ATE150455T1 - N-substituierte azaheterocyclische carbonsäuren - Google Patents
N-substituierte azaheterocyclische carbonsäurenInfo
- Publication number
- ATE150455T1 ATE150455T1 AT89123400T AT89123400T ATE150455T1 AT E150455 T1 ATE150455 T1 AT E150455T1 AT 89123400 T AT89123400 T AT 89123400T AT 89123400 T AT89123400 T AT 89123400T AT E150455 T1 ATE150455 T1 AT E150455T1
- Authority
- AT
- Austria
- Prior art keywords
- carboxylic acids
- substituted
- azaheterocyclic carboxylic
- pyrrolyl
- thienyl
- Prior art date
Links
- 150000001735 carboxylic acids Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000000946 synaptic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Bipolar Transistors (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK704488A DK704488D0 (da) | 1988-12-19 | 1988-12-19 | Nye n-substituerede azaheterocykliske carboxylsyrer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE150455T1 true ATE150455T1 (de) | 1997-04-15 |
Family
ID=8149197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89123400T ATE150455T1 (de) | 1988-12-19 | 1989-12-18 | N-substituierte azaheterocyclische carbonsäuren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5071859A (de) |
| EP (1) | EP0374801B1 (de) |
| JP (1) | JP2848534B2 (de) |
| AT (1) | ATE150455T1 (de) |
| AU (1) | AU634992B2 (de) |
| CA (1) | CA2005919C (de) |
| DE (1) | DE68927875T2 (de) |
| DK (1) | DK704488D0 (de) |
| ES (1) | ES2099067T3 (de) |
| FI (1) | FI93951C (de) |
| GR (1) | GR3023379T3 (de) |
| IL (1) | IL92652A0 (de) |
| NO (1) | NO177672C (de) |
| NZ (1) | NZ231836A (de) |
| PT (1) | PT92628B (de) |
| ZA (1) | ZA899736B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910312A (en) * | 1985-11-08 | 1990-03-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
| DE3609699A1 (de) * | 1986-03-20 | 1987-09-24 | Schering Ag | 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester |
| US5214054A (en) * | 1988-05-18 | 1993-05-25 | Novo Nordisk A/S | Azacyclic carboxylic acid derivatives and their preparation and use |
| FR2653123B1 (fr) * | 1989-10-17 | 1992-01-17 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| DK588189D0 (da) * | 1989-11-22 | 1989-11-22 | Novo Nordisk As | Nye heterocykliske carboxylsyrer |
| DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
| DK181190D0 (da) * | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
| DE4117904A1 (de) * | 1991-05-31 | 1992-12-03 | Basf Ag | Substituierte n-phenylpiperidine |
| DK93791D0 (da) * | 1991-05-17 | 1991-05-17 | Novo Nordisk As | Nye heterocykliske carboxylsyrer |
| EP0535496A1 (de) * | 1991-09-25 | 1993-04-07 | Hoechst-Roussel Pharmaceuticals Incorporated | (1-Indanon-2-yl)Methylpiperidine, Zwischenprodukte und Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0543780A3 (en) * | 1991-11-21 | 1993-09-01 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
| US5807872A (en) * | 1992-12-16 | 1998-09-15 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
| US5463074A (en) * | 1991-12-18 | 1995-10-31 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
| US5932596A (en) * | 1991-12-18 | 1999-08-03 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing nitrogen containing heterocyclic ring |
| US5633250A (en) * | 1991-12-18 | 1997-05-27 | Schering Corporation | Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
| GB9127306D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5286733A (en) * | 1992-11-20 | 1994-02-15 | Sterling Winthrop Inc. | Substituted 3-piperidinealkanoates and alkanones and compositions and method of use thereof |
| US5580877A (en) * | 1994-04-25 | 1996-12-03 | Merck Sharp & Dohme Ltd. | Pyrazolo-quinoline derivatives for treating cerebral ischemia |
| US5962449A (en) | 1995-04-07 | 1999-10-05 | Novo Nordisk A/S | Tricyclic compounds in treating hyperalgesic conditions and NIDDM |
| FR2735476B1 (fr) * | 1995-06-14 | 1997-07-18 | Rhone Poulenc Rorer Sa | Nouvelle application de derives du pyrrole |
| US5747523A (en) * | 1996-01-24 | 1998-05-05 | Guilford Pharmaceuticals Inc. | Substituted ethyl α,α-diarylmethyl ether derivatives |
| AU1506499A (en) * | 1997-12-12 | 1999-07-05 | Toyama Chemical Co. Ltd. | Alkyl ether derivatives or salts thereof and calcium antagonists containing the same |
| DE19840611A1 (de) * | 1998-09-05 | 2000-03-09 | Klaus Wanner | GABA-uptake-Inhibitoren mit Pyrrolidinstruktur |
| US7026335B2 (en) * | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| US20040010010A1 (en) * | 2002-04-30 | 2004-01-15 | Ebetino Frank Hallock | Melanocortin receptor ligands |
| EP4175635B1 (de) * | 2020-07-02 | 2026-03-25 | Sea Pharmaceuticals LLC | Pharmazeutische zusammensetzungen aus 6-(2-(2h-tetrazol-5-yl)ethyl)-6-fluordecahydroisochinolin-3-carbonsäure und esterderivaten davon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU552050B2 (en) * | 1981-05-26 | 1986-05-22 | Smithkline Beckman Corporation | N-substituted azeheterocyclic carboxylic acids and their esters |
| US4383999A (en) * | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
| US4514414A (en) * | 1982-10-25 | 1985-04-30 | Smithkline Beckman Corporation | N-Substituted pyrrolidineacetic acids and their esters |
| FI83957C (fi) * | 1984-09-28 | 1991-09-25 | Byk Gulden Lomberg Chem Fab | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara diarylfoereningar. |
| DK288385D0 (da) * | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
| FI864246A7 (fi) * | 1985-11-08 | 1987-05-09 | Warner Lambert Co | N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat. |
| US4910312A (en) * | 1985-11-08 | 1990-03-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
| DE3787657T2 (de) * | 1986-01-07 | 1994-02-03 | Novo Ind A S Bagsvaerd | Aminosäure-Derivate. |
| DK270488D0 (da) * | 1988-05-18 | 1988-05-18 | Novo Industri As | Hidtil ukendte o-substituerede ketoximer |
-
1988
- 1988-12-19 DK DK704488A patent/DK704488D0/da not_active Application Discontinuation
-
1989
- 1989-12-12 IL IL92652A patent/IL92652A0/xx not_active IP Right Cessation
- 1989-12-14 US US07/450,805 patent/US5071859A/en not_active Expired - Fee Related
- 1989-12-18 AU AU46889/89A patent/AU634992B2/en not_active Ceased
- 1989-12-18 NO NO895093A patent/NO177672C/no unknown
- 1989-12-18 DE DE68927875T patent/DE68927875T2/de not_active Expired - Fee Related
- 1989-12-18 ES ES89123400T patent/ES2099067T3/es not_active Expired - Lifetime
- 1989-12-18 AT AT89123400T patent/ATE150455T1/de not_active IP Right Cessation
- 1989-12-18 NZ NZ231836A patent/NZ231836A/xx unknown
- 1989-12-18 EP EP89123400A patent/EP0374801B1/de not_active Expired - Lifetime
- 1989-12-19 CA CA002005919A patent/CA2005919C/en not_active Expired - Fee Related
- 1989-12-19 PT PT92628A patent/PT92628B/pt not_active IP Right Cessation
- 1989-12-19 JP JP1327463A patent/JP2848534B2/ja not_active Expired - Lifetime
- 1989-12-19 ZA ZA899736A patent/ZA899736B/xx unknown
- 1989-12-19 FI FI896084A patent/FI93951C/fi not_active IP Right Cessation
-
1997
- 1997-05-09 GR GR970401032T patent/GR3023379T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ231836A (en) | 1992-11-25 |
| DE68927875D1 (de) | 1997-04-24 |
| DK704488D0 (da) | 1988-12-19 |
| DE68927875T2 (de) | 1997-06-26 |
| FI93951C (fi) | 1995-06-26 |
| FI93951B (fi) | 1995-03-15 |
| EP0374801A2 (de) | 1990-06-27 |
| NO895093D0 (no) | 1989-12-18 |
| ZA899736B (en) | 1990-09-26 |
| NO177672B (no) | 1995-07-24 |
| GR3023379T3 (en) | 1997-08-29 |
| EP0374801B1 (de) | 1997-03-19 |
| US5071859A (en) | 1991-12-10 |
| CA2005919C (en) | 1997-01-07 |
| EP0374801A3 (de) | 1991-08-07 |
| CA2005919A1 (en) | 1990-06-19 |
| JP2848534B2 (ja) | 1999-01-20 |
| NO895093L (no) | 1990-06-20 |
| AU4688989A (en) | 1990-06-21 |
| FI896084A0 (fi) | 1989-12-19 |
| JPH02223551A (ja) | 1990-09-05 |
| PT92628B (pt) | 1995-09-12 |
| NO177672C (no) | 1995-11-01 |
| PT92628A (pt) | 1990-06-29 |
| IL92652A0 (en) | 1990-08-31 |
| AU634992B2 (en) | 1993-03-11 |
| ES2099067T3 (es) | 1997-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE150455T1 (de) | N-substituierte azaheterocyclische carbonsäuren | |
| PL299559A1 (en) | Cyclic inhibitor of cell conglutination | |
| NO164574C (no) | Antimikrobielle blandinger paa basis av fenoksyarsiner. | |
| EP0421634A3 (en) | Bis(3,4-dialkylbenzylidene) sorbitol acetals and compositions containing same | |
| ES8307853A1 (es) | "un metodo de preparar un disiloxano". | |
| AU631070B2 (en) | Novel platelet-aggregation inhibitor | |
| FI941986A0 (fi) | Antifungaaliset tri-substituoidut tetrahydrofuraanit | |
| ATE233264T1 (de) | Polynalbuphinderivat | |
| DE60121523D1 (de) | Copolymer | |
| CO5011097A1 (es) | Derivados de 8-azabiciclo [3.2.1]octan-3-metanamina . | |
| EP0652211A4 (de) | Prostaglandinderivat. | |
| SI0668279T1 (en) | 6-Azaindole thromboxane synthase inhibitors | |
| FI890293A0 (fi) | Foerfarande foer framstaellning av tioformamidderivat. | |
| SG81900A1 (en) | A method for making a, b-unsaturated-b-trifluoromethyl-carboxylates and related compounds | |
| CA2073189A1 (en) | N-substituted azaheterocyclic carboxylic acids and a pharmaceutical composition | |
| TH31611A (de) | ||
| SE9802371D0 (sv) | Tillsats och komposition för belagt papper och belagt papper erhållet med användning av desamma | |
| GB9617822D0 (en) | Pharmaceutical compounds | |
| CO4750674A1 (es) | Inhibidores de hidrazil-, bis-hidrazil-y bis-aminometil-car- bonil-proteasas | |
| ATE92029T1 (de) | Verfahren zur herstellung von 2-cyclohexenylcarboxylaten. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |