ATE145404T1 - Verfahren zur reinigung von pentostatin - Google Patents

Verfahren zur reinigung von pentostatin

Info

Publication number: ATE145404T1
Authority: AT; Austria
Prior art keywords: pentostatin; eluting; applying; water; eluate
Prior art date: 1991-07-31

Application number

AT92916090T

Other languages

English (en)

Inventor

James Clark French

Peter Mcdonnell

Howard Daniel Hollis Showalter

Colin Rath Lower Castl Edmunds

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-31

Filing date

1992-07-16

Publication date

1996-12-15

1992-07-16 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE145404T1 publication Critical patent/ATE145404T1/de

Links

FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 title abstract 3
FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 title abstract 3
229960002340 pentostatin Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
238000000746 purification Methods 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000011324 bead Substances 0.000 abstract 2
235000013405 beer Nutrition 0.000 abstract 2
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 abstract 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
239000000908 ammonium hydroxide Substances 0.000 abstract 1
239000003957 anion exchange resin Substances 0.000 abstract 1
229940063013 borate ion Drugs 0.000 abstract 1
239000012607 strong cation exchange resin Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

AT92916090T 1991-07-31 1992-07-16 Verfahren zur reinigung von pentostatin ATE145404T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US73871591A	1991-07-31	1991-07-31

Publications (1)

Publication Number	Publication Date
ATE145404T1 true ATE145404T1 (de)	1996-12-15

Family

ID=24969187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92916090T ATE145404T1 (de)	1991-07-31	1992-07-16	Verfahren zur reinigung von pentostatin

Country Status (15)

Country	Link
US (1)	US5463035A (de)
EP (1)	EP0596943B1 (de)
JP (1)	JP3141029B2 (de)
AT (1)	ATE145404T1 (de)
AU (1)	AU2381792A (de)
DE (1)	DE69215375T2 (de)
DK (1)	DK0596943T3 (de)
ES (1)	ES2094919T3 (de)
GR (1)	GR3022387T3 (de)
HU (1)	HU215126B (de)
IE (1)	IE80618B1 (de)
MX (1)	MX9204460A (de)
PT (1)	PT100755B (de)
WO (1)	WO1993003048A1 (de)
ZA (1)	ZA925732B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60315790T2 (de) *	2003-01-16	2008-06-05	Adorkem Technology S.P.A., Costa Volpino	Immobilisierte Biokatalysatoren für die Herstellung von natürlichen Nukleosiden und modifizierten Analogen durch enzymatische Transglykosylierungsreaktionen
ITMI20052516A1 (it) *	2005-12-29	2007-06-30	Evultis Sa	PROCESSO PER L'ISOLAMENTO DI PèRINCIPI FARMACOLOGICAMENTE ATTIVI DI ORIGINE VEGETALE ED ANIMALE
CN101792722B (zh) *	2009-02-04	2013-04-10	杭州华东医药集团生物工程研究所有限公司	一种链霉菌及其应用
CN101798330A (zh) *	2009-02-06	2010-08-11	杭州华东医药集团生物工程研究所有限公司	一种喷司他丁的提取纯化方法
US20100261666A1 (en) *	2009-04-14	2010-10-14	The Board Of Trustees Of The University Of Illinois	Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis
CN102453065B (zh) *	2010-10-29	2014-12-17	上海医药工业研究院	一种去除喷司他丁发酵液中杂质的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3923785A (en) *	1974-04-22	1975-12-02	Parke Davis & Co	(R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol
US4713372A (en) *	1984-03-16	1987-12-15	Warner-Lambert Company	2-chloropentostatin compound having adenosine diaminase inhibitory activity
IT1182764B (it) *	1985-06-26	1987-10-05	Pietro Crocoli	Water closet, particolarmente adatto per veicoli
US4935342A (en) *	1986-12-01	1990-06-19	Syngene, Inc.	Method of isolating and purifying nucleic acids from biological samples
US4908441A (en) *	1988-07-19	1990-03-13	Warner-Lambert Company	Deoxyadenosine compounds and methods of making and using the same

1992
- 1992-07-16 EP EP92916090A patent/EP0596943B1/de not_active Expired - Lifetime
- 1992-07-16 DK DK92916090.1T patent/DK0596943T3/da active
- 1992-07-16 AU AU23817/92A patent/AU2381792A/en not_active Abandoned
- 1992-07-16 ES ES92916090T patent/ES2094919T3/es not_active Expired - Lifetime
- 1992-07-16 JP JP05503590A patent/JP3141029B2/ja not_active Expired - Lifetime
- 1992-07-16 DE DE69215375T patent/DE69215375T2/de not_active Expired - Lifetime
- 1992-07-16 WO PCT/US1992/005946 patent/WO1993003048A1/en not_active Ceased
- 1992-07-16 HU HU9400257A patent/HU215126B/hu unknown
- 1992-07-16 AT AT92916090T patent/ATE145404T1/de active
- 1992-07-30 IE IE922507A patent/IE80618B1/en not_active IP Right Cessation
- 1992-07-30 MX MX9204460A patent/MX9204460A/es unknown
- 1992-07-30 ZA ZA925732A patent/ZA925732B/xx unknown
- 1992-07-31 PT PT100755A patent/PT100755B/pt not_active IP Right Cessation
1995
- 1995-02-28 US US08/396,443 patent/US5463035A/en not_active Expired - Lifetime
1997
- 1997-01-29 GR GR960403293T patent/GR3022387T3/el unknown

Also Published As

Publication number	Publication date
DE69215375T2 (de)	1997-03-13
HU215126B (hu)	1998-09-28
IE922507A1 (en)	1993-02-10
PT100755A (pt)	1993-10-29
EP0596943A1 (de)	1994-05-18
EP0596943B1 (de)	1996-11-20
WO1993003048A1 (en)	1993-02-18
PT100755B (pt)	1999-07-30
HUT65981A (en)	1994-08-29
DK0596943T3 (da)	1997-04-21
GR3022387T3 (en)	1997-04-30
HU9400257D0 (en)	1994-05-30
IE80618B1 (en)	1998-10-21
AU2381792A (en)	1993-03-02
JP3141029B2 (ja)	2001-03-05
DE69215375D1 (de)	1997-01-02
MX9204460A (es)	1993-04-01
US5463035A (en)	1995-10-31
ZA925732B (en)	1994-01-31
ES2094919T3 (es)	1997-02-01
JPH06509355A (ja)	1994-10-20

Legal Events

Date	Code	Title	Description
1997-05-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
US5279744A (en)	1994-01-18	Method for purification of an amino acid using ion exchange resin
PT99248A (pt)	1993-06-30	Processo para a purificcao de anticorpos
PT893450E (pt)	2004-09-30	Metodo cromatografico para purificacao de elevado rendimento e inactivacao viral de anticorpos
AU5510490A (en)	1990-10-25	Purification, production and use of tumor necrosis factors
EP0712827A4 (de)	1996-11-06	Verfahren zur herstellung von d-chiro inositol
EP0949632A3 (de)	2003-08-13	Verfahren zur Erzeugung von (F-18)-Fluoridion
MY108512A (en)	1996-10-31	Method of purifying protein
ATE145404T1 (de)	1996-12-15	Verfahren zur reinigung von pentostatin
CA2143280A1 (en)	1994-06-23	Separation of phytate from plant protein using ion exchange
ES8207127A1 (es)	1982-09-01	Un procedimiento para recuperar betaina de melazas
US5300653A (en)	1994-04-05	Separation method of amino acids
MY108534A (en)	1996-10-31	Process for purifying n-phosphonomethylgycine
DE68908024D1 (de)	1993-09-09	Verfahren zur rueckgewinnung der zitronensaeure aus fluessigkeiten, die sie enthalten.
GB1435063A (en)	1976-05-12	Preparation of beta-aminopropionitrile
JPS62111953A (ja)	1987-05-22	グリシンとｌ−セリンの分離方法
MY109523A (en)	1997-02-28	Method of regenerating resin beads for use in water purification.
DE59813491D1 (de)	2006-05-24	Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
EP0155384A3 (de)	1986-04-16	Methode zur Behandlung wässriger Lösungen mit schwach sauren Kationen- und basischen Anionen-Austauscherharzen
GB811688A (en)	1959-04-08	Method for purification of glutamic acid
GB1201823A (en)	1970-08-12	Process for recovering glutamic acid
TW260624B (en)	1995-10-21	Process of separating tryptophan (Trp) from zymotic fluid by ion-exchange displacement chromatography
French et al.	1996	Process for purifying pentostatin
GB1143072A (en)	1969-02-19	Purification of esters
GB1177125A (en)	1970-01-07	A process for Purifying Proline
GB1285024A (en)	1972-08-09	Process of purifying insulin