ATE145560T1 - Verfahren zur reinigung von chelator-konjugierten verbindungen - Google Patents

Verfahren zur reinigung von chelator-konjugierten verbindungen

Info

Publication number
ATE145560T1
ATE145560T1 AT90915696T AT90915696T ATE145560T1 AT E145560 T1 ATE145560 T1 AT E145560T1 AT 90915696 T AT90915696 T AT 90915696T AT 90915696 T AT90915696 T AT 90915696T AT E145560 T1 ATE145560 T1 AT E145560T1
Authority
AT
Austria
Prior art keywords
chelator
purifying
labeling reagent
conjugate compounds
unbound
Prior art date
Application number
AT90915696T
Other languages
English (en)
Inventor
Ramaswamy Subramanian
Original Assignee
Akzo Nobel Nv
Ramaswamy Subramanian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Ramaswamy Subramanian filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE145560T1 publication Critical patent/ATE145560T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Forklifts And Lifting Vehicles (AREA)
  • Paper (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT90915696T 1989-10-11 1990-10-10 Verfahren zur reinigung von chelator-konjugierten verbindungen ATE145560T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/419,871 US5244816A (en) 1989-10-11 1989-10-11 Method for purifying chelator conjugated compounds

Publications (1)

Publication Number Publication Date
ATE145560T1 true ATE145560T1 (de) 1996-12-15

Family

ID=23664097

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90915696T ATE145560T1 (de) 1989-10-11 1990-10-10 Verfahren zur reinigung von chelator-konjugierten verbindungen

Country Status (16)

Country Link
US (1) US5244816A (de)
EP (1) EP0495878B1 (de)
JP (1) JP3078575B2 (de)
KR (1) KR100206060B1 (de)
AT (1) ATE145560T1 (de)
AU (1) AU656717B2 (de)
CA (1) CA2069303A1 (de)
DE (1) DE69029274T2 (de)
DK (1) DK48892D0 (de)
ES (1) ES2097156T3 (de)
FI (1) FI921579A0 (de)
GR (1) GR3022645T3 (de)
IE (1) IE75714B1 (de)
PT (1) PT95574B (de)
WO (1) WO1991006008A1 (de)
ZA (1) ZA908095B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800802A (en) * 1989-10-11 1998-09-01 Subramanian; Ramaswamy Chelator IDAC-2
US5459040A (en) * 1993-11-22 1995-10-17 The Regents Of The University Of California Enzyme amplified, complex linked, competitive and non-competitive assays for the detection of metal ions
DE4428874A1 (de) * 1994-08-08 1996-02-22 Schering Ag Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19612650C1 (de) * 1996-04-02 1997-07-31 Evotec Biosystems Gmbh Verfahren zur Fluoreszenzmarkierung von Molekülen
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
FR2762394B1 (fr) * 1997-04-16 1999-05-28 Bio Merieux Compose ligand de coordination et utilisation pour fixer un materiel biologique
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis
FR2791582B1 (fr) * 1999-04-02 2001-06-08 Expansia Sa Utilisation d'un support polymerique acrylique en catalyse supportee
AU2001232845A1 (en) * 2000-01-21 2001-07-31 Mallinckrodt, Inc. Methods for incorporating metal chelators at carboxyl-terminal site of peptides
GB0028879D0 (en) * 2000-11-27 2001-01-10 Prometic Biosciences Ltd Adsorbents and their use
US7514078B2 (en) 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
ATE535258T1 (de) 2001-06-01 2011-12-15 Cornell Res Foundation Inc Modifizierte antikörper gegen prostata- spezifisches membranantigen und ihre verwendungen
JP2005527474A (ja) 2001-09-20 2005-09-15 コーネル リサーチ ファンデーション インコーポレーテッド 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物
WO2003045546A1 (en) * 2001-11-27 2003-06-05 Prometic Biosciences Ltd. The use of metal-chelating adsorbents
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
DE10350484B4 (de) * 2003-12-20 2006-02-02 Ehrfeld Mikrotechnik Bts Gmbh Verfahren und Vorrichtung zur Markierung von Proteinen
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
US9650412B2 (en) 2013-03-08 2017-05-16 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
AU2019332764B2 (en) 2018-08-31 2025-05-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
JP7816003B2 (ja) * 2022-06-06 2026-02-18 Ｊｆｅエンジニアリング株式会社 放射性物質の標識方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
US4283382A (en) * 1977-12-28 1981-08-11 Eastman Kodak Company Fluorescent labels comprising rare earth chelates
GB2122641B (en) * 1982-06-07 1986-08-06 Otto A Gansow Metal chelate conjugated monoclonal antibodies where in the metal is an emitter
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US4775638A (en) * 1985-05-08 1988-10-04 Centocor, Inc. Single vial technique for radiolabeling protein
WO1988002635A1 (en) * 1986-10-17 1988-04-21 Cytogen Corporation Method for preparation of protein-chelator-metal ion compositions suitable for injection
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents

Also Published As

Publication number Publication date
FI921579A7 (fi) 1992-04-09
PT95574B (pt) 1997-08-29
IE75714B1 (en) 1997-09-24
DK48892A (da) 1992-04-10
KR100206060B1 (ko) 1999-07-01
US5244816A (en) 1993-09-14
PT95574A (pt) 1991-08-14
DE69029274T2 (de) 1997-05-28
DK48892D0 (da) 1992-04-10
CA2069303A1 (en) 1991-04-12
IE903585A1 (en) 1991-04-24
JPH05503354A (ja) 1993-06-03
EP0495878B1 (de) 1996-11-27
ES2097156T3 (es) 1997-04-01
KR920704139A (ko) 1992-12-19
JP3078575B2 (ja) 2000-08-21
AU656717B2 (en) 1995-02-16
DE69029274D1 (de) 1997-01-09
FI921579L (fi) 1992-04-09
EP0495878A4 (en) 1992-09-30
EP0495878A1 (de) 1992-07-29
WO1991006008A1 (en) 1991-05-02
FI921579A0 (fi) 1992-04-09
AU6547190A (en) 1991-05-16
GR3022645T3 (en) 1997-05-31
ZA908095B (en) 1991-11-27

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee