ES2098060T3 - Procedimiento para la preparacion de derivados del taxano. - Google Patents

Procedimiento para la preparacion de derivados del taxano.

Info

Publication number
ES2098060T3
ES2098060T3 ES93921984T ES93921984T ES2098060T3 ES 2098060 T3 ES2098060 T3 ES 2098060T3 ES 93921984 T ES93921984 T ES 93921984T ES 93921984 T ES93921984 T ES 93921984T ES 2098060 T3 ES2098060 T3 ES 2098060T3
Authority
ES
Spain
Prior art keywords
radical
taxane derivatives
trihalometilo
bacatine
cycloalcoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921984T
Other languages
English (en)
Inventor
Alain Commercon
Eric Didier
Elie Fouque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2098060T3 publication Critical patent/ES2098060T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESO DE PREPARACION DE DERIVADOS DE TAXANO DE FORMULA GENERAL (I) POR ESTERIFICACION DE LA BACATINA III O DE LA DESACETIL-10 BACATINA III PROTEGIDA MEDIANTE UN ACIDO DE FORMULA GENERAL (VII), ELIMINACION DE LOS GRUPOS PROTECTORES Y DESPUES ACILACION DE LA FUNCION AMINO DE LA CADENA LATERAL. LOS PRODUCTOS DE FORMULA (I) PRESENTAN PROPIEDADES ANTITUMORALES Y ANTILEUCEMICAS NOTABLES. EN LAS FORMULAS (I) Y (VII): AR REPRESENTA ARILO, R REPRESENTA HIDROGENO O ACETILO, R1 REPRESENTA BENZOILO O UN RADICAL R2-O-CO EN EL QUE R2 REPRESENTA ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO, BICILOALCOILO, FENILO O HETEROCICLILO, R3 REPRESENTA U RADICAL TRIHALOMETILO O FENILO SUSTITUIDO POR UN RADICAL TRIHALOMETILO, R4 REPRESENTA UN ATOMO DE HIDROPGENO O ES IDENTICO A R1.
ES93921984T 1992-10-05 1993-10-04 Procedimiento para la preparacion de derivados del taxano. Expired - Lifetime ES2098060T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211743A FR2696460B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
ES2098060T3 true ES2098060T3 (es) 1997-04-16

Family

ID=9434121

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921984T Expired - Lifetime ES2098060T3 (es) 1992-10-05 1993-10-04 Procedimiento para la preparacion de derivados del taxano.

Country Status (24)

Country Link
US (3) US5621121A (es)
EP (1) EP0663908B1 (es)
JP (1) JP3014762B2 (es)
KR (1) KR100301237B1 (es)
AT (1) ATE148882T1 (es)
AU (1) AU690080B2 (es)
CA (1) CA2146249A1 (es)
CZ (1) CZ283291B6 (es)
DE (1) DE69308154T2 (es)
DK (1) DK0663908T3 (es)
ES (1) ES2098060T3 (es)
FI (1) FI951592A7 (es)
FR (1) FR2696460B1 (es)
GR (1) GR3022616T3 (es)
HU (1) HUT72613A (es)
MX (1) MX9305768A (es)
NO (1) NO311255B1 (es)
NZ (1) NZ256447A (es)
PL (1) PL184556B1 (es)
RU (1) RU2115649C1 (es)
SK (1) SK280577B6 (es)
TW (1) TW393474B (es)
WO (1) WO1994007879A1 (es)
ZA (1) ZA937320B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
WO1994018186A1 (en) 1993-02-05 1994-08-18 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable a-ring side chains
DK1227093T3 (da) * 1993-03-22 2005-08-29 Univ Florida State Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde
DE69424166T2 (de) * 1993-06-11 2000-10-05 Pharmacia & Upjohn Co., Kalamazoo Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
EP0728130A1 (en) * 1993-11-12 1996-08-28 PHARMACIA & UPJOHN COMPANY Pyrimidine-thioalkyl and alkylether compounds
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
DE69715417T2 (de) * 1996-05-08 2003-06-05 Pharmacia & Upjohn Co., Kalamazoo Oxazolidinester
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
EP1019347B1 (en) * 1997-08-21 2003-03-19 Florida State University Method for the synthesis of taxanes
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
JP2004525860A (ja) 2000-09-22 2004-08-26 ブリストル−マイヤーズ スクイブ カンパニー 併用化学療法剤の毒性を低下させる方法
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
TWI293302B (en) * 2001-01-12 2008-02-11 Sod Conseils Rech Applic New derivatives of mikanolide, their preparation and their therapeutic uses
JP4108483B2 (ja) * 2001-03-23 2008-06-25 サイノファーム タイワン リミテッド タキサン誘導体の製造方法
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
DE102004034140A1 (de) * 2004-07-15 2006-02-23 Covion Organic Semiconductors Gmbh Verwendung von Polymeren für Up-conversion und Vorrichtungen zur Up-conversion
EP2330101A1 (en) * 2006-10-20 2011-06-08 Scinopharm Singapore Pte, Ltd. Process for making crystalline docetaxel
KR100847331B1 (ko) * 2006-12-14 2008-07-21 한미약품 주식회사 도세탁셀의 제조방법 및 이에 사용되는 중간체
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
KR101003820B1 (ko) 2008-06-19 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
JP2014079364A (ja) * 2012-10-16 2014-05-08 Tokai Medical Care Holdings Co Ltd 歩行訓練補助器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
DE69424166T2 (de) * 1993-06-11 2000-10-05 Pharmacia & Upjohn Co., Kalamazoo Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen

Also Published As

Publication number Publication date
NO951203D0 (no) 1995-03-29
DE69308154T2 (de) 1997-09-25
TW393474B (en) 2000-06-11
NZ256447A (en) 1997-01-29
PL184556B1 (pl) 2002-11-29
NO311255B1 (no) 2001-11-05
EP0663908B1 (fr) 1997-02-12
US5621121A (en) 1997-04-15
DE69308154D1 (de) 1997-03-27
FI951592L (fi) 1995-04-04
CA2146249A1 (fr) 1994-04-14
CZ84395A3 (en) 1995-09-13
NO951203L (no) 1995-03-29
JPH08501790A (ja) 1996-02-27
KR100301237B1 (ko) 2001-11-22
MX9305768A (es) 1994-05-31
ATE148882T1 (de) 1997-02-15
US5726318A (en) 1998-03-10
RU2115649C1 (ru) 1998-07-20
FI951592A0 (fi) 1995-04-04
KR950703548A (ko) 1995-09-20
EP0663908A1 (fr) 1995-07-26
RU95110682A (ru) 1996-12-27
SK43495A3 (en) 1995-08-09
SK280577B6 (sk) 2000-04-10
JP3014762B2 (ja) 2000-02-28
FR2696460A1 (fr) 1994-04-08
DK0663908T3 (es) 1997-03-17
FR2696460B1 (fr) 1994-11-25
PL308242A1 (en) 1995-07-24
HU9500968D0 (en) 1995-06-28
GR3022616T3 (en) 1997-05-31
HUT72613A (en) 1996-05-28
US5861515A (en) 1999-01-19
WO1994007879A1 (fr) 1994-04-14
AU5115293A (en) 1994-04-26
AU690080B2 (en) 1998-04-23
ZA937320B (en) 1994-04-25
FI951592A7 (fi) 1995-04-04
CZ283291B6 (cs) 1998-02-18

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