ATE156522T1 - Neue oligonukleotide konjugiert zu lanthanide- chelaten - Google Patents

Neue oligonukleotide konjugiert zu lanthanide- chelaten

Info

Publication number
ATE156522T1
ATE156522T1 AT92907537T AT92907537T ATE156522T1 AT E156522 T1 ATE156522 T1 AT E156522T1 AT 92907537 T AT92907537 T AT 92907537T AT 92907537 T AT92907537 T AT 92907537T AT E156522 T1 ATE156522 T1 AT E156522T1
Authority
AT
Austria
Prior art keywords
chelate
rare earth
lanthanide chelates
oligonucleotides conjugated
new oligonucleotides
Prior art date
Application number
AT92907537T
Other languages
English (en)
Inventor
David Gordon Sherman
Charlene Eleanor Bush
Laura Ann Beninsig
Kurt Mathew Vandenbrink
Original Assignee
Dade Microscan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Microscan Inc filed Critical Dade Microscan Inc
Application granted granted Critical
Publication of ATE156522T1 publication Critical patent/ATE156522T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
AT92907537T 1991-02-14 1992-02-10 Neue oligonukleotide konjugiert zu lanthanide- chelaten ATE156522T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65570791A 1991-02-14 1991-02-14

Publications (1)

Publication Number Publication Date
ATE156522T1 true ATE156522T1 (de) 1997-08-15

Family

ID=24630035

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92907537T ATE156522T1 (de) 1991-02-14 1992-02-10 Neue oligonukleotide konjugiert zu lanthanide- chelaten

Country Status (9)

Country Link
US (1) US5955601A (de)
EP (1) EP0525181B1 (de)
JP (1) JPH0657717B2 (de)
AT (1) ATE156522T1 (de)
AU (1) AU653012B2 (de)
CA (1) CA2079448C (de)
DE (1) DE69221404T2 (de)
ES (1) ES2108109T3 (de)
WO (1) WO1992014841A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
IL114235A0 (en) * 1994-07-14 1995-10-31 Schering Ag Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same
WO1998000435A2 (en) * 1996-07-03 1998-01-08 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
FR2769315B1 (fr) * 1997-10-03 2001-06-08 Cis Bio Int Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation
DE10018465A1 (de) * 2000-04-14 2001-10-18 Aventis Res & Tech Gmbh & Co Testsystem zum Nachweis einer Spleißreaktion, sowie dessen Verwendung
US7906343B2 (en) * 2005-01-24 2011-03-15 Sri International Surface-enhanced lanthanide chelates
WO2008020113A1 (en) 2006-08-18 2008-02-21 Abacus Diagnostica Oy Luminescent lanthanide labelling reagents and their use
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
EP2316035A2 (de) 2008-07-16 2011-05-04 Radiometer Medical ApS Thrombinsubstrat und testverfahren zur bestimmung des spiegels von biologisch aktivem thrombin in einer probe
ES2623859T3 (es) 2010-03-04 2017-07-12 Miacom Diagnostics Gmbh FISH múltiple mejorada
EP2825309B1 (de) 2012-03-16 2018-05-16 Stat-Diagnostica & Innovation, S.L. Messkartousche mit trasportmodul
EP2888392B1 (de) 2012-08-23 2017-10-11 The Regents of The University of California Spektralcodierte mikrokugeln sowie verfahren und vorrichtungen zu ihrer herstellung und verwendung
KR101918352B1 (ko) * 2016-09-30 2018-11-14 현대자동차주식회사 라이트가이드가 구비된 차량용 광원 모듈
CN114062328B (zh) * 2020-08-10 2024-08-27 深圳先进技术研究院 一种基于核酸杂交增强稀土配合物荧光的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
US4150295A (en) * 1978-01-05 1979-04-17 Analytical Radiation Corporation Method and apparatus for background correction in photoluminescent analysis
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
SE454781B (sv) * 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
SE8703682L (sv) * 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
AU2714988A (en) * 1987-10-23 1989-06-01 Siska Diagnostics, Inc. Lanthanide chelate-tagged nucleic acid probes
US5032677A (en) * 1987-11-06 1991-07-16 Baxter International Inc. Fluorescent poly(arylpyridine) rare earth chelates
SE8802575D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Terpyridine derivatives
SE8802573D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates

Also Published As

Publication number Publication date
JPH0657717B1 (de) 1994-08-03
EP0525181B1 (de) 1997-08-06
EP0525181A4 (en) 1993-03-10
WO1992014841A1 (en) 1992-09-03
JPH0657717B2 (ja) 1994-08-03
DE69221404D1 (de) 1997-09-11
AU1450792A (en) 1992-09-15
AU653012B2 (en) 1994-09-15
CA2079448A1 (en) 1992-08-15
US5955601A (en) 1999-09-21
ES2108109T3 (es) 1997-12-16
JPH05505201A (ja) 1993-08-05
DE69221404T2 (de) 1998-02-05
CA2079448C (en) 2000-05-23
EP0525181A1 (de) 1993-02-03

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