ATE150760T1 - Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden - Google Patents

Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden

Info

Publication number
ATE150760T1
ATE150760T1 AT91915182T AT91915182T ATE150760T1 AT E150760 T1 ATE150760 T1 AT E150760T1 AT 91915182 T AT91915182 T AT 91915182T AT 91915182 T AT91915182 T AT 91915182T AT E150760 T1 ATE150760 T1 AT E150760T1
Authority
AT
Austria
Prior art keywords
protecting groups
chemical synthesis
oligonucleotides
hydroxyl protecting
hydroxyl
Prior art date
Application number
AT91915182T
Other languages
English (en)
Inventor
Michael S Urdea
Thomas Horn
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE150760T1 publication Critical patent/ATE150760T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
AT91915182T 1990-07-27 1991-07-24 Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden ATE150760T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/558,881 US5430138A (en) 1990-07-27 1990-07-27 Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable

Publications (1)

Publication Number Publication Date
ATE150760T1 true ATE150760T1 (de) 1997-04-15

Family

ID=24231370

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915182T ATE150760T1 (de) 1990-07-27 1991-07-24 Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden

Country Status (7)

Country Link
US (2) US5430138A (de)
EP (1) EP0543906B1 (de)
JP (1) JP3081882B2 (de)
AT (1) ATE150760T1 (de)
CA (1) CA2088255A1 (de)
DE (1) DE69125380T2 (de)
WO (1) WO1992002533A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430138A (en) * 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
TW323284B (de) * 1992-03-23 1997-12-21 Novartis Ag
US5770725A (en) * 1992-05-25 1998-06-23 Gosselin; Gilles Phosphotriester type biologically active compounds
US6020482A (en) * 1992-05-25 2000-02-01 Gosselin; Gilles Phosphotriester type biologically active compounds
US5849905A (en) * 1994-11-23 1998-12-15 Centre National De La Recherche Scientifique Biologically active phosphotriester-type nucleosides and methods for preparing same
FR2692265B1 (fr) 1992-05-25 1996-11-08 Centre Nat Rech Scient Composes biologiquement actifs de type phosphotriesters.
US5955591A (en) * 1993-05-12 1999-09-21 Imbach; Jean-Louis Phosphotriester oligonucleotides, amidites and method of preparation
US5597909A (en) * 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5639875A (en) * 1995-02-01 1997-06-17 Hybridon, Inc. Methods for H-phosphonate syntheis of oligonucleotides using triphosgene
JP2002515730A (ja) * 1995-10-16 2002-05-28 カイロン コーポレイション 遺伝子発現を変調する因子のスクリーニング方法
AU2462497A (en) * 1996-04-17 1997-11-19 Hubert Koster A combinatorial protecting group strategy for multifunctional molecules
AU6659298A (en) 1997-02-18 1998-09-08 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
AU6270499A (en) * 1998-09-29 2000-04-17 Phylos, Inc. Synthesis of codon randomized nucleic acids
CA2370478A1 (en) 1999-03-24 2000-09-28 Serge L. Beaucage N-acylphosphoramidites and their use in oligonucleotide synthesis
CA2404431C (en) 2000-03-27 2011-06-07 Thomas Jefferson University Guanylyl cyclase c in the detection of stomach and esophageal cancers
US7829276B2 (en) * 2000-09-18 2010-11-09 Thomas Jefferson University Methods of using CRCA-1 as a stomach and esophageal cancer marker
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
DE10133779A1 (de) * 2001-07-16 2003-02-06 Chemogenix Gmbh Multimerpolynukleotidsynthese
AU2002353001A1 (en) * 2001-12-03 2003-06-17 The Government Of The United States Of America, Represented By The Secretary Of The Department Of He Thermolabile hydroxyl protecting groups and methods of use
AUPR975201A0 (en) * 2001-12-24 2002-01-24 Unisearch Limited Enzymatic redox labelling of nucleic acids
DE10247790A1 (de) * 2002-10-14 2004-04-22 Chemogenix Gmbh Verfahren zur Herstellung von Oligonukleotidkonjugaten
WO2004058159A2 (en) * 2002-12-23 2004-07-15 Dynavax Technologies Corporation Branched immunomodulatory compounds and methods of using the same
NZ542687A (en) 2003-04-13 2010-02-26 Enzon Pharmaceuticals Inc Polymeric oligonucleotide prodrugs
WO2006065751A2 (en) * 2004-12-13 2006-06-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
WO2006127009A1 (en) 2005-05-26 2006-11-30 Eragen Biosciences, Inc. Reagent for the improved synthesis of isoguanosine-containing oligonucleotides
KR100834812B1 (ko) 2006-07-04 2008-06-05 삼성전자주식회사 이동통신 시스템에서 세션 이동 횟수를 줄이는 핸드오프를위한 장치 및 방법
EP2056709A4 (de) 2006-08-11 2013-05-01 Univ New Jersey Med Zweifachsensibilisator mit lumineszenzverbindungen, konjugaten und verwendung
US9221759B2 (en) 2010-01-13 2015-12-29 Rutgers, The State University Of New Jersey Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency
WO2020236618A1 (en) * 2019-05-17 2020-11-26 Ionis Pharmaceuticals, Inc. Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphate diester linkages

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118802A (en) * 1983-12-20 1992-06-02 California Institute Of Technology DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
US4843122A (en) * 1984-01-30 1989-06-27 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
EP0300144A3 (de) * 1984-04-18 1989-09-27 Whitby Research Incorporated N-6-Alkyl substituierte Adenosinderivate als herzwirksame Vasodilatoren
US5367066A (en) * 1984-10-16 1994-11-22 Chiron Corporation Oligonucleotides with selectably cleavable and/or abasic sites
US5093232A (en) * 1985-12-11 1992-03-03 Chiron Corporation Nucleic acid probes
US4910300A (en) * 1985-12-11 1990-03-20 Chiron Corporation Method for making nucleic acid probes
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
CA1339351C (en) * 1987-10-15 1997-08-26 Michael S. Urdea Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5430138A (en) * 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable

Also Published As

Publication number Publication date
JPH05509317A (ja) 1993-12-22
US5430138A (en) 1995-07-04
US5703218A (en) 1997-12-30
EP0543906B1 (de) 1997-03-26
EP0543906A1 (de) 1993-06-02
WO1992002533A1 (en) 1992-02-20
DE69125380D1 (de) 1997-04-30
EP0543906A4 (en) 1993-07-14
JP3081882B2 (ja) 2000-08-28
DE69125380T2 (de) 1997-08-28
CA2088255A1 (en) 1992-01-28

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