ATE145918T1 - Monoquaternäre 2,16- bispiperidinglandrostanderivate - Google Patents

Monoquaternäre 2,16- bispiperidinglandrostanderivate

Info

Publication number: ATE145918T1
Authority: AT; Austria
Prior art keywords: monoquaternary; derivatives; bispiperidingland; rostan; pharmaceutically acceptable
Prior art date: 1992-04-22

Application number

AT93201128T

Other languages

English (en)

Inventor

Thomas Sleigh

Ian Craig Carlyle

Alan William Muir

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-22

Filing date

1993-04-20

Publication date

1996-12-15

1993-04-20 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE145918T1 publication Critical patent/ATE145918T1/de

Links

DMHAQWRUHROFSM-JOVDGUMFSA-N 1-[(5S,8S,9S,10S,13R,14S)-10,13-dimethyl-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl]piperidine Chemical group N1(CCCCC1)C1CC[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(CC(C[C@H]43)N4CCCCC4)C)[C@]2(C1)C DMHAQWRUHROFSM-JOVDGUMFSA-N 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000002232 neuromuscular Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Fats And Perfumes (AREA)

AT93201128T 1992-04-22 1993-04-20 Monoquaternäre 2,16- bispiperidinglandrostanderivate ATE145918T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP92303612		1992-04-22

Publications (1)

Publication Number	Publication Date
ATE145918T1 true ATE145918T1 (de)	1996-12-15

Family

ID=8211340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93201128T ATE145918T1 (de)	1992-04-22	1993-04-20	Monoquaternäre 2,16- bispiperidinglandrostanderivate

Country Status (16)

Country	Link
US (1)	US5418226A (de)
EP (1)	EP0571012B1 (de)
JP (1)	JP3344764B2 (de)
KR (1)	KR100281296B1 (de)
AT (1)	ATE145918T1 (de)
AU (1)	AU662277B2 (de)
CA (1)	CA2094457C (de)
CZ (1)	CZ286728B6 (de)
DE (1)	DE69306303T2 (de)
DK (1)	DK0571012T3 (de)
ES (1)	ES2097435T3 (de)
FI (1)	FI111644B (de)
GR (1)	GR3022316T3 (de)
HU (2)	HUT64970A (de)
MX (1)	MX9302303A (de)
NO (1)	NO301931B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9302455D0 (en) *	1993-02-08	1993-03-24	Lab Inpharm N V	Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
IT1277700B1 (it) *	1995-12-22	1997-11-11	Poli Ind Chimica Spa	Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
WO1999027914A1 (en) *	1997-11-27	1999-06-10	Akzo Nobel N.V.	A pharmaceutical formulation of monoquaternary 2,16-bispiperidinylandrostane for intramuscular administration
HU0402017D0 (en) *	2004-10-07	2004-12-28	Richter Gedeon Vegyeszet	Environment-friend process for the synthesis of quaternary ammonio-steroids
CN110251459A (zh) *	2013-07-01	2019-09-20	丸石制药株式会社	改善了血管痛的罗库铵制剂及其制造方法以及使用该罗库铵制剂的血管痛的抑制、缓和方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1138605A (en) *	1965-02-19	1969-01-01	Organon Labor Ltd	Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
EP0008824B1 (de) *	1978-09-05	1982-04-28	Akzo N.V.	Säureadditionssalze von 2-beta, 16-beta-bis-Piperidino-androstan-16-beta-monoquaternären Ammoniumderivaten und diese enthaltende pharmazeutische Zusammensetzungen
IE50675B1 (en) *	1979-12-12	1986-06-11	Akzo Nv	Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
US4337386A (en) *	1980-01-21	1982-06-29	Caterpillar Tractor Co.	Welder control

1993
- 1993-04-14 US US08/048,539 patent/US5418226A/en not_active Expired - Lifetime
- 1993-04-19 KR KR1019930006536A patent/KR100281296B1/ko not_active Expired - Fee Related
- 1993-04-20 CA CA002094457A patent/CA2094457C/en not_active Expired - Fee Related
- 1993-04-20 CZ CZ1993680A patent/CZ286728B6/cs not_active IP Right Cessation
- 1993-04-20 AU AU37030/93A patent/AU662277B2/en not_active Ceased
- 1993-04-20 AT AT93201128T patent/ATE145918T1/de not_active IP Right Cessation
- 1993-04-20 EP EP93201128A patent/EP0571012B1/de not_active Expired - Lifetime
- 1993-04-20 DK DK93201128.1T patent/DK0571012T3/da active
- 1993-04-20 ES ES93201128T patent/ES2097435T3/es not_active Expired - Lifetime
- 1993-04-20 DE DE69306303T patent/DE69306303T2/de not_active Expired - Fee Related
- 1993-04-21 MX MX9302303A patent/MX9302303A/es unknown
- 1993-04-21 HU HU9301173A patent/HUT64970A/hu unknown
- 1993-04-21 NO NO931466A patent/NO301931B1/no unknown
- 1993-04-21 FI FI931794A patent/FI111644B/fi active
- 1993-04-22 JP JP09616893A patent/JP3344764B2/ja not_active Expired - Fee Related
1995
- 1995-06-27 HU HU95P/P00449P patent/HU211859A9/hu unknown
1997
- 1997-01-17 GR GR970400081T patent/GR3022316T3/el unknown

Also Published As

Publication number	Publication date
JPH07267984A (ja)	1995-10-17
FI931794A0 (fi)	1993-04-21
DE69306303T2 (de)	1997-04-17
GR3022316T3 (en)	1997-04-30
MX9302303A (es)	1994-03-31
EP0571012B1 (de)	1996-12-04
CA2094457C (en)	2003-12-09
HU211859A9 (en)	1995-12-28
KR100281296B1 (ko)	2001-03-02
DK0571012T3 (da)	1997-05-12
NO931466D0 (no)	1993-04-21
AU662277B2 (en)	1995-08-24
FI931794L (fi)	1993-10-23
CZ68093A3 (en)	1994-01-19
KR930021653A (ko)	1993-11-22
FI111644B (fi)	2003-08-29
CZ286728B6 (en)	2000-06-14
EP0571012A2 (de)	1993-11-24
DE69306303D1 (de)	1997-01-16
JP3344764B2 (ja)	2002-11-18
HU9301173D0 (en)	1993-07-28
NO301931B1 (no)	1997-12-29
NO931466L (no)	1993-10-25
US5418226A (en)	1995-05-23
HUT64970A (en)	1994-03-28
ES2097435T3 (es)	1997-04-01
EP0571012A3 (de)	1995-04-12
AU3703093A (en)	1993-10-28
HK1001061A1 (en)	1998-05-22
CA2094457A1 (en)	1993-10-23

Legal Events

Date	Code	Title	Description
1997-07-15	UEP	Publication of translation of european patent specification
2010-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO2006018I2 (no)	2008-10-20	Entekavir
AU667920B2 (en)	1996-04-18	New piperidine derivatives of benzimidazole
KR0156747B1 (en)	1998-11-16	Use of 1,3-oxathiolan nucleoside analogues in the treatment of hepatitis-b
IL96882A0 (en)	1992-03-29	Uracil derivatives and pesticides containing the same as active ingredient
DK0423714T3 (da)	1994-07-25	Hårrevitaliseringsmiddel
GR3021777T3 (en)	1997-02-28	A pharmaceutical solution comprising derivatives of FK506
CA2064634A1 (en)	1992-10-05	9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
IL90271A0 (en)	1989-12-15	Antiviral drug
ATE172463T1 (de)	1998-11-15	Pyrrolocarbazol
DE68912438D1 (de)	1994-03-03	Antifungale Antibiotika.
DE69306303D1 (de)	1997-01-16	Monoquaternäre 2,16-Bispiperidinglandrostanderivate
ATE156486T1 (de)	1997-08-15	Fungizide 3,4-diaryl-(5h)-furan-2-onederivate
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
FI904449A0 (fi)	1990-09-10	N-azasicyklo/3.3.0/oktanamider av aromatiska syror.
ZA939604B (en)	1994-06-23	Imidazole derivatives