ATE152122T1 - Verfahren zur enzymatischen herstellung von basischen fibroblasten-wachstumsfaktors - Google Patents

Verfahren zur enzymatischen herstellung von basischen fibroblasten-wachstumsfaktors

Info

Publication number
ATE152122T1
ATE152122T1 AT91913996T AT91913996T ATE152122T1 AT E152122 T1 ATE152122 T1 AT E152122T1 AT 91913996 T AT91913996 T AT 91913996T AT 91913996 T AT91913996 T AT 91913996T AT E152122 T1 ATE152122 T1 AT E152122T1
Authority
AT
Austria
Prior art keywords
bfgf
thr
growth factors
fibroblast growth
adduct
Prior art date
Application number
AT91913996T
Other languages
English (en)
Inventor
Pierre Monsan
Francois Paul
Didier Betbeder
Paolo Sarmientos
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of ATE152122T1 publication Critical patent/ATE152122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT91913996T 1990-08-02 1991-07-30 Verfahren zur enzymatischen herstellung von basischen fibroblasten-wachstumsfaktors ATE152122T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017008A GB9017008D0 (en) 1990-08-02 1990-08-02 Process for the enzymatic preparation of basic fibroblast growth factor

Publications (1)

Publication Number Publication Date
ATE152122T1 true ATE152122T1 (de) 1997-05-15

Family

ID=10680087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91913996T ATE152122T1 (de) 1990-08-02 1991-07-30 Verfahren zur enzymatischen herstellung von basischen fibroblasten-wachstumsfaktors

Country Status (27)

Country Link
US (1) US5348863A (de)
EP (1) EP0495049B1 (de)
JP (1) JPH05501655A (de)
KR (1) KR100191697B1 (de)
CN (1) CN1033810C (de)
AT (1) ATE152122T1 (de)
AU (1) AU643822B2 (de)
CA (1) CA2066174A1 (de)
CZ (1) CZ286237B6 (de)
DE (1) DE69125810T2 (de)
DK (1) DK0495049T3 (de)
ES (1) ES2103822T3 (de)
FI (1) FI921428L (de)
GB (1) GB9017008D0 (de)
GR (1) GR3024111T3 (de)
HU (1) HU212671B (de)
IE (1) IE912729A1 (de)
IL (1) IL98988A (de)
MY (1) MY107334A (de)
NO (1) NO301480B1 (de)
NZ (1) NZ239204A (de)
PH (1) PH31240A (de)
PT (1) PT98544B (de)
RU (1) RU2093519C1 (de)
WO (1) WO1992002539A1 (de)
YU (1) YU48309B (de)
ZA (1) ZA916026B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU659723B2 (en) * 1992-02-14 1995-05-25 Kaken Pharmaceutical Co., Ltd. Remedy for airway diseases
DE69530689T2 (de) * 1994-04-21 2004-03-25 Leukotech A/S Heparin-binding protein zur behandlung von sepsis
US5939390A (en) * 1995-03-09 1999-08-17 Novo Nordisk A/S Pharmaceutical composition
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
RU2187118C2 (ru) * 2000-07-13 2002-08-10 Российский научно-исследовательский нейрохирургический институт им. проф. А.Л. Поленова Способ диагностики возможности рецидивов церебральных рацемозных артериовенозных мальформаций
IL141647A0 (en) 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
WO2004060403A2 (en) 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
JP2006516034A (ja) 2003-01-14 2006-06-15 テバ ファーマシューティカル インダストリーズ リミティド 全身性エリテマトーデスを治療するためのペプチドの非経口製剤
US8618054B2 (en) 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
EP1751175B1 (de) 2004-05-05 2012-07-25 VALORISATION-RECHERCHE, Société en Commandite Antagonisten des interleukin-1-rezeptors, zusammensetzungen und behandlungsverfahren
WO2007004060A2 (en) 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
AU2008255556B2 (en) 2007-05-29 2014-08-07 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
MX355683B (es) 2008-04-18 2018-04-26 Angiochem Inc Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso.
WO2010043049A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
CA2745524C (en) 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
US8853353B2 (en) 2008-12-17 2014-10-07 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
MX2011011023A (es) 2009-04-20 2012-01-20 Angiochem Inc Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
RU2012103240A (ru) 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
JP2013530993A (ja) 2010-07-02 2013-08-01 アンジオケム インコーポレーテッド 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用
SG11201509430WA (en) * 2013-05-16 2015-12-30 Agency Science Tech & Res Heparan sulphates
EP3220922B1 (de) 2014-11-19 2020-10-14 Agency For Science, Technology And Research Heparansulfate zur verwendung in der reparatur und/oder regeneration der haut
SG11201704086WA (en) 2014-11-19 2017-06-29 Agency Science Tech & Res Cosmetic use of heparan sulphate
EP3307326B9 (de) 2015-06-15 2021-02-24 Angiochem Inc. Verfahren zur behandlung von leptomeningealer karzinomatose
CN105294851B (zh) * 2015-12-07 2019-02-12 中国科学院长春应用化学研究所 与几丁质特异结合的碱性成纤维细胞生长因子及其编码基因、制备方法与应用
CN114965839A (zh) * 2022-05-11 2022-08-30 朗肽生物制药股份有限公司 人碱性成纤维细胞生长因子的肽图分析方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
DE3811921A1 (de) * 1988-04-09 1989-10-19 Hoechst Ag Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen
US5136025A (en) * 1990-04-04 1992-08-04 California Biotechnology Inc. Method to purify basic fibroblast growth factor

Also Published As

Publication number Publication date
CA2066174A1 (en) 1992-02-03
ES2103822T3 (es) 1997-10-01
CZ286237B6 (cs) 2000-02-16
DE69125810T2 (de) 1997-08-07
ZA916026B (en) 1992-04-29
YU131991A (sh) 1994-05-10
JPH05501655A (ja) 1993-04-02
AU8304491A (en) 1992-03-02
HU9201101D0 (en) 1992-08-28
GB9017008D0 (en) 1990-09-19
MY107334A (en) 1995-11-30
IE912729A1 (en) 1992-02-12
DK0495049T3 (da) 1997-08-25
PT98544B (pt) 1999-01-29
KR920702371A (ko) 1992-09-03
DE69125810D1 (de) 1997-05-28
IL98988A (en) 1997-02-18
CN1058597A (zh) 1992-02-12
NO921236L (no) 1992-03-30
CS236291A3 (en) 1992-02-19
FI921428A0 (fi) 1992-04-01
RU2093519C1 (ru) 1997-10-20
FI921428A7 (fi) 1992-04-01
EP0495049A1 (de) 1992-07-22
CN1033810C (zh) 1997-01-15
GR3024111T3 (en) 1997-10-31
HU212671B (en) 1996-09-30
FI921428L (fi) 1992-04-01
NZ239204A (en) 1993-11-25
NO301480B1 (no) 1997-11-03
PH31240A (en) 1998-06-18
PT98544A (pt) 1992-06-30
EP0495049B1 (de) 1997-04-23
HUT64564A (en) 1994-01-28
IL98988A0 (en) 1992-07-15
KR100191697B1 (ko) 1999-06-15
NO921236D0 (no) 1992-03-30
WO1992002539A1 (en) 1992-02-20
US5348863A (en) 1994-09-20
YU48309B (sh) 1998-05-15
AU643822B2 (en) 1993-11-25

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REN Ceased due to non-payment of the annual fee