ATE78831T1 - Biologisch wirksame lysin enthaltende octapeptide. - Google Patents

Biologisch wirksame lysin enthaltende octapeptide.

Info

Publication number: ATE78831T1
Authority: AT; Austria
Prior art keywords: sub; trp; cys; ala; thr
Prior art date: 1985-04-25

Application number

AT86810174T

Other languages

English (en)

Inventor

Andrew V Schally

Ren Zhi Cai

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-15

Publication date

1992-08-15

1985-04-25 Priority claimed from US06/727,105 external-priority patent/US4650787A/en

1986-04-15 Application filed by Univ Tulane filed Critical Univ Tulane

1992-08-15 Application granted granted Critical

1992-08-15 Publication of ATE78831T1 publication Critical patent/ATE78831T1/de

Links

KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title 1
239000004472 Lysine Substances 0.000 title 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
101100379081 Emericella variicolor andC gene Proteins 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT86810174T 1985-04-25 1986-04-15 Biologisch wirksame lysin enthaltende octapeptide. ATE78831T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US06/727,105 US4650787A (en)	1985-04-25	1985-04-25	Biologically active octapeptides
US06/843,539 US4725577A (en)	1985-04-25	1986-03-28	Biologically active lysine containing octapeptides
EP86810174A EP0203031B1 (de)	1985-04-25	1986-04-15	Biologisch wirksame Lysin enthaltende Octapeptide

Publications (1)

Publication Number	Publication Date
ATE78831T1 true ATE78831T1 (de)	1992-08-15

Family

ID=27111452

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86810174T ATE78831T1 (de)	1985-04-25	1986-04-15	Biologisch wirksame lysin enthaltende octapeptide.

Country Status (10)

Country	Link
US (1)	US4725577A (de)
EP (1)	EP0203031B1 (de)
AT (1)	ATE78831T1 (de)
AU (1)	AU600895B2 (de)
CA (1)	CA1333646C (de)
DE (1)	DE3686200T2 (de)
DK (1)	DK174920B1 (de)
HK (1)	HK68793A (de)
IE (1)	IE59621B1 (de)
SG (1)	SG57793G (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4904642A (en) *	1985-09-12	1990-02-27	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
GR862206B (en) *	1985-09-12	1986-12-31	Univ Tulane	Therapeutic somatostatin analogs
JPH085913B2 (ja) *	1985-09-12	1996-01-24	ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド	治療用ソマトスタチン同族体
US4853371A (en) *	1986-06-17	1989-08-01	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
DE3726517A1 (de) *	1986-08-18	1988-03-03	Sandoz Ag	Nasale zusammensetzungen, welche octreotid enthalten
DE3822557C2 (de) *	1987-07-10	1998-07-02	Ciba Geigy Ag	Arzneimittel, enthaltend Somatostatine
AU639371B2 (en) *	1987-07-10	1993-07-22	Novartis Ag	Method of treating breast cancer
US5073541A (en) *	1987-11-18	1991-12-17	Administrators Of The Tulane Educational Fund	Treatment of small cell lung cancer with somatostatin analogs
US5068221A (en) *	1989-05-09	1991-11-26	Mathias John R	Treatment of motility disorders with a gnrh analog
HU221294B1 (en) *	1989-07-07	2002-09-28	Novartis Ag	Process for producing retarde compositions containing the active ingredient in a polymeric carrier
PH30995A (en) *	1989-07-07	1997-12-23	Novartis Inc	Sustained release formulations of water soluble peptides.
US5538739A (en) *	1989-07-07	1996-07-23	Sandoz Ltd.	Sustained release formulations of water soluble peptides
ES2091907T3 (es) *	1989-12-08	1996-11-16	Univ Tulane	Analogos octapeptidos de somatostina con una threonina en la sexta posicion.
GB9004017D0 (en) *	1990-02-22	1990-04-18	Krenning Eric P	Improvements in or relating to organic compounds
ATE124054T1 (de) *	1990-04-06	1995-07-15	Univ Tulane	Somatostatinanaloge.
IT1240643B (it) *	1990-05-11	1993-12-17	Mediolanum Farmaceutici Spa	Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
US5668254A (en) *	1990-05-11	1997-09-16	Romano Deghenghi	D-2-alkyl-tryptophan and peptides containing same
US5872100A (en) *	1990-05-11	1999-02-16	Deghenghi; Romano	Peptides containing D-2-Alkyl-Tryptophan
US5434136A (en) *	1990-12-14	1995-07-18	Mathias; John R.	Treatment of motility disorders with a GNRH analog
HU207104B (en) *	1991-01-25	1993-03-01	Biosignal Kutato Fejlesztoe Kf	Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US5443815A (en) *	1991-11-27	1995-08-22	Diatech, Inc.	Technetium-99m labeled peptides for imaging
WO1995000553A1 (en)	1993-06-23	1995-01-05	Diatech, Inc.	Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en)	1992-06-23	1997-04-15	Diatech, Inc.	Radioactive peptides
US6017512A (en) *	1992-06-23	2000-01-25	Diatide, Inc.	Radiolabeled peptides
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
FR2701952B1 (fr) *	1993-02-22	1995-03-31	Adir	Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6051206A (en) *	1994-06-03	2000-04-18	Diatide, Inc	Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6100377A (en) *	1994-06-10	2000-08-08	The Trustees Of The University Of Pennsylvania	Constrained peptides
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds
DE69528531T2 (de) *	1994-09-27	2003-06-05	Ardana Bioscience Ltd., Edinburgh	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
US5770687A (en) *	1995-06-07	1998-06-23	Peptor Limited	Comformationally constrained backbone cyclized somatostatin analogs
US5830431A (en) *	1995-06-07	1998-11-03	Mallinckrodt Medical, Inc.	Radiolabeled peptide compositions for site-specific targeting
GB9513224D0 (en) *	1995-06-29	1995-09-06	Sandoz Ltd	Organic compounds
IT1277391B1 (it) *	1995-07-28	1997-11-10	Romano Deghenghi	Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
JPH09328499A (ja) *	1996-02-20	1997-12-22	American Cyanamid Co	純粋なソマトスタチンアンタゴニストおよびその使用方法
US6262229B1 (en)	1996-12-04	2001-07-17	Biomeasure Incorporated	Somatostatin antagonists
US5972895A (en) *	1996-12-11	1999-10-26	A. Glenn Braswell	Composition and method for increasing growth hormone levels
DK0979098T3 (da) *	1997-05-01	2003-07-14	Sod Conseils Rech Applic	Fremgangsmåde til behandling af hyperprolaktinæmi og prolaktinomer
EP1332762A1 (de) *	1997-05-01	2003-08-06	Cedars-Sinai Medical Center	Methode zur Behandlung von Hyperprolaktinämia und Prolaktinomen
US5972893A (en) *	1997-05-06	1999-10-26	Cedars-Sinai Medical Center	Method of treating hyperprolactinemia and prolactinomas
CA2289499C (en) *	1997-05-13	2010-02-23	Michael Anthony Cawthorne	Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
CA2290592A1 (en) *	1997-05-13	1998-11-19	Michael Anthony Cawthorne	Somatostatin and somatostatin agonists for decreasing body weight
EP0981364B1 (de) *	1997-05-13	2006-03-01	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Methoden und zusammensetzungen zur behandlung der hyperlipidämie
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
NZ530007A (en)	2001-06-08	2006-02-24	Sod Conseils Rech Applic	Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
CA2523197C (en)	2003-04-22	2016-05-24	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Peptide vectors
US20070111930A1 (en) *	2005-11-10	2007-05-17	Palle Venkata Raghavendra A	Process for preparing vapreotide
US8691761B2 (en)	2006-10-16	2014-04-08	Jean E. F. Rivier	Somatostatin receptor 2 antagonists
PL2383289T3 (pl)	2006-10-16	2015-03-31	Salk Inst Biological Studies	Antagoniści somatostatyny selektywni względem receptora (SSTR2)
WO2009150470A2 (en)	2008-06-12	2009-12-17	Syntaxin Limited	Suppression of cancers
EP2310028B1 (de)	2008-06-12	2016-11-16	Ipsen Bioinnovation Limited	Fusionsproteine zur Verwendung bei der Behandlung von Akromegalie
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
EP3007704B1 (de)	2013-06-13	2021-01-06	Antisense Therapeutics Ltd	Kombinationstherapie der akromegalie

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4209426A (en) *	1979-05-29	1980-06-24	American Home Products Corporation	Polypeptides related to somatostatin
DE3062075D1 (en) *	1979-11-27	1983-03-24	Sandoz Ag	Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
US4282143A (en) *	1980-06-13	1981-08-04	American Home Products Corporation	Octapeptides lowering growth hormone
DK81082A (da) *	1981-03-06	1982-09-07	Sandoz Ag	Fremgangsmaade til fremstilling af polypeptider
US4443434A (en) *	1982-08-18	1984-04-17	American Home Products Corporation	Antiulcer agent
CH655505B (de) *	1982-08-24	1986-04-30
US4451394A (en) *	1982-10-25	1984-05-29	American Home Products Corporation	Dodecapeptides preventing glucose and triglyceride assimilation
US4440904A (en) *	1983-01-31	1984-04-03	American Home Products Corporation	Nonapeptide anti-secretory agents
US4684620A (en) *	1984-09-04	1987-08-04	Gibson-Stephens Neuropharmaceuticals, Inc.	Cyclic polypeptides having mu-receptor specificity
JPH085913B2 (ja) *	1985-09-12	1996-01-24	ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド	治療用ソマトスタチン同族体

1986
- 1986-03-28 US US06/843,539 patent/US4725577A/en not_active Expired - Lifetime
- 1986-04-15 DE DE8686810174T patent/DE3686200T2/de not_active Expired - Lifetime
- 1986-04-15 AT AT86810174T patent/ATE78831T1/de not_active IP Right Cessation
- 1986-04-15 EP EP86810174A patent/EP0203031B1/de not_active Expired
- 1986-04-16 IE IE100486A patent/IE59621B1/en not_active IP Right Cessation
- 1986-04-17 AU AU56338/86A patent/AU600895B2/en not_active Expired
- 1986-04-22 DK DK198601854A patent/DK174920B1/da not_active IP Right Cessation
- 1986-04-24 CA CA000507490A patent/CA1333646C/en not_active Expired - Lifetime
1993
- 1993-05-04 SG SG577/93A patent/SG57793G/en unknown
- 1993-07-15 HK HK687/93A patent/HK68793A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0203031B1 (de)	1992-07-29
SG57793G (en)	1993-07-09
IE59621B1 (en)	1994-03-09
DE3686200T2 (de)	1993-03-11
CA1333646C (en)	1994-12-20
IE861004L (en)	1986-10-25
DK174920B1 (da)	2004-02-23
EP0203031A3 (en)	1988-09-21
AU600895B2 (en)	1990-08-30
DE3686200D1 (de)	1992-09-03
AU5633886A (en)	1986-10-30
HK68793A (en)	1993-07-23
EP0203031A2 (de)	1986-11-26
DK185486D0 (da)	1986-04-22
US4725577A (en)	1988-02-16
DK185486A (da)	1986-10-26

Legal Events

Date	Code	Title	Description
1993-02-15	UEP	Publication of translation of european patent specification
2006-07-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3686200D1 (de)	1992-09-03	Biologisch wirksame lysin enthaltende octapeptide.
WO1998021237A3 (en)	1998-07-30	Peptide compounds useful for modulating FGF receptor activity
US5244883A (en)	1993-09-14	Nonapeptide bombesin antagonists
AU633913B2 (en)	1993-02-11	Novel tnf-inhibit proteins and their preparation
EP0528312A3 (de)	1993-04-14	Zyklische Peptide und ihre Verwendung
KR960703015A (ko)	1996-06-19	후천성 면역결핍증 치료용 약물의 제조시 노나- 및 데카펩타이드의 용도(Use of nona-and decapeptides in the preparation of a durg for the treatment of AIDS)
AU6819294A (en)	1994-11-08	Oral drug delivery compositions and methods
HUT49891A (en)	1989-11-28	Process for production of peptides with antiaggregation effect and medical compositions containing them
CA2207078A1 (en)	1998-01-26	Insulin derivatives with increased zinc binding
CY1105865T1 (el)	2011-02-02	Ανταγωνιστικα πεπτιδια της il-6
US7189692B2 (en)	2007-03-13	Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
MX9702275A (es)	1997-06-28	Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento.
NZ335879A (en)	2000-11-24	Somatostatin antagonist peptides having a D-amino acid at the second residue
ES8701784A1 (es)	1986-12-01	Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
AU2002351536A1 (en)	2003-05-12	Analogs of human growth hormone-releasing hormone, their preparation and use
KR890009974A (ko)	1989-08-05	신규 화합물들
CA2257973A1 (en)	1997-12-18	T cell antigen receptor peptides
Hechter et al.	1975	Contribution of the peptide backbone to the action of oxytocin analogs.
CA2216704A1 (en)	1996-10-10	Novel peptides and remedy for bone diseases containing the same as active ingredient
GB1425099A (en)	1976-02-18	Psychopharmacologically active peptides
IT1276734B1 (it)	1997-11-03	Composti polipeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della
TH21704A (th)	1996-11-13	เพพไทด์ชนิดใหม่ที่มีผลปรับภูมิคุ้มกัน