ATE147737T1 - Wasserlösliche cumarderivate, ihre herstellung und ihre verwendung als enzymsubstrate oder für die zubereitung von solchen substraten - Google Patents

Wasserlösliche cumarderivate, ihre herstellung und ihre verwendung als enzymsubstrate oder für die zubereitung von solchen substraten

Info

Publication number
ATE147737T1
ATE147737T1 AT92401443T AT92401443T ATE147737T1 AT E147737 T1 ATE147737 T1 AT E147737T1 AT 92401443 T AT92401443 T AT 92401443T AT 92401443 T AT92401443 T AT 92401443T AT E147737 T1 ATE147737 T1 AT E147737T1
Authority
AT
Austria
Prior art keywords
preparation
substrates
derivatives
water
soluble
Prior art date
Application number
AT92401443T
Other languages
English (en)
Inventor
Joseph Chalom
Christine Griffoul
Michel Tod
Stephane Reveilleau
Original Assignee
Eurobio Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurobio Lab filed Critical Eurobio Lab
Application granted granted Critical
Publication of ATE147737T1 publication Critical patent/ATE147737T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/20—Coumarin derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT92401443T 1991-05-30 1992-05-26 Wasserlösliche cumarderivate, ihre herstellung und ihre verwendung als enzymsubstrate oder für die zubereitung von solchen substraten ATE147737T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9106551A FR2677023B1 (fr) 1991-05-30 1991-05-30 Derives de coumarine hydrosolubles, leur preparation et leur utilisation comme substrat d'enzyme.

Publications (1)

Publication Number Publication Date
ATE147737T1 true ATE147737T1 (de) 1997-02-15

Family

ID=9413303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401443T ATE147737T1 (de) 1991-05-30 1992-05-26 Wasserlösliche cumarderivate, ihre herstellung und ihre verwendung als enzymsubstrate oder für die zubereitung von solchen substraten

Country Status (7)

Country Link
US (1) US5342970A (de)
EP (1) EP0516532B1 (de)
JP (1) JPH0692955A (de)
AT (1) ATE147737T1 (de)
CA (1) CA2069697A1 (de)
DE (1) DE69216686D1 (de)
FR (1) FR2677023B1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2703683B1 (fr) * 1993-04-08 1995-07-07 Seractec Dérivés d'aminocoumarines hydrophobes, et leur utilisation comme substrats d'enzymes protéolytiques ou pour la préparation de tels substrats.
DE4323409A1 (de) * 1993-07-13 1995-01-19 Boehringer Mannheim Gmbh Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel
US5998593A (en) * 1998-03-10 1999-12-07 Abbott Laboratories Fluorescent enzyme substrates
US6680178B2 (en) 2000-06-02 2004-01-20 The Regents Of The University Of California Profiling of protease specificity using combinatorial fluorogenic substrate libraries
EP1462448B1 (de) * 2003-03-27 2006-05-10 Council of Scientific and Industrial Research Prozess zur Herstellung substituierter Cumarine
US7538233B2 (en) * 2003-09-05 2009-05-26 Aventis Pharmaceuticals Inc. Coumarins as iNOS inhibitors
US8053585B2 (en) * 2006-04-12 2011-11-08 Cornell Research Foundation, Inc. Protecting group for carboxylic acids that can be photolyzed by visible light
US9475901B2 (en) * 2009-12-08 2016-10-25 Transitions Optical, Inc. Photoalignment materials having improved adhesion
FR2964978B1 (fr) * 2010-09-21 2013-11-15 J Soufflet Ets Nouveaux substrats fluorescents, procede d'obtention de ces produits et leur application
US11199653B2 (en) 2015-10-30 2021-12-14 Transitions Optical, Inc. Optical article with gradient light influencing properties and method of making the same
WO2017074429A1 (en) 2015-10-30 2017-05-04 Transitions Optical Ltd. A method of making an optical article with an inkjet printing device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654713A (en) * 1951-11-22 1953-10-06 Sandoz Ag Pulverizable and readily soluble brightening agents
US2844594A (en) * 1955-09-21 1958-07-22 American Cyanamid Co 3-aryl-7-dialkylaminocoumarins
US3784600A (en) * 1971-10-22 1974-01-08 Warner Lambert Co 4-substituted coumarins
DE2301738A1 (de) * 1973-01-13 1974-07-18 Basf Ag 3-amidinocumarin-farbstoffe
JPS53108974A (en) * 1977-03-03 1978-09-22 Ajinomoto Co Inc 7-arginylamino-4-methylcoumarin
US4215047A (en) * 1977-06-06 1980-07-29 Ajinomoto Company Incorporated 7-(Arginylamino)-4-methylcoumarins
US4294923A (en) * 1979-04-23 1981-10-13 Smith Robert E Substrates and method for determining enzymes
CH649294A5 (de) * 1981-06-17 1985-05-15 Lonza Ag Verfahren zur herstellung von tetronsaeure.
ATE13289T1 (de) * 1981-10-01 1985-06-15 Lonza Ag Verfahren zur herstellung von 4alkoxyacetessigestern.
JPS6056985A (ja) * 1983-09-08 1985-04-02 Sankyo Co Ltd クマリン誘導体
US4918200A (en) * 1984-07-16 1990-04-17 Huls America Inc. Chromogenic and fluorogenic silanes and using the same
DE3614647A1 (de) * 1986-04-30 1987-11-05 Euratom 7-phenylessigsaeure-4-alkyl-coumarinylamide, verfahren zu ihrer herstellung sowie ihre verwendung in verfahren zur fluorometrischen bestimmung der aktivitaet von hydrolasen, insbesondere von penicillin-g-acylase
US5098820A (en) * 1990-05-07 1992-03-24 Eastman Kodak Company Solid particle dispersions of filter dyes for photographic elements
US5055594A (en) * 1990-07-19 1991-10-08 Becton, Dickinson And Company Fluorogenic trypotophanase substrates

Also Published As

Publication number Publication date
JPH0692955A (ja) 1994-04-05
FR2677023B1 (fr) 1994-02-25
FR2677023A1 (fr) 1992-12-04
EP0516532A1 (de) 1992-12-02
EP0516532B1 (de) 1997-01-15
US5342970A (en) 1994-08-30
DE69216686D1 (de) 1997-02-27
CA2069697A1 (en) 1992-12-01

Similar Documents

Publication Publication Date Title
ATE127797T1 (de) Aminocoumaranderivate, ihre herstellung und verwendung.
PT97888A (pt) Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
ATE141920T1 (de) Verfahren zur herstellung von taxan-derivaten
ATE50763T1 (de) Tetralin-derivate, ihre herstellung und verwendung.
ATE90092T1 (de) Thiazolidinon-derivate, ihre herstellung und ihre verwendung.
ATE132145T1 (de) Verfahren zur herstellung von bacchatin iii und von desacetyl-10-bacchatin iii derivate
DE69108138D1 (de) Imidazopyridinderivate und ihre Verwendung.
EA199800768A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
DE59308732D1 (de) Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
ATE167741T1 (de) Sensibilisatoren für photothermographische elemente
ATE147737T1 (de) Wasserlösliche cumarderivate, ihre herstellung und ihre verwendung als enzymsubstrate oder für die zubereitung von solchen substraten
ATE102196T1 (de) Glykosidase-inhibitor salbostatin, verfahren zu seiner herstellung und seine verwendung.
ATE106077T1 (de) Zyklopenta(d>pyrimidinderivate, ihre herstellung und verwendung.
DE69226815D1 (de) 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
ATE13178T1 (de) 2-oxoazetidin-derivate, ihre herstellung und verwendung.
DE3778508D1 (de) Substituierte triazinderivate.
ATE80390T1 (de) Barbitursaeure-verbindungen, diese enthaltende photoresists und verfahren zu deren herstellung.
LV10422A (lv) Jaunie fluor-naftacendioni to glikozetie atvasinajumi un vinu razosanas panemiens
DE3586314D1 (de) Bifunktionelle haptene, verfahren zu ihrer herstellung und ihre verwendung.
IT1264817B1 (it) Derivati di polialchil-4-piperidinoli atti all'impderivati di polialchil-4-piperidinoli atti all'impiego come stabilizzanti per materiali organici iego come stabilizzanti per materiali organici
DE69102762D1 (de) Beta-phenylisoserinderivate, ihre herstellung und ihre anwendung.
DK606286A (da) Anthracyclin-derivater og laegemidler indeholdende disse forbindelser
FI870460A0 (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter.
ATE151090T1 (de) Herstellung von aktivierten carbamaten von polyalkylenglycol und ihre verwendung
LV10094A (lv) Jauni pilokarpina atvasinajumi un to iegusanas metode

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties