ATE153855T1 - Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten - Google Patents

Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten

Info

Publication number
ATE153855T1
ATE153855T1 AT93923372T AT93923372T ATE153855T1 AT E153855 T1 ATE153855 T1 AT E153855T1 AT 93923372 T AT93923372 T AT 93923372T AT 93923372 T AT93923372 T AT 93923372T AT E153855 T1 ATE153855 T1 AT E153855T1
Authority
AT
Austria
Prior art keywords
compositions
treatment
clonidine derivatives
containing prostaglandins
glaucoma containing
Prior art date
Application number
AT93923372T
Other languages
English (en)
Inventor
Louis Desantis Jr
Verney L Sallee
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE153855T1 publication Critical patent/ATE153855T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93923372T 1992-10-13 1993-10-12 Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten ATE153855T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96006592A 1992-10-13 1992-10-13

Publications (1)

Publication Number Publication Date
ATE153855T1 true ATE153855T1 (de) 1997-06-15

Family

ID=25502747

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923372T ATE153855T1 (de) 1992-10-13 1993-10-12 Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten

Country Status (9)

Country Link
US (3) US5480900A (de)
EP (1) EP0664707B1 (de)
JP (1) JP3002258B2 (de)
AT (1) ATE153855T1 (de)
AU (1) AU674038B2 (de)
CA (1) CA2146127C (de)
DE (1) DE69311361T2 (de)
ES (1) ES2105333T3 (de)
WO (1) WO1994008585A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6184250B1 (en) 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
DE4330177A1 (de) * 1993-08-31 1995-03-02 Schering Ag Neue 9-Chlor-prostaglandin-derivate
WO1996013267A2 (en) * 1994-10-27 1996-05-09 Allergan Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US5631287A (en) * 1994-12-22 1997-05-20 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
US6353014B1 (en) 1996-11-12 2002-03-05 Alcon Laboratories, Inc. 15-ketal postaglandins for the treatment of glaucoma or ocular hypertension
WO1998039293A2 (en) * 1997-03-07 1998-09-11 Alcon Laboratories, Inc. 13-thia prostaglandins for use in glaucoma therapy
SE9702706D0 (sv) * 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
CA2337349A1 (en) * 1998-07-21 2000-02-03 Gerald S. Ponticello Ophthalmic compositions for treating ocular hypertension
US6417228B1 (en) 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6211226B1 (en) 1998-12-17 2001-04-03 Alcon Laboratories, Inc. 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6160013A (en) * 1998-12-17 2000-12-12 Alcon Laboratories, Inc. 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
AU2211700A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Prostaglandin e agonists for treatment of glaucoma
ATE283256T1 (de) * 1999-03-05 2004-12-15 Univ Duke C-16 ungesätigte fp-selektive prostaglandin analoge
CA2364948C (en) 1999-03-05 2011-04-26 Duke University C16 unsaturated fp-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020198210A1 (en) * 2001-05-03 2002-12-26 Allergan Sales Inc. Alpha-2-adrenergic agonist/fatty acid compositions
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
AU2002256471B2 (en) * 2001-05-03 2007-05-24 Allergan, Inc. Compositions having enhanced pharmacokinetic characteristics
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
KR20120005052A (ko) * 2003-08-21 2012-01-13 수캄포 아게 안과용 조성물
ES2767136T3 (es) 2004-01-05 2020-06-16 Nicox Sa Derivados de prostaglandinas
EP1899295A2 (de) * 2005-06-29 2008-03-19 Pfizer, Inc. Prostaglandinderivate
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
EP3421030A1 (de) 2009-11-09 2019-01-02 Allergan, Inc. Zusammensetzungen und verfahren zur stimulation des haarwuchses
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
JP2014522844A (ja) * 2011-06-29 2014-09-08 ザ ペン ステート リサーチ ファウンデーション 白血病を治療するための組成物、方法及びキット
ES2727203T3 (es) 2011-08-29 2019-10-14 Mati Therapeutics Inc Administración por liberación sostenida de agentes activos para tratar glaucoma e hipertensión ocular
CA2872338C (en) 2012-05-03 2021-09-14 Qlt Inc. Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
KR101984116B1 (ko) 2015-01-12 2019-05-31 켄달리온 테라퓨틱스 인코포레이티드 마이크로-액적 전달 장치 및 방법
US9827225B2 (en) 2016-01-25 2017-11-28 Jenivision Inc. Use of prostacyclin antagonists for treating ocular surface nociception
CA3043000A1 (en) 2016-11-08 2018-05-17 Bausch & Lomb Incorporated Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma
CA3039106A1 (en) 2017-01-20 2018-07-26 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
JP7436363B2 (ja) 2017-12-08 2024-02-21 ノバルティス アーゲー 流体送達アライメントシステム
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
US20190314197A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical Ocular Delivery Methods and Devices for Use in the Same
CA3102410A1 (en) 2018-07-03 2020-01-09 Kedalion Therapeutics, Inc. Topical ocular delivery devices and methods for using the same
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US12496218B1 (en) 2019-11-12 2025-12-16 Bausch + Lomb Ireland Limited Fractionated topical ocular drug delivery methods and devices for use in the same
WO2021212038A1 (en) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
JP7711090B2 (ja) 2020-04-17 2025-07-22 ボシュ + ロム アイルランド リミテッド 流体力学的に起動される防腐剤無添加分注システム

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202660A (en) * 1961-10-09 1965-08-24 Boehringer Sohn Ingelheim Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
US3755426A (en) * 1971-07-02 1973-08-28 American Home Prod 10-haloprostaglandin-a derivatives
US3873607A (en) * 1972-07-24 1975-03-25 American Cyanamid Co 3-Oxa(and thia) 11-deoxy PGE
CA1045131A (en) * 1972-07-24 1978-12-26 Middleton B. Floyd (Jr.) Derivatives of 9-hydroxy-13-trans-prostenoic acid
US4110368A (en) * 1972-07-24 1978-08-29 American Cyanamid Company Hydro substituted prostanoic acids and esters
US3884969A (en) * 1973-04-20 1975-05-20 American Cyanamid Co Novel prostaglandins
US4029681A (en) * 1976-02-13 1977-06-14 The Upjohn Company 13,14-Didehydro-PG analogs
US4321405A (en) * 1976-03-03 1982-03-23 American Cyanamid Company 15,16-Dioxy prostenoic acids and esters
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
US4343949A (en) * 1977-09-22 1982-08-10 American Cyanamid Company Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
US4288616A (en) * 1979-04-02 1981-09-08 The Upjohn Company 13,14-Didehydro-11-deoxy-11-hydroxymethyl-19-oxo-PGF2 compounds
US4291175A (en) * 1980-04-03 1981-09-22 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
NZ200429A (en) * 1981-04-30 1984-10-19 Smith & Nephew Ass Applicator for placing pharmaceutically active agent in contact with moist surface,e.g.,eye
US4730013A (en) * 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US4614825A (en) * 1982-05-17 1986-09-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4576962A (en) * 1983-10-19 1986-03-18 The Procter & Gamble Company Prostaglandin analogues
DE3347128A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4911920A (en) * 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
US4587257A (en) * 1984-12-14 1986-05-06 Alcon Laboratories, Inc. Control of ocular bleeding using clonidine derivatives
EP0286903B2 (de) * 1987-04-03 2000-03-29 The Trustees Of Columbia University In The City Of New York Anwendung eines Prostaglandins in Mischung mit einem adrenergischen Blocker zur Verminderung des Augen-Innendruckes
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
WO1989000559A1 (fr) * 1987-07-17 1989-01-26 Schering Aktiengesellschaft Berlin Und Bergkamen Derives de 9-halogene-(z)-prostaglandine, leur procede de production et leur utilisation comme medicaments
EP1348437A3 (de) * 1988-09-06 2003-11-19 Pharmacia Aktiebolag Prostaglandinderivative zur Behandlung von Glaukoma oder okuläre Hypertension
EP0366279B1 (de) * 1988-10-01 1994-09-21 R-Tech Ueno Ltd. Okulare hypotensive Mittel
CA2014038A1 (en) * 1989-05-25 1990-11-25 Charles Gluchowski Intraocular pressure reducing 15-acyl prostaglandins
DE3923797A1 (de) * 1989-07-14 1991-01-24 Schering Ag 9-fluor-prostaglandin-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5093329A (en) * 1990-03-12 1992-03-03 Allergan, Inc. Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives
HUT61666A (en) * 1990-03-19 1993-03-01 Allergan Inc Process for producing pharmaceutical composition containing 5-trans-prostaglandine f2a- for reducing eye-pressure
ATE117208T1 (de) * 1990-05-22 1995-02-15 R Tech Ueno Ltd Behandlung von intraokularem druck mit einer ophthalmischen synergistischen kombination.
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions

Also Published As

Publication number Publication date
AU674038B2 (en) 1996-12-05
US5605922A (en) 1997-02-25
CA2146127C (en) 2000-06-13
EP0664707B1 (de) 1997-06-04
DE69311361T2 (de) 1998-01-08
EP0664707A1 (de) 1995-08-02
ES2105333T3 (es) 1997-10-16
AU5328694A (en) 1994-05-09
US5811443A (en) 1998-09-22
WO1994008585A1 (en) 1994-04-28
JP3002258B2 (ja) 2000-01-24
HK1007102A1 (en) 1999-04-01
JPH08502485A (ja) 1996-03-19
DE69311361D1 (de) 1997-07-10
US5480900A (en) 1996-01-02

Similar Documents

Publication Publication Date Title
DE69311361D1 (de) Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
DE68929563D1 (de) Prostaglandin-Derivate zur Behandlung von Glaukom und ocularer Hypertension
SE7903186L (sv) Cerebralverksamt medel
NO854211L (no) Farmasoeytisk blanding og fremgangsmaate til behandling av legemet.
FR2411821A1 (fr) Nouveaux 1,9-dihydroxyoctahydrophenanthrenes et 1-hydroxyoctahydrophenanthrene-9-ones et medicament les contenant
FR2415112A1 (fr) Nouveaux derives spirothienohydantoines et composition pharmaceutique les contenant
FR2362834A1 (fr) Nouveaux derives 6-hemicetal ou 6-ceto de prostaglandine, leur procede de preparation et medicament les contenant
ES8206974A1 (es) Un procedimiento para preparar una composicion farmaceutica para aplicacion topica, empleada en el tratamiento del acne.
GB2075341B (en) Pharmaceutical compositions
ATE78031T1 (de) Prostaglandin-derivate zur behandlung von glaucoma oder augenueberdruck.
DE69232150D1 (de) Behandlung von Augenhochdruck mit Betablockern und Prostansäurederivaten
DE3873007D1 (de) Kathartica.
FR2361892A1 (fr) Esters et amides des acides pyrimido(4,5-b)quinolein-4(3h)-one-2-carboxyliques, en tant qu'agents anti-ulceres
FR2430418A1 (fr) Derives halogenomethyles d'a-aminoacides, leur preparation et leurs utilisations therapeutiques
ATE242220T1 (de) Benzimidazolderivate mit dopaminerger wirkung
FR2362587A1 (fr) Agents antimicrobie
KR880009656A (ko) 국소 치근막 질환의 치료 또는 예방법
FR2355846A1 (fr) Esters de penicillines utilisables comme medicaments
FR2449680A1 (fr) Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant
FR2409263A1 (fr) Medicament a base de bromure de butoxybenzylhyoscyamine utilisable dans le traitement de la surdite et des tintements d'oreille
KR900016130A (ko) 2-피리딜메틸티오 유도체 및 궤양 치료제
GB1115417A (en) Compositions containing raubasine and a new method of using raubasine
FR2392979A1 (fr) Esters pharmacologiquement actifs de l'acide 2-acetoxy-benzoique avec des derives 4-alcoxyl-3,5-dioxo-pyrazolidine, procedes pour leur preparation et intermediaires utiles dans ces procedes
ATE79756T1 (de) Arzneimittel zur behandlung von augenentzuendung.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties