ATE196927T1 - Verfahren zur herstellung von proteaseinhibitoren - Google Patents

Verfahren zur herstellung von proteaseinhibitoren

Info

Publication number
ATE196927T1
ATE196927T1 AT93810608T AT93810608T ATE196927T1 AT E196927 T1 ATE196927 T1 AT E196927T1 AT 93810608 T AT93810608 T AT 93810608T AT 93810608 T AT93810608 T AT 93810608T AT E196927 T1 ATE196927 T1 AT E196927T1
Authority
AT
Austria
Prior art keywords
protease inhibitors
producing protease
production
novel
yeast strains
Prior art date
Application number
AT93810608T
Other languages
English (en)
Inventor
Jutta Dr Heim
Peter Dr Fuerst
Thomas Dr Hottiger
Jochen Dr Kuhla
Gabriele Dr Pohlig
Original Assignee
Novartis Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Ucp Gen Pharma Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE196927T1 publication Critical patent/ATE196927T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Indole Compounds (AREA)
AT93810608T 1992-09-04 1993-08-25 Verfahren zur herstellung von proteaseinhibitoren ATE196927T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92810681 1992-09-04

Publications (1)

Publication Number Publication Date
ATE196927T1 true ATE196927T1 (de) 2000-10-15

Family

ID=8211979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93810608T ATE196927T1 (de) 1992-09-04 1993-08-25 Verfahren zur herstellung von proteaseinhibitoren

Country Status (20)

Country Link
US (1) US5726043A (de)
EP (2) EP1031628A1 (de)
JP (2) JP3949734B2 (de)
KR (1) KR940007180A (de)
AT (1) ATE196927T1 (de)
AU (1) AU675071B2 (de)
CA (1) CA2105425A1 (de)
DE (1) DE69329540T2 (de)
DK (1) DK0592358T3 (de)
ES (1) ES2152943T3 (de)
FI (1) FI933821A7 (de)
GR (1) GR3035201T3 (de)
HU (1) HU217094B (de)
IL (1) IL106897A0 (de)
MX (1) MX9305375A (de)
NO (1) NO933153L (de)
NZ (1) NZ248558A (de)
PT (1) PT592358E (de)
SG (1) SG49859A1 (de)
ZA (1) ZA936507B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990010008A (ko) * 1997-07-14 1999-02-05 구광시 효모용 프로모터 및 이 프로모터를 포함하는 효모용발현 벡터
US6358705B1 (en) 1998-07-16 2002-03-19 Novo Nordisk A/S Method of making proteins in transformed yeast cells
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
WO2008008967A2 (en) 2006-07-14 2008-01-17 Novozymes, Inc. Methods for increasing expression of genes in a fungal cell
CN102373216B (zh) * 2011-10-28 2013-06-05 元昊 一种含有医用水蛭素基因的重组真核汉逊酵母工程菌株的构建及重组水蛭素的生产工艺
EP3428282A1 (de) * 2017-07-11 2019-01-16 Alderys Ectoine-herstellende hefe

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4940661A (en) * 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
FR2593518B1 (fr) * 1985-05-02 1989-09-08 Transgene Sa Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
MC1834A1 (fr) * 1986-07-10 1988-06-03 Transgene Sa Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
AU614959B2 (en) * 1987-05-07 1991-09-19 Commonwealth Scientific And Industrial Research Organisation Expression system
PT88556B (pt) * 1987-09-28 1992-11-30 Smithkline Biolog Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche

Also Published As

Publication number Publication date
CA2105425A1 (en) 1994-03-05
JP2004000288A (ja) 2004-01-08
IL106897A0 (en) 1993-12-28
PT592358E (pt) 2001-03-30
JPH06165691A (ja) 1994-06-14
KR940007180A (ko) 1994-04-26
US5726043A (en) 1998-03-10
HUT67307A (en) 1995-03-28
NO933153L (no) 1994-03-07
FI933821L (fi) 1994-03-05
MX9305375A (es) 1994-03-31
DE69329540D1 (de) 2000-11-16
FI933821A7 (fi) 1994-03-05
EP0592358B1 (de) 2000-10-11
EP0592358A2 (de) 1994-04-13
SG49859A1 (en) 2002-03-19
HU9302503D0 (en) 1993-11-29
AU4499493A (en) 1994-03-10
NO933153D0 (no) 1993-09-03
NZ248558A (en) 1995-04-27
JP3949734B2 (ja) 2007-07-25
ZA936507B (en) 1994-03-23
EP1031628A1 (de) 2000-08-30
HU217094B (hu) 1999-11-29
DE69329540T2 (de) 2001-06-07
EP0592358A3 (en) 1994-09-28
DK0592358T3 (da) 2001-02-05
FI933821A0 (fi) 1993-09-01
ES2152943T3 (es) 2001-02-16
AU675071B2 (en) 1997-01-23
GR3035201T3 (en) 2001-04-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner