ATE301659T1 - Verfahren zur herstellung von campothecinderivate - Google Patents

Verfahren zur herstellung von campothecinderivate

Info

Publication number: ATE301659T1
Authority: AT; Austria
Prior art keywords: pct; date; producing; sec; formula
Prior art date: 1995-11-02

Application number

AT96938728T

Other languages

English (en)

Inventor

Francis G Fang

Shiping Xie

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-02

Filing date

1996-11-01

Publication date

2005-08-15

1996-11-01 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE301659T1 publication Critical patent/ATE301659T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 2
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
229940127093 camptothecin Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96938728T 1995-11-02 1996-11-01 Verfahren zur herstellung von campothecinderivate ATE301659T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US613895P	1995-11-02	1995-11-02
PCT/US1996/017574 WO1997016454A1 (en)	1995-11-02	1996-11-01	Method for preparing camptothecin derivatives

Publications (1)

Publication Number	Publication Date
ATE301659T1 true ATE301659T1 (de)	2005-08-15

Family

ID=21719492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96938728T ATE301659T1 (de)	1995-11-02	1996-11-01	Verfahren zur herstellung von campothecinderivate

Country Status (17)

Country	Link
US (2)	US6143891A (de)
EP (1)	EP0876373B1 (de)
JP (1)	JP3499246B2 (de)
AT (1)	ATE301659T1 (de)
AU (1)	AU717315B2 (de)
CA (1)	CA2236420A1 (de)
CZ (1)	CZ133898A3 (de)
DE (1)	DE69635057T2 (de)
EA (1)	EA001400B1 (de)
ES (1)	ES2247606T3 (de)
HU (1)	HUP9802407A3 (de)
IL (1)	IL124287A (de)
IS (1)	IS2274B (de)
NO (1)	NO324308B1 (de)
NZ (1)	NZ322318A (de)
PL (1)	PL186540B1 (de)
WO (1)	WO1997016454A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5491237A (en) *	1994-05-03	1996-02-13	Glaxo Wellcome Inc.	Intermediates in pharmaceutical camptothecin preparation
US6716982B2 (en)	1995-11-02	2004-04-06	Osi Pharmaceuticals, Inc.	Method for preparing camptothecin derivatives
US6559309B2 (en)	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
US6288072B1 (en) *	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition
TWI245768B (en)	2001-02-21	2005-12-21	Yakult Honsha Kk	Process for synthesizing camptothecin related compound(s)
AU2003207369A1 (en) *	2002-02-18	2003-09-04	Dr. Reddy's Laboratories Limited	A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
US6593334B1 (en)	2002-05-02	2003-07-15	The University Of North Carolina At Chapel Hill	Camptothecin-taxoid conjugates as antimitotic and antitumor agents
US7067666B2 (en) *	2003-06-27	2006-06-27	Research Triangle Institute	7-substituted camptothecin and camptothecin analogs and methods for producing the same
AU2005244768B2 (en)	2004-04-27	2011-06-09	Wellstat Biologics Corporation	Cancer treatment using viruses and camptothecins
AU2006270297B2 (en)	2005-07-14	2013-01-17	Wellstat Biologics Corporation	Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN103288842B (zh) *	2012-02-24	2016-01-13	中国人民解放军第二军医大学	氟取代e环喜树碱类似物及其作为药物的用途
WO2017053920A1 (en)	2015-09-25	2017-03-30	Zy Therapeutics Inc.	Drug formulation based on particulates comprising polysaccharide-vitamin conjugate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0555347A4 (en) *	1990-10-31	1995-01-11	Smithkline Beecham Corp	Substituted indolizino 1,2-b)quinolinones
AU3611093A (en) *	1992-02-21	1993-09-13	Smithkline Beecham Corporation	Substituted furo(3',4':6,7)indolizino(1,2-b)quinolinones

1996
- 1996-11-01 AT AT96938728T patent/ATE301659T1/de not_active IP Right Cessation
- 1996-11-01 AU AU76038/96A patent/AU717315B2/en not_active Ceased
- 1996-11-01 PL PL96326869A patent/PL186540B1/pl not_active IP Right Cessation
- 1996-11-01 EP EP96938728A patent/EP0876373B1/de not_active Expired - Lifetime
- 1996-11-01 CZ CZ981338A patent/CZ133898A3/cs unknown
- 1996-11-01 IL IL12428796A patent/IL124287A/en not_active IP Right Cessation
- 1996-11-01 JP JP51758897A patent/JP3499246B2/ja not_active Expired - Fee Related
- 1996-11-01 US US09/068,185 patent/US6143891A/en not_active Expired - Fee Related
- 1996-11-01 WO PCT/US1996/017574 patent/WO1997016454A1/en not_active Ceased
- 1996-11-01 EA EA199800354A patent/EA001400B1/ru not_active IP Right Cessation
- 1996-11-01 HU HU9802407A patent/HUP9802407A3/hu unknown
- 1996-11-01 DE DE69635057T patent/DE69635057T2/de not_active Expired - Fee Related
- 1996-11-01 ES ES96938728T patent/ES2247606T3/es not_active Expired - Lifetime
- 1996-11-01 NZ NZ322318A patent/NZ322318A/xx unknown
- 1996-11-01 CA CA002236420A patent/CA2236420A1/en not_active Abandoned
1998
- 1998-04-29 IS IS4730A patent/IS2274B/is unknown
- 1998-04-30 NO NO19981970A patent/NO324308B1/no unknown
2000
- 2000-08-15 US US09/638,945 patent/US6284891B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6284891B1 (en)	2001-09-04
PL186540B1 (pl)	2004-01-30
CZ133898A3 (cs)	1998-08-12
DE69635057D1 (de)	2005-09-15
IS2274B (is)	2007-09-15
WO1997016454A1 (en)	1997-05-09
DE69635057T2 (de)	2006-06-01
CA2236420A1 (en)	1997-05-09
US6143891A (en)	2000-11-07
IL124287A (en)	2004-06-01
EP0876373A1 (de)	1998-11-11
NO981970D0 (no)	1998-04-30
NO981970L (no)	1998-06-30
EA199800354A1 (ru)	1999-02-25
IS4730A (is)	1998-04-29
HUP9802407A3 (en)	2000-01-28
EA001400B1 (ru)	2001-02-26
JPH11515028A (ja)	1999-12-21
NO324308B1 (no)	2007-09-24
EP0876373B1 (de)	2005-08-10
PL326869A1 (en)	1998-10-26
JP3499246B2 (ja)	2004-02-23
AU717315B2 (en)	2000-03-23
AU7603896A (en)	1997-05-22
ES2247606T3 (es)	2006-03-01
NZ322318A (en)	2000-01-28
HUP9802407A1 (hu)	1999-04-28

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Legal Events

Date

Code

Title

Description

2006-05-15

UEP

Publication of translation of european patent specification

Ref document number: 0876373

Country of ref document: EP

2009-08-15

REN

Ceased due to non-payment of the annual fee