaceutici Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1991-07-15

Publication date

1996-12-15

1991-07-15 Application filed by Iketon Farmaceutici Srl filed Critical Iketon Farmaceutici Srl

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE145333T1 publication Critical patent/ATE145333T1/de

Links

WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 2
102000007625 Hirudins Human genes 0.000 title 1
108010007267 Hirudins Proteins 0.000 title 1
229940006607 hirudin Drugs 0.000 title 1
229940126701 oral medication Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Dispersion Chemistry (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91111733T 1990-07-23 1991-07-15 Hirudin enthaltende orale arzneimittel ATE145333T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina

Publications (1)

Publication Number	Publication Date
ATE145333T1 true ATE145333T1 (de)	1996-12-15

Family

ID=11175506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91111733T ATE145333T1 (de)	1990-07-23	1991-07-15	Hirudin enthaltende orale arzneimittel

Country Status (7)

Country	Link
EP (1)	EP0468327B1 (de)
JP (1)	JPH04270229A (de)
AT (1)	ATE145333T1 (de)
DE (1)	DE69123190D1 (de)
IE (1)	IE912566A1 (de)
IT (1)	IT1243358B (de)
PT (1)	PT98406A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI930265A0 (fi) *	1990-07-24	1993-01-22	Merrell Dow Pharma	Antikoagulantpeptider
KR100330465B1 (ko) *	1993-06-11	2002-11-23	메렐 파마슈티칼스 인크.	삼관능성항트롬빈및항혈소판펩티드
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
GB9401448D0 (en) *	1994-01-26	1994-03-23	Ciba Geigy Ag	Stable dry powders
WO2003022858A2 (de) *	2001-09-11	2003-03-20	Nascacell Gmbh	Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR3792M (fr) *	1964-08-21	1965-12-27	Egema	Médicaments nouveaux a base de constituants actifs extraits de sangsues.
NL7900459A (nl) *	1979-01-19	1980-07-22	Hendrik Coenraad Hemker Prof D	Farmaceutisch preparaat en werkwijze ter bereiding daarvan.
US4348384A (en) *	1980-10-17	1982-09-07	Dainippon Pharmaceutical Co., Ltd.	Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
EP0333356A3 (de) *	1988-03-04	1990-12-19	Biogen, Inc.	Hirudin-Peptide
WO1990006128A1 (en) *	1988-12-05	1990-06-14	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation

1990
- 1990-07-23 IT IT02102190A patent/IT1243358B/it active IP Right Grant
1991
- 1991-07-15 EP EP91111733A patent/EP0468327B1/de not_active Expired - Lifetime
- 1991-07-15 DE DE69123190T patent/DE69123190D1/de not_active Expired - Lifetime
- 1991-07-15 AT AT91111733T patent/ATE145333T1/de not_active IP Right Cessation
- 1991-07-22 IE IE256691A patent/IE912566A1/en unknown
- 1991-07-22 PT PT98406A patent/PT98406A/pt not_active Application Discontinuation
- 1991-07-22 JP JP3204613A patent/JPH04270229A/ja active Pending

Also Published As

Publication number	Publication date
DE69123190D1 (de)	1997-01-02
PT98406A (pt)	1992-05-29
EP0468327A2 (de)	1992-01-29
IT1243358B (it)	1994-06-10
IE912566A1 (en)	1992-01-29
EP0468327B1 (de)	1996-11-20
JPH04270229A (ja)	1992-09-25
IT9021021A0 (it)	1990-07-23
EP0468327A3 (en)	1992-08-26
IT9021021A1 (it)	1992-01-23

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Legal Events

Date	Code	Title	Description
1997-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties