ATE147751T1 - Nukleosidderivate von 2-halo-9(2-oxy-2-fluoro-beta-d-arabinofuranosyl)adenin - Google Patents

Nukleosidderivate von 2-halo-9(2-oxy-2-fluoro-beta-d-arabinofuranosyl)adenin

Info

Publication number
ATE147751T1
ATE147751T1 AT90909080T AT90909080T ATE147751T1 AT E147751 T1 ATE147751 T1 AT E147751T1 AT 90909080 T AT90909080 T AT 90909080T AT 90909080 T AT90909080 T AT 90909080T AT E147751 T1 ATE147751 T1 AT E147751T1
Authority
AT
Austria
Prior art keywords
arabinofuranosyl
adenine
oxy
halo
fluoro
Prior art date
Application number
AT90909080T
Other languages
English (en)
Inventor
John A Montgomery
John A Secrist Iii
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of ATE147751T1 publication Critical patent/ATE147751T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90909080T 1989-05-23 1990-05-23 Nukleosidderivate von 2-halo-9(2-oxy-2-fluoro-beta-d-arabinofuranosyl)adenin ATE147751T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/355,358 US5034518A (en) 1989-05-23 1989-05-23 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides

Publications (1)

Publication Number Publication Date
ATE147751T1 true ATE147751T1 (de) 1997-02-15

Family

ID=23397161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90909080T ATE147751T1 (de) 1989-05-23 1990-05-23 Nukleosidderivate von 2-halo-9(2-oxy-2-fluoro-beta-d-arabinofuranosyl)adenin

Country Status (10)

Country Link
US (1) US5034518A (de)
EP (1) EP0473708B1 (de)
JP (1) JP3160288B2 (de)
AT (1) ATE147751T1 (de)
AU (1) AU5831590A (de)
DE (2) DE69029733T2 (de)
ES (1) ES2098266T3 (de)
HK (1) HK1007561A1 (de)
NL (1) NL300247I2 (de)
WO (1) WO1990014352A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
WO1992011276A1 (en) * 1990-12-18 1992-07-09 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-'up' fluorinated 2''-deoxy-arabinofuranosylpurines
DE4141454A1 (de) * 1991-11-25 1993-05-27 Schering Ag Neues verfahren zur herstellung von 2-fluorpurin-derivaten
EP0642347A4 (de) * 1992-05-19 1997-06-18 Scripps Research Inst Verwendung von 2-halo-adeninderivaten als therapeutische wirkstoffe gegen chronisch-myeloische leukämie.
WO1996003134A1 (en) * 1994-07-21 1996-02-08 Thomas Jefferson University Treatment of diarrhea with 2-substituted adenosine derivatives
EA200700564A1 (ru) 1998-02-25 2007-08-31 Эмори Юниверсити 2`-фторнуклеозиды
KR20090089922A (ko) * 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
CA2381367A1 (en) * 2001-04-12 2002-10-12 Hironori Komatsu Method for purifying 5'-protected 2'-deoxypurine nucleosides
WO2003000200A2 (en) 2001-06-22 2003-01-03 Pharmasset Ltd. β-2'-OR 3'-HALONUCLEOSIDES
WO2004029025A2 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
EP1551386A4 (de) * 2002-09-27 2009-03-25 Bioenvision Inc Verfahren und zusammensetzungen zur behandlung von lupus mit clofarabin
AU2003287081A1 (en) * 2002-10-16 2004-05-04 Ilex Products, Inc. Clofarabine and taxane chemotherapy combination
ES2327252T3 (es) * 2004-08-23 2009-10-27 F. Hoffmann-La Roche Ag 4'-azido nucleosidos antivirales.
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
HRP20110193T1 (hr) * 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN103665075A (zh) * 2013-12-26 2014-03-26 南通康鑫药业有限公司 一种氯法拉滨的合成方法
EP2937420A1 (de) 2014-04-23 2015-10-28 Synbias Pharma AG Verfahren zur Synthese von Clofarabin
WO2018085307A1 (en) * 2016-11-03 2018-05-11 Wu Laurence I Prodrugs of clofarabine
JP7378764B2 (ja) * 2018-10-04 2023-11-14 国立大学法人 鹿児島大学 抗ｂ型肝炎ウイルス剤
EP3862004A4 (de) * 2018-10-04 2022-06-22 Daikin Industries, Ltd. Wirkstoff gegen hepatitis-b-virus
GB201816825D0 (en) 2018-10-16 2018-11-28 Phoremost Ltd Target for anti-cancer therapy
JP2020176082A (ja) * 2019-04-17 2020-10-29 ダイキン工業株式会社 核酸アナログ及び抗ｂ型肝炎ウイルス剤
KR20220034780A (ko) 2019-06-14 2022-03-18 써던 리서취 인스티튜트 2,4,7-치환된-7-데아자-2'-데옥시-2'-플루오로아라비노실 뉴클레오사이드 및 뉴클레오타이드 전구약물 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS542993A (en) * 1977-06-10 1979-01-10 Agency Of Ind Science & Technol Thermochemical production of hydrogen using wate as raw material
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4210745A (en) * 1978-01-04 1980-07-01 The United States Of America As Represented By The Department Of Health, Education And Welfare Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
FI895447A7 (fi) * 1988-03-16 1989-11-15 Scripps Clinic And Res Foundation Substituoidut terapeuttisina aineina käytettävät adeniinijohdannaiset

Also Published As

Publication number Publication date
DE122006000060I2 (de) 2010-10-21
EP0473708B1 (de) 1997-01-15
US5034518A (en) 1991-07-23
ES2098266T3 (es) 1997-05-01
NL300247I1 (nl) 2007-02-01
NL300247I2 (nl) 2007-02-01
WO1990014352A1 (en) 1990-11-29
DE69029733T2 (de) 1997-07-17
DE122006000060I1 (de) 2007-04-05
HK1007561A1 (en) 1999-04-16
JPH05502014A (ja) 1993-04-15
EP0473708A4 (en) 1992-04-22
JP3160288B2 (ja) 2001-04-25
DE69029733D1 (de) 1997-02-27
EP0473708A1 (de) 1992-03-11
AU5831590A (en) 1990-12-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties