ES2103822T3 - Procedimiento para la preparacion enzimatica del factor de crecimiento de los fibroblastos. - Google Patents

Procedimiento para la preparacion enzimatica del factor de crecimiento de los fibroblastos.

Info

Publication number
ES2103822T3
ES2103822T3 ES91913996T ES91913996T ES2103822T3 ES 2103822 T3 ES2103822 T3 ES 2103822T3 ES 91913996 T ES91913996 T ES 91913996T ES 91913996 T ES91913996 T ES 91913996T ES 2103822 T3 ES2103822 T3 ES 2103822T3
Authority
ES
Spain
Prior art keywords
bfgf
procedure
growth factor
fibroblast growth
enzymatic preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913996T
Other languages
English (en)
Inventor
Pierre Monsan
Francois Paul
Didier Betbeder
Paolo Sarmientos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2103822T3 publication Critical patent/ES2103822T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

UN BFGF SE PREPARA A BASE DE: (I) FORMAR UN ADUCTO ENTRE HEPARINA O SULFATO DE HEPARANO Y UN BFGF QUE TIENE EL ENLACE 9-10 LEU-PRO; (II) TRATAR EL ADUCTO CON PEPSINA A O CATEPFINA D, DISOCIANDO ASI EL ENLACE ANTEDICHO; Y (III) LIBERAR DEL ADUCTO EL BFGF ASI OBTENIDO. ESTE PROCESO PUEDE SER APLICADO PARA PREPARAR LA FORMA AMINOACIDA 146 DEL BFGF A PARTIR DE FORMAS MAS LARGAS DEL BFGF. TAMBIEN SE PUEDE UTILIZAR PARA PRODUCIR UNA SOLA FORMA DEL BFGF A PARTIR DE UNA MEZCLA DE BFGFS CUYAS SECUENCIAS AMINOACIDAS SOLO DIFIEREN PORQUE TIENEN N-TERMINOS DIFERENTES.
ES91913996T 1990-08-02 1991-07-30 Procedimiento para la preparacion enzimatica del factor de crecimiento de los fibroblastos. Expired - Lifetime ES2103822T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017008A GB9017008D0 (en) 1990-08-02 1990-08-02 Process for the enzymatic preparation of basic fibroblast growth factor

Publications (1)

Publication Number Publication Date
ES2103822T3 true ES2103822T3 (es) 1997-10-01

Family

ID=10680087

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913996T Expired - Lifetime ES2103822T3 (es) 1990-08-02 1991-07-30 Procedimiento para la preparacion enzimatica del factor de crecimiento de los fibroblastos.

Country Status (27)

Country Link
US (1) US5348863A (es)
EP (1) EP0495049B1 (es)
JP (1) JPH05501655A (es)
KR (1) KR100191697B1 (es)
CN (1) CN1033810C (es)
AT (1) ATE152122T1 (es)
AU (1) AU643822B2 (es)
CA (1) CA2066174A1 (es)
CZ (1) CZ286237B6 (es)
DE (1) DE69125810T2 (es)
DK (1) DK0495049T3 (es)
ES (1) ES2103822T3 (es)
FI (1) FI921428A0 (es)
GB (1) GB9017008D0 (es)
GR (1) GR3024111T3 (es)
HU (1) HU212671B (es)
IE (1) IE912729A1 (es)
IL (1) IL98988A (es)
MY (1) MY107334A (es)
NO (1) NO301480B1 (es)
NZ (1) NZ239204A (es)
PH (1) PH31240A (es)
PT (1) PT98544B (es)
RU (1) RU2093519C1 (es)
WO (1) WO1992002539A1 (es)
YU (1) YU48309B (es)
ZA (1) ZA916026B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0580874A4 (en) * 1992-02-14 1997-02-26 Kaken Pharma Co Ltd Remedy for airway diseases
RU2200573C2 (ru) * 1994-04-21 2003-03-20 Леукотех А/С Связывающий гепарин белок для лечения сепсиса
US5939390A (en) * 1995-03-09 1999-08-17 Novo Nordisk A/S Pharmaceutical composition
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
RU2187118C2 (ru) * 2000-07-13 2002-08-10 Российский научно-исследовательский нейрохирургический институт им. проф. А.Л. Поленова Способ диагностики возможности рецидивов церебральных рацемозных артериовенозных мальформаций
IL141647A0 (en) 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
CN1747747B (zh) 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
KR20050100616A (ko) 2003-01-14 2005-10-19 테바 파마슈티컬 인더스트리즈 리미티드 전신성 홍반성 낭창의 치료를 위한 펩티드의 비경구 제제
ES2395087T3 (es) 2004-05-05 2013-02-08 Valorisation-Recherche, Société en Commandite Antagonistas del receptor de interleuquina-1, composiciones y métodos de tratamiento
US8618054B2 (en) 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
WO2007004060A2 (en) 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
EP2789628A3 (en) 2007-05-29 2015-03-04 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
RU2518240C2 (ru) 2008-04-18 2014-06-10 Ангиочем Инк. Композиция, на основе гидрофобных агентов и способ ее получения(варианты)
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
MX2011005963A (es) 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
AU2010239069B2 (en) 2009-04-20 2015-05-14 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog
MX2012000016A (es) 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
WO2014185858A1 (en) * 2013-05-16 2014-11-20 Agency For Science, Technology And Research Heparan sulphates
US10471091B2 (en) 2014-11-19 2019-11-12 Agency For Science, Technology And Research Heparan sulphates for use in repair and/or regeneration of skin
US10493012B2 (en) 2014-11-19 2019-12-03 Agency For Science, Technology And Research Cosmetic use of heparan sulphate
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
CN105294851B (zh) * 2015-12-07 2019-02-12 中国科学院长春应用化学研究所 与几丁质特异结合的碱性成纤维细胞生长因子及其编码基因、制备方法与应用
CN114965839A (zh) * 2022-05-11 2022-08-30 朗肽生物制药股份有限公司 人碱性成纤维细胞生长因子的肽图分析方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
DE3811921A1 (de) * 1988-04-09 1989-10-19 Hoechst Ag Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen
US5136025A (en) * 1990-04-04 1992-08-04 California Biotechnology Inc. Method to purify basic fibroblast growth factor

Also Published As

Publication number Publication date
DE69125810T2 (de) 1997-08-07
FI921428A7 (fi) 1992-04-01
PH31240A (en) 1998-06-18
IL98988A0 (en) 1992-07-15
HU9201101D0 (en) 1992-08-28
EP0495049A1 (en) 1992-07-22
AU8304491A (en) 1992-03-02
YU131991A (sh) 1994-05-10
HU212671B (en) 1996-09-30
CZ286237B6 (cs) 2000-02-16
EP0495049B1 (en) 1997-04-23
CA2066174A1 (en) 1992-02-03
GB9017008D0 (en) 1990-09-19
KR100191697B1 (ko) 1999-06-15
PT98544B (pt) 1999-01-29
MY107334A (en) 1995-11-30
NZ239204A (en) 1993-11-25
CN1058597A (zh) 1992-02-12
PT98544A (pt) 1992-06-30
NO921236L (no) 1992-03-30
ZA916026B (en) 1992-04-29
JPH05501655A (ja) 1993-04-02
KR920702371A (ko) 1992-09-03
CN1033810C (zh) 1997-01-15
AU643822B2 (en) 1993-11-25
DK0495049T3 (da) 1997-08-25
HUT64564A (en) 1994-01-28
FI921428L (fi) 1992-04-01
NO921236D0 (no) 1992-03-30
GR3024111T3 (en) 1997-10-31
RU2093519C1 (ru) 1997-10-20
WO1992002539A1 (en) 1992-02-20
IL98988A (en) 1997-02-18
IE912729A1 (en) 1992-02-12
ATE152122T1 (de) 1997-05-15
CS236291A3 (en) 1992-02-19
FI921428A0 (fi) 1992-04-01
NO301480B1 (no) 1997-11-03
YU48309B (sh) 1998-05-15
DE69125810D1 (de) 1997-05-28
US5348863A (en) 1994-09-20

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