ATE156020T1 - Lipid-beschichtete mikrobläschen, ihre paramagnetische markierung und ihre therapeutische anwendung - Google Patents

Lipid-beschichtete mikrobläschen, ihre paramagnetische markierung und ihre therapeutische anwendung

Info

Publication number
ATE156020T1
ATE156020T1 AT91107692T AT91107692T ATE156020T1 AT E156020 T1 ATE156020 T1 AT E156020T1 AT 91107692 T AT91107692 T AT 91107692T AT 91107692 T AT91107692 T AT 91107692T AT E156020 T1 ATE156020 T1 AT E156020T1
Authority
AT
Austria
Prior art keywords
microbubbles
lipid
relates
therapeutic application
coated microbubbles
Prior art date
Application number
AT91107692T
Other languages
English (en)
Inventor
Arrigo Joseph S D
Original Assignee
Cavitation Control Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cavitation Control Technology filed Critical Cavitation Control Technology
Application granted granted Critical
Publication of ATE156020T1 publication Critical patent/ATE156020T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT91107692T 1990-07-10 1991-05-13 Lipid-beschichtete mikrobläschen, ihre paramagnetische markierung und ihre therapeutische anwendung ATE156020T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/550,620 US5215680A (en) 1990-07-10 1990-07-10 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles

Publications (1)

Publication Number Publication Date
ATE156020T1 true ATE156020T1 (de) 1997-08-15

Family

ID=24197921

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91107692T ATE156020T1 (de) 1990-07-10 1991-05-13 Lipid-beschichtete mikrobläschen, ihre paramagnetische markierung und ihre therapeutische anwendung

Country Status (5)

Country Link
US (1) US5215680A (de)
EP (1) EP0467031B1 (de)
AT (1) ATE156020T1 (de)
AU (1) AU657480B2 (de)
DE (1) DE69127032T2 (de)

Families Citing this family (335)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
CA2068334C (en) * 1990-10-05 1996-09-03 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5569180A (en) * 1991-02-14 1996-10-29 Wayne State University Method for delivering a gas-supersaturated fluid to a gas-depleted site and use thereof
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
EP0732106A3 (de) 1991-03-22 2003-04-09 Katsuro Tachibana Mikrobläschen enthaltende Verstärker zur Ultraschalltherapie von Erkrankungen
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
FI940027A7 (fi) * 1991-07-05 1994-01-04 Nycomed Imaging As Parannuksia itse varjoaineisiin tai parannuksia, jotka liittyvät niihi n
KR100191303B1 (ko) * 1991-09-17 1999-06-15 씨. 큐웨이 스티븐 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
CA2154590C (en) * 1993-01-25 2001-06-12 Steven C. Quay Phase shift colloids as ultrasound contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
AU731072B2 (en) * 1993-06-11 2001-03-22 Dupont Contrast Imaging, Inc Methods of preparing gas-filled liposomes
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
DE4330958A1 (de) * 1993-09-09 1995-03-16 Schering Ag Neue wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
US5433207A (en) * 1993-11-15 1995-07-18 Pretlow, Iii; Robert A. Method and apparatus to characterize ultrasonically reflective contrast agents
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PT682530E (pt) 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent
GB9402867D0 (en) * 1994-02-15 1994-04-06 Nycomed Imaging As Improvements in or relating to contrast agents
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
EP0699445A3 (de) * 1994-08-04 1996-04-17 Gakko Houjin Toin Gakuen Verfahren zur Herstellung eines Mikrobläschen-Ultraschallkontrastmittels mit einem Tensid
US5509896A (en) * 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
GB9423419D0 (en) 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
GB2313310B (en) * 1995-01-19 1999-03-17 Cate Folkert Jan Ten Local delivery and monitoring of drugs
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6027448A (en) * 1995-03-02 2000-02-22 Acuson Corporation Ultrasonic transducer and method for harmonic imaging
US6104670A (en) * 1995-03-02 2000-08-15 Acuson Corporation Ultrasonic harmonic imaging system and method
US6009046A (en) * 1995-03-02 1999-12-28 Acuson Corporation Ultrasonic harmonic imaging system and method
US5608690A (en) * 1995-03-02 1997-03-04 Acuson Corporation Transmit beamformer with frequency dependent focus
US6005827A (en) 1995-03-02 1999-12-21 Acuson Corporation Ultrasonic harmonic imaging system and method
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US5855775A (en) 1995-05-05 1999-01-05 Kerfoot; William B. Microporous diffusion apparatus
USRE43350E1 (en) 1995-05-05 2012-05-08 Think Village-Kerfoot, Llc Microporous diffusion apparatus
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
WO1997029678A2 (en) 1996-02-15 1997-08-21 Biosense Inc. Catheter calibration and usage monitoring system
US6453190B1 (en) 1996-02-15 2002-09-17 Biosense, Inc. Medical probes with field transducers
IL125761A (en) 1996-02-15 2005-05-17 Biosense Inc Independently positionable transducers for location system
US6253770B1 (en) 1996-02-15 2001-07-03 Biosense, Inc. Catheter with lumen
DE69726576T2 (de) 1996-02-15 2004-10-14 Biosense, Inc., Miami Probe zur Ortsmarkierung
ES2243976T3 (es) 1996-02-15 2005-12-01 Biosense Webster, Inc. Bobinas moviles de transmision o recepcion para sistema de localizacion.
DE69733815T2 (de) * 1996-02-15 2006-06-08 Biosense Webster, Inc., Diamond Bar Sonde zur exkavation
ES2241037T3 (es) 1996-02-15 2005-10-16 Biosense Webster, Inc. Determinacion precisa de la posicion de endoscopios.
DE69733341T2 (de) 1996-02-27 2006-02-02 Biosense Webster, Inc., Diamond Bar Ortungsverfahren mit feldbestätigungssequenzen
AU1983397A (en) * 1996-02-29 1997-09-16 Acuson Corporation Multiple ultrasound image registration system, method and transducer
BR9707936B1 (pt) * 1996-03-05 2010-12-14 composiÇço formadora de imagem atravÉs de ultra-som.
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5676692A (en) * 1996-03-28 1997-10-14 Indianapolis Center For Advanced Research, Inc. Focussed ultrasound tissue treatment method
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
DE19626530A1 (de) * 1996-07-02 1998-01-15 Byk Gulden Lomberg Chem Fab MR-Kontrastmittelzubereitungen
BE1010407A4 (fr) * 1996-07-04 1998-07-07 Undatim Ultrasonics Procede et installation de traitement des eaux.
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
ES2289188T3 (es) 1996-09-11 2008-02-01 Bristol-Myers Squibb Medical Imaging, Inc. Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador.
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
AU7104598A (en) 1997-04-09 1998-10-30 Philipp Lang New technique to monitor drug delivery noninvasively (in vivo)
US6110120A (en) * 1997-04-11 2000-08-29 Acuson Corporation Gated ultrasound imaging apparatus and method
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
DE19724796A1 (de) * 1997-06-06 1998-12-10 Max Delbrueck Centrum Mittel zur Antitumortherapie
US6193659B1 (en) 1997-07-15 2001-02-27 Acuson Corporation Medical ultrasonic diagnostic imaging method and apparatus
US5833614A (en) * 1997-07-15 1998-11-10 Acuson Corporation Ultrasonic imaging method and apparatus for generating pulse width modulated waveforms with reduced harmonic response
US5913823A (en) * 1997-07-15 1999-06-22 Acuson Corporation Ultrasound imaging method and system for transmit signal generation for an ultrasonic imaging system capable of harmonic imaging
US6023977A (en) 1997-08-01 2000-02-15 Acuson Corporation Ultrasonic imaging aberration correction system and method
US6312379B1 (en) * 1997-08-15 2001-11-06 Acuson Corporation Ultrasonic harmonic imaging system and method using waveform pre-distortion
US5944666A (en) * 1997-08-21 1999-08-31 Acuson Corporation Ultrasonic method for imaging blood flow including disruption or activation of contrast agent
US5928151A (en) * 1997-08-22 1999-07-27 Acuson Corporation Ultrasonic system and method for harmonic imaging in three dimensions
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6623430B1 (en) 1997-10-14 2003-09-23 Guided Therapy Systems, Inc. Method and apparatus for safety delivering medicants to a region of tissue using imaging, therapy and temperature monitoring ultrasonic system
US6050943A (en) 1997-10-14 2000-04-18 Guided Therapy Systems, Inc. Imaging, therapy, and temperature monitoring ultrasonic system
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6685640B1 (en) 1998-03-30 2004-02-03 Focus Surgery, Inc. Ablation system
US5957852A (en) * 1998-06-02 1999-09-28 Acuson Corporation Ultrasonic harmonic imaging system and method
US7686763B2 (en) * 1998-09-18 2010-03-30 University Of Washington Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy
US6309355B1 (en) * 1998-12-22 2001-10-30 The Regents Of The University Of Michigan Method and assembly for performing ultrasound surgery using cavitation
US7549960B2 (en) 1999-03-11 2009-06-23 Biosense, Inc. Implantable and insertable passive tags
US7174201B2 (en) * 1999-03-11 2007-02-06 Biosense, Inc. Position sensing system with integral location pad and position display
US7558616B2 (en) * 1999-03-11 2009-07-07 Biosense, Inc. Guidance of invasive medical procedures using implantable tags
US7590441B2 (en) * 1999-03-11 2009-09-15 Biosense, Inc. Invasive medical device with position sensing and display
US7575550B1 (en) 1999-03-11 2009-08-18 Biosense, Inc. Position sensing based on ultrasound emission
US7510536B2 (en) * 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US7520856B2 (en) * 1999-09-17 2009-04-21 University Of Washington Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology
JP2003513691A (ja) 1999-10-25 2003-04-15 シーラス、コーポレイション 血管を封止するための集束超音波の使用
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US6308705B1 (en) * 1999-12-21 2001-10-30 Siemens Aktiengesellschaft Integrated lung therapy method
US6582611B1 (en) 2000-07-06 2003-06-24 William B. Kerfoot Groundwater and subsurface remediation
US8557110B2 (en) * 2000-07-06 2013-10-15 Thinkvillage-Kerfoot, Llc Groundwater and subsurface remediation
US7008535B1 (en) 2000-08-04 2006-03-07 Wayne State University Apparatus for oxygenating wastewater
US7914453B2 (en) 2000-12-28 2011-03-29 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
US6793626B2 (en) * 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
US6805798B2 (en) * 2001-05-18 2004-10-19 William B. Kerfoot Environmental remediation method and apparatus
KR100915741B1 (ko) * 2001-06-15 2009-09-04 코너스톤 파마슈티칼스 표적 조직 및 세포를 치료하기에 유용한 나노입자를함유하는 약제학적 및 진단학적 조성물
US6797257B2 (en) * 2001-06-26 2004-09-28 The Board Of Trustees Of The University Of Illinois Paramagnetic polymerized protein microspheres and methods of preparation thereof
US7780785B2 (en) * 2001-10-26 2010-08-24 Applied Materials, Inc. Gas delivery apparatus for atomic layer deposition
US7220239B2 (en) 2001-12-03 2007-05-22 Ekos Corporation Catheter with multiple ultrasound radiating members
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
CA2418229A1 (en) * 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
ES2402270T3 (es) * 2002-10-10 2013-04-30 Visualsonics Inc. Sistema de formación de imágenes por ultrasonidos de alta frecuencia y de alta frecuencia de fotogramas
US6921371B2 (en) 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
CN100340302C (zh) * 2002-11-04 2007-10-03 亚什兰许可和知识产权有限公司 利用超声波处理液体介质以防止过度增殖或感染细胞生长的设备与方法
EP1562642B1 (de) * 2002-11-04 2007-01-10 Ashland Inc. Vorrichtung und verfahren zur behandlung eines flüssigen mediums mittels ultraschall zur verhinderung des wachstums von hyperproliferativen oder infizierten zellen
US7442313B2 (en) * 2003-08-27 2008-10-28 Thinkvillage-Kerfoot, Llc Environmental remediation method and system
US7666316B2 (en) 2004-07-20 2010-02-23 Thinkvillage-Kerfoot, Llc Permanganate-coated ozone for groundwater and soil treatment with in-situ oxidation
US6913251B2 (en) 2003-02-12 2005-07-05 William B. Kerfoot Deep well sparging
US8302939B2 (en) * 2003-02-12 2012-11-06 Thinkvillage-Kerfoot, Llc Soil and water remediation system and method
US20030191396A1 (en) * 2003-03-10 2003-10-09 Sanghvi Narendra T Tissue treatment method and apparatus
US7048863B2 (en) * 2003-07-08 2006-05-23 Ashland Licensing And Intellectual Property Llc Device and process for treating cutting fluids using ultrasound
US20110040171A1 (en) * 2003-12-16 2011-02-17 University Of Washington Image guided high intensity focused ultrasound treatment of nerves
US7621696B2 (en) * 2006-07-12 2009-11-24 Thinkvillage-Kerfoot, Llc Directional microporous diffuser and directional sparging
US8771507B2 (en) 2003-12-24 2014-07-08 Thinkvillage-Kerfoot, Llc Directional microporous diffuser and directional sparging
US7651611B2 (en) * 2006-07-12 2010-01-26 Thinkvillage-Kerfoot, Llc Directional microporous diffuser and directional sparging
US7401767B2 (en) * 2003-12-24 2008-07-22 Kerfoot William B Directional microporous diffuser and directional sparging
US7569140B2 (en) * 2005-11-10 2009-08-04 Thinkvillage-Kerfoot, Llc Directional spargewell system
US7341569B2 (en) * 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US7662114B2 (en) * 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
WO2005107601A2 (en) * 2004-05-06 2005-11-17 Focus Surgery, Inc. Method and apparatus for the selective treatment of tissue
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
WO2006038926A1 (en) 2004-06-23 2006-04-13 Ashland Licensing And Intellectual Property Llc Devices and methods for treating fluids utilized in electrocoating processes with ultrasound
US9066679B2 (en) 2004-08-31 2015-06-30 University Of Washington Ultrasonic technique for assessing wall vibrations in stenosed blood vessels
US7393325B2 (en) 2004-09-16 2008-07-01 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment with a multi-directional transducer
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US7824348B2 (en) 2004-09-16 2010-11-02 Guided Therapy Systems, L.L.C. System and method for variable depth ultrasound treatment
AU2005284695A1 (en) * 2004-09-16 2006-03-23 University Of Washington Acoustic coupler using an independent water pillow with circulation for cooling a transducer
US7530958B2 (en) * 2004-09-24 2009-05-12 Guided Therapy Systems, Inc. Method and system for combined ultrasound treatment
US8444562B2 (en) 2004-10-06 2013-05-21 Guided Therapy Systems, Llc System and method for treating muscle, tendon, ligament and cartilage tissue
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
US7758524B2 (en) 2004-10-06 2010-07-20 Guided Therapy Systems, L.L.C. Method and system for ultra-high frequency ultrasound treatment
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US8690778B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Energy-based tissue tightening
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
EP2279699B1 (de) 2004-10-06 2019-07-24 Guided Therapy Systems, L.L.C. Verfahren zur nicht invasiven kosmetischen Verbesserung von Cellulitis
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US20060111744A1 (en) 2004-10-13 2006-05-25 Guided Therapy Systems, L.L.C. Method and system for treatment of sweat glands
KR20240113495A (ko) 2004-10-06 2024-07-22 가이디드 테라피 시스템스, 엘.엘.씨. 초음파 치료 시스템
US8133180B2 (en) 2004-10-06 2012-03-13 Guided Therapy Systems, L.L.C. Method and system for treating cellulite
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US8364256B2 (en) * 2004-11-15 2013-01-29 Coraje, Inc. Method and apparatus of removal of intravascular blockages
ES2440778T3 (es) 2004-11-17 2014-01-30 Ashland Licensing And Intellectual Property Llc Método para tratar fluidos refrigerantes utilizados en la fabricación de neumáticos
JP2008536562A (ja) * 2005-04-12 2008-09-11 イコス コーポレイション 空洞形成推進面が設けられた超音波カテーテル
EP1875327A2 (de) 2005-04-25 2008-01-09 Guided Therapy Systems, L.L.C. Verfahren und system zum verbessern der computerperipheriesicherheit
JP4630127B2 (ja) * 2005-05-17 2011-02-09 株式会社日立製作所 超音波診断治療装置
US8038631B1 (en) 2005-06-01 2011-10-18 Sanghvi Narendra T Laparoscopic HIFU probe
US20070038096A1 (en) * 2005-07-06 2007-02-15 Ralf Seip Method of optimizing an ultrasound transducer
US20070010805A1 (en) * 2005-07-08 2007-01-11 Fedewa Russell J Method and apparatus for the treatment of tissue
EP1921976A2 (de) * 2005-08-12 2008-05-21 University of Washington Verfahren und gerät zur vorbereitung von organen und geweben für eine laparoskopische operation
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7967763B2 (en) * 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
EP1928540A4 (de) * 2005-09-07 2010-03-10 The Foundry Inc Gerät und verfahren zur unterbrechung von subkutanen strukturen
US8414494B2 (en) * 2005-09-16 2013-04-09 University Of Washington Thin-profile therapeutic ultrasound applicators
US10219815B2 (en) 2005-09-22 2019-03-05 The Regents Of The University Of Michigan Histotripsy for thrombolysis
US8057408B2 (en) * 2005-09-22 2011-11-15 The Regents Of The University Of Michigan Pulsed cavitational ultrasound therapy
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy
JP2009509535A (ja) * 2005-09-27 2009-03-12 アムニクス， インコーポレイテッド タンパク様薬剤およびその使用
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US8016757B2 (en) * 2005-09-30 2011-09-13 University Of Washington Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
US8257338B2 (en) * 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US20080200863A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080014627A1 (en) * 2005-12-02 2008-01-17 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9248317B2 (en) * 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US8430863B2 (en) * 2005-12-02 2013-04-30 Abbott Cardiovascular Systems Inc. Visualization of a catheter viewed under ultrasound imaging
US20080200864A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080197517A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080195036A1 (en) * 2005-12-02 2008-08-14 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
ES2530526T3 (es) 2005-12-30 2015-03-03 Zensun Shanghai Science And Technology Ltd Liberación extendida de neurregulina para mejorar la función cardíaca
US7820137B2 (en) * 2006-08-04 2010-10-26 Enerdel, Inc. Lithium titanate and method of forming the same
EP2015846A2 (de) 2006-04-24 2009-01-21 Ekos Corporation Ultraschalltherapiesystem
EP2020988B1 (de) 2006-04-28 2017-08-16 Children's Hospital Medical Center Zusammensetzungen mit fusogenen proteinen oder polypeptiden aus prosaposin zur anwendung auf transmembrane wirkstofffreisetzungssysteme
WO2008018019A2 (en) * 2006-08-09 2008-02-14 Koninklijke Philips Electronics N. V. A device for and a method of activating a physiologically effective substance by ultrasonic waves, and a capsule
US20080039724A1 (en) * 2006-08-10 2008-02-14 Ralf Seip Ultrasound transducer with improved imaging
US9566454B2 (en) 2006-09-18 2017-02-14 Guided Therapy Systems, Llc Method and sysem for non-ablative acne treatment and prevention
US7559905B2 (en) * 2006-09-21 2009-07-14 Focus Surgery, Inc. HIFU probe for treating tissue with in-line degassing of fluid
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
FR2914303A1 (fr) * 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
EP2152351B1 (de) 2007-05-07 2016-09-21 Guided Therapy Systems, L.L.C. Verfahren und systeme zur modulierung von medikamenten mit akustischer energie
US20150174388A1 (en) 2007-05-07 2015-06-25 Guided Therapy Systems, Llc Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue
JP4279328B2 (ja) * 2007-05-07 2009-06-17 株式会社日立製作所 超音波撮像システム
ES2471118T3 (es) 2007-06-22 2014-06-25 Ekos Corporation Método y aparato para el tratamiento de hemorragias intracraneales
JP2010536341A (ja) * 2007-08-15 2010-12-02 アムニクス， インコーポレイテッド 生物学的に活性なポリペプチドの特性を改変するための組成物および方法
US8235902B2 (en) * 2007-09-11 2012-08-07 Focus Surgery, Inc. System and method for tissue change monitoring during HIFU treatment
US20090093723A1 (en) * 2007-10-05 2009-04-09 Cabochon Aesthetics, Inc. Ultrasound device including dispenser
US20090093738A1 (en) * 2007-10-09 2009-04-09 Cabochon Aesthetics, Inc. Device and method for monitoring a treatment area
WO2009048969A1 (en) * 2007-10-09 2009-04-16 Cabochon Aesthetics, Inc. Ultrasound apparatus with treatment lens
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
EP2227147A1 (de) 2007-11-21 2010-09-15 Focus Surgery, Inc. Verfahren zur diagnose und behandlung von tumoren mit fokussiertem hochintensitäts-ultraschall
WO2009079415A1 (en) * 2007-12-14 2009-06-25 Ekos Corporation Ultrasound pulse shaping
US12102473B2 (en) 2008-06-06 2024-10-01 Ulthera, Inc. Systems for ultrasound treatment
KR102087909B1 (ko) 2008-06-06 2020-03-12 얼테라, 인크 코스메틱 치료 시스템
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
EP2168666A1 (de) * 2008-09-25 2010-03-31 Gambro Lundia AB Bestrahlte Membran für Zellexpansion
US20100106063A1 (en) * 2008-10-29 2010-04-29 Cabochon Aesthetics, Inc. Ultrasound Enhancing Target for Treating Subcutaneous Tissue
US20100160781A1 (en) * 2008-12-09 2010-06-24 University Of Washington Doppler and image guided device for negative feedback phased array hifu treatment of vascularized lesions
JP2012513837A (ja) 2008-12-24 2012-06-21 ガイデッド セラピー システムズ， エルエルシー 脂肪減少および／またはセルライト処置のための方法およびシステム
US8201811B2 (en) * 2009-01-12 2012-06-19 Jason International, Inc. Microbubble therapy method and generating apparatus
US9060916B2 (en) 2009-01-12 2015-06-23 Jason International, Inc. Microbubble therapy method and generating apparatus
US8322634B2 (en) * 2009-01-12 2012-12-04 Jason International, Inc. Microbubble therapy method and generating apparatus
US8579266B2 (en) * 2009-01-12 2013-11-12 Jason International, Inc. Microbubble therapy method and generating apparatus
US8720867B2 (en) * 2009-01-12 2014-05-13 Jason International, Inc. Microbubble therapy method and generating apparatus
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
US8167280B2 (en) * 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
US20100256596A1 (en) * 2009-04-07 2010-10-07 Cabochon Aesthetics, Inc. Fiber growth promoting implants for reducing the appearance of cellulite
WO2010123918A1 (en) 2009-04-20 2010-10-28 Drexel University Encapsulation of microbubbles within the aqueous core of microcapsules
WO2010144508A1 (en) 2009-06-08 2010-12-16 Amunix Operating Inc. Glucose-regulating polypeptides and methods of making and using same
KR101813727B1 (ko) 2009-06-08 2018-01-02 아뮤닉스 오퍼레이팅 인코포레이티드 성장 호르몬 폴리펩타이드 및 이를 제조하고 사용하는 방법
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
WO2011022411A2 (en) 2009-08-17 2011-02-24 Histosonics, Inc. Disposable acoustic coupling medium container
CA2771999A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
US9901753B2 (en) 2009-08-26 2018-02-27 The Regents Of The University Of Michigan Ultrasound lithotripsy and histotripsy for using controlled bubble cloud cavitation in fractionating urinary stones
US9943708B2 (en) 2009-08-26 2018-04-17 Histosonics, Inc. Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time
US8539813B2 (en) 2009-09-22 2013-09-24 The Regents Of The University Of Michigan Gel phantoms for testing cavitational ultrasound (histotripsy) transducers
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US11998266B2 (en) 2009-10-12 2024-06-04 Otsuka Medical Devices Co., Ltd Intravascular energy delivery
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
CN102695723A (zh) 2009-10-30 2012-09-26 中枢神经系统治疗学公司 改进的神经营养因子分子
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
EP2600783A4 (de) 2010-08-02 2017-05-17 Guided Therapy Systems, L.L.C. Ultraschallbehandlungssysteme und -verfahren
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
DE102011000264B4 (de) 2011-01-21 2019-01-17 Surflay Nanotec Gmbh Mikrogasbläschen mit PVA-Wand, Herstellung und Verwendung von solchen Mikrogasbläschen
ITRM20110022A1 (it) * 2011-01-21 2012-07-22 Gaio Paradossi Metodo per la preparazione di microbolle comprendenti un agente di contrasto
WO2013009785A2 (en) 2011-07-10 2013-01-17 Guided Therapy Systems, Llc. Systems and methods for improving an outside appearance of skin using ultrasound as an energy source
KR20190080967A (ko) 2011-07-11 2019-07-08 가이디드 테라피 시스템스, 엘.엘.씨. 조직에 초음파원을 연결하는 시스템 및 방법
US9144694B2 (en) 2011-08-10 2015-09-29 The Regents Of The University Of Michigan Lesion generation through bone using histotripsy therapy without aberration correction
JP6256882B2 (ja) 2012-02-15 2018-01-10 アムニクス オペレーティング インコーポレイテッド 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
EP2822577B1 (de) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Rekombinante faktor-viii-proteine
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
US9049783B2 (en) 2012-04-13 2015-06-02 Histosonics, Inc. Systems and methods for obtaining large creepage isolation on printed circuit boards
US9636133B2 (en) 2012-04-30 2017-05-02 The Regents Of The University Of Michigan Method of manufacturing an ultrasound system
US20150196638A1 (en) * 2012-07-08 2015-07-16 Sunnybrook Health Sciences Centre System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
EP2903688A4 (de) 2012-10-05 2016-06-15 Univ Michigan Blaseninduziertes farbdoppler-feedback während einer histotripsie
US9694401B2 (en) 2013-03-04 2017-07-04 Kerfoot Technologies, Inc. Method and apparatus for treating perfluoroalkyl compounds
CN204017181U (zh) 2013-03-08 2014-12-17 奥赛拉公司 美学成像与处理系统、多焦点处理系统和执行美容过程的系统
US10561862B2 (en) 2013-03-15 2020-02-18 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
US11432900B2 (en) 2013-07-03 2022-09-06 Histosonics, Inc. Articulating arm limiter for cavitational ultrasound therapy system
EP4166194A1 (de) 2013-07-03 2023-04-19 Histosonics, Inc. Für blasenwolkenbildung mittels schockstreuung optimierte histotripsieerregungssequenzen
TW202003554A (zh) 2013-08-14 2020-01-16 美商百歐維拉提夫治療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
US10780298B2 (en) 2013-08-22 2020-09-22 The Regents Of The University Of Michigan Histotripsy using very short monopolar ultrasound pulses
AU2015236106A1 (en) 2014-03-25 2016-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Army Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (MPLA)-containing liposome composition and a saponin
SG11201608691YA (en) 2014-04-18 2016-11-29 Ulthera Inc Band transducer ultrasound therapy
CN104353088A (zh) * 2014-09-30 2015-02-18 东南大学 一种脂质气泡的制备方法
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
EP3307388B1 (de) 2015-06-10 2022-06-22 Ekos Corporation Ultraschallkatheter
EP4230262A3 (de) 2015-06-24 2023-11-22 The Regents Of The University Of Michigan System für histotripsietherapie zur behandlung des hirngewebes
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
CN108778289B (zh) 2015-11-06 2020-11-17 佐剂技术公司 三萜皂苷类似物
US11110185B2 (en) * 2015-11-30 2021-09-07 Ge Healthcare As Combination formulation
CA3007665A1 (en) 2016-01-18 2017-07-27 Ulthera, Inc. Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
IL264440B (en) 2016-08-16 2022-07-01 Ulthera Inc Systems and methods for cosmetic treatment of the skin using ultrasound
MX2019006444A (es) 2016-12-02 2019-10-30 Bioverativ Therapeutics Inc Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
CA3061205A1 (en) 2017-04-25 2018-11-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues
SG11202001826YA (en) 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues
TW202529848A (zh) 2018-01-26 2025-08-01 美商奧賽拉公司 用於多個維度中的同時多聚焦超音治療的系統和方法
WO2019164836A1 (en) 2018-02-20 2019-08-29 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
KR102289921B1 (ko) * 2018-03-20 2021-08-17 (주)바이오인프라생명과학 약물전달을 위한 초음파 반응형 미소기포를 포함하는 리포좀 제조 방법 및 이를 이용한 리포좀
PL3793588T3 (pl) 2018-05-18 2025-09-01 Bioverativ Therapeutics Inc. Sposoby leczenia hemofilii a
CN113286552B (zh) 2018-11-28 2025-05-02 希斯托索尼克斯公司 组织摧毁术系统及方法
JP2022513577A (ja) 2018-11-30 2022-02-09 ウルセラ インコーポレイテッド 超音波処置の効能を増強させるためのシステムおよび方法
CA3137928A1 (en) 2019-07-15 2021-01-21 Ulthera, Inc. Systems and methods for measuring elasticity with imaging of ultrasound multi-focus shearwaves in multiple dimensions
WO2021155026A1 (en) 2020-01-28 2021-08-05 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
JP2023530477A (ja) 2020-06-18 2023-07-18 ヒストソニックス，インコーポレーテッド 組織破砕音響／患者結合システムおよび方法
KR20230041711A (ko) 2020-06-25 2023-03-24 아뮤닉스 파마슈티컬스, 인크. Her-2 표적화 이중특이적 조성물 및 이의 제조 및 사용 방법
EP4204084A4 (de) 2020-08-27 2024-10-09 The Regents Of The University Of Michigan Ultraschallwandler mit sende-empfangs-fähigkeit für histotripsie
EP4351718A4 (de) 2021-06-07 2025-03-26 The Regents of The University of Michigan Minimal invasive histotripsiesysteme und verfahren
IL308943A (en) 2021-06-07 2024-01-01 Univ Michigan Regents All-inclusive ultrasound systems and methods that include histotripsy
JP2025509460A (ja) 2022-03-14 2025-04-11 ファイザー・インク アジュバントを生産するための方法
AU2023366591A1 (en) 2022-10-28 2025-04-24 Histosonics, Inc. Histotripsy systems and methods
WO2024221001A2 (en) 2023-04-20 2024-10-24 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy
TWI909678B (zh) 2023-09-13 2025-12-21 美商輝瑞股份有限公司 產製佐劑之方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
DE3577185D1 (de) * 1984-11-01 1990-05-23 Nycomed As Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon.
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
DK175531B1 (da) * 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Leveringsvehikel med amphiphil-associeret aktiv bestanddel
DE3741199A1 (de) * 1987-12-02 1989-08-17 Schering Ag Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie
US4927637A (en) * 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US5078986A (en) * 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same

Also Published As

Publication number Publication date
EP0467031A3 (en) 1992-11-25
US5215680A (en) 1993-06-01
DE69127032T2 (de) 1998-02-26
AU8029791A (en) 1992-01-16
EP0467031B1 (de) 1997-07-30
DE69127032D1 (de) 1997-09-04
AU657480B2 (en) 1995-03-16
EP0467031A2 (de) 1992-01-22

Similar Documents

Publication Publication Date Title
ATE156020T1 (de) Lipid-beschichtete mikrobläschen, ihre paramagnetische markierung und ihre therapeutische anwendung
EP0788348A4 (de) Behälter mit einer mehrphasigen zusammensetzung zur verwendung in der diagnostik und therapie
FR2627075B1 (fr) Procede, implants et appareillage pour produire des images d'organes ou de l'organisme
DE69412552D1 (de) Medizinisches Instrument zur Behandlung von Sinusitis
FR2551967B1 (fr) Appareil chirurgical utilise pour l'immobilisation de fractures osseuses
NO844017L (no) Spormerkede konjugater av metallothionein og maalsoekende biologiske aktive molekyler
ITMI940241A0 (it) Sistema catalitico e processo per la produzione di polidiolefine
FR2669465B1 (fr) Source d'electrons et procede de realisation.
IT1181194B (it) Procedimento per attivare biologicamente la depurazione di acque di scarico contenenti materiali azotati, e dispositivo per l'effettuazione di tale procedimento
EP0855891A4 (de) Absorbierendes material mit verbesserter, absorbierender durchlässigkeit und zugehöriges herstellungsverfahren
MA21922A1 (fr) Procede de purification d'acides aminomethylene-phosphoniques .
FR2577130B1 (fr) Endoscope pour l'examen de l'uretere et du rein
FR2778661B1 (fr) Procede de preparation d'aminonitrile et de diamine
FR2687687B1 (fr) Procede pour mesurer la taille de fragments d'adn.
FR2727750B1 (fr) Procede et dispositif pour la preparation d'air de qualite medicale
DE69521777D1 (de) Methode und Vorrichtung zur Bandbegrenzung von Bildbewegungssignalen
FR2644161B1 (fr) Procede de preparation d'amides n-arylsubstitues
FR2757179B1 (fr) Procede de preparation d'amides de l'acide acrylique ou methacrylique
FR2663325B1 (fr) Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide a partir de la 2,3-dihydro 2-methyl 1h-indole et de l'acide hydroxylamine-o-sulfonique.
MA21723A1 (fr) Procede et appareil d'infusion de mais.
EP0974581A4 (de) Verfahren zur herstellung von peroxysäure im gleichgewicht und verfahren zur herstellung von lacton
FR2758135B1 (fr) Procedes et dispositifs pour la desinfection et le recyclage d'un effluent aqueux
FR2697249B1 (fr) Procédé de préparation du bis(1,3-dihydroxypropylamide) d'acide L-5-(2-acétoxypropionylamino)-2,4,6-triiodo-isophtalique.
FR2769624B1 (fr) Procede de preparation d'acide carboxylique
FR2510127B1 (fr) Appareil chirurgical en polyamide aliphatique et procede pour sa fabrication

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties