ATE156482T1 - 1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen - Google Patents

1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen

Info

Publication number: ATE156482T1
Authority: AT; Austria
Prior art keywords: methyl; triphenyl; inflammatory; hydrido; trifluoromethyl
Prior art date: 1993-11-30

Application number

AT95901779T

Other languages

English (en)

Inventor

Len F Lee

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-30

Filing date

1994-11-14

Publication date

1997-08-15

1994-11-14 Application filed by Searle & Co filed Critical Searle & Co

1997-08-15 Application granted granted Critical

1997-08-15 Publication of ATE156482T1 publication Critical patent/ATE156482T1/de

Links

GAAAZLAWPPVHHL-UHFFFAOYSA-N 1,4,5-triphenylpyrazole Chemical class C1=NN(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 GAAAZLAWPPVHHL-UHFFFAOYSA-N 0.000 title abstract 2
206010061218 Inflammation Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
208000035475 disorder Diseases 0.000 title abstract 2
230000004054 inflammatory process Effects 0.000 title abstract 2
-1 hydrido, methyl Chemical group 0.000 abstract 10
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 2
206010003246 arthritis Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
125000006343 heptafluoro propyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT95901779T 1993-11-30 1994-11-14 1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen ATE156482T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/161,004 US5401765A (en)	1993-11-30	1993-11-30	1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders

Publications (1)

Publication Number	Publication Date
ATE156482T1 true ATE156482T1 (de)	1997-08-15

Family

ID=22579400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95901779T ATE156482T1 (de)	1993-11-30	1994-11-14	1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen

Country Status (11)

Country	Link
US (2)	US5401765A (de)
EP (1)	EP0731794B1 (de)
JP (1)	JPH09505829A (de)
AT (1)	ATE156482T1 (de)
AU (1)	AU1088795A (de)
CA (1)	CA2177573A1 (de)
DE (1)	DE69404860T2 (de)
DK (1)	DK0731794T3 (de)
ES (1)	ES2105874T3 (de)
GR (1)	GR3024939T3 (de)
WO (1)	WO1995015317A1 (de)

Families Citing this family (38)

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US5908852A (en) *	1994-11-14	1999-06-01	G. D. Searle & Co.	1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5643933A (en) *	1995-06-02	1997-07-01	G. D. Searle & Co.	Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
CA2223154A1 (en) *	1995-06-02	1996-12-05	G.D. Searle & Co.	Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5756529A (en) *	1995-09-29	1998-05-26	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
ATE233743T1 (de)	1996-04-12	2003-03-15	Searle & Co	N-((4-(5-methyl-3-phenylisoxazol-4- yl)phenyl)sulphonylpropylamid und sein natriumsalz als pro-pharmakon von cox-2 inhibitoren
US6677364B2 (en) *	1998-04-20	2004-01-13	G.D. Searle & Co.	Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5677318A (en) *	1996-07-11	1997-10-14	Merck Frosst Canada, Inc.	Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
US6174330B1 (en) *	1997-08-01	2001-01-16	Schneider (Usa) Inc	Bioabsorbable marker having radiopaque constituents
WO1999051580A1 (en) *	1998-04-08	1999-10-14	Abbott Laboratories	Pyrazole inhibitors of cytokine production
US6727238B2 (en)	1998-06-11	2004-04-27	Pfizer Inc.	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6294558B1 (en)	1999-05-31	2001-09-25	Pfizer Inc.	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
JP2003508401A (ja) *	1999-08-27	2003-03-04	アボット・ラボラトリーズ	Ｃｏｘ−２阻害薬として有用なスルホニルフェニルピラゾール化合物
OA12100A (en)	1999-12-03	2006-05-04	Pfizer Prod Inc	Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents.
CA2326970C (en)	1999-12-03	2004-11-23	Pfizer Products Inc.	Acetylene derivatives as anti-inflammatory/analgesic agents
PT1104760E (pt)	1999-12-03	2003-06-30	Pfizer Prod Inc	Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
EP1104759B1 (de)	1999-12-03	2003-10-22	Pfizer Products Inc.	Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
KR100793668B1 (ko) *	1999-12-08	2008-01-10	파마시아 코포레이션	강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브
AU2001255600A1 (en) *	2000-04-25	2001-11-07	Pharmacia Corporation	Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes
PE20020146A1 (es) *	2000-07-13	2002-03-31	Upjohn Co	Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
JP2004503601A (ja) *	2000-07-13	2004-02-05	ファルマシア・コーポレーション	眼のｃｏｘ−２媒介疾患の処置及び予防におけるｃｏｘ−２阻害剤の使用法
US7115565B2 (en) *	2001-01-18	2006-10-03	Pharmacia & Upjohn Company	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PE20021017A1 (es)	2001-04-03	2002-11-24	Pharmacia Corp	Composicion parenteral reconstituible
US20030105144A1 (en)	2001-04-17	2003-06-05	Ping Gao	Stabilized oral pharmaceutical composition
US6673818B2 (en)	2001-04-20	2004-01-06	Pharmacia Corporation	Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
ES2241964T3 (es)	2001-07-05	2005-11-01	Pfizer Products Inc.	Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos.
UA80682C2 (en) *	2001-08-06	2007-10-25	Pharmacia Corp	Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
EP1444207A2 (de)	2001-09-19	2004-08-11	Pharmacia Corporation	Substituierte pyrazolylverbindungen zur behandlung von entzündungen
GT200200183A (es)	2001-09-28	2003-05-23		Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
WO2003037336A1 (en)	2001-11-02	2003-05-08	Pfizer Products Inc.	1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
US7329401B2 (en) *	2002-04-15	2008-02-12	The Regents Of The University Of California	Cyclooxygenase-2 selective agents useful as imaging probes and related methods
JP2005535642A (ja)	2002-06-28	2005-11-24	ニトロメッドインコーポレーティッド	オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
ES2275218T3 (es)	2003-05-07	2007-06-01	Osteologix A/S	Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
US20060079566A1 (en) *	2003-10-03	2006-04-13	Ching-Shih Chen	PDK-1/Akt signaling inhibitors
CN1889949B (zh) *	2003-10-03	2010-06-16	俄亥俄州州立大学研究基金会	PDK-1/Akt信号传导抑制剂
EP2114461A2 (de) *	2007-01-19	2009-11-11	Mallinckrodt Inc.	Diagnostische und therapeutische cyclooxygenase-2-bindende liganden
US8039502B2 (en)	2007-07-24	2011-10-18	The Ohio State University Research Foundation	Anti-infective agents against intracellular pathogens
US20120108823A1 (en)	2009-04-22	2012-05-03	The Ohio State University Research Foundation	Anti-francisella agents
CA3121202A1 (en)	2018-11-30	2020-06-04	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1373212A (en) *	1970-12-07	1974-11-06	Wyeth John & Brother Ltd	Pyrazole compounds
US3984431A (en) *	1972-03-15	1976-10-05	Claude Gueremy	Derivatives of pyrazole-5-acetic acid
PH27357A (en) *	1989-09-22	1993-06-21	Fujisawa Pharmaceutical Co	Pyrazole derivatives and pharmaceutical compositions comprising the same
US5466823A (en) *	1993-11-30	1995-11-14	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides

1993
- 1993-11-30 US US08/161,004 patent/US5401765A/en not_active Expired - Fee Related
1994
- 1994-11-14 AT AT95901779T patent/ATE156482T1/de not_active IP Right Cessation
- 1994-11-14 US US08/648,118 patent/US5639777A/en not_active Expired - Fee Related
- 1994-11-14 WO PCT/US1994/012721 patent/WO1995015317A1/en not_active Ceased
- 1994-11-14 EP EP95901779A patent/EP0731794B1/de not_active Expired - Lifetime
- 1994-11-14 CA CA002177573A patent/CA2177573A1/en not_active Abandoned
- 1994-11-14 AU AU10887/95A patent/AU1088795A/en not_active Abandoned
- 1994-11-14 ES ES95901779T patent/ES2105874T3/es not_active Expired - Lifetime
- 1994-11-14 DK DK95901779.9T patent/DK0731794T3/da active
- 1994-11-14 JP JP7515612A patent/JPH09505829A/ja not_active Ceased
- 1994-11-14 DE DE69404860T patent/DE69404860T2/de not_active Expired - Fee Related
1997
- 1997-10-03 GR GR970402580T patent/GR3024939T3/el unknown

Also Published As

Publication number	Publication date
AU1088795A (en)	1995-06-19
EP0731794A1 (de)	1996-09-18
ES2105874T3 (es)	1997-10-16
WO1995015317A1 (en)	1995-06-08
GR3024939T3 (en)	1998-01-30
EP0731794B1 (de)	1997-08-06
DE69404860D1 (de)	1997-09-11
JPH09505829A (ja)	1997-06-10
US5639777A (en)	1997-06-17
US5401765A (en)	1995-03-28
CA2177573A1 (en)	1995-06-08
DK0731794T3 (da)	1998-03-09
DE69404860T2 (de)	1998-01-02

Legal Events

Date	Code	Title	Description
2006-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE156482T1 (de)	1997-08-15	1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen
ATE195118T1 (de)	2000-08-15	1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen
DE69413834D1 (de)	1998-11-12	1,2-diarylcyclopentenylverbindungen zur behandlung von entzündungen
PT923933E (pt)	2002-10-31	Pirazolil-benzenossulfonamidas substituidas para usar no tratamento de inflamacao
PT809636E (pt)	2002-12-31	Isoxazoles substituidos utilizaveis para o tratamento de inflamacoes
DE59409312D1 (de)	2000-05-31	Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten
DZ2103A1 (fr)	2002-07-22	(Méthylsulfonyl)phenyl-2-(5H)-furannones et tant qu'inhibiteurs de cox-2.
NO971766D0 (no)	1997-04-17	Anvendelsen av dioksomorfoliner for bekjempning av endoparasitter, nye dioksomorfoliner samt deres fremstilling
ATE114151T1 (de)	1994-12-15	Benzocyclobutyl- oder indanyl-alkyl-amino-alkyl substituierte 3-benzazepin-2-ones, verwendbar in der behandlung von kardiovaskularen krankheiten.
DK0607775T3 (da)	1999-08-16	Anvendelse af leflunomid til inhibering af interleukin 1 beta
ATE170530T1 (de)	1998-09-15	Thiazolidinderivate, ihre herstellung und medikamente, die sie enthalten
KR890003385A (ko)	1989-04-14	항 증식제로서 유용한 5-아미노 또는 치환된 아미도 1,2,3-트리아졸
DK0751941T3 (da)	1999-06-14	Kemiske mellemprodukter, som kan anvendes i landbruget
DK0607777T3 (da)	1999-08-16	Anvendelse af leflunomid til inhibering af interleukin 8
DK0720598T3 (da)	1999-06-21	Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
EE9400233A (et)	1996-02-15	1,5,6,7-tetrahüdro-4H-indasool-4-ooni sisaldav ravim, uus 1,5,6,7-tetrahüdro-4H-indasool-4-oon ja meetodid nende saamiseks
ES2097688A1 (es)	1997-04-01	Hexahidroazepinonas y tetrahidrobenzazepinonas sustituidas.