ATE149518T1 - Hexapeptide - Google Patents

Hexapeptide

Info

Publication number: ATE149518T1
Authority: AT; Austria
Prior art keywords: agent; alkyl group; isoleucine; valine; leucine
Prior art date: 1991-07-30

Application number

AT92306942T

Other languages

English (en)

Inventor

Sakae Amagaya

Tadami Fujiwara

Masaki Aburada

Michio Nagasawa

Tsutomu Oyama

Original Assignee

Tsumura & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-30

Filing date

1992-07-30

Publication date

1997-03-15

1992-07-30 Application filed by Tsumura & Co filed Critical Tsumura & Co

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149518T1 publication Critical patent/ATE149518T1/de

Links

239000003795 chemical substances by application Substances 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
239000004475 Arginine Substances 0.000 abstract 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 2
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
239000004472 Lysine Substances 0.000 abstract 2
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
229960000310 isoleucine Drugs 0.000 abstract 2
239000004474 valine Substances 0.000 abstract 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
230000003501 anti-edematous effect Effects 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
230000000703 anti-shock Effects 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
239000003357 wound healing promoting agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)

AT92306942T 1991-07-30 1992-07-30 Hexapeptide ATE149518T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP21141691		1991-07-30

Publications (1)

Publication Number	Publication Date
ATE149518T1 true ATE149518T1 (de)	1997-03-15

Family

ID=16605597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92306942T ATE149518T1 (de)	1991-07-30	1992-07-30	Hexapeptide

Country Status (11)

Country	Link
US (1)	US5393740A (de)
EP (1)	EP0526192B1 (de)
JP (1)	JP2803477B2 (de)
KR (1)	KR100251496B1 (de)
AT (1)	ATE149518T1 (de)
AU (1)	AU661003B2 (de)
CA (1)	CA2074967A1 (de)
DE (1)	DE69217763T2 (de)
DK (1)	DK0526192T3 (de)
ES (1)	ES2101037T3 (de)
GR (1)	GR3023058T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995007705A1 (en) *	1993-09-15	1995-03-23	The Regents Of The University Of California	Method for inhibiting vascular leakage and anti-inflammatory compounds
US5955430A (en) *	1993-09-24	1999-09-21	University Of Southern California	Use of angiotensin II fragments and analogs thereof in tissue repair
JPH0848634A (ja) *	1994-08-05	1996-02-20	Akio Okamoto	角膜治療剤
GB9425582D0 (en) *	1994-12-19	1995-02-15	Iaf Biochem Int	Peptides having immunomodulatory activity
WO1999052539A1 (en) *	1998-04-10	1999-10-21	Mayo Foundation For Medical Education And Research	Neo-tryptophan
US7087575B2 (en) *	2002-07-18	2006-08-08	Mayo Foundation For Medical Education And Research	Treating the effect of nicotine
EP1768951A4 (de) *	2004-06-17	2011-06-15	Musc Found For Res Dev	Nicht-natürliche aminosäuren
WO2006085417A1 (ja) *	2005-02-10	2006-08-17	Nagase Chemtex Corporation	生活習慣病を予防する食品
WO2007100718A2 (en) *	2006-02-24	2007-09-07	Denise Barbut	Neurotensin receptor agonists and opioid receptor agonists
WO2010085661A1 (en) *	2009-01-23	2010-07-29	Musc Foundation For Reasearch Development	Modified peptides and their use
CA2883447A1 (en) *	2012-09-04	2014-03-13	Jonathan B. Rothbard	Therapeutic compositions and related methods
CN105541642A (zh) *	2016-01-11	2016-05-04	罗梅	一种手性（s）-亮氨醇盐酸盐的合成方法
CZ309857B6 (cs) *	2022-03-31	2023-12-20	Contipro A.S.	Hexapeptid, kompozice zahrnující tento hexapeptid a jejich topické použití

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4411890A (en) *	1981-04-14	1983-10-25	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4110321A (en)	1976-07-12	1978-08-29	Folkers Karl	Synthetic tridecapeptide [Gln4 ]-neurotensin having hormonal activity
US4425269A (en) *	1982-06-07	1984-01-10	Merck & Co., Inc.	Metabolically protected analogs of neurotensin
IT1190389B (it) *	1985-09-19	1988-02-16	Eniricerche Spa	Esapeptidi ad attivita' ipotensiva
JP2714425B2 (ja) *	1988-03-11	1998-02-16	エーザイ株式会社	ポリペプチド
FI890918A7 (fi) *	1988-03-11	1989-09-12	Eisai Co Ltd	Polypeptider.

1992
- 1992-07-28 US US07/920,878 patent/US5393740A/en not_active Expired - Fee Related
- 1992-07-30 AT AT92306942T patent/ATE149518T1/de not_active IP Right Cessation
- 1992-07-30 CA CA002074967A patent/CA2074967A1/en not_active Abandoned
- 1992-07-30 JP JP4203816A patent/JP2803477B2/ja not_active Expired - Lifetime
- 1992-07-30 EP EP92306942A patent/EP0526192B1/de not_active Expired - Lifetime
- 1992-07-30 ES ES92306942T patent/ES2101037T3/es not_active Expired - Lifetime
- 1992-07-30 AU AU20657/92A patent/AU661003B2/en not_active Ceased
- 1992-07-30 DE DE69217763T patent/DE69217763T2/de not_active Expired - Fee Related
- 1992-07-30 DK DK92306942.1T patent/DK0526192T3/da active
- 1992-07-30 KR KR1019920013692A patent/KR100251496B1/ko not_active Expired - Fee Related
1997
- 1997-04-08 GR GR970400726T patent/GR3023058T3/el unknown

Also Published As

Publication number	Publication date
EP0526192B1 (de)	1997-03-05
DE69217763T2 (de)	1997-07-10
KR100251496B1 (ko)	2000-05-01
EP0526192A3 (en)	1993-12-08
AU661003B2 (en)	1995-07-13
JPH05194590A (ja)	1993-08-03
KR930002373A (ko)	1993-02-23
AU2065792A (en)	1993-02-04
ES2101037T3 (es)	1997-07-01
DE69217763D1 (de)	1997-04-10
US5393740A (en)	1995-02-28
EP0526192A2 (de)	1993-02-03
GR3023058T3 (en)	1997-07-30
DK0526192T3 (da)	1997-07-28
JP2803477B2 (ja)	1998-09-24
CA2074967A1 (en)	1993-01-31

Legal Events

Date	Code	Title	Description
1997-08-15	UEP	Publication of translation of european patent specification
2002-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69217763D1 (de)	1997-04-10	Hexapeptide
US4692459A (en)	1987-09-15	Anti-hypertensive agents
KR970015598A (ko)	1997-04-28	환상 결합 억제제
IL129238A0 (en)	2000-02-17	N-(aryl/heteroarylacetyl) amino acid esters pharmaceutical compositions comprising same and methods for inhibiting b-amyloid peptide release and/ or its synthesis by use of such compounds
TR200100438T2 (tr)	2001-06-21	Hepatit C inhibitörü peptitler
ES2164218T3 (es)	2002-02-16	Derivados de camptotecina.
NO911787D0 (no)	1991-05-07	Peptidaminer samt fremgangsmaate for fremstilling derav.
DK0973801T3 (da)	2003-04-07	GnRH-antagonister
MY123908A (en)	2006-06-30	Meta-azacyclic amino benzoic acid compounds and derivatives thereof
ATE14226T1 (de)	1985-07-15	Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
AR006523A1 (es)	1999-09-08	Compuestos ciclicos, inhibidores de la adhesion
DE69013742D1 (de)	1994-12-08	Peptide und diese Peptide enthaltende Wirkstoffe gegen Dementia.
EP0215410A3 (de)	1989-07-05	Retro-inverso-Hexapeptid-Neurotensin-Analoga, Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
HU9301520D0 (en)	1993-09-28	Methods for producing cyclopeptides promoting absorption of peptides and albumins through mucous membrane as well as pharmaceutical preparations containing said compounds as auxiliary agents
DK0513613T3 (da)	1995-04-18	Hidtil ukendte polypeptider med affinitet for lipopolysaccharider og anvendelse heraf
KR910002899A (ko)	1991-02-26	혈조절 펩타이드
CO5160245A1 (es)	2002-05-30	Compuestos organicos inhibidores de las proteinasas de cisteina, en particular inhibidores de catepsina k de arilaminoalquilamida, y su uso farmaceutico para el tratamiento o la profilaxis de enfermedades o condiciones medicas en donde este implicada
NO894720D0 (no)	1989-11-27	Farmasoeytisk aktivt protein.
KR940007059A (ko)	1994-04-26	변형된 혈소판 인자-4
KR940011479A (ko)	1994-06-21	시클로 펩티드
KR970704462A (ko)	1997-09-06	각막치료제(corneal therapeutic agent)
ATE92078T1 (de)	1993-08-15	Pharmakologisch aktive peptide.
CO5611158A2 (es)	2006-02-28	Metodos y composiciones para tratar toxicidad gastrointestinal inducida por terapia citoablativa
KR890009974A (ko)	1989-08-05	신규 화합물들
DE60137340D1 (de)	2009-02-26	Inhibitoren von hiv-replikation und verfahren zur behandlung einer der von hiv verursachten infektionen