ES2108109T3 - Nuevos oligonucleotidos conjugados con quelatos de lantanidos. - Google Patents

Nuevos oligonucleotidos conjugados con quelatos de lantanidos.

Info

Publication number
ES2108109T3
ES2108109T3 ES92907537T ES92907537T ES2108109T3 ES 2108109 T3 ES2108109 T3 ES 2108109T3 ES 92907537 T ES92907537 T ES 92907537T ES 92907537 T ES92907537 T ES 92907537T ES 2108109 T3 ES2108109 T3 ES 2108109T3
Authority
ES
Spain
Prior art keywords
chelates
chelate
lantanides
rare earth
oligonucleotides conjugated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92907537T
Other languages
English (en)
Inventor
David Gordon Sherman
Charlene Eleanor Bush
Laura Ann Beninsig
Kurt Mathew Vandenbrink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
Dade MicroScan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade MicroScan Inc filed Critical Dade MicroScan Inc
Application granted granted Critical
Publication of ES2108109T3 publication Critical patent/ES2108109T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE PRESENTAN OLIGONUCLEOTIDOS CONJUGADOS CON QUELATOS DE TIERRAS RARAS UTILES EN ENSAYOS DE HIBRIDIZACION DEL ACIDO NUCLEICO Y PARA GENERAR SONDAS ETIQUETADAS DE QUELATO DE CUALQUIER SECUENCIA DESEADA. LA CLASE PARTICULAR DE QUELATOS UTILIZADOS EXHIBE UNA ALTA EFICIENCIA INUSUAL DE LA CAPTURA DE ELEMENTOS DE TIERRA RARA, QUE SE CORRESPONDE CON LA EMISION DE UN ALTO NIVEL DE SEÑAL EN LA ESPECTROSCOPIA FLUORESCENTE EN COMPARACION CON OTROS COMPUESTOS DE QUELATO ESTRUCTURALMENTE RELACIONADOS.
ES92907537T 1991-02-14 1992-02-10 Nuevos oligonucleotidos conjugados con quelatos de lantanidos. Expired - Lifetime ES2108109T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65570791A 1991-02-14 1991-02-14

Publications (1)

Publication Number Publication Date
ES2108109T3 true ES2108109T3 (es) 1997-12-16

Family

ID=24630035

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92907537T Expired - Lifetime ES2108109T3 (es) 1991-02-14 1992-02-10 Nuevos oligonucleotidos conjugados con quelatos de lantanidos.

Country Status (9)

Country Link
US (1) US5955601A (es)
EP (1) EP0525181B1 (es)
JP (1) JPH0657717B2 (es)
AT (1) ATE156522T1 (es)
AU (1) AU653012B2 (es)
CA (1) CA2079448C (es)
DE (1) DE69221404T2 (es)
ES (1) ES2108109T3 (es)
WO (1) WO1992014841A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
IL114235A0 (en) * 1994-07-14 1995-10-31 Schering Ag Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same
CA2259493A1 (en) * 1996-07-03 1998-01-08 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
FR2769315B1 (fr) * 1997-10-03 2001-06-08 Cis Bio Int Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation
DE10018465A1 (de) * 2000-04-14 2001-10-18 Aventis Res & Tech Gmbh & Co Testsystem zum Nachweis einer Spleißreaktion, sowie dessen Verwendung
WO2007084141A2 (en) * 2005-01-24 2007-07-26 Sri International Surface-enhanced lanthanide chelates
US8216856B2 (en) 2006-08-18 2012-07-10 Abacus Diagnostica Oy Luminescent lanthanide labelling reagents and their use
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
WO2010006605A2 (en) 2008-07-16 2010-01-21 Radiometer Medical Aps Thrombin substrate and assay for determining the level of bioactive thrombin in a sample
ES2623859T3 (es) 2010-03-04 2017-07-12 Miacom Diagnostics Gmbh FISH múltiple mejorada
CN107099445B (zh) 2012-03-16 2020-06-16 统计诊断与创新有限公司 具有集成传送模块的测试盒
WO2014031902A2 (en) 2012-08-23 2014-02-27 The Regents Of The University Of California Spectrally encoded microbeads and methods and devices for making and using same
KR101918352B1 (ko) * 2016-09-30 2018-11-14 현대자동차주식회사 라이트가이드가 구비된 차량용 광원 모듈
CN114062328B (zh) * 2020-08-10 2024-08-27 深圳先进技术研究院 一种基于核酸杂交增强稀土配合物荧光的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
US4150295A (en) * 1978-01-05 1979-04-17 Analytical Radiation Corporation Method and apparatus for background correction in photoluminescent analysis
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
SE454781B (sv) * 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
SE8703682L (sv) * 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
AU2714988A (en) * 1987-10-23 1989-06-01 Siska Diagnostics, Inc. Lanthanide chelate-tagged nucleic acid probes
US5032677A (en) * 1987-11-06 1991-07-16 Baxter International Inc. Fluorescent poly(arylpyridine) rare earth chelates
SE8802575D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Terpyridine derivatives
SE8802573D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates

Also Published As

Publication number Publication date
EP0525181B1 (en) 1997-08-06
ATE156522T1 (de) 1997-08-15
JPH0657717B1 (es) 1994-08-03
JPH05505201A (ja) 1993-08-05
EP0525181A4 (en) 1993-03-10
JPH0657717B2 (ja) 1994-08-03
CA2079448C (en) 2000-05-23
AU653012B2 (en) 1994-09-15
DE69221404T2 (de) 1998-02-05
AU1450792A (en) 1992-09-15
EP0525181A1 (en) 1993-02-03
WO1992014841A1 (en) 1992-09-03
DE69221404D1 (de) 1997-09-11
CA2079448A1 (en) 1992-08-15
US5955601A (en) 1999-09-21

Similar Documents

Publication Publication Date Title
ES2108109T3 (es) Nuevos oligonucleotidos conjugados con quelatos de lantanidos.
ATE340869T1 (de) Massenmarkierte hybridisierungssonden
FI880719L (fi) Homogeenisia fluorimetrisiä määritysmenetelmiä, joissa käytetään fluoresoivan taustan poissulkemista ja fluoroforeina vesiliukoisia harvinaisten maametallien kelaatteja
DE69525186D1 (de) Fluoreszenzenergieübertragung und intramolekulare energieübertragung in teilchen unter verwendung neuer verbindungen
DK1032705T3 (da) Probearrays og fremgangsmåder til at benytte probearrays til at skelne mellem DNA
NO875476D0 (no) Elektrokjemiluminiscente proever.
SE8604436L (sv) Hybridiseringsforfarande for detektion av polynukleotidsekvens
DE69530286D1 (de) Mit energieübertragungsvermittelnden verbindungen markierte proben
DE69825051D1 (de) Schwefel-überführungs-reagenz für oligonukleotid-synthese
ATE270298T1 (de) Reaktionssystem und verfahren zur verstärkung der lumineszenz von makrocyclischen lanthanid(iii)- komplexen
ATE207614T1 (de) Fluoreszenzkorrelationsspektroskopiemodul für ein mikroskop
ATE156592T1 (de) Verfahren zum nachweis von substanzen
CA2058771A1 (en) Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
ES2187800T3 (es) Reactivos formadores de complejos con compuestos boronicos y complejos correspondientes.
SE8801011D0 (sv) Time-resolved electroluminescence in solution
Rahe et al. Development of donor–acceptor modified DNA hairpins for the investigation of charge hopping kinetics in DNA
PT1119528E (pt) Construtor quimicos e seus usos
ATE338283T1 (de) Strahlungsidentifizierung mit hilfe eines proportionalgaszählers
DE60131176D1 (de) Fluoreszierende verbindungen
Thorpe et al. Radiative lifetime of the Te2 B0+ u and A0+ u states excited by a pulsed dye laser
여정아 et al. Interaction between Norfolxacin and Single Stranded DNA
BG28058A4 (bg) Метод за получаване на дибензо(в,d)пирани
IT1277836B1 (it) Alluminati di ittrio e/o terre rare a struttura perovskitica, loro preparazione e uso come pigmenti
Kazakov et al. Application of a synchronous integrator in phase fluorometry
FI906440A7 (fi) Anordning foer kontinuerlig avgjutning av smaelt metall till tunna remsor mellan tvao valsar.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 525181

Country of ref document: ES