ES2097840T3 - Adyuvante de vacuna que comprende un tetrapoliol. - Google Patents

Adyuvante de vacuna que comprende un tetrapoliol.

Info

Publication number
ES2097840T3
ES2097840T3 ES92113037T ES92113037T ES2097840T3 ES 2097840 T3 ES2097840 T3 ES 2097840T3 ES 92113037 T ES92113037 T ES 92113037T ES 92113037 T ES92113037 T ES 92113037T ES 2097840 T3 ES2097840 T3 ES 2097840T3
Authority
ES
Spain
Prior art keywords
emulsion
amount
tetrapoliol
vaccine adjuvant
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92113037T
Other languages
English (en)
Inventor
Anthony Clifford Allison
Noelene Elva Byars
Cherng-Chyi Fu
Deborah Marilyn Lidgate
Philip Lewis Felgner
Linda Cheryl Foster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2097840T3 publication Critical patent/ES2097840T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE MUESTRA UN ADJUTOR PARA POTENCIAR LA INMUNOGENICIDAD DE UN ANTIGENO, QUE SE PUEDE FABRICAR A ESCALA COMERCIAL, Y QUE ES UNA EMULSION CON PARTICULAS ACEITOSAS DISPERSADAS EN UNA FASE ACUOSA CONTINUA; DICHA EMULSION COMPRENDE: UNA CANTIDAD FORMANTE DE EMULSION DE UN TRETA E, UN CANTIDAD FORMANTE DE EMULSION DE UN ACEITE METABOLIZABLE NO TOXICO; OPCIONALMENTE UNA CANTIDAD ESTABILIZANTE DE EMULSION DE UNA SUPERFICIATIVO BASADO EN ETER GLICOL; Y UNA CANTIDAD INMUNOPOTENCIADORA DE UN GLICOPEPTIDO.
ES92113037T 1987-11-03 1988-11-02 Adyuvante de vacuna que comprende un tetrapoliol. Expired - Lifetime ES2097840T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11642587A 1987-11-03 1987-11-03

Publications (1)

Publication Number Publication Date
ES2097840T3 true ES2097840T3 (es) 1997-04-16

Family

ID=22367122

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92113037T Expired - Lifetime ES2097840T3 (es) 1987-11-03 1988-11-02 Adyuvante de vacuna que comprende un tetrapoliol.
ES88118263T Expired - Lifetime ES2052674T3 (es) 1987-11-03 1988-11-02 Adyuvante de vacunas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES88118263T Expired - Lifetime ES2052674T3 (es) 1987-11-03 1988-11-02 Adyuvante de vacunas.

Country Status (11)

Country Link
EP (2) EP0315153B1 (es)
JP (2) JP2746272B2 (es)
AT (1) ATE149091T1 (es)
AU (1) AU626271B2 (es)
CA (1) CA1338618C (es)
DE (2) DE3855807T2 (es)
ES (2) ES2097840T3 (es)
HU (1) HU210825A9 (es)
IE (1) IE63692B1 (es)
NZ (1) NZ226811A (es)
ZA (1) ZA888209B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
US5709860A (en) * 1991-07-25 1998-01-20 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
ES2053402B1 (es) * 1993-01-15 1995-02-01 Hipra Lab Sa Metodo de preparacion de vacunas inactivadas y vacunas vivas adyuvantadas asi como las vacunas obtenidas por dicho metodo.
DE4333376C2 (de) * 1993-09-30 1995-09-07 Gerbu Biotechnik Gmbh Mittel zur Steigerung der Ausbeute von Antikörpern in der Immunologie
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
WO2000050006A2 (en) 1999-02-26 2000-08-31 Chiron Corporation Microemulsions with adsorbed macromoelecules and microparticles
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
US7824687B2 (en) 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
ATE325803T1 (de) 1999-08-20 2006-06-15 Sloan Kettering Inst Cancer Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
WO2001045670A2 (en) * 1999-12-23 2001-06-28 Aphton Corporation A stable immunogenic composition for frozen storage
FR2804026B1 (fr) * 2000-01-21 2004-06-11 Merial Sas Vaccination contre l'herpesvirose canine et vaccins
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
MY129765A (en) 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
RU2541809C2 (ru) * 2003-04-04 2015-02-20 Зоетис Пи ЛЛК Микрофлюидизированные эмульсии "масло в воде" и композиции вакцины
CA2801922A1 (en) 2010-06-11 2011-12-15 Sloan-Kettering Institute For Cancer Research Multivalent glycopeptide constructs and uses thereof
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
EP0283505B1 (en) * 1986-09-22 1994-07-06 Emory University Vaccine and method of preparation

Also Published As

Publication number Publication date
EP0513861B1 (en) 1997-02-26
JP2746272B2 (ja) 1998-05-06
DE3855807T2 (de) 1997-06-12
HU210825A9 (en) 1995-08-28
AU626271B2 (en) 1992-07-30
JPH01157918A (ja) 1989-06-21
DE3889521T2 (de) 1994-12-08
DE3889521D1 (de) 1994-06-16
ES2052674T3 (es) 1994-07-16
ZA888209B (en) 1990-07-25
DE3855807D1 (de) 1997-04-03
ATE149091T1 (de) 1997-03-15
IE883305L (en) 1989-05-03
NZ226811A (en) 1991-06-25
AU2458888A (en) 1989-05-04
JPH1053535A (ja) 1998-02-24
CA1338618C (en) 1996-10-01
EP0315153A2 (en) 1989-05-10
EP0513861A1 (en) 1992-11-19
JP2816337B2 (ja) 1998-10-27
IE63692B1 (en) 1995-05-31
EP0315153B1 (en) 1994-05-11
EP0315153A3 (en) 1989-08-09

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