ATE147753T1 - Prozess zur rückfaltung von (pro-)chymosin, unter rückführung von harnstoff - Google Patents

Prozess zur rückfaltung von (pro-)chymosin, unter rückführung von harnstoff

Info

Publication number: ATE147753T1
Authority: AT; Austria
Prior art keywords: chymosin; refolding; recirculation; urea; pro
Prior art date: 1993-11-10

Application number

AT94307839T

Other languages

English (en)

Inventor

James G Crawford

Stanley R Stober

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-10

Filing date

1994-10-25

Publication date

1997-02-15

1994-10-25 Application filed by Pfizer filed Critical Pfizer

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE147753T1 publication Critical patent/ATE147753T1/de

Links

108090000746 Chymosin Proteins 0.000 title 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
239000004202 carbamide Substances 0.000 title 1
229940080701 chymosin Drugs 0.000 title 1
GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 title 1
238000002955 isolation Methods 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000000108 ultra-filtration Methods 0.000 abstract 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Water Supply & Treatment (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Cephalosporin Compounds (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

AT94307839T 1993-11-10 1994-10-25 Prozess zur rückfaltung von (pro-)chymosin, unter rückführung von harnstoff ATE147753T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US15063293A	1993-11-10	1993-11-10

Publications (1)

Publication Number	Publication Date
ATE147753T1 true ATE147753T1 (de)	1997-02-15

Family

ID=22535379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94307839T ATE147753T1 (de)	1993-11-10	1994-10-25	Prozess zur rückfaltung von (pro-)chymosin, unter rückführung von harnstoff

Country Status (7)

Country	Link
EP (1)	EP0657466B1 (de)
JP (1)	JP2749269B2 (de)
AT (1)	ATE147753T1 (de)
DE (1)	DE69401490T2 (de)
DK (1)	DK0657466T3 (de)
ES (1)	ES2096416T3 (de)
GR (1)	GR3022653T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU707719B2 (en) *	1995-07-21	1999-07-15	Amgen, Inc.	Process for protein refolding by means of buffer exchange using a continuous stationary phase capable of separating proteins from salt
NZ503576A (en) *	1999-03-26	2002-10-25	Snow Brand Milk Products Co Ltd	Method of isolating urea from an urea containing solution using a nanofiltration membrane or reverse osmotic membrane
JP2000281638A (ja)	1999-03-26	2000-10-10	Snow Brand Milk Prod Co Ltd	尿素の分離方法
EP1627920A1 (de) *	2000-01-24	2006-02-22	Polymun Scientific Immunbiologische Forschung GmbH	Verfahren zur Herstellung von rekombinantem Trypsin
EP1334182B2 (de)	2000-11-06	2021-03-24	Chr. Hansen A/S	Verfahren zur herstellung von nicht aus dem rind stammendem chymosin und dessen anwendung
US20050092664A1 (en) *	2003-11-05	2005-05-05	Ghosh Pushpito K.	Improvised device for concentrating the aqueous solution and a pocess thereof
SG176963A1 (en)	2009-06-22	2012-02-28	Amgen Inc	Refolding proteins using a chemically controlled redox state
LT3660032T (lt)	2009-06-25	2026-02-25	Amgen Inc.	Ne žinduolių sistemoje ekspresuotų baltymų surišamojo gryninimo būdai
CN103211035B (zh) *	2013-04-12	2014-11-05	江南大学	一种液态型凝乳酶制剂的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD146751A3 (de) *	1980-02-22	1981-03-04	Lothar Guenther	Verfahren zur aufarbeitung von prozessabwasser der harnstoffherstellung

1994
- 1994-10-25 ES ES94307839T patent/ES2096416T3/es not_active Expired - Lifetime
- 1994-10-25 EP EP94307839A patent/EP0657466B1/de not_active Expired - Lifetime
- 1994-10-25 DE DE69401490T patent/DE69401490T2/de not_active Expired - Fee Related
- 1994-10-25 DK DK94307839.4T patent/DK0657466T3/da active
- 1994-10-25 AT AT94307839T patent/ATE147753T1/de not_active IP Right Cessation
- 1994-11-04 JP JP6271536A patent/JP2749269B2/ja not_active Expired - Lifetime
1997
- 1997-02-26 GR GR970400340T patent/GR3022653T3/el unknown

Also Published As

Publication number	Publication date
JPH07184650A (ja)	1995-07-25
GR3022653T3 (en)	1997-05-31
EP0657466A1 (de)	1995-06-14
DK0657466T3 (da)	1997-07-14
DE69401490D1 (de)	1997-02-27
DE69401490T2 (de)	1997-04-30
ES2096416T3 (es)	1997-03-01
JP2749269B2 (ja)	1998-05-13
EP0657466B1 (de)	1997-01-15

Legal Events

Date	Code	Title
1997-07-15	UEP	Publication of translation of european patent specification
1998-01-15	EEIH	Change in the person of patent owner
1999-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE125865T1 (de)	1995-08-15	Rekombinante humicola-lipase und verfahren zur herstellung von rekombinanten humicola-lipasen.
ES2142363T3 (es)	2000-04-16	Materiales y metodos para la hipersecrecion de aminoacidos.
AU615413B2 (en)	1991-10-03	Production of thrombin inhibitors
DE69401490D1 (de)	1997-02-27	Prozess zur Rückfaltung von (pro-)Chymosin, unter Rückführung von Harnstoff
DE59814364D1 (de)	2009-07-16	Verfahren zur Herstellung von funktionalem rekombinantem Gewebsfaktor
DE59108128D1 (de)	1996-10-10	Verfahren zur Herstellung von Fremdproteinen in Streptomyceten
DE69430975D1 (de)	2002-08-22	Verfahren zur Herstellung von Proteinen
EP0776972A4 (de)	1998-12-30	FÜR DAS IgG-Fc-BINDENDE PROTEIN KODIERENDES GEN
DE3888386D1 (de)	1994-04-21	Verfahren zur Herstellung von Proteinen.
BR9000445A (pt)	1991-01-15	Processo para a producao de glucagon,sequencia de dna codificando glucagon,vetor de expressao,transformante e glucagon purificado
ATE196927T1 (de)	2000-10-15	Verfahren zur herstellung von proteaseinhibitoren
ATE192780T1 (de)	2000-05-15	Verfahren zur rekombinanten herstellung von proteinen in hefe
ATE28897T1 (de)	1987-08-15	Verfahren zur enzymatischen hydrolyse von nukleinsaeuren.
ATE91303T1 (de)	1993-07-15	Verfahren zur herstellung von peptiden durch spezifische spaltung von gentechnisch gewonnenen fusionsproteinen mit collagenasen.
HUT49151A (en)	1989-08-28	Process for production of biotinilated proteins