IT9021021A0 - Composizioni farmaceutiche per la somministrazione orale di irudina - Google Patents

Composizioni farmaceutiche per la somministrazione orale di irudina

Info

Publication number: IT9021021A0
Authority: IT; Italy
Prior art keywords: hirudin; pharmaceutical compositions; oral administration; oral; administration
Prior art date: 1990-07-23

Application number

IT21021A

Other languages

English (en)

Other versions

IT1243358B (it

IT9021021A1 (it

Inventor

Riccardo Niada

Adriano Butti

Original Assignee

Iketon Farmaceeutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1990-07-23

Publication date

1990-07-23

1990-07-23 Application filed by Iketon Farmaceeutici filed Critical Iketon Farmaceeutici

1990-07-23 Priority to IT02102190A priority Critical patent/IT1243358B/it

1990-07-23 Publication of IT9021021A0 publication Critical patent/IT9021021A0/it

1991-07-15 Priority to AT91111733T priority patent/ATE145333T1/de

1991-07-15 Priority to DE69123190T priority patent/DE69123190D1/de

1991-07-15 Priority to EP91111733A priority patent/EP0468327B1/en

1991-07-22 Priority to PT98406A priority patent/PT98406A/pt

1991-07-22 Priority to JP3204613A priority patent/JPH04270229A/ja

1991-07-22 Priority to IE256691A priority patent/IE912566A1/en

1992-01-23 Publication of IT9021021A1 publication Critical patent/IT9021021A1/it

1994-06-10 Application granted granted Critical

1994-06-10 Publication of IT1243358B publication Critical patent/IT1243358B/it

Links

102000007625 Hirudins Human genes 0.000 title 1
108010007267 Hirudins Proteins 0.000 title 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title 1
229940006607 hirudin Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Dispersion Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IT02102190A 1990-07-23 1990-07-23 Composizioni farmaceutiche per la somministrazione orale di irudina IT1243358B (it)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina
AT91111733T ATE145333T1 (de)	1990-07-23	1991-07-15	Hirudin enthaltende orale arzneimittel
DE69123190T DE69123190D1 (de)	1990-07-23	1991-07-15	Hirudin enthaltende orale Arzneimittel
EP91111733A EP0468327B1 (en)	1990-07-23	1991-07-15	Oral pharmaceutical compositions containing hirudin
PT98406A PT98406A (pt)	1990-07-23	1991-07-22	Processo para a preparacao de composicoes farmaceuticas orais contendo hirudina
JP3204613A JPH04270229A (ja)	1990-07-23	1991-07-22	ヒルジンを含む経口用製薬学的組成物
IE256691A IE912566A1 (en)	1990-07-23	1991-07-22	Oral pharmaceutical compositions containing hirudin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina

Publications (3)

Publication Number	Publication Date
IT9021021A0 true IT9021021A0 (it)	1990-07-23
IT9021021A1 IT9021021A1 (it)	1992-01-23
IT1243358B IT1243358B (it)	1994-06-10

Family

ID=11175506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT02102190A IT1243358B (it)	1990-07-23	1990-07-23	Composizioni farmaceutiche per la somministrazione orale di irudina

Country Status (7)

Country	Link
EP (1)	EP0468327B1 (it)
JP (1)	JPH04270229A (it)
AT (1)	ATE145333T1 (it)
DE (1)	DE69123190D1 (it)
IE (1)	IE912566A1 (it)
IT (1)	IT1243358B (it)
PT (1)	PT98406A (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0540574T3 (da) *	1990-07-24	1996-09-30	Merrell Pharma Inc	Antikoagulationspeptider
NZ268159A (en) *	1993-06-11	1997-03-24	Merrell Pharma Inc	Anticoagulant and antiplatelet peptides and their use
GB9401448D0 (en) *	1994-01-26	1994-03-23	Ciba Geigy Ag	Stable dry powders
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
WO2003022858A2 (de) *	2001-09-11	2003-03-20	Nascacell Gmbh	Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR3792M (fr) *	1964-08-21	1965-12-27	Egema	Médicaments nouveaux a base de constituants actifs extraits de sangsues.
NL7900459A (nl) *	1979-01-19	1980-07-22	Hendrik Coenraad Hemker Prof D	Farmaceutisch preparaat en werkwijze ter bereiding daarvan.
US4348384A (en) *	1980-10-17	1982-09-07	Dainippon Pharmaceutical Co., Ltd.	Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
AU3098289A (en) *	1988-03-04	1989-09-07	Biogen, Inc.	Hirudin peptides
WO1990006128A1 (en) *	1988-12-05	1990-06-14	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation

1990
- 1990-07-23 IT IT02102190A patent/IT1243358B/it active IP Right Grant
1991
- 1991-07-15 AT AT91111733T patent/ATE145333T1/de not_active IP Right Cessation
- 1991-07-15 DE DE69123190T patent/DE69123190D1/de not_active Expired - Lifetime
- 1991-07-15 EP EP91111733A patent/EP0468327B1/en not_active Expired - Lifetime
- 1991-07-22 PT PT98406A patent/PT98406A/pt not_active Application Discontinuation
- 1991-07-22 IE IE256691A patent/IE912566A1/en unknown
- 1991-07-22 JP JP3204613A patent/JPH04270229A/ja active Pending

Also Published As

Publication number	Publication date
DE69123190D1 (de)	1997-01-02
EP0468327A3 (en)	1992-08-26
IT1243358B (it)	1994-06-10
IE912566A1 (en)	1992-01-29
JPH04270229A (ja)	1992-09-25
IT9021021A1 (it)	1992-01-23
PT98406A (pt)	1992-05-29
ATE145333T1 (de)	1996-12-15
EP0468327A2 (en)	1992-01-29
EP0468327B1 (en)	1996-11-20

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Legal Events

Date	Code	Title	Description
1994-06-10	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19960725