ATE147860T1 - Verfahren zur immobilisierung von nukleinsäure an einer festen oberfläche zur anwendung in nukleinsäure-hybridizierungstests - Google Patents

Verfahren zur immobilisierung von nukleinsäure an einer festen oberfläche zur anwendung in nukleinsäure-hybridizierungstests

Info

Publication number
ATE147860T1
ATE147860T1 AT90313007T AT90313007T ATE147860T1 AT E147860 T1 ATE147860 T1 AT E147860T1 AT 90313007 T AT90313007 T AT 90313007T AT 90313007 T AT90313007 T AT 90313007T AT E147860 T1 ATE147860 T1 AT E147860T1
Authority
AT
Austria
Prior art keywords
nucleic acid
solid surface
immobilizing
acid strand
modified
Prior art date
Application number
AT90313007T
Other languages
English (en)
Inventor
Chander Bahl
Rhonda Lang
Leo Mendoza
Original Assignee
Ortho Diagnostic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Diagnostic Systems Inc filed Critical Ortho Diagnostic Systems Inc
Application granted granted Critical
Publication of ATE147860T1 publication Critical patent/ATE147860T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT90313007T 1989-11-30 1990-11-29 Verfahren zur immobilisierung von nukleinsäure an einer festen oberfläche zur anwendung in nukleinsäure-hybridizierungstests ATE147860T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/444,031 US5215882A (en) 1989-11-30 1989-11-30 Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays

Publications (1)

Publication Number Publication Date
ATE147860T1 true ATE147860T1 (de) 1997-02-15

Family

ID=23763208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90313007T ATE147860T1 (de) 1989-11-30 1990-11-29 Verfahren zur immobilisierung von nukleinsäure an einer festen oberfläche zur anwendung in nukleinsäure-hybridizierungstests

Country Status (7)

Country Link
US (1) US5215882A (de)
EP (1) EP0435470B1 (de)
AT (1) ATE147860T1 (de)
CA (1) CA2031026A1 (de)
DE (1) DE69029717T2 (de)
GR (1) GR1001043B (de)
HK (1) HK95097A (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
WO1992008788A1 (en) * 1990-11-19 1992-05-29 The Board Of Trustees Of The University Of Illinois Mutant orientable proteins and coated substrates
WO1992010588A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
US6849462B1 (en) 1991-11-22 2005-02-01 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
EP0647719A4 (de) * 1992-03-19 1997-08-20 Nippon Gene Kk Ein festphasenanker, der eine nukleinsäure trägt, und verfahren zu seiner anpassung.
FR2716263B1 (fr) * 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5922534A (en) * 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6103535A (en) * 1996-05-31 2000-08-15 University Of Maryland Optical fiber evanescent field excited fluorosensor and method of manufacture
ATE335845T1 (de) * 1997-05-16 2006-09-15 Exact Sciences Corp Elektrophoretische analyse von molekülen mit immobilisierten sonden
US6255051B1 (en) 1997-11-06 2001-07-03 Mosaic Technologies Inc. Multiple sequential polynucleotide displacement reactions for signal amplification and processing
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
WO1999066078A1 (en) 1998-06-18 1999-12-23 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
CA2330732A1 (en) * 1998-06-19 1999-12-23 Mosaic Technologies Detection of non-viral organisms with srp rna
US6238927B1 (en) 1998-10-05 2001-05-29 Mosaic Technologies, Incorporated Reverse displacement assay for detection of nucleic acid sequences
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
ATE265040T1 (de) * 1999-02-26 2004-05-15 Exact Sciences Corp Biochemische reinigungsgeräte mit immobilisierten fangsonden und ihre anwendungen
US6194563B1 (en) * 1999-03-26 2001-02-27 Vysis, Inc. Solid phase nucleic acid labeling by transamination
US6248537B1 (en) 1999-05-28 2001-06-19 Institut Pasteur Use of the combing process for the identification of DNA origins of replication
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
EP1111069A1 (de) * 1999-12-22 2001-06-27 BioChip Technologies GmbH Modifizierte Nukleinsäuren und deren Verwendung
KR100382703B1 (ko) * 2000-03-15 2003-05-09 주식회사 바이오메드랩 인유두종바이러스의 유전형 진단키트 및 상기 진단키트의제조방법
AU2001255518A1 (en) * 2000-06-07 2001-12-17 Baylor College Of Medicine Compositions and methods for array-based nucleic acid hybridization
KR100420785B1 (ko) * 2000-09-29 2004-03-02 한국과학기술원 코돈검색 알고리즘을 이용한 탐침의 제조방법
EP1334113A4 (de) * 2000-10-20 2007-08-08 Expression Diagnostics Inc Erstellen von leukozytenexpressionsprofilen
US6861214B1 (en) 2000-10-23 2005-03-01 Beckman Coulter, Inc. Immobilization of biopolymers to aminated substrates by direct adsorption
US6500921B1 (en) * 2000-11-07 2002-12-31 Amersham Biosciences Ab Schiff base reductant co-dispense process
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7189509B2 (en) * 2001-08-16 2007-03-13 Zhifeng Shao Analysis of gene expression profiles using sequential hybridization
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
EP1451318A4 (de) * 2001-10-12 2007-06-27 Perkinelmer Las Inc Zusammenstellungen von nukleinsäuren und arrays und verfahren zu ihrer verwendung
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
US6987180B2 (en) * 2002-02-07 2006-01-17 President And Fellows Of Harvard College Uridine analogs and techniques for making and using
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20060263813A1 (en) * 2005-05-11 2006-11-23 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006102497A2 (en) * 2005-03-22 2006-09-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
DE102005039726B3 (de) * 2005-08-19 2007-01-11 Universität Rostock Verfahren zur Markierung und Analyse von Nukleinsäuren
CA2648580A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
US8148067B2 (en) * 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
EP2658864A1 (de) * 2010-12-30 2013-11-06 LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES (Groupement d Interet public) Verfahren zur immobilisierung von nukleinsäureliganden
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
WO2013095941A1 (en) 2011-12-19 2013-06-27 Valley Health System Methods and kits for detecting subjects at risk of having cancer
EP3182126A3 (de) 2012-06-15 2017-08-02 Wayne State University Biomarkertest zur vorhersage oder früherkennung von präeklampsie und/oder hellp-syndrom
EP3339861B8 (de) 2012-06-15 2023-11-01 Genesis Theranostix Korlatolt Felelossegu Tarsasag Biomarkertest zur vorhersage oder früherkennung von präeklampsie
ES2765573T3 (es) 2012-08-13 2020-06-09 Univ Rockefeller Tratamiento y diagnóstico de melanoma
JP6109951B2 (ja) 2012-10-31 2017-04-05 ザ ロックフェラー ユニバーシティー 結腸癌の処置および診断
US20160370356A1 (en) * 2014-02-24 2016-12-22 President And Fellows Of Harvard College Paper-based immunoassay with polymerization-based signal amplification
CN106795557A (zh) 2014-06-02 2017-05-31 瓦利保健系统公司 用于肺癌诊断的方法和系统
FR3035799B1 (fr) * 2015-05-06 2017-05-05 Elicityl Support pour la purification de liquides biologiques
FR3035794B1 (fr) * 2015-05-06 2017-05-05 Elicityl Procede pour la purification du sang total ou d'un produit issu du sang
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
EP3660172A1 (de) 2018-11-28 2020-06-03 Bioscreening and Diagnostics LLC Verfahren zur diagnose von traumatischen hirnverletzungen
EP4073025B1 (de) 2019-12-13 2024-03-27 Inspirna, Inc. Metallsalze und verwendungen davon
WO2025212475A2 (en) 2024-04-03 2025-10-09 Mars, Incorporated Compositions and methods to detect infectious organisms

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE361631C (de) * 1922-10-17 Karl Kramb Reihenstuhl fuer Theater-, Lichtspiel- und Konzertsaele
US3594037A (en) * 1970-04-09 1971-07-20 Mc Donnell Douglas Corp Cabin attendant seat
US4423208A (en) * 1982-02-24 1983-12-27 Peter Grandics Affinity gel-adsorbent
US4687808A (en) * 1982-08-12 1987-08-18 Biospecific Technologies, Inc. Activation of biocompatible polymers with biologicals whose binding complements are pathological effectors
IT1218348B (it) * 1983-05-13 1990-04-12 Farmaceutico Lofarma S A S Ora Metodo per legare in modo stabile antigenti e allergeni a supporti solidi
US4549011A (en) * 1983-09-19 1985-10-22 Orgenics Ltd. Modified sheet of material and method of making and using same in connection with biochemical procedures
DE177497T1 (de) * 1984-04-05 1986-11-27 Life Technologies Inc., Gaithersburg, Md. Immobilisierung von nukleinsaeuren.
FR2567523B1 (fr) * 1984-07-12 1987-11-13 Pasteur Institut Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention
EP0209996A3 (de) * 1985-06-25 1987-09-02 Siska Diagnostics,Inc. N4-(Amino-substituierte) Cytidin enthaltendes Nukleinsäuretestmittel
DE8521459U1 (de) * 1985-07-25 1985-09-19 Hohenloher Spezialmöbelwerk Schaffitzel GmbH + Co, 7110 Öhringen Hörsaalgestühl
JP2641880B2 (ja) * 1986-08-11 1997-08-20 シスカ・ダイアグノスティックス・インコーポレーテッド 核酸プローブアッセイ法および組成物
GB2197720A (en) * 1986-11-20 1988-05-25 Nat Res Dev Immobilisation of polynucleotides
US4824870A (en) * 1987-09-14 1989-04-25 Gelman Sciences, Inc. Polyaldehyde activated membranes

Also Published As

Publication number Publication date
GR1001043B (el) 1993-03-31
GR900100828A (en) 1992-04-17
EP0435470A1 (de) 1991-07-03
US5215882A (en) 1993-06-01
DE69029717D1 (de) 1997-02-27
DE69029717T2 (de) 1997-06-05
EP0435470B1 (de) 1997-01-15
HK95097A (en) 1997-08-01
CA2031026A1 (en) 1991-05-31

Similar Documents

Publication Publication Date Title
DE69029717D1 (de) Verfahren zur Immobilisierung von Nukleinsäure an einer festen Oberfläche zur Anwendung in Nukleinsäure-Hybridizierungstests
DE3689412D1 (de) Verfahren zur durchführung von hybridisierungstests von nukleinsäuren.
DE68915202D1 (de) Verfahren zur Vermehrung und zum Nachweis von Nukleinsäuresequenzen.
DE3784374D1 (de) Verfahren zur rueckgewinnung von kohlenwasserstoffdaempfen.
ATA44185A (de) Verfahren zur herstellung von nucleinsaeure-reagenzien
DE68907407D1 (de) Verfahren zur sequenzanalyse von dna.
DE69003104D1 (de) Verfahren zum nachweis von spezifischen sequenzen von nukleinsäuren und ihre verwendungen.
DE68902375D1 (de) Verfahren zur vorsulfidierung von kohlenwasserstoffbehandlungskatalysatoren.
DE3674152D1 (de) Verfahren und vorrichtung zur entdeckung von metall.
DE3766319D1 (de) Verfahren und vorrichtung zur hydrodynamischen mischung.
ATA229286A (de) Verfahren zur herstellung von stahl
DE68901960D1 (de) Verfahren zur katalytischen spaltung von kohlenwasserstoffeinsaetzen.
DE3774360D1 (de) Verfahren zur hydroraffinierung von kohlenwasserstoff enthaltenden einsaetzen.
DE3879253D1 (de) Verfahren zur ammoxidation und katalysatorzusammensetzung dafuer.
DE3882075D1 (de) Verfahren zur ammoxidation und katalysatorzusammensetzung dafuer.
ATA43187A (de) Verfahren zur quantitativen bestimmung von nucleinsaeure-molekuelen und reagenziensatz hierfuer
DE3880857D1 (de) Katalysatorzusammensetzungen und verfahren zur copolymerisation von co mit einer oder mehreren ungesaettigten olefinischen verbindungen.
DE69012440D1 (de) Verfahren zur Bestimmung von Nukleinsäuren.
DE68914372D1 (de) Verfahren und Ausrüstung zur Identifizierung von DNS-Basen.
DE68906768D1 (de) Verfahren und anlage zur herstellung von gewoelbt gehaerteten automobilscheiben.
DE69231400D1 (de) Verfahren zur Unterscheidung von Nukleinsäurebasentypen
DE3581204D1 (de) Verfahren zur polymerisation von buten-1.
DE3688965D1 (de) Verfahren und aufbau einer nukleinsäure zur erzeugung von reagenzienkomplexen zur verwendung bei der bestimmung von zielnukleotidsequenzen.
DE3765881D1 (de) Verfahren zur polymerisation von alpha-olefinen.
DE3871898D1 (de) Verfahren zur selektiven monohydroformylierung von diolefinen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties