ES2105333T3 - Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. - Google Patents
Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma.Info
- Publication number
- ES2105333T3 ES2105333T3 ES93923372T ES93923372T ES2105333T3 ES 2105333 T3 ES2105333 T3 ES 2105333T3 ES 93923372 T ES93923372 T ES 93923372T ES 93923372 T ES93923372 T ES 93923372T ES 2105333 T3 ES2105333 T3 ES 2105333T3
- Authority
- ES
- Spain
- Prior art keywords
- prostaglandins
- combinations
- glaucoma
- treatment
- clonidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LAS COMBINACIONES DE AL MENOS UN DERIVADO DE LA CLONIDINA Y DE AL MENOS UNA PROSTAGLANDINA SE UTILIZAR PARA TRATAR EL GLAUCOMA Y LA HIPERTENSION OCULAR SIN QUE APAREZCAN LOS EFECTOS SECUNDARIOS NORMALMENTE ASOCIADOS A LA ADMINISTRACION TOPICA DE PROSTAGLANDINAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96006592A | 1992-10-13 | 1992-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2105333T3 true ES2105333T3 (es) | 1997-10-16 |
Family
ID=25502747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93923372T Expired - Lifetime ES2105333T3 (es) | 1992-10-13 | 1993-10-12 | Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5480900A (es) |
| EP (1) | EP0664707B1 (es) |
| JP (1) | JP3002258B2 (es) |
| AT (1) | ATE153855T1 (es) |
| AU (1) | AU674038B2 (es) |
| CA (1) | CA2146127C (es) |
| DE (1) | DE69311361T2 (es) |
| ES (1) | ES2105333T3 (es) |
| WO (1) | WO1994008585A1 (es) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US6184250B1 (en) | 1993-08-03 | 2001-02-06 | Alcon Laboratories, Inc. | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension |
| DE4330177A1 (de) * | 1993-08-31 | 1995-03-02 | Schering Ag | Neue 9-Chlor-prostaglandin-derivate |
| WO1996013267A2 (en) * | 1994-10-27 | 1996-05-09 | Allergan | Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma |
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| AU5258698A (en) * | 1996-11-12 | 1998-06-03 | Alcon Laboratories, Inc. | 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension |
| US6172109B1 (en) | 1997-03-07 | 2001-01-09 | Alcon Laboratories, Inc. | 13-Thia prostaglandins for use in glaucoma therapy |
| SE9702706D0 (sv) * | 1997-07-11 | 1997-07-11 | Pharmacia & Upjohn Ab | Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma |
| AU5114499A (en) * | 1998-07-21 | 2000-02-14 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| US6417228B1 (en) | 1998-11-02 | 2002-07-09 | Alcon Manufacturing, Ltd.. | 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
| US6211226B1 (en) | 1998-12-17 | 2001-04-03 | Alcon Laboratories, Inc. | 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
| US6160013A (en) * | 1998-12-17 | 2000-12-12 | Alcon Laboratories, Inc. | 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension |
| WO2000038667A2 (en) * | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of glaucoma |
| AU763715B2 (en) * | 1999-03-05 | 2003-07-31 | Duke University | C16 unsaturated fp-selective prostaglandins analogs |
| ATE281432T1 (de) | 1999-03-05 | 2004-11-15 | Univ Duke | C-16 ungesätigte fp-selektive prostaglandin analoge |
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
| US20020198210A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Alpha-2-adrenergic agonist/fatty acid compositions |
| WO2002089853A2 (en) * | 2001-05-03 | 2002-11-14 | Allergan, Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US20020198209A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US8580851B2 (en) | 2002-08-21 | 2013-11-12 | Sucampo Ag | Ophthalmic solution |
| ES2431640T3 (es) * | 2003-08-21 | 2013-11-27 | Sucampo Ag | Composición oftálmica que comprende éster isopropílico de unoprostona y un agente de viscosidad |
| BRPI0418245B8 (pt) | 2004-01-05 | 2021-05-25 | Nicox Sa | composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes |
| EP1899295A2 (en) * | 2005-06-29 | 2008-03-19 | Pfizer, Inc. | Prostaglandin derivatives |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8623918B2 (en) * | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| WO2010116270A1 (en) | 2009-04-10 | 2010-10-14 | Pfizer Inc. | Ep2/4 agonists |
| DK2498783T3 (en) | 2009-11-09 | 2018-12-10 | Allergan Inc | COMPOSITIONS AND PROCEDURES FOR STIMULATING HAIR GROWTH |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US8859616B2 (en) | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| WO2013003729A1 (en) * | 2011-06-29 | 2013-01-03 | The Penn State Research Foundation | Compositions, methods and kits for treating leukemia |
| EP3290024B1 (en) | 2011-08-29 | 2019-04-17 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
| HK1222810A1 (zh) | 2012-05-03 | 2017-07-14 | 麦提疗法有限公司 | 治疗开角型青光眼和高眼压症的药物递送系统和方法 |
| CN113230021A (zh) | 2015-01-12 | 2021-08-10 | 科达莱昂治疗公司 | 微滴递送设备和方法 |
| US9827225B2 (en) * | 2016-01-25 | 2017-11-28 | Jenivision Inc. | Use of prostacyclin antagonists for treating ocular surface nociception |
| US11058691B2 (en) | 2016-11-08 | 2021-07-13 | Nicox S.A. | Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma |
| CN109906120A (zh) | 2017-01-20 | 2019-06-18 | 科达莱昂治疗公司 | 压电流体分配器 |
| WO2019113483A1 (en) | 2017-12-08 | 2019-06-13 | Kedalion Therapeutics, Inc. | Fluid delivery alignment system |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| US20190314197A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| WO2020010116A1 (en) | 2018-07-03 | 2020-01-09 | Kedalion Therapeutics, Inc. | Topical ocular delivery devices and methods for using the same |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12496218B1 (en) | 2019-11-12 | 2025-12-16 | Bausch + Lomb Ireland Limited | Fractionated topical ocular drug delivery methods and devices for use in the same |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| EP4120973A4 (en) | 2020-04-17 | 2024-04-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| CN115768384A (zh) | 2020-04-17 | 2023-03-07 | 科达隆治疗公司 | 流体动力致动的不含防腐剂分配系统 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3202660A (en) * | 1961-10-09 | 1965-08-24 | Boehringer Sohn Ingelheim | Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes |
| DE1670274A1 (de) * | 1966-10-31 | 1970-07-16 | Boehringer Sohn Ingelheim | Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2) |
| US3755426A (en) * | 1971-07-02 | 1973-08-28 | American Home Prod | 10-haloprostaglandin-a derivatives |
| CA1045131A (en) * | 1972-07-24 | 1978-12-26 | Middleton B. Floyd (Jr.) | Derivatives of 9-hydroxy-13-trans-prostenoic acid |
| US3873607A (en) * | 1972-07-24 | 1975-03-25 | American Cyanamid Co | 3-Oxa(and thia) 11-deoxy PGE |
| US4110368A (en) * | 1972-07-24 | 1978-08-29 | American Cyanamid Company | Hydro substituted prostanoic acids and esters |
| US3884969A (en) * | 1973-04-20 | 1975-05-20 | American Cyanamid Co | Novel prostaglandins |
| US4029681A (en) * | 1976-02-13 | 1977-06-14 | The Upjohn Company | 13,14-Didehydro-PG analogs |
| US4321405A (en) * | 1976-03-03 | 1982-03-23 | American Cyanamid Company | 15,16-Dioxy prostenoic acids and esters |
| US4097489A (en) * | 1977-06-17 | 1978-06-27 | The Upjohn Company | 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds |
| US4343949A (en) * | 1977-09-22 | 1982-08-10 | American Cyanamid Company | Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones |
| US4288616A (en) * | 1979-04-02 | 1981-09-08 | The Upjohn Company | 13,14-Didehydro-11-deoxy-11-hydroxymethyl-19-oxo-PGF2 compounds |
| US4291175A (en) * | 1980-04-03 | 1981-09-22 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives |
| NZ200429A (en) * | 1981-04-30 | 1984-10-19 | Smith & Nephew Ass | Applicator for placing pharmaceutically active agent in contact with moist surface,e.g.,eye |
| US4730013A (en) * | 1981-10-08 | 1988-03-08 | Merck & Co., Inc. | Biosoluble ocular insert |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
| US4614825A (en) * | 1982-05-17 | 1986-09-30 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane and 7-oxabicycloheptene compounds |
| US4576962A (en) * | 1983-10-19 | 1986-03-18 | The Procter & Gamble Company | Prostaglandin analogues |
| DE3347128A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4911920A (en) * | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| US4587257A (en) * | 1984-12-14 | 1986-05-06 | Alcon Laboratories, Inc. | Control of ocular bleeding using clonidine derivatives |
| DE3871596T3 (de) * | 1987-04-03 | 2000-09-07 | Pharmacia & Upjohn Ab, Stockholm | Anwendung eines Prostaglandins in Mischung mit einem adrenergischen Blocker zur Verminderung des Augen-Innendruckes. |
| CA1324129C (en) * | 1987-04-30 | 1993-11-09 | Ryuzo Ueno | Prostaglandins of the f series |
| IL87116A (en) * | 1987-07-17 | 1993-03-15 | Schering Ag | 9-halogen-(z)-prostaglandin derivatives and pharmaceutical compositions containing the same |
| WO1990002553A1 (en) * | 1988-09-06 | 1990-03-22 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| EP0366279B1 (en) * | 1988-10-01 | 1994-09-21 | R-Tech Ueno Ltd. | Ocular hypotensive agents |
| CA2014038A1 (en) * | 1989-05-25 | 1990-11-25 | Charles Gluchowski | Intraocular pressure reducing 15-acyl prostaglandins |
| DE3923797A1 (de) * | 1989-07-14 | 1991-01-24 | Schering Ag | 9-fluor-prostaglandin-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| US4994274A (en) * | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| US5093329A (en) * | 1990-03-12 | 1992-03-03 | Allergan, Inc. | Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives |
| WO1991014428A1 (en) * | 1990-03-19 | 1991-10-03 | Allergan, Inc. | USE OF 5-TRANS PROSTAGLANDIN F2α AS AN OCULAR HYPOTENSIVE AGENT |
| ATE117208T1 (de) * | 1990-05-22 | 1995-02-15 | R Tech Ueno Ltd | Behandlung von intraokularem druck mit einer ophthalmischen synergistischen kombination. |
| US5212162A (en) * | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
-
1993
- 1993-10-12 AT AT93923372T patent/ATE153855T1/de not_active IP Right Cessation
- 1993-10-12 EP EP93923372A patent/EP0664707B1/en not_active Expired - Lifetime
- 1993-10-12 AU AU53286/94A patent/AU674038B2/en not_active Ceased
- 1993-10-12 ES ES93923372T patent/ES2105333T3/es not_active Expired - Lifetime
- 1993-10-12 CA CA002146127A patent/CA2146127C/en not_active Expired - Fee Related
- 1993-10-12 DE DE69311361T patent/DE69311361T2/de not_active Expired - Lifetime
- 1993-10-12 WO PCT/US1993/009742 patent/WO1994008585A1/en not_active Ceased
- 1993-10-12 JP JP6510215A patent/JP3002258B2/ja not_active Expired - Fee Related
-
1995
- 1995-04-10 US US08/422,570 patent/US5480900A/en not_active Expired - Lifetime
- 1995-12-12 US US08/571,326 patent/US5605922A/en not_active Expired - Lifetime
-
1997
- 1997-02-21 US US08/803,667 patent/US5811443A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0664707B1 (en) | 1997-06-04 |
| CA2146127C (en) | 2000-06-13 |
| HK1007102A1 (en) | 1999-04-01 |
| EP0664707A1 (en) | 1995-08-02 |
| DE69311361T2 (de) | 1998-01-08 |
| US5480900A (en) | 1996-01-02 |
| JPH08502485A (ja) | 1996-03-19 |
| US5605922A (en) | 1997-02-25 |
| AU674038B2 (en) | 1996-12-05 |
| US5811443A (en) | 1998-09-22 |
| AU5328694A (en) | 1994-05-09 |
| WO1994008585A1 (en) | 1994-04-28 |
| JP3002258B2 (ja) | 2000-01-24 |
| ATE153855T1 (de) | 1997-06-15 |
| DE69311361D1 (de) | 1997-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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