ATE148713T1 - Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor - Google Patents
Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitorInfo
- Publication number
- ATE148713T1 ATE148713T1 AT91913108T AT91913108T ATE148713T1 AT E148713 T1 ATE148713 T1 AT E148713T1 AT 91913108 T AT91913108 T AT 91913108T AT 91913108 T AT91913108 T AT 91913108T AT E148713 T1 ATE148713 T1 AT E148713T1
- Authority
- AT
- Austria
- Prior art keywords
- glycosaminoglycan
- lipid
- derivative
- phospholipide
- mixed
- Prior art date
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 150000002632 lipids Chemical class 0.000 title abstract 3
- 239000002257 antimetastatic agent Substances 0.000 title abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2193817A JP2997018B2 (ja) | 1990-07-24 | 1990-07-24 | 燐脂質又は脂質結合グリコサミノグリカン |
| JP2193816A JP2986518B2 (ja) | 1990-07-24 | 1990-07-24 | 癌転移抑制剤 |
| JP2193818A JP2986519B2 (ja) | 1990-07-24 | 1990-07-24 | 燐脂質結合グリコサミノグリカン |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE148713T1 true ATE148713T1 (de) | 1997-02-15 |
Family
ID=27326820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91913108T ATE148713T1 (de) | 1990-07-24 | 1991-07-24 | Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5464942A (de) |
| EP (1) | EP0493622B1 (de) |
| KR (1) | KR0181295B1 (de) |
| AT (1) | ATE148713T1 (de) |
| AU (1) | AU647814B2 (de) |
| CA (1) | CA2067211C (de) |
| DE (1) | DE69124590T2 (de) |
| FI (1) | FI103279B1 (de) |
| NO (1) | NO305368B1 (de) |
| WO (1) | WO1992001720A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3199405B2 (ja) * | 1991-08-30 | 2001-08-20 | 生化学工業株式会社 | 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法 |
| IT1260137B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato |
| KR20030097604A (ko) * | 1992-07-13 | 2003-12-31 | 유카리언, 인코포레이티드 | 세포의 세포내 구획으로 지질화된 면역글로불린을전달하기 위한 조성물, 지질화된 단백질 및 지질화된 항체 |
| JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
| JP2787279B2 (ja) * | 1994-05-17 | 1998-08-13 | 雪印乳業株式会社 | 糖リン脂質及びその調製法 |
| US6228998B1 (en) | 1994-07-22 | 2001-05-08 | Seikagaku Kogyo Kabushiki Kaisha | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide |
| FR2725622A1 (fr) * | 1994-10-14 | 1996-04-19 | Fabre Pierre Dermo Cosmetique | Ceramide greffee anti-elastase |
| CA2175282A1 (en) * | 1996-04-29 | 1997-10-30 | Rudolf Edgar Falk | Use of forms of hyaluronic acid (ha) for the treatment of cancer |
| WO2000040253A1 (en) * | 1999-01-08 | 2000-07-13 | The Board Of Trustees Of The University Of Arkansas | Synthetic, highly charged molecules and uses thereof |
| JP3032824B1 (ja) * | 1999-01-28 | 2000-04-17 | 東京医科歯科大学長 | 骨誘導促進剤 |
| AU6472900A (en) * | 1999-08-10 | 2001-03-13 | Seikagaku Corporation | Glycosaminoglycan derivatives and utilization thereof |
| US20090325876A1 (en) * | 2004-09-29 | 2009-12-31 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases associated with vasculature |
| US9040078B2 (en) * | 2000-01-10 | 2015-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases of the nervous system |
| US8304395B2 (en) * | 2000-01-10 | 2012-11-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Lipid conjugates in the treatment of disease |
| US7504384B2 (en) * | 2000-01-10 | 2009-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of infection |
| US7772196B2 (en) * | 2000-01-10 | 2010-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7101859B2 (en) * | 2000-01-10 | 2006-09-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7608598B2 (en) | 2000-01-10 | 2009-10-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of conjunctivitis |
| US8916539B2 (en) * | 2000-01-10 | 2014-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US7393938B2 (en) * | 2000-01-10 | 2008-07-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7893226B2 (en) | 2004-09-29 | 2011-02-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
| US8076312B2 (en) * | 2000-01-10 | 2011-12-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Use of lipid conjugates in the treatment of disease |
| US7141552B2 (en) * | 2000-01-10 | 2006-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7811999B2 (en) * | 2000-01-10 | 2010-10-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
| US8501701B2 (en) * | 2000-01-10 | 2013-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Use of lipid conjugates in the treatment of disease |
| US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
| US8883761B2 (en) * | 2001-01-10 | 2014-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases associated with vasculature |
| US7280612B2 (en) * | 2003-07-25 | 2007-10-09 | Zarbana Digital Fund Llc | Digital branch calibrator for an RF transmitter |
| ES2406555T3 (es) * | 2003-10-29 | 2013-06-07 | Teijin Limited | Compuesto de ácido hialurónico, hidrogel del mismo y material para tratar articulaciones |
| KR20080065269A (ko) * | 2005-08-03 | 2008-07-11 | 모리아 바이오파마슈티컬스 | 낭포성 섬유증에 대한 리피드 접합체의 용도 및 그의 적용 |
| JP4744973B2 (ja) * | 2005-08-05 | 2011-08-10 | 株式会社トプコン | 眼底カメラ |
| US8475694B2 (en) | 2005-10-25 | 2013-07-02 | Zephyros, Inc. | Shaped expandable material |
| WO2010132402A1 (en) * | 2009-05-11 | 2010-11-18 | Morria Biopharmaceuticals, Inc | Lipid-polymer conjugates, their preparation and uses thereof |
| US8906882B2 (en) | 2005-11-17 | 2014-12-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of allergic rhinitis |
| US8859524B2 (en) | 2005-11-17 | 2014-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of chronic rhinosinusitis |
| US20080183282A1 (en) * | 2006-03-09 | 2008-07-31 | Saul Yedgar | Use of lipid conjugates for the coating of stents and catheters |
| AU2007320737B2 (en) * | 2006-11-14 | 2014-04-03 | Celsus Therapeutics Plc | Contact lens compositions |
| CA2705785A1 (en) * | 2006-11-14 | 2008-05-22 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases or disorders of the eye |
| GB0916205D0 (en) | 2009-09-15 | 2009-10-28 | Zephyros Inc | Improvements in or relating to cavity filling |
| WO2011113892A2 (en) * | 2010-03-17 | 2011-09-22 | Ktb Tumorforschungsgesellschaft Mbh | Combined use of phospholipid and sulfate groups-carrying polysaccharides for inhibiting metastatic spread |
| CA2703532C (en) * | 2010-05-10 | 2018-05-01 | Eva Turley | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
| CN114096567A (zh) | 2019-04-29 | 2022-02-25 | 鲍希与洛姆伯股份有限公司 | 糖磷脂聚合物网络及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2374910A1 (fr) * | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
| FR2492259A1 (fr) * | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
| US4362737A (en) * | 1981-04-13 | 1982-12-07 | Schaefer Rolf | Transdermal carrier materials |
| US4604376A (en) * | 1982-04-21 | 1986-08-05 | Research Corporation | Enteric compounds and complexes |
| US4654327A (en) * | 1982-04-21 | 1987-03-31 | Research Corp. | Quaternary ammonium complexes of heparin |
| CA1226816A (en) * | 1982-12-20 | 1987-09-15 | Moses J. Folkman | Inhibition of angiogenesis |
| JPS6117A (ja) * | 1984-06-11 | 1986-01-06 | Seikagaku Kogyo Co Ltd | ムコ多糖系癌転移抑制剤 |
| AU6593386A (en) * | 1985-10-24 | 1987-05-19 | Research Corp. Ltd. | Biochemical reagent |
| IL79255A0 (en) * | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
| IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| US5169636A (en) * | 1988-03-17 | 1992-12-08 | Nippon Fine Chemical Co., Ltd. | Liposomes |
| JPH0219393A (ja) * | 1988-07-08 | 1990-01-23 | Higeta Shoyu Kk | Ｎ‐アセチルガラクトサミノオリゴ糖及びその製造方法 |
| JPH0258501A (ja) * | 1988-08-25 | 1990-02-27 | Mitsubishi Gas Chem Co Inc | リポ多糖およびその用途 |
| JPH03220201A (ja) * | 1988-11-18 | 1991-09-27 | Eisai Co Ltd | プロスタグランジン類と多糖類の結合体 |
-
1991
- 1991-07-24 US US07/847,065 patent/US5464942A/en not_active Expired - Lifetime
- 1991-07-24 DE DE69124590T patent/DE69124590T2/de not_active Expired - Fee Related
- 1991-07-24 WO PCT/JP1991/000995 patent/WO1992001720A1/ja not_active Ceased
- 1991-07-24 KR KR1019920700665A patent/KR0181295B1/ko not_active Expired - Fee Related
- 1991-07-24 CA CA002067211A patent/CA2067211C/en not_active Expired - Fee Related
- 1991-07-24 AU AU82266/91A patent/AU647814B2/en not_active Ceased
- 1991-07-24 AT AT91913108T patent/ATE148713T1/de not_active IP Right Cessation
- 1991-07-24 EP EP91913108A patent/EP0493622B1/de not_active Expired - Lifetime
-
1992
- 1992-02-19 FI FI920717A patent/FI103279B1/fi active
- 1992-03-19 NO NO921083A patent/NO305368B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0493622A4 (en) | 1993-10-27 |
| NO921083D0 (no) | 1992-03-19 |
| EP0493622B1 (de) | 1997-02-05 |
| NO305368B1 (no) | 1999-05-18 |
| FI103279B (fi) | 1999-05-31 |
| DE69124590D1 (de) | 1997-03-20 |
| NO921083L (no) | 1992-05-21 |
| KR0181295B1 (ko) | 1999-04-01 |
| DE69124590T2 (de) | 1997-06-12 |
| EP0493622A1 (de) | 1992-07-08 |
| FI920717A0 (fi) | 1992-02-19 |
| KR920702377A (ko) | 1992-09-03 |
| WO1992001720A1 (fr) | 1992-02-06 |
| AU647814B2 (en) | 1994-03-31 |
| CA2067211C (en) | 2004-06-15 |
| FI103279B1 (fi) | 1999-05-31 |
| CA2067211A1 (en) | 1992-01-25 |
| US5464942A (en) | 1995-11-07 |
| AU8226691A (en) | 1992-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |