ATE156492T1 - Bombesinanaloge - Google Patents

Bombesinanaloge

Info

Publication number: ATE156492T1
Authority: AT; Austria
Prior art keywords: bombesin; derivatives; antagonist; bomb; analogues
Prior art date: 1991-05-23

Application number

AT92913859T

Other languages

English (en)

Inventor

Judson V Edwards

Bradford O Fanger

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-23

Filing date

1992-04-21

Publication date

1997-08-15

1992-04-21 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1997-08-15 Application granted granted Critical

1997-08-15 Publication of ATE156492T1 publication Critical patent/ATE156492T1/de

Links

DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 abstract 3
102000013585 Bombesin Human genes 0.000 abstract 2
108010051479 Bombesin Proteins 0.000 abstract 2
239000000556 agonist Substances 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 2
QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
238000010256 biochemical assay Methods 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000012875 competitive assay Methods 0.000 abstract 1
230000009137 competitive binding Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000004072 lung Anatomy 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Immunology (AREA)
Nutrition Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Compounds Of Unknown Constitution (AREA)
Silicon Polymers (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT92913859T 1991-05-23 1992-04-21 Bombesinanaloge ATE156492T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US70486391A	1991-05-23	1991-05-23

Publications (1)

Publication Number	Publication Date
ATE156492T1 true ATE156492T1 (de)	1997-08-15

Family

ID=24831155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92913859T ATE156492T1 (de)	1991-05-23	1992-04-21	Bombesinanaloge

Country Status (11)

Country	Link
US (1)	US5428019A (de)
EP (1)	EP0585397B1 (de)
JP (1)	JP3350701B2 (de)
AT (1)	ATE156492T1 (de)
AU (1)	AU659659B2 (de)
CA (1)	CA2109322C (de)
DE (1)	DE69221486T2 (de)
DK (1)	DK0585397T3 (de)
ES (1)	ES2106188T3 (de)
GR (1)	GR3025003T3 (de)
WO (1)	WO1992020707A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5877277A (en)	1987-09-24	1999-03-02	Biomeasure, Inc.	Octapeptide bombesin analogs
US5723578A (en) *	1987-09-24	1998-03-03	The Administrators Of Tulane Educational Fund	Peptide analogs of bombesin
WO1991004040A1 (en) *	1989-09-15	1991-04-04	Biomeasure, Inc.	Treatment of colon cancer
US5650395A (en) *	1995-03-13	1997-07-22	Hurel; Steven	Treatment of pulmonary hypertension
US5786335A (en) *	1995-11-06	1998-07-28	Warner-Lambert Company	Sulfhydryl containing peptides for treating vascular disease
US7078413B2 (en)	1996-04-19	2006-07-18	Wisconsin Alumni Research Foundation	Compositions and methods of use for a bombesin peptide
US6989371B1 (en)	1996-08-16	2006-01-24	Dabur Research Foundation	Bombesin analogs for treatment of cancer
US5861532A (en) *	1997-03-04	1999-01-19	Chiron Corporation	Solid-phase synthesis of N-alkyl amides
DE69840647D1 (de) *	1997-04-22	2009-04-23	Curator Of The University Of M	Konjugate aus peptiden, die liganden von gastrinrezeptoren sind
CA2346154A1 (en) *	2001-05-02	2002-11-02	University Of Missouri	Gastrin receptor-avid peptide conjugates
WO1999013738A1 (en) *	1997-09-16	1999-03-25	Societe Des Produits Nestle S.A.	Organ specific nutrition
US20060239923A1 (en) *	2003-01-13	2006-10-26	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US8420050B2 (en) *	2003-01-13	2013-04-16	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7611692B2 (en)	2003-01-13	2009-11-03	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7922998B2 (en) *	2003-01-13	2011-04-12	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7226577B2 (en)	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
AU2003303714B2 (en) *	2003-01-13	2009-02-19	Bracco Imaging S.P.A.	Improved linkers for radiopharmaceutical compounds
US7850947B2 (en) *	2003-01-13	2010-12-14	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
JP2006522100A (ja) *	2003-03-10	2006-09-28	バイオジェンアイデックインク	標的化ペプチドに対するチオール媒介性薬物結合
CN111500612A (zh) *	2020-03-30	2020-08-07	扬州大学	一种可溶性猪胃泌素释放肽融合蛋白表达载体及其应用
CN116333041A (zh) *	2023-04-10	2023-06-27	湖南中晟全肽生化有限公司	一种激活grp受体的多肽化合物及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1592552A (en) *	1976-12-10	1981-07-08	Inst Nat Sante Rech Med	Pseudopeptides used as medicaments
US4631270A (en) *	1978-11-20	1986-12-23	Research Corporation	Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
EP0076557B1 (de) *	1981-06-22	1985-11-13	Imperial Chemical Industries Plc	Peptide und Pseudopeptide, die zwei Substituenten am N-Terminus aufweisen
US4871717A (en) *	1987-01-07	1989-10-03	Administrators Of The Tulane Educational Fund	Peptides
JP2795449B2 (ja) *	1987-09-24	1998-09-10	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ペプチド
EP0313158A3 (de) *	1987-10-23	1990-08-22	Merck & Co. Inc.	Antagonisten von Gastrin freisetzenden Peptiden
US5047502A (en) *	1987-10-23	1991-09-10	Merck And Co., Inc.	Gastrin releasing peptide antagonist
AU618029B2 (en) *	1987-11-02	1991-12-12	Imperial Chemical Industries Plc	Polypeptide compounds
GB8806644D0 (en) *	1988-03-21	1988-04-20	Imp Cancer Res Tech	Neuropeptide antagonists
GB8808768D0 (en) *	1988-04-14	1988-05-18	Erba Carlo Spa	Peptide ligands for bombesin receptors
GB8813356D0 (en) *	1988-06-06	1988-07-13	Ici Plc	Polypeptide compounds
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
GR1000608B (el) *	1988-07-21	1992-08-31	Erba Carlo Spa	Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
MC2144A1 (fr) *	1988-10-14	1992-02-19	Univ Tulane	Peptides therapeutiques
US5028692A (en) *	1989-04-25	1991-07-02	Merck & Co., Inc.	Gastrin releasing peptide antagonist
CA2045494A1 (en) *	1989-11-06	1991-05-07	Luigia Gozzini	Reduced irreversible bombesin antagonists
NZ236114A (en) *	1989-11-22	1993-04-28	Merrell Dow Pharma	Peptide antagonists of bombesin and of gastrin releasing peptide, and pharmaceutical compositions

1992
- 1992-04-21 AU AU21840/92A patent/AU659659B2/en not_active Ceased
- 1992-04-21 DE DE69221486T patent/DE69221486T2/de not_active Expired - Fee Related
- 1992-04-21 AT AT92913859T patent/ATE156492T1/de not_active IP Right Cessation
- 1992-04-21 ES ES92913859T patent/ES2106188T3/es not_active Expired - Lifetime
- 1992-04-21 JP JP50004393A patent/JP3350701B2/ja not_active Expired - Fee Related
- 1992-04-21 DK DK92913859.2T patent/DK0585397T3/da active
- 1992-04-21 EP EP92913859A patent/EP0585397B1/de not_active Expired - Lifetime
- 1992-04-21 CA CA002109322A patent/CA2109322C/en not_active Expired - Fee Related
- 1992-04-21 WO PCT/US1992/003287 patent/WO1992020707A1/en not_active Ceased
1994
- 1994-03-14 US US08/213,378 patent/US5428019A/en not_active Expired - Fee Related
1997
- 1997-10-09 GR GR970402646T patent/GR3025003T3/el unknown

Also Published As

Publication number	Publication date
DK0585397T3 (da)	1997-08-25
DE69221486T2 (de)	1998-03-19
US5428019A (en)	1995-06-27
DE69221486D1 (de)	1997-09-11
EP0585397A1 (de)	1994-03-09
JP3350701B2 (ja)	2002-11-25
GR3025003T3 (en)	1998-01-30
ES2106188T3 (es)	1997-11-01
AU659659B2 (en)	1995-05-25
JPH06508126A (ja)	1994-09-14
AU2184092A (en)	1992-12-30
WO1992020707A1 (en)	1992-11-26
EP0585397B1 (de)	1997-08-06
CA2109322C (en)	2002-11-05
CA2109322A1 (en)	1992-11-24

Legal Events

Date	Code	Title	Description
2004-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE156492T1 (de)	1997-08-15	Bombesinanaloge
DE3888310T2 (de)	1994-08-11	Peptidderivate des Blutplättchen-Aggregations-Inhibitors.
LU91857I2 (fr)	2011-10-24	Abarelix, optionnellement sous forme de sel pharmaceutiquement acceptable
SE8703938L (sv)	1988-04-14	Peptidderivat
MXPA05002991A (es)	2005-10-05	Analogos de ghrh.
DE69434181D1 (de)	2005-01-13	Therapeutische Peptid Derivate
NZ502872A (en)	2002-10-25	Mevinolin and compaction as LFA-1 antagonists for treating autoimmune diseases
AU3576597A (en)	1998-01-07	Endoderm, cardiac and neural inducing factors
MY109309A (en)	1997-01-31	Improvements in or relating to somatostatins
CA2123049A1 (en)	1994-11-08	Pharmaceutical containing the p40 subunit of interleukin 12
MX9703642A (es)	1998-11-29	Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.
MX9801987A (es)	1998-08-30	Nuevos derivados de aminoacido, su obtencion y su uso.
KR880012641A (ko)	1988-11-28	아미노산 유도체
NO942919L (no)	1994-08-05	Fenylalaninanaloger av bombesin
EP0228192A3 (de)	1989-08-23	Renin-hemmende Oligopeptide, deren Herstellung und Anwendung
WO2002058589A3 (en)	2003-07-17	Agents and methods for promoting bone growth
NZ236114A (en)	1993-04-28	Peptide antagonists of bombesin and of gastrin releasing peptide, and pharmaceutical compositions
EP0347802A3 (de)	1991-07-17	Neurokinin-A-Antagonisten
CA2022740A1 (en)	1991-02-11	Cyclic neurokinin a antagonists
NO894720L (no)	1990-01-29	Farmasoeytisk aktivt protein.
ES8701784A1 (es)	1986-12-01	Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina
BR9911756A (pt)	2001-04-03	Composto, uso de um secretagogo do hormÈnio do crescimento ou um seu sal farmaceuticamente aceitável, composição farmacêutica, método para estimular a liberação do hormÈnio do crescimento pela pituitária de um mamìfero, e, uso de um composto
WO2002007676A3 (en)	2002-05-10	Compounds having affinity for the granulocyte-colony stimulating factor receptor (g-csfr)
YU60199A (sh)	2002-09-19	Nove soli bpc peptida sa organo-zaštitnom aktivnošću, postupak za njihovo dobijanje i njihova primena u terapiji
ATE105841T1 (de)	1994-06-15	5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen.