ES2116612T3 - Nuevas bis-naftalimidas para el tratamiento del cancer. - Google Patents

Nuevas bis-naftalimidas para el tratamiento del cancer.

Info

Publication number
ES2116612T3
ES2116612T3 ES94924854T ES94924854T ES2116612T3 ES 2116612 T3 ES2116612 T3 ES 2116612T3 ES 94924854 T ES94924854 T ES 94924854T ES 94924854 T ES94924854 T ES 94924854T ES 2116612 T3 ES2116612 T3 ES 2116612T3
Authority
ES
Spain
Prior art keywords
cancer
treatment
naftalimides
new bis
presented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94924854T
Other languages
English (en)
Inventor
Gerhard Keilhauer
Cynthia Romerdahl
Brana Miguel Fernandez
Xiao-Dong Qian
Peter Bousquet
Berlanga Jose Maria Castellano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2116612T3 publication Critical patent/ES2116612T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS, COMPOSICIONES FARMACEUTICAS QUE CONTIENE LOS MISMOS DE LA FORMULA (I). SE PRESENTA UN COMPUESTO DE LA FORMULA (I) EN DONDE X, X'', X2 Y X''", A, D, R, Y R'' SON SEGUN SE HA IDENTIFICADO EN LAS ESPECIFICACIONES ASI COMO SU PREPARACION. LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN EL MISMO PUEDEN UTILIZARSE EN EL TRATAMIENTO DEL CANCER.
ES94924854T 1993-08-18 1994-08-08 Nuevas bis-naftalimidas para el tratamiento del cancer. Expired - Lifetime ES2116612T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10894993A 1993-08-18 1993-08-18

Publications (1)

Publication Number Publication Date
ES2116612T3 true ES2116612T3 (es) 1998-07-16

Family

ID=22324990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94924854T Expired - Lifetime ES2116612T3 (es) 1993-08-18 1994-08-08 Nuevas bis-naftalimidas para el tratamiento del cancer.

Country Status (28)

Country Link
US (3) US5616589A (es)
EP (1) EP0714387B1 (es)
JP (1) JPH09501662A (es)
KR (1) KR960703863A (es)
CN (1) CN1039414C (es)
AT (1) ATE166647T1 (es)
AU (1) AU677696B2 (es)
BR (2) BR9407257A (es)
CA (1) CA2169059A1 (es)
CZ (1) CZ34296A3 (es)
DE (1) DE69410614T2 (es)
DK (1) DK0714387T3 (es)
ES (1) ES2116612T3 (es)
FI (1) FI960658A7 (es)
HR (1) HRP940458B1 (es)
HU (1) HU219232B (es)
IL (1) IL110460A (es)
NO (1) NO305554B1 (es)
NZ (1) NZ271374A (es)
PH (1) PH31395A (es)
PL (1) PL313078A1 (es)
RU (1) RU2138484C1 (es)
SG (1) SG64906A1 (es)
SI (1) SI9420053A (es)
TW (1) TW408112B (es)
UA (1) UA42733C2 (es)
WO (1) WO1995005365A1 (es)
ZA (1) ZA946196B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
EP0930883B1 (en) * 1996-10-21 2006-01-11 Allelix Biopharmaceuticals Inc. Neurotrophin antagonists for the treatment of epilepsy, alzheimer's disease and pain
US6420344B1 (en) 1999-03-16 2002-07-16 The Regents Of The University Of California Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) * 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
DE60100855T2 (de) * 2000-03-07 2004-07-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 1,8-naphthalimid imidazo[4,5,1-de]acridone mit antitumorwirkung
ATE506079T1 (de) 2003-11-05 2011-05-15 Photobiomed Corp Verbindungsgewebe und vernetzungsproteine mit naphthalimid-verbindungen
WO2005105753A2 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
EP1817059A2 (en) 2004-12-01 2007-08-15 Genentech, Inc. Conjugates of 1,8-bis-naphthalimides with an antibody
BRPI0615930A2 (pt) 2005-09-15 2016-08-23 Painceptor Pharma Corp métodos de modular a interação de uma neurotrofina e um receptor de neurotrofina, de tratar dor em um indivíduo, de tratar distúrbio inflamatório em um indivíduo, de tratar um distúrbio neurológico em um indivíduo, e de tratar uma doença ou distúrbio associado aos sistemas geniturinário e/ou gastrointestinal de um indivíduo, e, composto
WO2009089537A2 (en) 2008-01-11 2009-07-16 Northwestern University Anti-cancer compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
CA2125142A1 (en) * 1991-12-11 1993-06-24 Jung-Hui Sun Highly water soluble bis-naphthalimides useful as anticancer agents
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Also Published As

Publication number Publication date
CZ34296A3 (en) 1996-08-14
HRP940458B1 (en) 2000-02-29
US5981753A (en) 1999-11-09
NO305554B1 (no) 1999-06-21
BR9407257A (pt) 1996-09-24
ZA946196B (en) 1996-02-19
UA42733C2 (uk) 2001-11-15
KR960703863A (ko) 1996-08-31
BR1100143A (pt) 2000-03-14
FI960658L (fi) 1996-02-14
EP0714387A1 (en) 1996-06-05
AU7498494A (en) 1995-03-14
EP0714387B1 (en) 1998-05-27
FI960658A0 (fi) 1996-02-14
PL313078A1 (en) 1996-05-27
JPH09501662A (ja) 1997-02-18
US5616589A (en) 1997-04-01
ATE166647T1 (de) 1998-06-15
HU9600360D0 (en) 1996-04-29
AU677696B2 (en) 1997-05-01
NO960632D0 (no) 1996-02-16
US5789418A (en) 1998-08-04
SG64906A1 (en) 1999-05-25
PH31395A (en) 1998-10-29
DK0714387T3 (da) 1998-10-12
DE69410614D1 (de) 1998-07-02
DE69410614T2 (de) 1998-09-24
IL110460A0 (en) 1994-10-21
TW408112B (en) 2000-10-11
NZ271374A (en) 1997-05-26
IL110460A (en) 2001-01-11
WO1995005365A1 (en) 1995-02-23
CA2169059A1 (en) 1995-02-23
HRP940458A2 (en) 1997-06-30
HUT73529A (en) 1996-08-28
HU219232B (en) 2001-03-28
CN1039414C (zh) 1998-08-05
CN1132506A (zh) 1996-10-02
RU2138484C1 (ru) 1999-09-27
SI9420053A (en) 1996-08-31
NO960632L (no) 1996-02-16
FI960658A7 (fi) 1996-02-14

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