ATE149091T1 - Einen tetra-polyol enthaltendes impfstoff- adjuvans - Google Patents

Einen tetra-polyol enthaltendes impfstoff- adjuvans

Info

Publication number: ATE149091T1
Authority: AT; Austria
Prior art keywords: emulsion; polyol; tetra; amount; vaccine adjuvant
Prior art date: 1987-11-03

Application number

AT92113037T

Other languages

English (en)

Inventor

Anthony Clifford Allison

Noelene Elva Byars

Cherng-Chyi Fu

Deborah Marilyn Lidgate

Philip Lewis Felgner

Linda Cheryl Foster

William Alfred Lee

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-03

Filing date

1988-11-02

Publication date

1997-03-15

1988-11-02 Application filed by Syntex Inc filed Critical Syntex Inc

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149091T1 publication Critical patent/ATE149091T1/de

Links

229920005862 polyol Polymers 0.000 title abstract 2
239000012646 vaccine adjuvant Substances 0.000 title 1
229940124931 vaccine adjuvant Drugs 0.000 title 1
239000000839 emulsion Substances 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
102000002068 Glycopeptides Human genes 0.000 abstract 1
108010015899 Glycopeptides Proteins 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000008346 aqueous phase Substances 0.000 abstract 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 1
230000005847 immunogenicity Effects 0.000 abstract 1
230000002434 immunopotentiative effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Dispersion Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AT92113037T 1987-11-03 1988-11-02 Einen tetra-polyol enthaltendes impfstoff- adjuvans ATE149091T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11642587A	1987-11-03	1987-11-03

Publications (1)

Publication Number	Publication Date
ATE149091T1 true ATE149091T1 (de)	1997-03-15

Family

ID=22367122

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92113037T ATE149091T1 (de)	1987-11-03	1988-11-02	Einen tetra-polyol enthaltendes impfstoff- adjuvans

Country Status (11)

Country	Link
EP (2)	EP0315153B1 (de)
JP (2)	JP2746272B2 (de)
AT (1)	ATE149091T1 (de)
AU (1)	AU626271B2 (de)
CA (1)	CA1338618C (de)
DE (2)	DE3855807T2 (de)
ES (2)	ES2097840T3 (de)
HU (1)	HU210825A9 (de)
IE (1)	IE63692B1 (de)
NZ (1)	NZ226811A (de)
ZA (1)	ZA888209B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0832638B2 (ja)	1989-05-25	1996-03-29	カイロンコーポレイション	サブミクロン油滴乳剤を含んで成るアジュバント製剤
US5709860A (en) *	1991-07-25	1998-01-20	Idec Pharmaceuticals Corporation	Induction of cytotoxic T-lymphocyte responses
ES2053402B1 (es) *	1993-01-15	1995-02-01	Hipra Lab Sa	Metodo de preparacion de vacunas inactivadas y vacunas vivas adyuvantadas asi como las vacunas obtenidas por dicho metodo.
DE4333376C2 (de) *	1993-09-30	1995-09-07	Gerbu Biotechnik Gmbh	Mittel zur Steigerung der Ausbeute von Antikörpern in der Immunologie
GB9326253D0 (en) *	1993-12-23	1994-02-23	Smithkline Beecham Biolog	Vaccines
CA2363141C (en)	1999-02-26	2010-04-06	Novartis Vaccines And Diagnostics, Inc.	Microemulsions with adsorbed macromolecules and microparticles
ES2267559T3 (es)	1999-08-20	2007-03-16	Sloan-Kettering Institute For Cancer Research	Glicoconjugados, glicoamino, acidos sus intermediarios y el uso de los mismos.
US7854934B2 (en)	1999-08-20	2010-12-21	Sloan-Kettering Institute For Cancer Research	Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
US7824687B2 (en)	1999-08-20	2010-11-02	Sloan-Kettering Institute For Cancer Research	Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
EP1246645A2 (de) *	1999-12-23	2002-10-09	Aphton Corporation	Stabile immunogenische zusammensetzung zur gefrorene lagerung
FR2804026B1 (fr) *	2000-01-21	2004-06-11	Merial Sas	Vaccination contre l'herpesvirose canine et vaccins
MY129765A (en)	2000-12-19	2007-04-30	Wyeth Corp	Improved mycoplasma hyopneumoniae bacterin vaccine
US7018638B2 (en) *	2000-12-19	2006-03-28	Wyeth	Mycoplasma hyopneumoniae bacterin vaccine
PL1613346T3 (pl) *	2003-04-04	2013-03-29	Zoetis Services Llc	Poddane mikrofluidyzacji emulsje typu olej w wodzie i kompozycje szczepionek
NZ604089A (en)	2010-06-11	2015-03-27	Sloan Kettering Inst Cancer	Multivalent glycopeptide constructs and uses thereof
US9120859B2 (en)	2012-04-04	2015-09-01	Zoetis Services Llc	Mycoplasma hyopneumoniae vaccine
UA114503C2 (uk)	2012-04-04	2017-06-26	Зоетіс Сервісіз Ллс	Комбінована вакцина pcv та mycoplasma hyopneumoniae
UA114504C2 (uk)	2012-04-04	2017-06-26	Зоетіс Сервісіз Ллс	Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4606918A (en) *	1983-08-22	1986-08-19	Syntex (U.S.A.) Inc.	Polyoxypropylene-polyoxyethylene block polymer based adjuvants
DE3750176T2 (de) *	1986-09-22	1994-10-13	Emory University, Atlanta, Ga.	Impfstoff und verfahren zur herstellung.

1988
- 1988-11-02 AT AT92113037T patent/ATE149091T1/de not_active IP Right Cessation
- 1988-11-02 ZA ZA888209A patent/ZA888209B/xx unknown
- 1988-11-02 NZ NZ226811A patent/NZ226811A/en unknown
- 1988-11-02 JP JP63278546A patent/JP2746272B2/ja not_active Expired - Fee Related
- 1988-11-02 DE DE3855807T patent/DE3855807T2/de not_active Expired - Fee Related
- 1988-11-02 ES ES92113037T patent/ES2097840T3/es not_active Expired - Lifetime
- 1988-11-02 IE IE330588A patent/IE63692B1/en not_active IP Right Cessation
- 1988-11-02 ES ES88118263T patent/ES2052674T3/es not_active Expired - Lifetime
- 1988-11-02 CA CA000582048A patent/CA1338618C/en not_active Expired - Fee Related
- 1988-11-02 DE DE3889521T patent/DE3889521T2/de not_active Expired - Fee Related
- 1988-11-02 EP EP88118263A patent/EP0315153B1/de not_active Expired - Lifetime
- 1988-11-02 AU AU24588/88A patent/AU626271B2/en not_active Ceased
- 1988-11-02 EP EP92113037A patent/EP0513861B1/de not_active Expired - Lifetime
1995
- 1995-02-17 HU HU95P/P00082P patent/HU210825A9/hu unknown
1997
- 1997-04-21 JP JP9103566A patent/JP2816337B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE883305L (en)	1989-05-03
DE3889521D1 (de)	1994-06-16
JPH01157918A (ja)	1989-06-21
JP2746272B2 (ja)	1998-05-06
JPH1053535A (ja)	1998-02-24
DE3855807D1 (de)	1997-04-03
EP0315153A3 (en)	1989-08-09
EP0315153B1 (de)	1994-05-11
CA1338618C (en)	1996-10-01
ES2052674T3 (es)	1994-07-16
ES2097840T3 (es)	1997-04-16
DE3889521T2 (de)	1994-12-08
ZA888209B (en)	1990-07-25
EP0513861A1 (de)	1992-11-19
AU2458888A (en)	1989-05-04
DE3855807T2 (de)	1997-06-12
JP2816337B2 (ja)	1998-10-27
EP0315153A2 (de)	1989-05-10
EP0513861B1 (de)	1997-02-26
NZ226811A (en)	1991-06-25
IE63692B1 (en)	1995-05-31
AU626271B2 (en)	1992-07-30
HU210825A9 (en)	1995-08-28

Legal Events

Date	Code	Title	Description
2007-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE149091T1 (de)	1997-03-15	Einen tetra-polyol enthaltendes impfstoff- adjuvans
ATE95425T1 (de)	1993-10-15	Impfstofformulierung.
EP0489153A4 (en)	1993-04-21	Vaccine compositions containing liposomes
ES2081102T5 (es)	2001-09-01	Vacuna para el herpes simple compuesta por glicoproteina gd del hsv y lipido a de monofosforilo 3-desacilado.
AU4897590A (en)	1990-08-09	Tocols as adjuvant in vaccine
GB2303855B (en)	1998-10-28	Helicobacter pylori antigenic protein preparation and immunoassays
ATE410183T1 (de)	2008-10-15	Verbesserte adjuvant zusammensetzungen auf basis von saponin und damit zusammenhängende methoden
LU91486I2 (fr)	2008-12-15	Emulsion huile-dans-eau comprenant du squalène, duDL-a-tocophérol et du polysorbate 80
DE3483553D1 (de)	1990-12-13	Polyoxypropylen-polyoxyaethylen blockcopolymer enthaltende adjuvantien und ihre verwendung in impfstoffen.
FI953608L (fi)	1995-09-19	Rokoteyhdisteet ja menetelmä immuunireaktion aikaansaamiseksi limakalvossa järjestelmällisellä rokottamisella
HUP9901901A2 (hu)	1999-09-28	Hepatitis C elleni vakcinák
DE3473825D1 (en)	1988-10-13	Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained
CA2352563A1 (en)	2000-06-29	Method to produce inactivated w/o emulsion adjuvanted vaccines
ITRM910385A1 (it)	1992-12-03	Vaccini utilizzanti eritrociti come veicoli di antigeni
Magri et al.	1982	The flux laminar horizontal in the prevention of the surgical infections.
ES2053402A1 (es)	1994-07-16	Metodo de preparacion de vacunas inactivadas y vacunas vivas adyuvantadas asi como las vacunas obtenidas por dicho metodo.
IT8919110A0 (it)	1989-01-17	Peptidi sintetici e loro uso come carriers universali per la preparazione di coniugati immunogenici adatti per lo sviluppo di vaccini sintetici.