ATE156358T1 - Verfahren zur behandlung von androgener lopecia mit 5-alpha-reduktase-hemmern - Google Patents

Verfahren zur behandlung von androgener lopecia mit 5-alpha-reduktase-hemmern

Info

Publication number
ATE156358T1
ATE156358T1 AT94930701T AT94930701T ATE156358T1 AT E156358 T1 ATE156358 T1 AT E156358T1 AT 94930701 T AT94930701 T AT 94930701T AT 94930701 T AT94930701 T AT 94930701T AT E156358 T1 ATE156358 T1 AT E156358T1
Authority
AT
Austria
Prior art keywords
alpha
lopecia
reductase inhibitors
treating
treating androgenic
Prior art date
Application number
AT94930701T
Other languages
English (en)
Inventor
Glenn J Gormley
Keith D Kaufman
Elizabeth Stoner
Joanne Waldstreicher
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26836279&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE156358(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/214,905 external-priority patent/US5547957A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE156358T1 publication Critical patent/ATE156358T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94930701T 1993-10-15 1994-10-11 Verfahren zur behandlung von androgener lopecia mit 5-alpha-reduktase-hemmern ATE156358T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13852093A 1993-10-15 1993-10-15
US08/214,905 US5547957A (en) 1993-10-15 1994-03-17 Method of treating androgenic alopecia with 5-α reductase inhibitors

Publications (1)

Publication Number Publication Date
ATE156358T1 true ATE156358T1 (de) 1997-08-15

Family

ID=26836279

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94930701T ATE156358T1 (de) 1993-10-15 1994-10-11 Verfahren zur behandlung von androgener lopecia mit 5-alpha-reduktase-hemmern

Country Status (28)

Country Link
US (3) US5824686A (de)
EP (1) EP0724444B1 (de)
JP (1) JP3058351B2 (de)
CN (1) CN1096861C (de)
AT (1) ATE156358T1 (de)
BG (1) BG62756B1 (de)
BR (1) BR9407824A (de)
CA (1) CA2173457C (de)
CY (1) CY2071B1 (de)
CZ (1) CZ287104B6 (de)
DE (1) DE69404854T2 (de)
DK (1) DK0724444T3 (de)
DZ (1) DZ1817A1 (de)
ES (1) ES2105774T3 (de)
FI (1) FI961632L (de)
GR (1) GR3024375T3 (de)
HR (1) HRP940673B1 (de)
HU (1) HU227861B1 (de)
IL (1) IL111293A (de)
LV (1) LV12103B (de)
MX (1) MXPA99002296A (de)
NO (1) NO309927B1 (de)
NZ (1) NZ275678A (de)
PL (1) PL184930B1 (de)
RO (1) RO116864B1 (de)
SK (1) SK282352B6 (de)
TW (1) TW382595B (de)
WO (1) WO1995010284A1 (de)

Families Citing this family (26)

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US5547957A (en) * 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
NL1005445C2 (nl) * 1997-03-05 1998-09-21 Gho St Holding B V Werkwijze voor het vermenigvuldigen van haar.
US5935968A (en) * 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
CA2298851A1 (en) 1997-07-29 1999-02-11 Sankyo Company Limited Remedial agent for baldness and other diseases
US6348348B1 (en) 1998-04-07 2002-02-19 The Carnegie Institution Of Washington Human hairless gene and protein
IL124764A0 (en) * 1998-06-04 1999-01-26 Univ Ben Gurion Topical composition for treatment of baldness
JP2002530332A (ja) 1998-11-20 2002-09-17 ザ ゼネラル ホスピタル コーポレーション 毛の成長を促進するためのピレスロイド化合物の使用
WO2001005364A1 (en) * 1999-07-15 2001-01-25 The Procter & Gamble Company Nitrogen-containing steroid compounds and their use to regulate hair growth
ES2158828B1 (es) * 2000-02-22 2002-03-16 Tobajas Maximo Gomez Metodo cosmetico para estimular el nacimiento y el crecimiento del cabello.
DE60027332D1 (de) * 2000-09-04 2006-05-24 Ravi Shrivastava Synergistische pflanzenmischung gegen haarausfall
ES2267945T3 (es) * 2001-05-31 2007-03-16 Pfizer Products Inc. Uso medico de compuestos tiromimeticos para tratar la perdida del cabello y composiciones.
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
ES2287474T3 (es) 2002-04-24 2007-12-16 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Combinacion farmaceutica para el tratamiento de la hiperplasia prostatica benigna o para la prevencion a la largo plazo de la retencion urinaria aguda.
CN100581532C (zh) * 2004-03-16 2010-01-20 Lg生活健康株式会社 毛发生长剂组合物
FR2954124B1 (fr) * 2009-12-18 2012-04-06 Fabre Pierre Dermo Cosmetique Utilisation du 2,3-dihydroxypropyl dodecanoate pour le traitement de la seborrhee
CN103313693A (zh) * 2010-08-05 2013-09-18 传世健康护理控股有限公司 用于刺激毛发生长的方法
BR112013018679B1 (pt) * 2011-01-21 2022-04-12 Igisu Co. Ltd. Agente para o tratamento da alopecia e uso de um peptídeo natriurético do tipo c
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
EP2757881A4 (de) 2011-09-15 2014-11-12 Univ Kansas Kappa-opiatrezeptor-effektoren und verwendungen davon
EP2703003A1 (de) 2012-08-31 2014-03-05 Probelte Biotecnologia S.L. Granatapfelextrakt und Zusammensetzungen mit Polyphenolen aus Granatäpfeln zur Behandlung oder Vorbeugung von Krankheiten oder physiopathologischen Zuständen, die mit einer überschiessenden Genexpression und/oder physiologischen Aktivität von Interleukin-6 einhergehen
US11696883B2 (en) * 2014-05-23 2023-07-11 Triple Hair Inc. Compositions for reducing hair loss and/or increasing hair regrowth
HRP20211765T1 (hr) * 2017-06-16 2022-02-18 Capilli Med Gmbh Kompozicija za sprječavanje opadanja kose i za pospješivanje rasta kose
US11331300B2 (en) * 2017-12-22 2022-05-17 Richard Postrel Reversing baldness through follicle regeneration
US12661364B2 (en) 2019-06-28 2026-06-23 Koff Investments Llp Remedy for hair growth enhancing
FR3106058B1 (fr) * 2020-01-09 2022-01-07 Oreal Procédé de traitement cosmétique
CN113398263B (zh) * 2021-08-06 2022-11-11 广东巧巧生物科技有限公司 一种治疗脱发的洗发水

Family Cites Families (28)

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US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
US4396615A (en) * 1981-06-24 1983-08-02 Duke University Method of treating androgen-related disorders
US4885289A (en) * 1983-12-12 1989-12-05 Breuer Miklos M Alteration of character of male beard growth
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
ZA851426B (en) 1984-02-27 1986-10-29 Merck & Co Inc 17 beta-n-monosubstituted carbamoyl-4-aza-5 alpha-androst-1-en-3-ones as 5 alpha reductase inhibitors
US5571817A (en) * 1984-02-27 1996-11-05 Merck & Co., Inc. Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US4684635A (en) * 1984-05-11 1987-08-04 Norman Orentreich Compositions and methods for inhibiting the action of androgens
US5053403A (en) * 1984-05-11 1991-10-01 Norman Orentreich Methods for treatment of male-pattern baldness
DE3888994T2 (de) * 1987-04-03 1994-11-03 Merck & Co Inc Behandlung von androgener Alopecia mit 17-beta-n-mono-substituierten-carbamoyl-4-aza-5-alpha-androst-1-en-3-onen.
US5228431A (en) * 1990-04-26 1993-07-20 Giarretto Ralph R Drug-free method for treatment of the scalp for therapeutic purposes
WO1992002225A1 (en) * 1990-08-10 1992-02-20 The Upjohn Company STIMULATION OF HAIR GROWTH WITH POTASSIUM CHANNEL OPENERS AND 5α-REDUCTASE INHIBITORS
US5175155A (en) * 1991-10-07 1992-12-29 Sterling Winthrop Inc. Win 49596-finasteride method of use and compositions
ATE198601T1 (de) * 1992-05-20 2001-01-15 Merck & Co Inc Ester derivate von 4-aza-steroiden
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
US5407944A (en) * 1993-02-19 1995-04-18 Goldman; Boris E. Compositions and methods for promoting hair growth
US5438061A (en) * 1993-07-16 1995-08-01 Merck & Co., Inc. 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5547957A (en) * 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
US5708001A (en) * 1993-12-17 1998-01-13 Glaxo Wellcome Inc. Substituted 6-azaandrostenones
US5525608A (en) * 1994-04-20 1996-06-11 Merck & Co., Inc. 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
US5512555A (en) * 1994-07-21 1996-04-30 Merck & Co., Inc. Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
US5777134A (en) * 1995-10-26 1998-07-07 Merck & Co., Inc. 4-oxa and 4-thia steriods
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
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Also Published As

Publication number Publication date
BG62756B1 (bg) 2000-07-31
CZ108196A3 (en) 1996-08-14
HUT74426A (en) 1996-12-30
FI961632A0 (fi) 1996-04-12
IL111293A0 (en) 1994-12-29
SK44896A3 (en) 1997-03-05
JPH09505034A (ja) 1997-05-20
AU688395B2 (en) 1998-03-12
NZ275678A (en) 1999-09-29
DZ1817A1 (fr) 2002-02-17
NO961497L (no) 1996-04-15
CZ287104B6 (en) 2000-09-13
TW382595B (en) 2000-02-21
US5824686A (en) 1998-10-20
FI961632A7 (fi) 1996-04-12
US5981543A (en) 1999-11-09
NO309927B1 (no) 2001-04-23
RO116864B1 (ro) 2001-07-30
BG100510A (bg) 1996-11-29
US5760046A (en) 1998-06-02
WO1995010284A1 (en) 1995-04-20
SK282352B6 (sk) 2002-01-07
FI961632L (fi) 1996-04-12
CA2173457A1 (en) 1995-04-20
NO961497D0 (no) 1996-04-15
LV12103A (lv) 1998-08-20
PL316854A1 (en) 1997-02-17
HRP940673B1 (en) 2000-02-29
MXPA99002296A (es) 2004-08-27
CA2173457C (en) 1999-03-23
PL184930B1 (pl) 2003-01-31
HU9600976D0 (en) 1996-06-28
LV12103B (en) 1998-10-20
IL111293A (en) 1998-08-16
EP0724444B1 (de) 1997-08-06
EP0724444A1 (de) 1996-08-07
DE69404854T2 (de) 1998-02-19
CY2071B1 (en) 1998-09-11
DK0724444T3 (da) 1997-09-15
ES2105774T3 (es) 1997-10-16
HRP940673A2 (en) 1997-02-28
AU7974294A (en) 1995-05-04
HU227861B1 (en) 2012-05-02
JP3058351B2 (ja) 2000-07-04
DE69404854D1 (de) 1997-09-11
GR3024375T3 (en) 1997-11-28
CN1096861C (zh) 2002-12-25
CN1137237A (zh) 1996-12-04
BR9407824A (pt) 1997-05-06

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