ATE148882T1 - Verfahren zur herstellung von taxan-derivaten - Google Patents

Verfahren zur herstellung von taxan-derivaten

Info

Publication number
ATE148882T1
ATE148882T1 AT93921984T AT93921984T ATE148882T1 AT E148882 T1 ATE148882 T1 AT E148882T1 AT 93921984 T AT93921984 T AT 93921984T AT 93921984 T AT93921984 T AT 93921984T AT E148882 T1 ATE148882 T1 AT E148882T1
Authority
AT
Austria
Prior art keywords
pct
radical
vii
formula
date apr
Prior art date
Application number
AT93921984T
Other languages
English (en)
Inventor
Alain Commercon
Eric Didier
Elie Fouque
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE148882T1 publication Critical patent/ATE148882T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT93921984T 1992-10-05 1993-10-04 Verfahren zur herstellung von taxan-derivaten ATE148882T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211743A FR2696460B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
ATE148882T1 true ATE148882T1 (de) 1997-02-15

Family

ID=9434121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93921984T ATE148882T1 (de) 1992-10-05 1993-10-04 Verfahren zur herstellung von taxan-derivaten

Country Status (24)

Country Link
US (3) US5621121A (de)
EP (1) EP0663908B1 (de)
JP (1) JP3014762B2 (de)
KR (1) KR100301237B1 (de)
AT (1) ATE148882T1 (de)
AU (1) AU690080B2 (de)
CA (1) CA2146249A1 (de)
CZ (1) CZ283291B6 (de)
DE (1) DE69308154T2 (de)
DK (1) DK0663908T3 (de)
ES (1) ES2098060T3 (de)
FI (1) FI951592A0 (de)
FR (1) FR2696460B1 (de)
GR (1) GR3022616T3 (de)
HU (1) HUT72613A (de)
MX (1) MX9305768A (de)
NO (1) NO311255B1 (de)
NZ (1) NZ256447A (de)
PL (1) PL184556B1 (de)
RU (1) RU2115649C1 (de)
SK (1) SK280577B6 (de)
TW (1) TW393474B (de)
WO (1) WO1994007879A1 (de)
ZA (1) ZA937320B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
ATE253563T1 (de) 1993-02-05 2003-11-15 Bryn Mawr College Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
DK0690867T3 (da) * 1993-03-22 2003-06-10 Univ Florida State Taxaner med furyl- eller thienylsubstitueret sidekæde
ES2205663T3 (es) * 1993-06-11 2004-05-01 PHARMACIA & UPJOHN COMPANY Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
KR100354309B1 (ko) * 1993-11-12 2003-01-06 파마시아 앤드 업존 캄파니 피리미딘-티오알킬및알킬에테르화합물
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
ATE223889T1 (de) * 1996-05-08 2002-09-15 Upjohn Co Oxazolidinester
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6111144A (en) 1997-08-21 2000-08-29 Florida State University Method for the synthesis of a taxane intermediate
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
CZ2003837A3 (cs) * 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
TWI293302B (en) * 2001-01-12 2008-02-11 Sod Conseils Rech Applic New derivatives of mikanolide, their preparation and their therapeutic uses
DE60144113D1 (de) * 2001-03-23 2011-04-07 Scinopharm Taiwan Ltd Verfahren zur herstellung von taxanderivaten
US20040132991A1 (en) * 2002-10-09 2004-07-08 Phytogen Life Sciences Inc. Novel taxanes and methods related to use and preparation thereof
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
DE102004034140A1 (de) * 2004-07-15 2006-02-23 Covion Organic Semiconductors Gmbh Verwendung von Polymeren für Up-conversion und Vorrichtungen zur Up-conversion
EP2094084A4 (de) * 2006-10-20 2010-01-13 Scinopharm Singapore Pte Ltd Verfahren zur herstellung von kristallinem wasserfreiem docetaxel
KR100847331B1 (ko) * 2006-12-14 2008-07-21 한미약품 주식회사 도세탁셀의 제조방법 및 이에 사용되는 중간체
EP2080764B1 (de) 2008-01-18 2012-08-22 INDENA S.p.A. Feste Formen von Ortataxel
KR101003820B1 (ko) 2008-06-19 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
JP2014079364A (ja) * 2012-10-16 2014-05-08 Tokai Medical Care Holdings Co Ltd 歩行訓練補助器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
ES2205663T3 (es) * 1993-06-11 2004-05-01 PHARMACIA & UPJOHN COMPANY Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
PL308242A1 (en) 1995-07-24
JPH08501790A (ja) 1996-02-27
PL184556B1 (pl) 2002-11-29
CZ84395A3 (en) 1995-09-13
SK43495A3 (en) 1995-08-09
MX9305768A (es) 1994-05-31
HUT72613A (en) 1996-05-28
FI951592A7 (fi) 1995-04-04
SK280577B6 (sk) 2000-04-10
US5621121A (en) 1997-04-15
EP0663908A1 (de) 1995-07-26
AU690080B2 (en) 1998-04-23
ZA937320B (en) 1994-04-25
KR950703548A (ko) 1995-09-20
DE69308154D1 (de) 1997-03-27
GR3022616T3 (en) 1997-05-31
AU5115293A (en) 1994-04-26
CA2146249A1 (fr) 1994-04-14
FI951592L (fi) 1995-04-04
JP3014762B2 (ja) 2000-02-28
RU2115649C1 (ru) 1998-07-20
EP0663908B1 (de) 1997-02-12
KR100301237B1 (ko) 2001-11-22
FR2696460A1 (fr) 1994-04-08
WO1994007879A1 (fr) 1994-04-14
ES2098060T3 (es) 1997-04-16
NZ256447A (en) 1997-01-29
HU9500968D0 (en) 1995-06-28
TW393474B (en) 2000-06-11
US5726318A (en) 1998-03-10
FR2696460B1 (fr) 1994-11-25
NO311255B1 (no) 2001-11-05
US5861515A (en) 1999-01-19
FI951592A0 (fi) 1995-04-04
DK0663908T3 (de) 1997-03-17
CZ283291B6 (cs) 1998-02-18
NO951203L (no) 1995-03-29
DE69308154T2 (de) 1997-09-25
RU95110682A (ru) 1996-12-27
NO951203D0 (no) 1995-03-29

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Legal Events

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REN Ceased due to non-payment of the annual fee