ATE147433T1 - Protein- und polypeptidvarianten mit erhöhter affinität für metallgebundene affinitätsmatrizen - Google Patents

Protein- und polypeptidvarianten mit erhöhter affinität für metallgebundene affinitätsmatrizen

Info

Publication number: ATE147433T1
Authority: AT; Austria
Prior art keywords: protein; metal; affinity; polypeptide variants; bonded
Prior art date: 1989-07-21

Application number

AT90870109T

Other languages

English (en)

Inventor

Barry Lant Haymore

Gary Stephen Bild

Gwen Grabowski Krivi

Original Assignee

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-21

Filing date

1990-07-16

Publication date

1997-01-15

1990-07-16 Application filed by Monsanto Co filed Critical Monsanto Co

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE147433T1 publication Critical patent/ATE147433T1/de

Links

102000004169 proteins and genes Human genes 0.000 title abstract 5
108090000623 proteins and genes Proteins 0.000 title abstract 5
229920001184 polypeptide Polymers 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
235000018102 proteins Nutrition 0.000 abstract 4
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Feed For Specific Animals (AREA)
Fodder In General (AREA)

AT90870109T 1989-07-21 1990-07-16 Protein- und polypeptidvarianten mit erhöhter affinität für metallgebundene affinitätsmatrizen ATE147433T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/383,778 US5115102A (en)	1989-07-21	1989-07-21	Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices

Publications (1)

Publication Number	Publication Date
ATE147433T1 true ATE147433T1 (de)	1997-01-15

Family

ID=23514691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90870109T ATE147433T1 (de)	1989-07-21	1990-07-16	Protein- und polypeptidvarianten mit erhöhter affinität für metallgebundene affinitätsmatrizen

Country Status (9)

Country	Link
US (1)	US5115102A (de)
EP (1)	EP0409814B1 (de)
JP (1)	JP3576161B2 (de)
AT (1)	ATE147433T1 (de)
CA (1)	CA2021722C (de)
DE (1)	DE69029615T2 (de)
DK (1)	DK0409814T3 (de)
ES (1)	ES2096584T3 (de)
GR (1)	GR3023052T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5821088A (en) *	1990-05-11	1998-10-13	Siga Pharmaceuticals, Inc.	Use of gram-positive bacteria to express recombinant proteins
WO1992008788A1 (en) *	1990-11-19	1992-05-29	The Board Of Trustees Of The University Of Illinois	Mutant orientable proteins and coated substrates
US5646016A (en) *	1991-02-06	1997-07-08	Genetics Institute, Inc.	Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
DE4105480A1 (de) *	1991-02-21	1992-08-27	Boehringer Mannheim Gmbh	Verbesserte aktivierung von rekombinanten proteinen
JPH10504971A (ja) *	1994-09-08	1998-05-19	カイロンコーポレイション	インスリン様増殖因子の改善された生産方法
US6068993A (en) *	1997-07-02	2000-05-30	Biobras Sa	Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US5932102A (en) *	1998-01-12	1999-08-03	Schering Corporation	Immobilized metal, affinity chromatography
DE19822823A1 (de) *	1998-05-20	2000-02-10	Basf Ag	Neue Peptidfragmente zur Reinigung von Proteinen
US20100233678A1 (en) *	2007-11-13	2010-09-16	Beadling Leslie C	Tunable affinity ligands for the separation and detection of target substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4569794A (en) *	1984-12-05	1986-02-11	Eli Lilly And Company	Process for purifying proteins and compounds useful in such process
WO1988008028A1 (en) *	1987-04-06	1988-10-20	Genex Corporation	The engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins

1989
- 1989-07-21 US US07/383,778 patent/US5115102A/en not_active Expired - Lifetime
1990
- 1990-07-16 AT AT90870109T patent/ATE147433T1/de not_active IP Right Cessation
- 1990-07-16 DE DE69029615T patent/DE69029615T2/de not_active Expired - Fee Related
- 1990-07-16 ES ES90870109T patent/ES2096584T3/es not_active Expired - Lifetime
- 1990-07-16 EP EP90870109A patent/EP0409814B1/de not_active Expired - Lifetime
- 1990-07-16 DK DK90870109.7T patent/DK0409814T3/da active
- 1990-07-20 JP JP19379990A patent/JP3576161B2/ja not_active Expired - Fee Related
- 1990-07-20 CA CA002021722A patent/CA2021722C/en not_active Expired - Lifetime
1997
- 1997-04-07 GR GR970400719T patent/GR3023052T3/el unknown

Also Published As

Publication number	Publication date
JP3576161B2 (ja)	2004-10-13
GR3023052T3 (en)	1997-07-30
EP0409814B1 (de)	1997-01-08
US5115102A (en)	1992-05-19
CA2021722A1 (en)	1991-01-22
DK0409814T3 (da)	1997-06-30
EP0409814A1 (de)	1991-01-23
DE69029615T2 (de)	1997-06-12
JPH03101693A (ja)	1991-04-26
CA2021722C (en)	2002-12-17
DE69029615D1 (de)	1997-02-20
ES2096584T3 (es)	1997-03-16

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Legal Events

Date	Code	Title	Description
1997-08-15	UEP	Publication of translation of european patent specification
2010-04-15	REN	Ceased due to non-payment of the annual fee