ATE148499T1 - Herstellung monoklonaler antikörper gegen menschliches vbeta t-zellrezeptorelement unter verwendung rekombinanter dna-vektoren - Google Patents

Herstellung monoklonaler antikörper gegen menschliches vbeta t-zellrezeptorelement unter verwendung rekombinanter dna-vektoren

Info

Publication number
ATE148499T1
ATE148499T1 AT91915852T AT91915852T ATE148499T1 AT E148499 T1 ATE148499 T1 AT E148499T1 AT 91915852 T AT91915852 T AT 91915852T AT 91915852 T AT91915852 T AT 91915852T AT E148499 T1 ATE148499 T1 AT E148499T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
recombinant dna
antibodies against
vbeta
dna vectors
Prior art date
Application number
AT91915852T
Other languages
English (en)
Inventor
Yongwon Choi
Av York
John Kappler
Philitpa Marrack
Original Assignee
Nat Jewish Ct Immun & Respirat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Jewish Ct Immun & Respirat filed Critical Nat Jewish Ct Immun & Respirat
Application granted granted Critical
Publication of ATE148499T1 publication Critical patent/ATE148499T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT91915852T 1990-08-09 1991-08-08 Herstellung monoklonaler antikörper gegen menschliches vbeta t-zellrezeptorelement unter verwendung rekombinanter dna-vektoren ATE148499T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56543990A 1990-08-09 1990-08-09

Publications (1)

Publication Number Publication Date
ATE148499T1 true ATE148499T1 (de) 1997-02-15

Family

ID=24258606

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915852T ATE148499T1 (de) 1990-08-09 1991-08-08 Herstellung monoklonaler antikörper gegen menschliches vbeta t-zellrezeptorelement unter verwendung rekombinanter dna-vektoren

Country Status (12)

Country Link
US (1) US5616472A (de)
EP (1) EP0542897B1 (de)
JP (1) JPH06502529A (de)
KR (1) KR930701620A (de)
AT (1) ATE148499T1 (de)
AU (1) AU652959B2 (de)
CA (1) CA2088905A1 (de)
DE (1) DE69124518T2 (de)
DK (1) DK0542897T3 (de)
ES (1) ES2098368T3 (de)
GR (1) GR3023102T3 (de)
WO (1) WO1992002629A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766947A (en) * 1988-12-14 1998-06-16 Astra Ab Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor
US5552300A (en) * 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
JP2001519143A (ja) * 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖ｔ細胞レセプタータンパク質
WO2000023087A1 (en) * 1998-10-21 2000-04-27 Sunol Molecular Corporation Polyspecific binding molecules and uses thereof
EP1613724A4 (de) * 2002-11-18 2010-09-01 Us Gov Health & Human Serv Zellinien und wirtsnukleinsäuresequenzen in verbindung mit infektionskrankheiten
SG11201606583VA (en) * 2014-03-05 2016-09-29 Ucl Business Plc Chimeric antigen receptor (car) with antigen binding domains to the t cell receptor beta constant region
US11885806B2 (en) 2014-03-05 2024-01-30 Autolus Limited Method for depleting malignant T-cells
NZ737400A (en) 2015-06-01 2019-09-27 Medigene Immunotherapies Gmbh T cell receptor library
WO2016193300A1 (en) 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
BR112018012694A2 (pt) 2015-12-23 2018-12-04 Medigene Immunotherapies Gmbh composição de célula dendrítica, vacina de célula dendrítica, composição e kit

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189147A (en) * 1984-06-13 1993-02-23 Massachusetts Institute Of Technology Meterodimeric T lymphocyte receptor antibody
US5223426A (en) * 1988-12-15 1993-06-29 T Cell Sciences, Inc. Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor

Also Published As

Publication number Publication date
EP0542897A4 (en) 1993-08-18
ES2098368T3 (es) 1997-05-01
AU652959B2 (en) 1994-09-15
US5616472A (en) 1997-04-01
DK0542897T3 (da) 1997-02-17
DE69124518T2 (de) 1997-05-15
WO1992002629A1 (en) 1992-02-20
JPH06502529A (ja) 1994-03-24
KR930701620A (ko) 1993-06-12
EP0542897B1 (de) 1997-01-29
CA2088905A1 (en) 1992-02-10
DE69124518D1 (de) 1997-03-13
AU8500691A (en) 1992-03-02
EP0542897A1 (de) 1993-05-26
GR3023102T3 (en) 1997-07-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee