ATE149165T1 - Stickstoff enthaltende bizyklische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents

Stickstoff enthaltende bizyklische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE149165T1
Authority: AT; Austria
Prior art keywords: bizyclic; production; pharmaceutical preparations; substituted; nitrogen
Prior art date: 1991-09-27

Application number

AT92402631T

Other languages

English (en)

Inventor

Michel Vincent

Georges Remond

Bernard Portevin

Yolande Herve

Jean Lepagnol

Nanteuil Guillaume De

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-27

Filing date

1992-09-25

Publication date

1997-03-15

1992-09-25 Application filed by Adir filed Critical Adir

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149165T1 publication Critical patent/ATE149165T1/de

Links

IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 4
229910052757 nitrogen Inorganic materials 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 benzyloxy, phenoxy Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Quinoline Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT92402631T 1991-09-27 1992-09-25 Stickstoff enthaltende bizyklische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen ATE149165T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9111893A FR2681864B1 (fr)	1991-09-27	1991-09-27	Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
ATE149165T1 true ATE149165T1 (de)	1997-03-15

Family

ID=9417343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92402631T ATE149165T1 (de)	1991-09-27	1992-09-25	Stickstoff enthaltende bizyklische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Country Status (13)

Country	Link
US (2)	US5286732A (de)
EP (1)	EP0541407B1 (de)
JP (1)	JPH07119212B2 (de)
AT (1)	ATE149165T1 (de)
AU (1)	AU651495B2 (de)
CA (1)	CA2079185A1 (de)
DE (1)	DE69217613T2 (de)
DK (1)	DK0541407T3 (de)
ES (1)	ES2101059T3 (de)
FR (1)	FR2681864B1 (de)
GR (1)	GR3023444T3 (de)
HK (1)	HK113597A (de)
ZA (1)	ZA927381B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2672598A1 (fr) *	1991-02-11	1992-08-14	Adir	Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2703050B1 (fr) *	1993-03-24	1995-04-28	Adir	Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6025355A (en)	1997-05-19	2000-02-15	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
DE19616509A1 (de)	1996-04-25	1998-01-15	Asta Medica Ag	Neue spezifische Immunophilin-Liganden als Antiasthmatika, Immunsuppressiva
FR2748026B1 (fr) *	1996-04-26	1998-06-05	Adir	Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6242198B1 (en)	1996-07-25	2001-06-05	Cambridge Neuroscience, Inc.	Methods of treatment of eye trauma and disorders
GB2460976B (en) *	2005-03-24	2010-02-17	John Marcell Davis	Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders
EP1760076A1 (de) *	2005-09-02	2007-03-07	Ferring B.V.	FAP Inhibitoren
WO2011083150A2 (en) *	2010-01-07	2011-07-14	Akron Molecules Gmbh	Obesity small molecules
EP3031458A1 (de)	2014-12-09	2016-06-15	Iproteos S.L.	Verwendung von 1-[(2-phenylcycloprop-1-yl)carbonyl]-2-[(1,3-thiazolidin-3-yl)carbonyl]perhydroindol bei der Behandlung von mit Schizophrenie assoziierten kognitiven Defiziten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0813740B2 (ja) *	1987-02-28	1996-02-14	麒麟麦酒株式会社	抗健忘薬
JPH0742309B2 (ja) *	1987-11-30	1995-05-10	キッセイ薬品工業株式会社	チアゾリジン誘導体
DE3742431A1 (de) *	1987-12-15	1989-07-13	Hoechst Ag	Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
JPH01250370A (ja) *	1987-12-23	1989-10-05	Zeria Pharmaceut Co Ltd	新規アミノ酸イミド誘導体、製法ならびに用途
US5053414A (en) *	1988-04-08	1991-10-01	Ono Pharmaceutical Co., Ltd.	Heterocyclic compounds
US5164372A (en) *	1989-04-28	1992-11-17	Fujisawa Pharmaceutical Company, Ltd.	Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
FI925500A7 (fi) *	1990-06-04	1992-12-03	Pfizer	Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja

1991
- 1991-09-27 FR FR9111893A patent/FR2681864B1/fr not_active Expired - Fee Related
1992
- 1992-09-24 AU AU25334/92A patent/AU651495B2/en not_active Ceased
- 1992-09-25 US US07/950,958 patent/US5286732A/en not_active Expired - Fee Related
- 1992-09-25 EP EP92402631A patent/EP0541407B1/de not_active Expired - Lifetime
- 1992-09-25 AT AT92402631T patent/ATE149165T1/de not_active IP Right Cessation
- 1992-09-25 ZA ZA927381A patent/ZA927381B/xx unknown
- 1992-09-25 DK DK92402631.3T patent/DK0541407T3/da active
- 1992-09-25 ES ES92402631T patent/ES2101059T3/es not_active Expired - Lifetime
- 1992-09-25 CA CA002079185A patent/CA2079185A1/fr not_active Abandoned
- 1992-09-25 DE DE69217613T patent/DE69217613T2/de not_active Expired - Fee Related
- 1992-09-28 JP JP4258082A patent/JPH07119212B2/ja not_active Expired - Lifetime
1993
- 1993-09-30 US US08/129,651 patent/US5384322A/en not_active Expired - Fee Related
1997
- 1997-05-16 GR GR970401093T patent/GR3023444T3/el unknown
- 1997-06-26 HK HK113597A patent/HK113597A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5384322A (en)	1995-01-24
AU2533492A (en)	1993-04-01
JPH05262730A (ja)	1993-10-12
GR3023444T3 (en)	1997-08-29
US5286732A (en)	1994-02-15
FR2681864A1 (fr)	1993-04-02
CA2079185A1 (fr)	1993-03-28
ES2101059T3 (es)	1997-07-01
JPH07119212B2 (ja)	1995-12-20
ZA927381B (en)	1993-04-26
EP0541407B1 (de)	1997-02-26
AU651495B2 (en)	1994-07-21
DK0541407T3 (da)	1997-08-25
DE69217613T2 (de)	1997-09-25
FR2681864B1 (fr)	1995-03-31
DE69217613D1 (de)	1997-04-03
HK113597A (en)	1997-08-29
EP0541407A1 (de)	1993-05-12

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Legal Events

Date	Code	Title	Description
1997-07-15	UEP	Publication of translation of european patent specification
2002-06-15	REN	Ceased due to non-payment of the annual fee