ATE147383T1 - Benzo(b>thiophen enthaltende lipoxygenaseinhibierende verbindungen - Google Patents

Benzo(b>thiophen enthaltende lipoxygenaseinhibierende verbindungen

Info

Publication number: ATE147383T1
Authority: AT; Austria
Prior art keywords: group; inhibiting compounds; benzo; metabolically cleavable; substituted
Prior art date: 1989-09-07

Application number

AT90117171T

Other languages

English (en)

Inventor

Dee W Brooks

James B Summers

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-07

Filing date

1990-09-06

Publication date

1997-01-15

1990-09-06 Application filed by Abbott Lab filed Critical Abbott Lab

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE147383T1 publication Critical patent/ATE147383T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
230000002401 inhibitory effect Effects 0.000 title abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 2
102000003820 Lipoxygenases Human genes 0.000 title 1
108090000128 Lipoxygenases Proteins 0.000 title 1
229930192474 thiophene Natural products 0.000 title 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000002829 nitrogen Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000004962 sulfoxyl group Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT90117171T 1989-09-07 1990-09-06 Benzo(b>thiophen enthaltende lipoxygenaseinhibierende verbindungen ATE147383T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40430089A	1989-09-07	1989-09-07
US57245190A	1990-08-28	1990-08-28

Publications (1)

Publication Number	Publication Date
ATE147383T1 true ATE147383T1 (de)	1997-01-15

Family

ID=27018591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90117171T ATE147383T1 (de)	1989-09-07	1990-09-06	Benzo(b>thiophen enthaltende lipoxygenaseinhibierende verbindungen

Country Status (14)

Country	Link
EP (1)	EP0416609B1 (de)
JP (1)	JP2923014B2 (de)
KR (1)	KR0173116B1 (de)
AT (1)	ATE147383T1 (de)
AU (1)	AU631244B2 (de)
CA (1)	CA2024672C (de)
DE (1)	DE69029626T2 (de)
DK (1)	DK0416609T3 (de)
ES (1)	ES2099079T3 (de)
GR (1)	GR3022833T3 (de)
IE (1)	IE903206A1 (de)
IL (1)	IL95584A (de)
PH (1)	PH30133A (de)
PT (1)	PT95231B (de)

Families Citing this family (53)

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US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
FR2674522B1 (fr) *	1991-03-26	1993-07-16	Lipha	Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
DE4125270A1 (de) *	1991-07-31	1993-02-04	Bayer Ag	Chinolin-2-yl-methoxybenzylhydroxyharnstoffe
DE4128871A1 (de) *	1991-08-30	1993-03-04	Boehringer Mannheim Gmbh	Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel
US5530141A (en) *	1992-03-04	1996-06-25	Center For Innovative Technology	2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) *	1992-03-04	1997-06-17	Center For Innovative Technology	Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
CA2115988E (en) *	1992-06-18	1999-06-15	Jeffrey M. Sullivan	Process for producing amine-boranes
US5463083A (en) *	1992-07-13	1995-10-31	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5358938A (en) *	1992-07-13	1994-10-25	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5434151A (en) *	1992-08-24	1995-07-18	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
PT650485E (pt)	1992-07-13	2001-03-30	Millennium Pharm Inc	2,5-diaril-tetra-hidro-tiofenos -furanos e analogos para o tratamento de desordens inflamatorias e imunitarias
US5541218A (en) *	1992-07-23	1996-07-30	Pfizer Inc.	Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors
JP2661841B2 (ja) *	1992-07-23	1997-10-08	ファイザー製薬株式会社	インドリン誘導体
US5439923A (en) *	1993-12-21	1995-08-08	Eli Lilly And Company	Method of inhibiting seborrhea and acne
US5792776A (en) *	1994-06-27	1998-08-11	Cytomed, Inc.,	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) *	1995-05-25	1998-05-12	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) *	1995-05-31	1997-12-30	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5514703A (en) *	1995-03-13	1996-05-07	Eli Lilly And Company	Benzothiophene compounds useful for inhibiting lipoxygenase
US5532382A (en) *	1995-03-13	1996-07-02	Eli Lilly And Company	Benzothiophenes substituted at the 3-carbonyl
US5514704A (en) *	1995-03-13	1996-05-07	Eli Lilly And Company	Benzothiophenes to inhibit leukotrienes
US5516789A (en) *	1995-04-12	1996-05-14	Abbott Laboratories	Lipoxygenase and cyclooxygenase inhibiting compounds
TWI224101B (en)	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7074817B2 (en)	2001-06-20	2006-07-11	Wyeth	Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
EP1569900B1 (de)	2002-12-10	2006-06-28	Wyeth	Substituierte 3-carbonyl-1-yl essigsäure derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren
CA2509222A1 (en)	2002-12-10	2004-06-24	Wyeth	Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
UA80453C2 (en)	2002-12-10	2007-09-25		Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2509170A1 (en)	2002-12-10	2004-06-24	Wyeth	Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DE60324183D1 (en)	2002-12-10	2008-11-27	Wyeth Corp	Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
US7582773B2 (en)	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
US7420083B2 (en)	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7534894B2 (en)	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
US7265148B2 (en)	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7411083B2 (en)	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US7141592B2 (en)	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
US7268159B2 (en)	2003-09-25	2007-09-11	Wyeth	Substituted indoles
US7446201B2 (en)	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7332521B2 (en)	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7342039B2 (en)	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
US7163954B2 (en)	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7442805B2 (en)	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
US7351726B2 (en)	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
AR050253A1 (es)	2004-06-24	2006-10-11	Smithkline Beecham Corp	Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
AU2005277137A1 (en)	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as PAI-1 inhibitors
CN101044127A (zh)	2004-08-23	2007-09-26	惠氏公司	用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸
WO2006023865A1 (en)	2004-08-23	2006-03-02	Wyeth	Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases
PE20060748A1 (es)	2004-09-21	2006-10-01	Smithkline Beecham Corp	Derivados de indolcarboxamida como inhibidores de quinasa ikk2
CN101111491A (zh)	2005-01-27	2008-01-23	惠氏公司	用于制备被取代的萘基吲哚衍生物的方法和化合物
US8063071B2 (en)	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
BRPI0614340A2 (pt)	2005-08-17	2011-04-12	Wyeth Corp	indóis substituìdos e métodos de seu uso
PE20081889A1 (es)	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
WO2010102968A1 (en)	2009-03-10	2010-09-16	Glaxo Group Limited	Indole derivatives as ikk2 inhibitors
WO2015054662A1 (en)	2013-10-10	2015-04-16	Eastern Virginia Medical School	4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors

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US4873259A (en) *	1987-06-10	1989-10-10	Abbott Laboratories	Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
ES2059408T3 (es) *	1987-02-10	1994-11-16	Abbott Lab	Un proceso para la preparacion de un compuesto.
US4822811A (en) *	1987-11-13	1989-04-18	Abbott Laboratories	Carbazole lipoxygenase inhibiting compounds, compositions and use
CA1334975C (en) *	1987-11-13	1995-03-28	James H. Holms	Furan and pyrrole containing lipoxygenase inhibiting compounds

1990
- 1990-09-04 IE IE320690A patent/IE903206A1/en not_active IP Right Cessation
- 1990-09-04 IL IL9558490A patent/IL95584A/en unknown
- 1990-09-04 PH PH41128A patent/PH30133A/en unknown
- 1990-09-05 CA CA002024672A patent/CA2024672C/en not_active Expired - Lifetime
- 1990-09-05 AU AU62201/90A patent/AU631244B2/en not_active Expired
- 1990-09-06 PT PT95231A patent/PT95231B/pt not_active IP Right Cessation
- 1990-09-06 DK DK90117171.0T patent/DK0416609T3/da active
- 1990-09-06 ES ES90117171T patent/ES2099079T3/es not_active Expired - Lifetime
- 1990-09-06 EP EP90117171A patent/EP0416609B1/de not_active Expired - Lifetime
- 1990-09-06 JP JP2238819A patent/JP2923014B2/ja not_active Expired - Lifetime
- 1990-09-06 DE DE69029626T patent/DE69029626T2/de not_active Expired - Lifetime
- 1990-09-06 AT AT90117171T patent/ATE147383T1/de not_active IP Right Cessation
- 1990-09-07 KR KR1019900014102A patent/KR0173116B1/ko not_active Expired - Lifetime
1997
- 1997-03-17 GR GR970400508T patent/GR3022833T3/el unknown

Also Published As

Publication number	Publication date
EP0416609A2 (de)	1991-03-13
AU6220190A (en)	1991-03-14
IL95584A (en)	1995-03-15
ES2099079T3 (es)	1997-05-16
EP0416609B1 (de)	1997-01-08
PH30133A (en)	1997-01-21
CA2024672A1 (en)	1991-03-08
DK0416609T3 (da)	1997-06-30
DE69029626D1 (de)	1997-02-20
AU631244B2 (en)	1992-11-19
CA2024672C (en)	2002-02-26
JPH03148272A (ja)	1991-06-25
DE69029626T2 (de)	1997-07-17
IE903206A1 (en)	1991-03-13
IL95584A0 (en)	1991-06-30
KR910006271A (ko)	1991-04-29
JP2923014B2 (ja)	1999-07-26
PT95231A (pt)	1991-05-22
EP0416609A3 (en)	1992-01-02
GR3022833T3 (en)	1997-06-30
KR0173116B1 (ko)	1999-02-01
PT95231B (pt)	1997-06-30

Legal Events

Date	Code	Title	Description
2010-12-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE147383T1 (de)	1997-01-15	Benzo(b>thiophen enthaltende lipoxygenaseinhibierende verbindungen
DE3854932D1 (de)	1996-03-07	Am Brückenkopf substituierte Azabicyclenderivate
EP0976732A4 (de)	2000-06-14	1,4-substituierte cyclische aminderivate
TW274541B (de)	1996-04-21
MX166257B (es)	1992-12-24	Composicion de revestimiento que contiene grupos de carbamato de hidroxialquilo
MY107474A (en)	1995-12-31	Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents.
NZ212231A (en)	1989-01-06	Cephalosporin derivatives; intermediates and pharmaceutical compositions
IL94027A0 (en)	1991-01-31	Diaminoethylene compounds
KR900700470A (ko)	1990-08-13	1, 3-티아졸라딘의 β-카르보닐-카르복시아미드
ES8706690A1 (es)	1987-06-16	Un procedimiento para la preparacion de nuevos derivados de penem.
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
NZ218404A (en)	1990-01-29	Cephalosporin derivatives and pharmaceutical compositions
ZA935074B (en)	1994-03-30	Alkylenediamine derivatives
DE69222818D1 (de)	1997-11-27	Kondensierte Naphthyridinderivate
DE60221894D1 (de)	2007-09-27	Vollständige synthese der galanthamin, deren analogen und derivaten
ATE172200T1 (de)	1998-10-15	Pyrazoloacridonderivate
HUT50564A (en)	1990-03-28	Animal keeping pig-pen particularly for dropping swine and after-breeding of piglets