ZA937112B - 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same - Google Patents

17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same

Info

Publication number: ZA937112B
Authority: ZA; South Africa
Prior art keywords: androstene; androstane; heterocyclyl; aryl; preparation
Prior art date: 1992-09-29

Application number

ZA937112A

Other languages

English (en)

Inventor

Peiro Melloni

Mara Ferrandi

Marina Mauro

Luigi Bernardi

Marco Frigerio

Luisa Quadri

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-29

Filing date

1993-09-24

Publication date

1995-07-25

1993-09-24 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1995-07-25 Publication of ZA937112B publication Critical patent/ZA937112B/xx

Links

NXQOQNROJJFYCJ-FZFXZXLVSA-N androst-16-ene Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC21 NXQOQNROJJFYCJ-FZFXZXLVSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
210000000748 cardiovascular system Anatomy 0.000 title 1
150000001439 androstadienes Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA937112A 1992-09-29 1993-09-24 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same ZA937112B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4232681A DE4232681C2 (de)	1992-09-29	1992-09-29	17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung

Publications (1)

Publication Number	Publication Date
ZA937112B true ZA937112B (en)	1995-07-25

Family

ID=6469164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA937112A ZA937112B (en)	1992-09-29	1993-09-24	17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same

Country Status (11)

Country	Link
US (2)	US5556846A (de)
EP (1)	EP0590271B1 (de)
JP (1)	JPH06192287A (de)
KR (1)	KR940007054A (de)
AT (1)	ATE145649T1 (de)
CA (1)	CA2106916A1 (de)
DE (2)	DE4232681C2 (de)
DK (1)	DK0590271T3 (de)
ES (1)	ES2094974T3 (de)
GR (1)	GR3021789T3 (de)
ZA (1)	ZA937112B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1279386B1 (it) *	1994-11-07	1997-12-10	Sigma Tau Ind Farmaceuti	1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
US5847172A (en) *	1995-06-07	1998-12-08	Magainin Pharmaceuticals Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994334A (en) *	1997-02-05	1999-11-30	University Of Maryland	Androgen synthesis inhibitors
US5994335A (en) *	1997-10-17	1999-11-30	The University Of Maryland, Baltimore	17-azolyl steroids useful as androgen synthesis inhibitors
US20100047338A1 (en)	2008-03-14	2010-02-25	Angela Brodie	Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009137335A1 (en) *	2008-05-05	2009-11-12	The Scripps Research Institute	Synthesis of (+) corstistatin a and related compounds
AU2010210422A1 (en)	2009-02-05	2011-08-18	Tokai Pharmaceuticals, Inc.	Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
JP5738267B2 (ja)	2009-03-23	2015-06-24	シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−ＴａｕＩｎｄｕｓｔｒｉｅＦａｒｍａｃｅｕｔｉｃｈｅＲｉｕｎｉｔｅＳｏｃｉｅｔａＰｅｒＡｚｉｏｎｉ	タンパク尿、糸球体硬化、及び腎不全の治療に有用な５−β，１４−β−アンドロスタン誘導体
EP2499151A4 (de) *	2009-11-13	2013-03-20	Tokai Pharmaceuticals Inc	Säugetier-metabolite aus steroiden
ES2738526T3 (es)	2011-10-14	2020-01-23	Sage Therapeutics Inc	Compuestos 19-norpregnano 3,3-disustituidos, composiciones y usos de los mismos
KR20150127720A (ko)	2013-03-14	2015-11-17	유니버시티 오브 매릴랜드, 발티모어	안드로겐 수용체 하향 조절제 및 그의 용도
US20160068563A1 (en)	2013-04-17	2016-03-10	Boyd L. Harrison	19-nor neuroactive steroids and methods of use thereof
WO2014169831A1 (en)	2013-04-17	2014-10-23	Sage Therapeutics, Inc.	19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
HRP20190232T1 (hr)	2013-04-17	2019-03-22	Sage Therapeutics, Inc.	19-nor c3,3-disupstituirani c21-n-pirazolil steroidi i postupci za njihovu upotrebu
HRP20200995T1 (hr)	2013-04-17	2020-11-27	Sage Therapeutics, Inc.	19-nor neuroaktivni steroidi za metode liječenja
SMT202100229T1 (it)	2013-07-19	2021-05-07	Sage Therapeutics Inc	Steroidi neuroattivi, composizioni e loro usi
WO2015023710A1 (en)	2013-08-12	2015-02-19	Tokai Pharmaceuticals, Inc.	Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
SMT202100048T1 (it)	2013-08-23	2021-03-15	Sage Therapeutics Inc	Steroidi neuroattivi, composizioni e loro usi
WO2015195962A1 (en)	2014-06-18	2015-12-23	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
AU2015331749A1 (en)	2014-10-16	2017-05-04	Sage Therapeutics, Inc.	Compositions and methods for treating CNS disorders
JP6742308B2 (ja)	2014-10-16	2020-08-19	セージセラピューティクス，インコーポレイテッド	Ｃｎｓ障害を処置するための組成物および方法
ES2793237T3 (es)	2014-11-27	2020-11-13	Sage Therapeutics Inc	Composiciones y métodos para el tratamiento de trastornos del SNC
SI3250210T1 (sl) *	2015-01-26	2021-07-30	Sage Therapeutics, Inc.	Sestavki in metode za zdravljenje CNS motenj
US10329320B2 (en)	2015-02-20	2019-06-25	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
CN109689673B (zh)	2016-07-11	2023-03-14	萨奇治疗股份有限公司	C17、c20和c21取代的神经活性类固醇及其使用方法
AU2017296295B2 (en)	2016-07-11	2022-02-24	Sage Therapeutics, Inc.	C7, C12, and C16 substituted neuroactive steroids and their methods of use
CN114206900A (zh)	2019-05-31	2022-03-18	萨奇治疗股份有限公司	神经活性类固醇及其组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3405127A (en) *	1965-07-13	1968-10-08	Sterling Drug Inc	12, 17-dioxygenated steroids
DE1768800C3 (de) *	1968-07-02	1978-07-06	Hoechst Ag, 6000 Frankfurt	Verfahren zur Herstellung von 14 ß- Hydroxy-3oxo-5 a-card-20(22)- enoliden
DE2614046C2 (de) *	1976-04-01	1984-08-02	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3832303A1 (de) *	1988-09-20	1990-04-12	Schering Ag	11ss-phenyl-14ssh-steroide
IT1250410B (it) *	1991-02-14	1995-04-07	Simes	Composti steroidei attivi sul sistema cardiovascolare
DE4232638C2 (de) *	1992-09-29	1994-11-17	Sigma Tau Ind Farmaceuti	17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

1992
- 1992-09-29 DE DE4232681A patent/DE4232681C2/de not_active Expired - Fee Related
1993
- 1993-08-03 ES ES93112408T patent/ES2094974T3/es not_active Expired - Lifetime
- 1993-08-03 EP EP93112408A patent/EP0590271B1/de not_active Expired - Lifetime
- 1993-08-03 DE DE69306212T patent/DE69306212T2/de not_active Expired - Fee Related
- 1993-08-03 DK DK93112408.5T patent/DK0590271T3/da active
- 1993-08-03 AT AT93112408T patent/ATE145649T1/de not_active IP Right Cessation
- 1993-09-24 CA CA002106916A patent/CA2106916A1/en not_active Abandoned
- 1993-09-24 ZA ZA937112A patent/ZA937112B/xx unknown
- 1993-09-27 KR KR1019930019823A patent/KR940007054A/ko not_active Ceased
- 1993-09-29 US US08/128,116 patent/US5556846A/en not_active Expired - Fee Related
- 1993-09-29 JP JP5243361A patent/JPH06192287A/ja active Pending
1995
- 1995-11-03 US US08/552,796 patent/US5721227A/en not_active Expired - Fee Related
1996
- 1996-11-28 GR GR960402277T patent/GR3021789T3/el unknown

Also Published As

Publication number	Publication date
CA2106916A1 (en)	1994-03-30
HK1005880A1 (en)	1999-01-29
EP0590271A3 (en)	1994-07-06
GR3021789T3 (en)	1997-02-28
DE4232681A1 (de)	1994-03-31
DK0590271T3 (da)	1996-12-16
DE69306212D1 (de)	1997-01-09
US5721227A (en)	1998-02-24
DE4232681C2 (de)	1994-11-24
ES2094974T3 (es)	1997-02-01
EP0590271B1 (de)	1996-11-27
DE69306212T2 (de)	1997-04-24
EP0590271A2 (de)	1994-04-06
JPH06192287A (ja)	1994-07-12
ATE145649T1 (de)	1996-12-15
US5556846A (en)	1996-09-17
KR940007054A (ko)	1994-04-26

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