ATE149175T1 - Lactam dipeptide mit hle inhibierende aktivität. - Google Patents

Lactam dipeptide mit hle inhibierende aktivität.

Info

Publication number: ATE149175T1
Authority: AT; Austria
Prior art keywords: heterocyclic compounds; hle; dipeptide; lactam; inhibiting activity
Prior art date: 1992-04-16

Application number

AT93910157T

Other languages

English (en)

Inventor

Peter Robert Berstein

Royston Martin Thomas

Peter Warner

Donald John Wolanin

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-16

Filing date

1993-04-15

Publication date

1997-03-15

1992-04-16 Priority claimed from GB929208380A external-priority patent/GB9208380D0/en

1992-04-16 Priority claimed from GB929208379A external-priority patent/GB9208379D0/en

1992-07-08 Priority claimed from GB929214448A external-priority patent/GB9214448D0/en

1992-08-14 Priority claimed from GB929217362A external-priority patent/GB9217362D0/en

1992-08-14 Priority claimed from GB929217363A external-priority patent/GB9217363D0/en

1992-08-14 Priority claimed from GB929217364A external-priority patent/GB9217364D0/en

1993-04-15 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149175T1 publication Critical patent/ATE149175T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT93910157T 1992-04-16 1993-04-15 Lactam dipeptide mit hle inhibierende aktivität. ATE149175T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB929208380A GB9208380D0 (en)	1992-04-16	1992-04-16	Heterocyclic compounds
GB929208379A GB9208379D0 (en)	1992-04-16	1992-04-16	Heterocyclic amines
GB929214448A GB9214448D0 (en)	1992-07-08	1992-07-08	Heterocyclic agents
GB929217362A GB9217362D0 (en)	1992-08-14	1992-08-14	Heterocyclic compounds
GB929217363A GB9217363D0 (en)	1992-08-14	1992-08-14	Heterocyclic amines
GB929217364A GB9217364D0 (en)	1992-08-14	1992-08-14	Heterocyclic agents

Publications (1)

Publication Number	Publication Date
ATE149175T1 true ATE149175T1 (de)	1997-03-15

Family

ID=27547161

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93910157T ATE149175T1 (de)	1992-04-16	1993-04-15	Lactam dipeptide mit hle inhibierende aktivität.

Country Status (13)

Country	Link
EP (1)	EP0630382B1 (de)
JP (1)	JPH07505873A (de)
AT (1)	ATE149175T1 (de)
AU (1)	AU4076993A (de)
CA (1)	CA2132543A1 (de)
DE (1)	DE69308291T2 (de)
FI (1)	FI944802L (de)
GB (1)	GB9307555D0 (de)
HU (1)	HUT70430A (de)
IL (1)	IL105424A0 (de)
MX (1)	MX9302215A (de)
NO (1)	NO943909L (de)
WO (1)	WO1993021212A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5618792A (en) *	1994-11-21	1997-04-08	Cortech, Inc.	Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6159938A (en) *	1994-11-21	2000-12-12	Cortech, Inc.	Serine protease inhibitors comprising α-keto heterocycles
US5998379A (en) *	1994-11-21	1999-12-07	Cortech Inc.	Serine protease inhibitors-proline analogs
US6001814A (en) *	1994-11-21	1999-12-14	Cortech Inc.	Serine protease inhibitors
US20020119985A1 (en)	1994-11-21	2002-08-29	Albert Gyorkos	Serine protease inhibitors
US6001811A (en) *	1994-11-21	1999-12-14	Cortech Inc.	Serine protease inhibitors--N-substituted derivatives
US6150334A (en) *	1994-11-21	2000-11-21	Cortech, Inc.	Serine protease inhibitors-tripeptoid analogs
US6001813A (en) *	1994-11-21	1999-12-14	Cortech Inc.	Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6015791A (en) *	1994-11-21	2000-01-18	Cortech Inc.	Serine protease inhibitors-cycloheptane derivatives
US6100238A (en) *	1994-11-21	2000-08-08	Cortech Inc.	Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
CN1188401C (zh) *	1995-04-27	2005-02-09	三菱制药株式会社	杂环类酰胺化合物及其医药用途
TR199901681T2 (xx) *	1996-12-06	2000-03-21	Cortech, Inc.	Serin proteas inhibit�rleri.
US6656910B2 (en)	1997-12-04	2003-12-02	Cortech, Inc.	Serine protease inhibitors
US6255453B1 (en)	1998-06-03	2001-07-03	Cortech, Inc.	Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
US7375150B2 (en)	2001-07-30	2008-05-20	Sanko Chemical Industry Co., Ltd.	Anti-static composition and method for production thereof
IL163453A0 (en)	2004-08-10	2009-02-11	Yeda Res & Dev	Enzyme inhibitor in leukemia
SG10201401836RA (en) *	2009-04-27	2014-10-30	Elan Pharm Inc	Pyridinone antagonists of alpha-4 integrins
AU2020349353A1 (en)	2019-09-17	2022-04-14	Duke University	Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
HUE064089T2 (hu)	2020-04-16	2024-02-28	Mereo Biopharma 4 Ltd	Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére
AU2022373971A1 (en)	2021-10-20	2024-04-04	Mereo Biopharma 4 Limited	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0369391A3 (de) *	1988-11-15	1991-09-25	Boehringer Ingelheim Pharmaceuticals Inc.	N-substituierte Amide
GB9207145D0 (en) *	1991-04-18	1992-05-13	Ici Plc	Heterocyclic amides

1993
- 1993-04-13 GB GB939307555A patent/GB9307555D0/en active Pending
- 1993-04-15 JP JP5518137A patent/JPH07505873A/ja active Pending
- 1993-04-15 AU AU40769/93A patent/AU4076993A/en not_active Abandoned
- 1993-04-15 CA CA002132543A patent/CA2132543A1/en not_active Abandoned
- 1993-04-15 AT AT93910157T patent/ATE149175T1/de active
- 1993-04-15 WO PCT/GB1993/000794 patent/WO1993021212A1/en not_active Ceased
- 1993-04-15 DE DE69308291T patent/DE69308291T2/de not_active Expired - Fee Related
- 1993-04-15 HU HU9402968A patent/HUT70430A/hu unknown
- 1993-04-15 FI FI944802A patent/FI944802L/fi not_active Application Discontinuation
- 1993-04-15 EP EP93910157A patent/EP0630382B1/de not_active Expired - Lifetime
- 1993-04-16 MX MX9302215A patent/MX9302215A/es unknown
- 1993-04-16 IL IL105424A patent/IL105424A0/xx unknown
1994
- 1994-10-14 NO NO943909A patent/NO943909L/no unknown

Also Published As

Publication number	Publication date
FI944802A7 (fi)	1994-10-12
NO943909D0 (no)	1994-10-14
WO1993021212A1 (en)	1993-10-28
IL105424A0 (en)	1993-08-18
FI944802A0 (fi)	1994-10-12
NO943909L (no)	1994-10-14
JPH07505873A (ja)	1995-06-29
FI944802L (fi)	1994-10-12
DE69308291T2 (de)	1997-06-26
HU9402968D0 (en)	1995-02-28
EP0630382A1 (de)	1994-12-28
AU4076993A (en)	1993-11-18
HUT70430A (en)	1995-10-30
GB9307555D0 (en)	1993-06-02
DE69308291D1 (de)	1997-04-03
CA2132543A1 (en)	1993-10-28
MX9302215A (es)	1993-10-01
EP0630382B1 (de)	1997-02-26

Publication	Publication Date	Title
NO943910D0 (no)	1994-10-14	Laktam-peptider med HLE-hemmende virkning
NO923197D0 (no)	1992-08-14	Substituerte heterocykliske forbindelser
TW262475B (en)	1995-11-11	Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them
DE69314169D1 (de)	1997-10-30	Peptide mit eine alphaaminoboronaire gruppe and ihre verwendung als elastasehemmer
DE69308291D1 (de)	1997-04-03	Lactam Dipeptide mit HLE inhibierende Aktivität.
FI946202A0 (fi)	1994-12-30	Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan
FI945696A0 (fi)	1994-12-02	Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus
ATE105302T1 (de)	1994-05-15	Fluoramid-derivate mit hemmender aktivitaet gegen menschliche leukozytenelastase.
ES2055866T3 (es)	1994-09-01	Derivados trifluorcetopeptidos utiles como inhibidores de elastasa de leucocitos humanos.
NO944659L (no)	1995-01-24	Laktam-dipeptider med HLE-inhiberende aktivitet