ATE153024T1 - Azabicyclische verbindungen - Google Patents

Azabicyclische verbindungen

Info

Publication number: ATE153024T1
Authority: AT; Austria
Prior art keywords: group; alkyl; hydrogen; nitrogen; sulphur
Prior art date: 1989-08-16

Application number

AT90308899T

Other languages

English (en)

Inventor

Paul Adrian Wyman

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-16

Filing date

1990-08-13

Publication date

1997-05-15

1989-08-16 Priority claimed from GB898918658A external-priority patent/GB8918658D0/en

1989-08-16 Priority claimed from GB898918659A external-priority patent/GB8918659D0/en

1990-02-28 Priority claimed from GB909004437A external-priority patent/GB9004437D0/en

1990-08-13 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE153024T1 publication Critical patent/ATE153024T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
239000005864 Sulphur Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90308899T 1989-08-16 1990-08-13 Azabicyclische verbindungen ATE153024T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB898918658A GB8918658D0 (en)	1989-08-16	1989-08-16	Novel compounds
GB898918659A GB8918659D0 (en)	1989-08-16	1989-08-16	Novel compounds
GB909004437A GB9004437D0 (en)	1990-02-28	1990-02-28	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE153024T1 true ATE153024T1 (de)	1997-05-15

Family

ID=27264638

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90308899T ATE153024T1 (de)	1989-08-16	1990-08-13	Azabicyclische verbindungen

Country Status (9)

Country	Link
US (1)	US5043343A (de)
EP (1)	EP0413545B1 (de)
JP (1)	JP2976128B2 (de)
KR (1)	KR910004608A (de)
AT (1)	ATE153024T1 (de)
AU (1)	AU627612B2 (de)
DE (1)	DE69030695T2 (de)
IE (1)	IE902943A1 (de)
NZ (1)	NZ234903A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
GB8717446D0 (en) *	1987-07-23	1987-08-26	Merck Sharp & Dohme	Chemical compounds
US5574028A (en) *	1994-10-31	1996-11-12	Eli Lilly And Company	Method for treating anxiety
US5908891A (en) *	1996-04-19	1999-06-01	Dow Corning Corporation	Dispersible silicone compositions
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO2012033956A1 (en)	2010-09-08	2012-03-15	Mithridion, Inc.	Cognition enhancing compounds and compositions, methods of making, and methods of treating

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
EP0287356B1 (de) *	1987-04-15	1996-01-24	Beecham Group Plc	Am Brückenkopf substituierte Azabicyclenderivate
EP0307141B1 (de) *	1987-09-10	1993-01-13	MERCK SHARP & DOHME LTD.	Oxazole und Thiazole zur Behandlung seniler Demenz
NZ225999A (en) *	1987-09-10	1992-04-28	Merck Sharp & Dohme	Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) *	1987-11-13	1995-06-14	Novo Nordisk As	Azabicyclic compounds and their preparation and use
EP0322182A3 (de) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL88846A0 (en) *	1988-01-08	1989-07-31	Merck Sharp & Dohme	Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
NZ227684A (en) *	1988-01-30	1991-07-26	Merck Sharp & Dohme	Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
PT90266B (pt) *	1988-04-15	1994-07-29	Beecham Group Plc	Processo para a preparacao de compostos azabiciclicos
GB8808926D0 (en) *	1988-04-15	1988-05-18	Beecham Group Plc	Novel compounds
CA2000041A1 (en) *	1988-10-13	1990-04-13	Barry S. Orlek	Compounds
GB8911080D0 (en) *	1989-05-15	1989-06-28	Merck Sharp & Dohme	Chemical process
EP0398617A3 (de) *	1989-05-15	1991-11-06	Merck Sharp & Dohme Ltd.	Verfahren zur optischen Spaltung von 1-Azabicyclo[2.2.1]heptan-3-carbonsäure
EP0402056A3 (de) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

1990
- 1990-08-13 AT AT90308899T patent/ATE153024T1/de not_active IP Right Cessation
- 1990-08-13 EP EP90308899A patent/EP0413545B1/de not_active Expired - Lifetime
- 1990-08-13 DE DE69030695T patent/DE69030695T2/de not_active Expired - Fee Related
- 1990-08-14 AU AU61003/90A patent/AU627612B2/en not_active Ceased
- 1990-08-14 US US07/566,980 patent/US5043343A/en not_active Expired - Fee Related
- 1990-08-14 NZ NZ234903A patent/NZ234903A/xx unknown
- 1990-08-14 IE IE294390A patent/IE902943A1/en unknown
- 1990-08-16 KR KR1019900012606A patent/KR910004608A/ko not_active Withdrawn
- 1990-08-16 JP JP2216459A patent/JP2976128B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69030695D1 (de)	1997-06-19
JP2976128B2 (ja)	1999-11-10
AU6100390A (en)	1991-02-21
JPH0386883A (ja)	1991-04-11
EP0413545B1 (de)	1997-05-14
NZ234903A (en)	1993-01-27
EP0413545A3 (en)	1991-11-06
DE69030695T2 (de)	1998-01-08
AU627612B2 (en)	1992-08-27
US5043343A (en)	1991-08-27
IE902943A1 (en)	1991-02-27
EP0413545A2 (de)	1991-02-20
KR910004608A (ko)	1991-03-29

Legal Events

Date	Code	Title	Description
1997-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE133415T1 (de)	1996-02-15	Am brückenkopf substituierte azabicyclenderivate
DK504889D0 (da)	1989-10-11	Hidtil ukendte forbindelser
HUP0401335A2 (hu)	2004-12-28	Herbicid hatású [(piridil-propinil)-oxi]-fenil-származékok, előállításuk és alkalmazásuk
ES2062009T4 (es)	2006-07-01	Agentes antifungicos derivados de triazol
NZ506574A (en)	2003-06-30	Cyclic amino derivative having a sulphinyl, sulphonyl or disulphanyl group useful in the treatment of thrombosis or embolism
TR200002671T2 (tr)	2000-12-21	Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler
SE7908995L (sv)	1980-05-01	Heterocykliska foreningar
DK0409406T3 (da)	1994-02-07	Arylsubstituerede aminderivater, der er anvendelige ved cancerterapi
DE69030695D1 (de)	1997-06-19	Azabicyclische Verbindungen
ZA906127B (en)	1991-06-26	Azabicyclic compounds
EP0427390A3 (en)	1992-02-12	Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
ATE207058T1 (de)	2001-11-15	Amine derivate, ihre herstellung und anwendung
DK0805153T3 (da)	2002-03-18	Hidtil ukendte muskarine receptoragonister
NZ225099A (en)	1990-09-26	Ergoline n-oxide derivatives and pharmaceutical compositions
ATE180386T1 (de)	1999-06-15	Molluskizide
JO1047B1 (en)	1982-07-10	Vehicles